ATE184702T1 - Hochleistungsflüssigchromatographieverfahren und vorrichtung - Google Patents
Hochleistungsflüssigchromatographieverfahren und vorrichtungInfo
- Publication number
- ATE184702T1 ATE184702T1 AT97904852T AT97904852T ATE184702T1 AT E184702 T1 ATE184702 T1 AT E184702T1 AT 97904852 T AT97904852 T AT 97904852T AT 97904852 T AT97904852 T AT 97904852T AT E184702 T1 ATE184702 T1 AT E184702T1
- Authority
- AT
- Austria
- Prior art keywords
- column
- fluids
- eluant
- injections
- entrance
- Prior art date
Links
- 238000004128 high performance liquid chromatography Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000012530 fluid Substances 0.000 abstract 7
- 239000007924 injection Substances 0.000 abstract 3
- 238000002347 injection Methods 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
- B01D15/163—Pressure or speed conditioning
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
- B01D15/203—Equilibration or regeneration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
- G01N2030/324—Control of physical parameters of the fluid carrier of pressure or speed speed, flow rate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N2030/387—Turbulent flow of mobile phase
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58887496A | 1996-01-19 | 1996-01-19 | |
| US2721696P | 1996-09-30 | 1996-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE184702T1 true ATE184702T1 (de) | 1999-10-15 |
Family
ID=26702215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97904852T ATE184702T1 (de) | 1996-01-19 | 1997-01-21 | Hochleistungsflüssigchromatographieverfahren und vorrichtung |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US5795469A (de) |
| EP (1) | EP0840893B1 (de) |
| JP (1) | JP3452936B2 (de) |
| AT (1) | ATE184702T1 (de) |
| AU (1) | AU712735B2 (de) |
| CA (1) | CA2242885C (de) |
| DE (1) | DE69700523T2 (de) |
| DK (1) | DK0840893T3 (de) |
| ES (1) | ES2140209T3 (de) |
| NZ (1) | NZ330867A (de) |
| PL (1) | PL327920A1 (de) |
| WO (1) | WO1997026532A1 (de) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6423233B1 (en) * | 2000-08-15 | 2002-07-23 | Biogal Gyogyszergyar Rt. | Purification process |
| US6110362A (en) * | 1997-11-19 | 2000-08-29 | Cohesive Technologies, Inc. | Chemical analysis |
| US6406632B1 (en) | 1998-04-03 | 2002-06-18 | Symyx Technologies, Inc. | Rapid characterization of polymers |
| US6416663B1 (en) | 1998-04-03 | 2002-07-09 | Symyx Technologies, Inc. | Chromatographic column for rapid characterizations of polymers |
| US6866786B2 (en) * | 1998-04-03 | 2005-03-15 | Symyx Technologies, Inc. | Rapid characterization of polymers |
| JP4067685B2 (ja) * | 1999-03-26 | 2008-03-26 | 山善株式会社 | インジェクション装置 |
| US6855258B2 (en) * | 1999-04-02 | 2005-02-15 | Symyx Technologies, Inc. | Methods for characterization of polymers using multi-dimensional liquid chromatography with parallel second-dimension sampling |
| US6190550B1 (en) * | 1999-09-30 | 2001-02-20 | Cohesive Technologies, Inc. | Monitoring high performance liquid chromatography |
| US6299767B1 (en) | 1999-10-29 | 2001-10-09 | Waters Investments Limited | High pressure capillary liquid chromatography solvent delivery system |
| US6460420B1 (en) * | 2000-04-13 | 2002-10-08 | Sandia National Laboratories | Flowmeter for pressure-driven chromatography systems |
| EP1352235B1 (de) * | 2000-11-21 | 2013-05-08 | Waters Technologies Corporation | Schema zur verdünnung der mobilen phase für verbesserte chromatographie |
| US6635173B2 (en) * | 2000-12-28 | 2003-10-21 | Cohesive Technologies, Inc. | Multi column chromatography system |
| US6730228B2 (en) * | 2001-08-28 | 2004-05-04 | Symyx Technologies, Inc. | Methods and apparatus for characterization of polymers using multi-dimensional liquid chromatography with regular second-dimension sampling |
| US6780315B2 (en) | 2002-12-09 | 2004-08-24 | Waters Investments Limited | Backflow prevention for high pressure gradient systems |
| JP3823092B2 (ja) * | 2003-03-11 | 2006-09-20 | 株式会社日立ハイテクノロジーズ | 分離分析装置 |
| US6977143B1 (en) | 2003-09-08 | 2005-12-20 | Quest Diagnostics Investments Incorporated | Determination of testosterone by mass spectrometry |
| JP4377761B2 (ja) * | 2004-07-01 | 2009-12-02 | 株式会社日立ハイテクノロジーズ | 液体クロマトグラフ装置 |
| JP4399304B2 (ja) * | 2004-03-29 | 2010-01-13 | 富士フイルム株式会社 | 自動核酸分離精製方法およびその装置 |
| US20060169640A1 (en) * | 2005-02-01 | 2006-08-03 | Hubert Quinn | High throughput screening, purification and recovery system for large and small molecules |
| US7745226B2 (en) | 2005-04-06 | 2010-06-29 | Quest Diagnostics Investments Incorporated | Methods for detecting vitamin D metabolites |
| US7972867B2 (en) | 2005-04-06 | 2011-07-05 | Quest Diagnostics Investments Incorporated | Methods for detecting vitamin D metabolites by mass spectrometry |
| CA2820957A1 (en) * | 2006-05-26 | 2007-12-06 | Laboratory Corporation Of America Holdings | Liquid chromatography with tandem mass spectrometry of estrone, estradiol and free thyroxine |
| US8877051B2 (en) * | 2006-07-21 | 2014-11-04 | Waters Technologies Corporation | Time delay for sample collection in chromatography systems |
| US8017015B2 (en) | 2006-10-20 | 2011-09-13 | Quest Diagnostics Investments Incorporated | Monolithic column chromatography |
| WO2008150488A1 (en) * | 2007-06-01 | 2008-12-11 | Laboratory Corporation Of America Holdings | Methods and systems for quantification of peptides and other analytes |
| US8017403B2 (en) | 2007-06-14 | 2011-09-13 | Quest Diagnostics Investments Incorporated | Mass spectrometry method for measuring vitamin B6 in body fluid |
| US20090134325A1 (en) * | 2007-11-27 | 2009-05-28 | Goldman Mildred M | Methods for detecting estradiol by mass spectrometry |
| US7972868B2 (en) * | 2007-11-28 | 2011-07-05 | Quest Diagnostics Investments Incorporated | Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry |
| US8916385B2 (en) * | 2007-12-13 | 2014-12-23 | Quest Diagnostics Investments, Inc. | Methods for detecting estrone by mass spectrometry |
| TW200933195A (en) * | 2008-01-28 | 2009-08-01 | Ind Tech Res Inst | Autostereoscopic display |
| US7834313B2 (en) | 2008-08-08 | 2010-11-16 | Quest Diagnostics Investments Incorporated | Mass spectrometry assay for plasma-renin |
| US7893399B2 (en) * | 2008-09-09 | 2011-02-22 | Quest Diagnostics Investments Incorporated | Methods for detecting dehydroepiandrosterone by mass spectrometry |
| US7804063B2 (en) * | 2008-10-06 | 2010-09-28 | Quest Diagnostics Investments Incorporated | Methods for detecting dihydrotestosterone by mass spectrometry |
| US7952067B2 (en) * | 2008-10-06 | 2011-05-31 | Quest Diagnostics Investments Incorporated | Methods for detecting vitamin C by mass spectrometry |
| US8039794B2 (en) | 2008-12-16 | 2011-10-18 | Quest Diagnostics Investments Incorporated | Mass spectrometry assay for thiopurine-S-methyl transferase activity and products generated thereby |
| US7952068B2 (en) | 2008-12-16 | 2011-05-31 | Quest Diagnostics Investments Incorporated | Methods for detecting catecholamines by mass spectrometry |
| US8399829B2 (en) | 2008-12-18 | 2013-03-19 | Quest Diagnostics Investments Incorporated | Vitamin B2 detection by mass spectrometry |
| WO2010075175A1 (en) | 2008-12-23 | 2010-07-01 | Quest Diagnostics Investments Incorporated | Mass spectrometry assay for estrogenic compounds |
| EP2384437B1 (de) | 2008-12-24 | 2018-12-12 | Quest Diagnostics Investments Incorporated | Massenspektrometrisches testverfahren für pregnenolon und 17-hydroxypregnenolon |
| CN102596230B (zh) | 2009-11-05 | 2015-08-05 | 奎斯特诊断投资公司 | 用高分辨率质谱法量化胰岛素样生长因子-i和胰岛素样生长因子-ii |
| US7977117B2 (en) | 2009-12-03 | 2011-07-12 | Quest Diagnostics Investments Incorprated | Vitamin D metabolite determination utilizing mass spectrometry following derivatization |
| US8034627B2 (en) | 2009-12-03 | 2011-10-11 | Quest Diagnostics Investments Incorporated | Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry |
| US20120025067A1 (en) | 2009-12-11 | 2012-02-02 | Quest Diagnostics Investments Incorporated | Mass spectrometric determination of non-derivatized, non-metabolized vitamin d |
| EP4711765A2 (de) | 2009-12-11 | 2026-03-18 | Quest Diagnostics Investments Incorporated | Massenspektrometrie steroidaler verbindungen in multiplexproben |
| WO2011084751A1 (en) | 2009-12-21 | 2011-07-14 | Quest Diagnostics Investments Incorporated | Glucagon detection and quantitation by mass spectrometry |
| US10837972B2 (en) | 2010-06-09 | 2020-11-17 | Quest Diagnostics Investments Incorporated | Mass spectrometric determination of derivatized methylmalonic acid |
| US10215765B2 (en) | 2010-09-15 | 2019-02-26 | Quest Diagnostics Investments Incorporated | Detection of vitamins A and E by tandem mass spectrometry |
| WO2012037365A1 (en) | 2010-09-16 | 2012-03-22 | Quest Diagnostics Investments Incorporated | Mass spectrometric determination of eicosapentaenoic acid and docosahexaenoic acid |
| WO2012058614A1 (en) | 2010-10-29 | 2012-05-03 | Cohesive Technologies Inc. | Lc-ms separation and detection of vitamin d metabolites |
| US9625429B2 (en) | 2010-10-29 | 2017-04-18 | Cohesive Technologies Inc. | LC-MS configuration for purification and detection of analytes having a broad range of hydrophobicites |
| US9012835B2 (en) | 2010-11-08 | 2015-04-21 | Georgetown University | Methods for simultaneous quantification of thyroid hormones and metabolites thereof by mass spectrometry |
| CA2823324C (en) | 2010-12-28 | 2019-12-31 | Quest Diagnostics Investments Incorporated | Quantitation of insulin by mass spectrometry |
| US9177766B2 (en) | 2010-12-30 | 2015-11-03 | Quest Diagnostics Investments Incorporated | Mass spectrometric quantitation assay for metabolites of leflunomide |
| US8728824B2 (en) | 2011-06-22 | 2014-05-20 | Quest Diagnostics Investments Inc. | Mass spectrometric determination of fatty acids |
| JP6444736B2 (ja) | 2011-11-23 | 2018-12-26 | クエスト ダイアグノスティックス インヴェストメンツ インコーポレイテッド | タンデム質量分析によるキスペプチン−５４の検出 |
| US8669519B2 (en) | 2011-12-05 | 2014-03-11 | Quest Diagnostics Investments, Inc. | Methods for detecting reverse triiodothyronine by mass spectrometry |
| US8779355B2 (en) | 2011-12-28 | 2014-07-15 | Quest Diagnostics Investments, Inc. | Methods for detecting lacosamide by mass spectrometry |
| EP2680005A1 (de) | 2012-06-28 | 2014-01-01 | Rheinische Friedrich-Wilhelms-Universität Bonn | Lipidanalyse |
| US9594074B2 (en) | 2012-12-26 | 2017-03-14 | Quest Diagnostics Investments Incorporated | C peptide detection by mass spectrometry |
| US9966243B2 (en) | 2013-01-29 | 2018-05-08 | Georgetown University | Apparatus and methods for plasma-assisted reaction chemical ionization (PARCI) mass spectrometry |
| CN105431853B (zh) | 2013-05-23 | 2018-12-28 | 艾弗诺泰普有限责任公司 | 表型整合的社会研究数据库和方法 |
| EP3097414A4 (de) * | 2014-01-24 | 2017-10-11 | DH Technologies Development PTE. Ltd. | Systeme und verfahren zur zufuhr einer flüssigkeit zu einer ionenquelle |
| CN121016264A (zh) | 2014-05-30 | 2025-11-28 | 帝肯样品制备股份有限公司 | 分析物的提取、衍生化和定量 |
| US10324082B2 (en) | 2015-03-03 | 2019-06-18 | Quest Diagnostics Investments Llc | Methods for quantitation of insulin levels by mass spectrometry |
| EP3118619A1 (de) | 2015-07-14 | 2017-01-18 | Vrije Universiteit Brussel | Hochleistungsflüssigkeitschromatografie |
| US11360098B2 (en) | 2015-09-28 | 2022-06-14 | Quest Diagnostics Investments Llc | Amyloid beta detection by mass spectrometry |
| US10564062B2 (en) * | 2016-10-19 | 2020-02-18 | Honeywell International Inc. | Human-machine interface for gas valve |
| CN118883748A (zh) | 2017-03-31 | 2024-11-01 | 奎斯特诊断投资有限公司 | 用于定量胰岛素和c-肽的方法 |
| WO2019028080A1 (en) | 2017-07-31 | 2019-02-07 | Quest Diagnostics Investments Llc | DETECTION OF THE ISOTYPE OF APOLIPOPROTEIN E BY MASS SPECTROMETRY |
| US11860141B2 (en) | 2017-08-14 | 2024-01-02 | Quest Diagnostics Investments Llc | Detection and quantitation of guanidinoacetate, creatine, and creatinine by mass spectrometry |
| GB201802123D0 (en) | 2018-02-09 | 2018-03-28 | Metabolomic Diagnostics Ltd | A method of processomg a biological sample |
| JP7273865B2 (ja) | 2018-03-16 | 2023-05-15 | クエスト ダイアグノスティックス インヴェストメンツ エルエルシー | マススペクトロメトリーによるクロモグラニンａの検出方法 |
| WO2019217899A2 (en) | 2018-05-11 | 2019-11-14 | Laboratory Corporation Of America Holdings | Compositions and methods to detect kidney fibrosis |
| JP7109596B2 (ja) | 2018-06-01 | 2022-07-29 | ラボラトリー コーポレイション オブ アメリカ ホールディングス | Ｌｃ－ｍｓ／ｍｓプロテオーム遺伝子型解析のための方法およびシステム |
| JP7378469B2 (ja) | 2018-10-03 | 2023-11-13 | ラボラトリー コーポレイション オブ アメリカ ホールディングス | アスコルビン酸を測定するための方法およびシステム |
| EP3956669A1 (de) | 2019-04-16 | 2022-02-23 | Laboratory Corporation of America Holdings | Verfahren und systeme zum nachweis von 11-oxo-androgenen durch lc-ms/ms |
| WO2022056282A1 (en) | 2020-09-10 | 2022-03-17 | Laboratory Corporation Of America Holdings | Methods and systems for detecting prostaglandins by lc-ms/ms |
| WO2022196275A1 (ja) | 2021-03-17 | 2022-09-22 | 日本水産株式会社 | 精製の方法および精製された製品 |
| CN118140145A (zh) | 2021-10-27 | 2024-06-04 | 美国控股实验室公司 | 用于测量孕酮代谢物的方法和系统 |
| CN115236217B (zh) * | 2022-06-17 | 2023-07-21 | 北京科技大学 | 一种三轴围压煤体氧化升温特性测定装置及方法 |
| KR20250156182A (ko) | 2023-03-17 | 2025-10-31 | 퀘스트 다이아그노스틱스 인베스트먼츠 엘엘씨 | 질량 분광측정법에 의한 다중화 샘플 내의 테스토스테론의 정량 개선 |
| EP4689669A1 (de) | 2023-03-31 | 2026-02-11 | Quest Diagnostics Investments LLC | Verfahren zur quantifizierung von adiponectin durch massenspektrometrie |
| WO2025106989A1 (en) | 2023-11-16 | 2025-05-22 | Laboratory Corporation Of America Holdings | Methods and systems for using isotopically labeled analytes for calibration for quantification of analytes in dried samples |
| WO2025255166A2 (en) | 2024-06-04 | 2025-12-11 | Laboratory Corporation Of America Holdings | Methods and systems for detecting protein biomarkers of rheumatoid arthritis in a biological sample using lc-ms/ms |
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-
1997
- 1997-01-21 ES ES97904852T patent/ES2140209T3/es not_active Expired - Lifetime
- 1997-01-21 AU AU17537/97A patent/AU712735B2/en not_active Ceased
- 1997-01-21 DE DE69700523T patent/DE69700523T2/de not_active Expired - Lifetime
- 1997-01-21 US US08/785,324 patent/US5795469A/en not_active Expired - Lifetime
- 1997-01-21 DK DK97904852T patent/DK0840893T3/da active
- 1997-01-21 PL PL97327920A patent/PL327920A1/xx unknown
- 1997-01-21 WO PCT/US1997/001096 patent/WO1997026532A1/en not_active Ceased
- 1997-01-21 EP EP97904852A patent/EP0840893B1/de not_active Expired - Lifetime
- 1997-01-21 NZ NZ330867A patent/NZ330867A/en unknown
- 1997-01-21 AT AT97904852T patent/ATE184702T1/de not_active IP Right Cessation
- 1997-01-21 JP JP52630597A patent/JP3452936B2/ja not_active Expired - Lifetime
- 1997-01-21 CA CA002242885A patent/CA2242885C/en not_active Expired - Lifetime
-
1998
- 1998-01-07 US US09/003,856 patent/US5968367A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69700523D1 (de) | 1999-10-21 |
| DK0840893T3 (da) | 2000-04-03 |
| WO1997026532A1 (en) | 1997-07-24 |
| CA2242885C (en) | 2006-08-15 |
| US5968367A (en) | 1999-10-19 |
| DE69700523T2 (de) | 2000-04-27 |
| ES2140209T3 (es) | 2000-02-16 |
| EP0840893B1 (de) | 1999-09-15 |
| PL327920A1 (en) | 1999-01-04 |
| NZ330867A (en) | 1998-11-25 |
| JP3452936B2 (ja) | 2003-10-06 |
| CA2242885A1 (en) | 1997-07-24 |
| US5795469A (en) | 1998-08-18 |
| AU712735B2 (en) | 1999-11-11 |
| AU1753797A (en) | 1997-08-11 |
| EP0840893A1 (de) | 1998-05-13 |
| JP2000504414A (ja) | 2000-04-11 |
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