|
US6849708B1
(en)
|
1986-05-05 |
2005-02-01 |
The General Hospital Corporation |
Insulinotropic hormone and uses thereof
|
|
US5614492A
(en)
*
|
1986-05-05 |
1997-03-25 |
The General Hospital Corporation |
Insulinotropic hormone GLP-1 (7-36) and uses thereof
|
|
US7138486B2
(en)
|
1986-05-05 |
2006-11-21 |
The General Hospital Corporation |
Insulinotropic hormone derivatives and uses thereof
|
|
US5846747A
(en)
*
|
1992-03-25 |
1998-12-08 |
Novo Nordisk A/S |
Method for detecting glucagon-like peptide-1 antagonists and agonists
|
|
DK39892D0
(da)
*
|
1992-03-25 |
1992-03-25 |
Bernard Thorens |
Peptid
|
|
EP0969016A2
(de)
*
|
1992-06-15 |
2000-01-05 |
Scios Inc. |
Dem Glukagon ähnliche Peptide und Insulinotropin-Derivate
|
|
HU219674B
(hu)
*
|
1992-08-28 |
2001-06-28 |
Novo Nordisk A/S |
Glukagon-receptort kódoló DNS-molekulák, glukagon-receptor peptidek, glukagon-receptort blokkoló monoklonális ellenanyagok, és eljárások előállításukra
|
|
US6284727B1
(en)
|
1993-04-07 |
2001-09-04 |
Scios, Inc. |
Prolonged delivery of peptides
|
|
WO1995004821A1
(en)
*
|
1993-08-09 |
1995-02-16 |
Merck & Co., Inc. |
Human glucagon-like 1 peptide receptor
|
|
GB9502830D0
(en)
*
|
1995-02-14 |
1995-04-05 |
Ecole Polytech |
Regulation of polypeptide production in cells
|
|
US7048906B2
(en)
|
1995-05-17 |
2006-05-23 |
Cedars-Sinai Medical Center |
Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
|
|
DE69737561T2
(de)
*
|
1996-12-13 |
2008-03-06 |
Nps Allelix Corp., Toronto |
Klonierte rezeptoren des glukagon-ähnlichen peptids-2
|
|
US8592553B2
(en)
|
1996-12-13 |
2013-11-26 |
Nps Pharmaceuticals, Inc. |
Cloned glucagon-like peptide-2 receptors
|
|
ATE251465T1
(de)
|
1998-07-31 |
2003-10-15 |
Novo Nordisk As |
In-vitro stimulation von beta zellen vermehrung
|
|
JP2002528721A
(ja)
*
|
1998-10-23 |
2002-09-03 |
グラクソ グループ リミテッド |
核内受容体のリガンド用のアッセイ
|
|
ES2253353T3
(es)
|
2000-03-08 |
2006-06-01 |
Novo Nordisk A/S |
Reduccion del colesterol serico.
|
|
US6448045B1
(en)
|
2000-03-10 |
2002-09-10 |
The Regents Of The University Of California |
Inducing insulin gene expression in pancreas cells expressing recombinant PDX-1
|
|
US20020123071A1
(en)
*
|
2000-12-04 |
2002-09-05 |
Knudsen Sanne Moller |
Method of identifying compounds capable of acting as agonists or antagonists of G-protein coupled receptors
|
|
US6642003B2
(en)
|
2001-08-02 |
2003-11-04 |
Cedars-Sinai Medical Center |
Human glucose-dependent insulin-secreting cell line
|
|
CN100350968C
(zh)
|
2001-09-24 |
2007-11-28 |
皇家创新有限公司 |
饮食行为的改进
|
|
US6911324B2
(en)
*
|
2001-10-18 |
2005-06-28 |
The Regents Of The University Of California |
Induction of beta cell differentiation in human cells
|
|
EP1474163A2
(de)
|
2002-01-10 |
2004-11-10 |
Imperial College Innovations Limited |
Veränderung des fütterungsverhaltens
|
|
US7141240B2
(en)
*
|
2002-03-12 |
2006-11-28 |
Cedars-Sinai Medical Center |
Glucose-dependent insulin-secreting cells transfected with a nucleotide sequence encoding GLP-1
|
|
WO2004005342A1
(en)
|
2002-07-04 |
2004-01-15 |
Zealand Pharma A/S |
Glp-1 and methods for treating diabetes
|
|
BR0314996A
(pt)
*
|
2002-10-02 |
2005-08-09 |
Zealand Pharma As |
Composição, composição farmaceuticamente aceitável, método para produzir a composição, métodos para estabilizar a exendina-4 (1-39) ou uma sua variante, derivado ou análogo contra a degradação, antes, durante ou após o uso pretendido, para tratar doenças, para tratar de estados de doenças associados com nìveis elevados de glicose do sangue, para a regulação dos nìveis de glicose do sangue, para a regulação do esvaziamento gástrico, para estimular a liberação de insulina em um mamìfero para reduzir o nìvel de glicose do sangue em um mamìfero, para reduzir o nìvel de lipìdeos plasmáticos em um mamìfero, para reduzir a mortalidade e a morbidez após o infarto miocárdico em um mamìfero, para estimular a liberação de insulina em um mamìfero, e para produzir uma exendina (1-39) estabilizada, e, exendina (1-39) estabilizada
|
|
US20040209803A1
(en)
*
|
2002-12-19 |
2004-10-21 |
Alain Baron |
Compositions for the treatment and prevention of nephropathy
|
|
US7790681B2
(en)
*
|
2002-12-17 |
2010-09-07 |
Amylin Pharmaceuticals, Inc. |
Treatment of cardiac arrhythmias with GLP-1 receptor ligands
|
|
GB0300571D0
(en)
|
2003-01-10 |
2003-02-12 |
Imp College Innovations Ltd |
Modification of feeding behaviour
|
|
WO2004071393A2
(en)
*
|
2003-02-13 |
2004-08-26 |
Bayer Healthcare Ag |
Diagnostics and therapeutics for diseases associated with glucagon-like peptide 1 receptor (glp1r)
|
|
WO2005018536A2
(en)
*
|
2003-05-23 |
2005-03-03 |
Human Genome Sciences, Inc. |
Agonist antibodies that specifically bind the glucagon like peptide-1 receptor
|
|
DK3300721T4
(da)
|
2003-11-20 |
2025-03-03 |
Novo Nordisk As |
Propylenglycol-holdige peptidformuleringer hvilke er optimale til fremstilling og til anvendelse i injektionsindretninger
|
|
EP2298337B1
(de)
|
2003-12-09 |
2017-02-22 |
Novo Nordisk A/S |
Regulierung des bevorzuchtes nahrungsaufnahmen mit verwendung von GLP-1 agonisten
|
|
EP1758575A1
(de)
|
2004-06-11 |
2007-03-07 |
Novo Nordisk A/S |
Bekämpfung von arzneimittel-induzierter fettleibigkeit unter verwendung von glp-1-agonisten
|
|
WO2006133333A2
(en)
|
2005-06-07 |
2006-12-14 |
The Rockefeller University |
Stimulation of pancreatic b cell proliferation
|
|
TWI428346B
(zh)
|
2006-12-13 |
2014-03-01 |
Imp Innovations Ltd |
新穎化合物及其等對進食行為影響
|
|
US8718994B2
(en)
*
|
2008-04-09 |
2014-05-06 |
Transtech Pharma, Llc |
Ligands for the GLP-1 receptor and methods for discovery thereof
|
|
RS59913B1
(sr)
|
2008-10-17 |
2020-03-31 |
Sanofi Aventis Deutschland |
Kombinacija insulina i glp-1-agonista
|
|
CN102596175A
(zh)
|
2009-07-06 |
2012-07-18 |
赛诺菲-安万特德国有限公司 |
含有甲硫氨酸的水性胰岛素制备物
|
|
PT3345593T
(pt)
|
2009-11-13 |
2023-11-27 |
Sanofi Aventis Deutschland |
Composição farmacêutica compreendendo despro36exendina- 4(1-39)-lys6-nh2 e metionina
|
|
MY180661A
(en)
|
2009-11-13 |
2020-12-04 |
Sanofi Aventis Deutschland |
Pharmaceutical composition comprising a glp-1 agonist, an insulin and methionine
|
|
WO2011123943A1
(en)
|
2010-04-09 |
2011-10-13 |
Mount Sinai Hospital |
Methods for treating disorders of the gastrointestinal tract using a glp-1 agonist
|
|
CN107129538B
(zh)
|
2010-04-27 |
2021-07-16 |
西兰制药公司 |
Glp-1受体激动剂和胃泌素的肽缀合物及其用途
|
|
PL2611458T3
(pl)
|
2010-08-30 |
2017-02-28 |
Sanofi-Aventis Deutschland Gmbh |
Zastosowanie AVE0010 do produkcji leku do leczenia cukrzycy typu 2
|
|
SI2651398T1
(en)
|
2010-12-16 |
2018-04-30 |
Novo Nordisk A/S |
SOLID COMPOSITIONS CONTAINING GLP-1 AGONIST AND SOL N- (8- (2-HYDROXYBENZOIL) AMINO) CAPRICULATE ACIDS
|
|
US9821032B2
(en)
|
2011-05-13 |
2017-11-21 |
Sanofi-Aventis Deutschland Gmbh |
Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
|
|
AR087693A1
(es)
|
2011-08-29 |
2014-04-09 |
Sanofi Aventis Deutschland |
Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2
|
|
TWI559929B
(en)
|
2011-09-01 |
2016-12-01 |
Sanofi Aventis Deutschland |
Pharmaceutical composition for use in the treatment of a neurodegenerative disease
|
|
TW201326194A
(zh)
|
2011-11-03 |
2013-07-01 |
Zealand Pharma As |
Glp-1胃泌素受體促效劑肽結合物
|
|
EP2788027A2
(de)
|
2011-12-09 |
2014-10-15 |
Novo Nordisk A/S |
Glp-1-agonisten
|
|
HRP20181447T1
(hr)
|
2012-03-22 |
2018-11-02 |
Novo Nordisk A/S |
Pripravci glp-1 peptida i njihova priprava
|
|
ES2965469T3
(es)
|
2012-03-22 |
2024-04-15 |
Novo Nordisk As |
Composiciones que comprenden un agente de suministro y preparación de estas
|
|
EP2866825B1
(de)
|
2012-07-01 |
2020-04-08 |
Novo Nordisk A/S |
Verwendung von glp-1-peptiden mit langzeitwirkung
|
|
IN2015DN00544A
(de)
|
2012-07-23 |
2015-06-26 |
Zealand Pharma As |
|
|
TWI608013B
(zh)
|
2012-09-17 |
2017-12-11 |
西蘭製藥公司 |
升糖素類似物
|
|
WO2014060472A1
(en)
|
2012-10-17 |
2014-04-24 |
Novo Nordisk A/S |
Fatty acid acylated amino acids for oral peptide delivery
|
|
TWI780236B
(zh)
|
2013-02-04 |
2022-10-11 |
法商賽諾菲公司 |
胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
|
|
US9988429B2
(en)
|
2013-10-17 |
2018-06-05 |
Zealand Pharma A/S |
Glucagon analogues
|
|
PL3057984T3
(pl)
|
2013-10-17 |
2018-12-31 |
Zealand Pharma A/S |
Acylowane analogi glukagonu
|
|
WO2015067715A2
(en)
|
2013-11-06 |
2015-05-14 |
Zealand Pharma A/S |
Gip-glp-1 dual agonist compounds and methods
|
|
CN105829339B
(zh)
|
2013-11-06 |
2021-03-12 |
西兰制药公司 |
胰高血糖素-glp-1-gip三重激动剂化合物
|
|
BR112016015851A2
(pt)
|
2014-01-09 |
2017-08-08 |
Sanofi Sa |
Formulações farmacêuticas estabilizadas de insulina aspart
|
|
MX2016008979A
(es)
|
2014-01-09 |
2016-10-04 |
Sanofi Sa |
Formulaciones farmaceuticas estabilizadas de analogos de insulina y/o derivados de insulina.
|
|
MX2016008978A
(es)
|
2014-01-09 |
2016-10-04 |
Sanofi Sa |
Formulaciones farmaceuticas de analogos de insulina y/o derivados de insulina estabilizadas y que estan libres de glicerol.
|
|
ES2630106T3
(es)
|
2014-10-07 |
2017-08-18 |
Cyprumed Gmbh |
Formulaciones farmacéuticas para la administración oral de fármacos peptídicos o proteicos
|
|
KR102620911B1
(ko)
|
2014-10-29 |
2024-01-05 |
질랜드 파마 에이/에스 |
Gip 효능제 화합물 및 방법
|
|
EP3229828B1
(de)
|
2014-12-12 |
2023-04-05 |
Sanofi-Aventis Deutschland GmbH |
Insulin-glargin/lixisenatid-fixierte verhältnisformulierung
|
|
TWI748945B
(zh)
|
2015-03-13 |
2021-12-11 |
德商賽諾菲阿凡提斯德意志有限公司 |
第2型糖尿病病患治療
|
|
TW201705975A
(zh)
|
2015-03-18 |
2017-02-16 |
賽諾菲阿凡提斯德意志有限公司 |
第2型糖尿病病患之治療
|
|
DK3283507T3
(da)
|
2015-04-16 |
2020-01-02 |
Zealand Pharma As |
Acyleret glucagonanalog
|
|
JP2018529749A
(ja)
|
2015-10-07 |
2018-10-11 |
シプルメット・ゲーエムベーハー |
ペプチド薬物を経口送達するための医薬製剤
|
|
WO2018065634A1
(en)
|
2016-10-07 |
2018-04-12 |
Cyprumed Gmbh |
Pharmaceutical compositions for the nasal delivery of peptide or protein drugs
|
|
EP3551651B1
(de)
|
2016-12-09 |
2024-03-06 |
Zealand Pharma A/S |
Acylierte glp-1/glp-2 duale agoniste
|
|
KR102665710B1
(ko)
|
2017-08-24 |
2024-05-14 |
노보 노르디스크 에이/에스 |
Glp-1 조성물 및 그 용도
|
|
JP6898518B2
(ja)
|
2018-02-02 |
2021-07-07 |
ノヴォ ノルディスク アー/エス |
Glp−1アゴニスト、n−(8−(2−ヒドロキシベンゾイル)アミノ)カプリル酸の塩及び滑沢剤を含む固形組成物
|
|
WO2019193204A1
(en)
|
2018-04-06 |
2019-10-10 |
Cyprumed Gmbh |
Pharmaceutical compositions for the transmucosal delivery of therapeutic peptides and proteins
|
|
TWI829687B
(zh)
|
2018-05-07 |
2024-01-21 |
丹麥商諾佛 儂迪克股份有限公司 |
包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物
|
|
CN111423506B
(zh)
*
|
2019-11-08 |
2023-06-27 |
成都奥达生物科技有限公司 |
一种glp-1化合物
|
|
JP7761567B2
(ja)
|
2020-02-18 |
2025-10-28 |
ノヴォ ノルディスク アー/エス |
医薬製剤
|
|
US11478533B2
(en)
|
2020-04-27 |
2022-10-25 |
Novo Nordisk A/S |
Semaglutide for use in medicine
|
|
CN115461044B
(zh)
|
2020-04-29 |
2025-06-10 |
诺和诺德股份有限公司 |
包含glp-1激动剂和组氨酸的固体组合物
|
|
EP4210680A1
(de)
|
2020-09-07 |
2023-07-19 |
Cyprumed GmbH |
Verbesserte pharmazeutische formulierungen von glp-1-rezeptoragonisten
|
|
WO2023012263A1
(en)
|
2021-08-04 |
2023-02-09 |
Novo Nordisk A/S |
Solid oral peptide formulations
|
|
JP2026502943A
(ja)
|
2022-12-30 |
2026-01-27 |
アルギファルマ エーエス |
経口投与されるポリペプチド治療剤の全身バイオアベイラビリティを高める組成物および方法
|
|
WO2024165571A2
(en)
|
2023-02-06 |
2024-08-15 |
E-Therapeutics Plc |
Inhibitors of expression and/or function
|
|
WO2025125576A2
(en)
|
2023-12-15 |
2025-06-19 |
E-Therapeutics Plc |
Inhibitors of expression and/or function
|
|
EP4686757A1
(de)
|
2024-07-31 |
2026-02-04 |
e-therapeutics PLC |
Inhibitoren der expression und/oder funktion
|
|
WO2025133348A1
(en)
|
2023-12-22 |
2025-06-26 |
E-Therapeutics Plc |
Inhibitors of expression and/or function
|
|
WO2025196502A1
(en)
|
2024-03-20 |
2025-09-25 |
North Carolina Agricultural & Technical State University |
Choline kinase inhibitors as a therapeutic treatment for obesity
|
|
DK182293B1
(en)
|
2025-01-16 |
2026-02-25 |
Novo Nordisk As |
Semaglutide for use in medical therapy including weight management
|