ATE184646T1 - Kallus-zellen-induktion und herstellung von taxanen - Google Patents

Kallus-zellen-induktion und herstellung von taxanen

Info

Publication number: ATE184646T1
Authority: AT; Austria
Prior art keywords: taxanes; production; cell induction; callus cell; callus
Prior art date: 1992-04-07

Application number

AT93105668T

Other languages

English (en)

Inventor

Paul M Cino

Steven R Schwarz

Dana L Cazzulino

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-07

Filing date

1993-04-06

Publication date

1999-10-15

1993-04-06 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1999-10-15 Application granted granted Critical

1999-10-15 Publication of ATE184646T1 publication Critical patent/ATE184646T1/de

Links

206010020649 Hyperkeratosis Diseases 0.000 title abstract 3
229940123237 Taxane Drugs 0.000 title abstract 3
230000006698 induction Effects 0.000 title abstract 2
238000000034 method Methods 0.000 abstract 2
229930012538 Paclitaxel Natural products 0.000 abstract 1
238000004113 cell culture Methods 0.000 abstract 1
239000007788 liquid Substances 0.000 abstract 1
229960001592 paclitaxel Drugs 0.000 abstract 1
239000000725 suspension Substances 0.000 abstract 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/04—Plant cells or tissues
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Botany (AREA)
Cell Biology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Plant Substances (AREA)

AT93105668T 1992-04-07 1993-04-06 Kallus-zellen-induktion und herstellung von taxanen ATE184646T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US86482692A	1992-04-07	1992-04-07

Publications (1)

Publication Number	Publication Date
ATE184646T1 true ATE184646T1 (de)	1999-10-15

Family

ID=25344160

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93105668T ATE184646T1 (de)	1992-04-07	1993-04-06	Kallus-zellen-induktion und herstellung von taxanen

Country Status (9)

Country	Link
US (2)	US5527702A (de)
EP (1)	EP0568821B1 (de)
JP (1)	JP3228592B2 (de)
AT (1)	ATE184646T1 (de)
CA (2)	CA2434692A1 (de)
DE (1)	DE69326377T2 (de)
DK (1)	DK0568821T3 (de)
ES (1)	ES2136099T3 (de)
GR (1)	GR3032105T3 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7264951B1 (en)	1992-02-20	2007-09-04	Phyton, Inc.	Enhanced production of taxol and taxanes by cell cultures of Taxus species
CA2434692A1 (en) *	1992-04-07	1993-10-08	Paul M. Cino	Callus cell induction and the preparation of taxanes
AU3265195A (en) *	1994-08-26	1996-03-22	Institute Of Materia Medica Chinese Academy Of Medical Sciences	Novel taxol derivative
US20050158699A1 (en) *	1995-06-07	2005-07-21	Kadkade Prakash G.	Cryopreservation of plant cells
US5965438A (en) *	1995-06-07	1999-10-12	Phyton, Inc.	Cryopreservation of plant cells
DK0954596T3 (da)	1996-05-24	2006-05-15	Phyton Inc	Foröget produktion af taxaner ved celledyrkning af Taxus-art
JP4776843B2 (ja)	1999-10-01	2011-09-21	イムノゲンインコーポレーティッド	免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
US6452024B1 (en)	2000-02-22	2002-09-17	Chaichem Pharmaceuticals International	Process for extraction and purification of paclitaxel from natural sources
US6759539B1 (en)	2003-02-27	2004-07-06	Chaichem Pharmaceuticals International	Process for isolation and purification of paclitaxel from natural sources
DE602004026717D1 (de)	2003-05-23	2010-06-02	Fotofresh Ltd	Methoden zur änderung des gehalts an phytochechemischen verbindungen in pflanzenzellen umfassend die anwendung von licht der wellenlänge von 400-700 nm sowie dazugehörende apparat
EP1739184A1 (de) *	2005-06-28	2007-01-03	Centro Biotecnologie Avanzate	Verfahren zur Herstellung von Taxol und/oder Taxanen aus Haselnusszellkulturen
CN1932024B (zh) *	2006-09-15	2010-09-29	清华大学	紫杉醇的生物合成方法及其专用培养基
CN100427588C (zh) *	2006-09-15	2008-10-22	清华大学	紫杉细胞的培养方法及其专用培养基
JP4563493B2 (ja) *	2009-02-25	2010-10-13	タヒボジャパン株式会社	ナフトキノン系抗がん活性成分の効率的製造

Family Cites Families (28)

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US2747334A (en) *	1952-05-20	1956-05-29	Pfizer & Co C	Cultivation of plant tissue
GB1495709A (en) *	1974-01-28	1977-12-21	British Petroleum Co	Method and apparatus for growing plant cells
US4038778A (en) *	1976-09-27	1977-08-02	Gte Laboratories Incorporated	Tissue culture technique for asexual plant reproduction and a medium for use therewith
US4152214A (en) *	1977-10-07	1979-05-01	The United States Of America As Represented By The Secretary Of Agriculture	Production of homodeoxyharringtonine and other cephalotaxine esters by tissue culture
US4206221A (en)	1979-01-03	1980-06-03	The United States Of America As Represented By The Secretary Of Agriculture	Cephalomannine and its use in treating leukemic tumors
US4463522A (en) *	1979-07-26	1984-08-07	Eckhart Lindemann	System and apparatus for plant tissue culture propagation
US4501815A (en) *	1979-10-29	1985-02-26	Albert Einstein College Of Medicine Of Yeshiva University	Article for culturing differentiated cells
US4352887A (en) *	1979-10-29	1982-10-05	Albert Einstein College Of Medicine Of Yeshiva University	Method and article for culturing differentiated cells
DE3165272D1 (en) *	1980-11-06	1984-09-06	Albright & Wilson	Callus culture in nutrient flow
IL69333A (en) *	1983-07-26	1986-04-29	Biolog Ind	Process for plant tissue culture propagation
CH665217A5 (de) *	1985-02-15	1988-04-29	Agrogen Stiftung	Verfahren und vorrichtung zur in vitro kultur von pflanzenzellen, pflanzengeweben, pflanzenorganen, pflanzenteilen sowie zur mikropropagation und regeneration von ganzen pflanzen.
JPS61254127A (ja) *	1985-05-02	1986-11-11	三浦　喜温	ニチニチソウ器官培養によるインド−ルアルカロイドの製造方法
US4960703A (en) *	1986-04-23	1990-10-02	Personnalite Juridique De La Station Des Cultures Fruitieres Et Maraicheres	Composition for in vitro micropropagation of plants
CA1289902C (en) *	1987-05-15	1991-10-01	Jean Archambault	Surface immobilization of plant cells
US5019504A (en)	1989-03-23	1991-05-28	The United States Of America As Represented By The Secretary Of Agriculture	Production of taxol or taxol-like compounds in cell culture
WO1992013961A1 (en) *	1991-02-12	1992-08-20	Nippon Steel Corporation	Process for producing taxol by cell culture of taxus species
US5413928A (en) *	1991-06-21	1995-05-09	Worcester Polytechnic Institute	Process for extracting enhanced amounts of plant secondary metabolites with limited loss of plant viability
KR930702323A (ko) *	1991-07-17	1993-09-08	하지메 나까가와	항종양 활성을 가진 화합물(nsc-lsc1) 및 그의 제조방법
US5344775A (en) *	1991-11-15	1994-09-06	Escagenetics Corporation	Synthesis of taxanes in culture using pseudocalluscells
IT1258838B (it) *	1992-01-31	1996-02-29	Indena Spa	Processo per l'estrazione di tassolo e derivati da cultivar del genere taxus
US5407816A (en) *	1992-02-20	1995-04-18	Phyton Catalytic, Inc.	Enhanced production of taxol and taxanes by cell cultures of taxus species
JPH05244971A (ja) *	1992-03-06	1993-09-24	Nippon Oil Co Ltd	タキサン類化合物の製造方法
CA2131532A1 (en) *	1992-04-01	1993-10-14	Steven R. Wann	Induction of somatic embryogenesis in taxus, and the production of taxane-ring containing alkaloids therefrom
CA2434692A1 (en) *	1992-04-07	1993-10-08	Paul M. Cino	Callus cell induction and the preparation of taxanes
US5322779A (en) *	1992-04-16	1994-06-21	The Research And Development Institute, Inc. At Montana State University	Taxol production by taxomyces andreanae
AU4242993A (en) *	1992-05-21	1993-12-13	Penn State Research Foundation, The	Cultured (taxus) tissues as a source of taxol, related taxanes and other novel anti-tumor/anti-viral compounds
CA2069122A1 (en) *	1992-05-21	1993-11-22	Richard N. Arteca	Methods and compositions for the production of taxol, taxol precursors and derivatives of taxol from plant tissue culture
JP2967532B2 (ja) *	1992-06-11	1999-10-25	日石三菱株式会社	タキサン類化合物の製造方法

1993
- 1993-03-29 CA CA002434692A patent/CA2434692A1/en not_active Abandoned
- 1993-03-29 CA CA002092849A patent/CA2092849C/en not_active Expired - Fee Related
- 1993-04-06 DK DK93105668T patent/DK0568821T3/da active
- 1993-04-06 AT AT93105668T patent/ATE184646T1/de not_active IP Right Cessation
- 1993-04-06 EP EP93105668A patent/EP0568821B1/de not_active Expired - Lifetime
- 1993-04-06 ES ES93105668T patent/ES2136099T3/es not_active Expired - Lifetime
- 1993-04-06 DE DE69326377T patent/DE69326377T2/de not_active Expired - Fee Related
- 1993-04-07 JP JP08051193A patent/JP3228592B2/ja not_active Expired - Fee Related
1994
- 1994-02-23 US US08/202,718 patent/US5527702A/en not_active Expired - Fee Related
1995
- 1995-06-07 US US08/476,286 patent/US5665576A/en not_active Expired - Fee Related
1999
- 1999-12-13 GR GR990403196T patent/GR3032105T3/el unknown

Also Published As

Publication number	Publication date
CA2092849A1 (en)	1993-10-08
US5665576A (en)	1997-09-09
DE69326377T2 (de)	2000-05-11
ES2136099T3 (es)	1999-11-16
GR3032105T3 (en)	2000-03-31
EP0568821A1 (de)	1993-11-10
JPH0678758A (ja)	1994-03-22
CA2434692A1 (en)	1993-10-08
DE69326377D1 (de)	1999-10-21
CA2092849C (en)	2003-11-18
DK0568821T3 (da)	2000-03-06
EP0568821B1 (de)	1999-09-15
JP3228592B2 (ja)	2001-11-12
US5527702A (en)	1996-06-18

Legal Events

Date	Code	Title	Description
2000-03-15	UEP	Publication of translation of european patent specification
2008-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69333358D1 (de)	2004-01-22	Erhöhte Produktion von Taxol und Taxanen mittels Taxus-Spezies-Zellkulturen
DE69326377D1 (de)	1999-10-21	Kallus-Zellen-Induktion und Herstellung von Taxanen
BR9204506A (pt)	1993-06-01	Dispositivo de cultura para producao por fermentacao por meio de cultura aerobica,e,processo anti-espumacao e de controle das espumas na producao por fermentacao por meio de cultura aerobica
DE69426692D1 (de)	2001-03-22	Methode zur herstellung von taxan-diterpen und methode zum einten von kulturzellen, die taxan-diterpen in hohen ausbeuten herstellen
CA2058930A1 (en)	1990-12-15	Media for cell growth and method for making them
EP0145197A3 (en)	1987-06-16	Method of culturing freeze-dried microorganisms
WO1998036636A3 (en)	1998-12-03	Method for generating embryogenic cell cultures for the production of bananas (musa spp.)
EP1227155A4 (de)	2004-07-28	Verfahren zur herstellung von ubiquinon-10
ATE449162T1 (de)	2009-12-15	Herstellung von tcr gamma delta t-zellen
AU5391886A (en)	1986-09-10	Method and device for the in vitro culture of plant cells and organs, as well as for the micropropagation and regeneration of complete plants
EP1127104A4 (de)	2005-04-27	Methoden zur massenkultivierung von zellen die rekombinantes menschliches erythropoietin produzieren
AU631651B2 (en)	1992-12-03	Method for culturing cells
ATE96843T1 (de)	1993-11-15	Verfahren zur herstellung von mikrobieller cellulose.
DE3854472D1 (de)	1995-10-19	Erhaltung der Viabilität von Mikroorganismen zur Anwendung in mikrobiellen Inokulantien.
DE69006512D1 (de)	1994-03-17	Epoxygruppen enthaltende thiuram-disulfide, ihre herstellung und ihre verwendung in der polymerisation.
DE3671603D1 (de)	1990-07-05	Verfahren zur zucht von babesia canis, verwendung zur herstellung von antigenen und impfstoffen und antigene und impfstoffe gegen piroplasmose.
DE3868104D1 (de)	1992-03-12	Reaktivfarbstoffe, deren herstellung und verwendung.
ATE118780T1 (de)	1995-03-15	Antibiotika und verfahren zu deren herstellung.
DE3872161D1 (de)	1992-07-23	Reaktivfarbstoffe, deren herstellung und verwendung.
DE69419592D1 (de)	1999-08-26	Verfahren zur Herstellung von Pilocarpin
DE3865033D1 (de)	1991-10-31	Reaktivfarbstoffe, deren herstellung und verwendung.
IT8022418A0 (it)	1980-05-30	Digestore anaerobico discontinuo per la produzione di biogas erelativo procedimento produttivo.
ATE103634T1 (de)	1994-04-15	Landwirtschaftchemikalien erzeugende endosymbiotische mikroorganismen und deren herstellung und verwendung.