ES2140209T3 - Procedimiento y dispositivo de cromatografia de liquidos de alto rendimiento. - Google Patents

Procedimiento y dispositivo de cromatografia de liquidos de alto rendimiento.

Info

Publication number
ES2140209T3
ES2140209T3 ES97904852T ES97904852T ES2140209T3 ES 2140209 T3 ES2140209 T3 ES 2140209T3 ES 97904852 T ES97904852 T ES 97904852T ES 97904852 T ES97904852 T ES 97904852T ES 2140209 T3 ES2140209 T3 ES 2140209T3
Authority
ES
Spain
Prior art keywords
column
fluids
eluant
injections
entrance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97904852T
Other languages
English (en)
Inventor
Hubert M Quinn
Rebecca A Menapace
Charles J Oberhauser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cohesive Technologies Inc
Original Assignee
Cohesive Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cohesive Technologies Inc filed Critical Cohesive Technologies Inc
Application granted granted Critical
Publication of ES2140209T3 publication Critical patent/ES2140209T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
    • B01D15/163—Pressure or speed conditioning
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
    • B01D15/203—Equilibration or regeneration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G01N2030/324—Control of physical parameters of the fluid carrier of pressure or speed speed, flow rate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N2030/387—Turbulent flow of mobile phase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

APARATO DE CROMATOGRAFIA LIQUIDA DE ALTA PRESION EN CUYA COLUMNA SE CARGA UNA MEZCLA DE FLUIDOS QUE CONTIENE COMO MINIMO UN SOLUTO QUE ES REACTIVO CON LAS SUPERFICIES CROMATOGRAFICAMENTE REACTIVAS DE LA COLUMNA, Y SE INYECTAN UN NUMERO DE VOLUMENES DE DIFERENTES FLUIDOS ELUYENTES EN ESA COLUMNA. LAS INYECCIONES SE REALIZAN DE FORMA QUE SE MINIMICE LA CANTIDAD REQUERIDA DE ELUYENTE. LAS INYECCIONES CORRESPONDIENTES A UNA OPERACION SE EFECTUAN DE FORMA QUE SE ASEGURE QUE, COMO MINIMO, SE PRODUZCA EL FLUJO DE LOS LIQUIDOS ELUYENTES POR LA COLUMNA, PREFERIBLEMENTE CON UN FRENTE DE ONDA PRACTICAMENTE PLANO, A UNAS VELOCIDADES CORRESPONDIENTES A UNAS VELOCIDADES REDUCIDAS SUPERIORES A 5.000, POR EJEMPLO, Y UNOS FLUJOS SUFICIENTES PARA PROVOCAR UN FLUJO TURBULENTO EN AQUELLOS FLUIDOS, LO QUE MINIMIZA EL TIEMPO REQUERIDO PARA QUE PASE TODA LA MEZCLA Y LOS FLUIDOS ELUYENTES POR LA COLUMNA. EN OTRAS OPERACIONES, LAS INYECCIONES SE REALIZAN PRACTICAMENTE SIMULTANEAS EN PUNTOS ESPACIALMENTE SEPARADOS ADYACENTES A LA ENTRADA DE LA COLUMNA O EN SECUENCIA EN UNA UNICA LOCALIZACION ADYACENTE A LA ENTRADA DE LA COLUMNA, PERO EN TODOS LOS CASOS LOS FLUIDOS TIENDEN A VIAJAR POR LA COLUMNA A UNA VELOCIDAD DE GRUPO COMUN, COMO SI SE TRATARA DE CILINDROS DE FLUIDOS ESTRECHAMENTE AGRUPADOS.
ES97904852T 1996-01-19 1997-01-21 Procedimiento y dispositivo de cromatografia de liquidos de alto rendimiento. Expired - Lifetime ES2140209T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58887496A 1996-01-19 1996-01-19
US2721696P 1996-09-30 1996-09-30

Publications (1)

Publication Number Publication Date
ES2140209T3 true ES2140209T3 (es) 2000-02-16

Family

ID=26702215

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97904852T Expired - Lifetime ES2140209T3 (es) 1996-01-19 1997-01-21 Procedimiento y dispositivo de cromatografia de liquidos de alto rendimiento.

Country Status (12)

Country Link
US (2) US5795469A (es)
EP (1) EP0840893B1 (es)
JP (1) JP3452936B2 (es)
AT (1) ATE184702T1 (es)
AU (1) AU712735B2 (es)
CA (1) CA2242885C (es)
DE (1) DE69700523T2 (es)
DK (1) DK0840893T3 (es)
ES (1) ES2140209T3 (es)
NZ (1) NZ330867A (es)
PL (1) PL327920A1 (es)
WO (1) WO1997026532A1 (es)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6423233B1 (en) * 2000-08-15 2002-07-23 Biogal Gyogyszergyar Rt. Purification process
US6110362A (en) * 1997-11-19 2000-08-29 Cohesive Technologies, Inc. Chemical analysis
US6406632B1 (en) 1998-04-03 2002-06-18 Symyx Technologies, Inc. Rapid characterization of polymers
US6416663B1 (en) 1998-04-03 2002-07-09 Symyx Technologies, Inc. Chromatographic column for rapid characterizations of polymers
US6866786B2 (en) * 1998-04-03 2005-03-15 Symyx Technologies, Inc. Rapid characterization of polymers
JP4067685B2 (ja) * 1999-03-26 2008-03-26 山善株式会社 インジェクション装置
US6855258B2 (en) * 1999-04-02 2005-02-15 Symyx Technologies, Inc. Methods for characterization of polymers using multi-dimensional liquid chromatography with parallel second-dimension sampling
US6190550B1 (en) * 1999-09-30 2001-02-20 Cohesive Technologies, Inc. Monitoring high performance liquid chromatography
US6299767B1 (en) 1999-10-29 2001-10-09 Waters Investments Limited High pressure capillary liquid chromatography solvent delivery system
US6460420B1 (en) * 2000-04-13 2002-10-08 Sandia National Laboratories Flowmeter for pressure-driven chromatography systems
EP1352235B1 (en) * 2000-11-21 2013-05-08 Waters Technologies Corporation Mobile phase dilution scheme for enhanced chromatography
US6635173B2 (en) * 2000-12-28 2003-10-21 Cohesive Technologies, Inc. Multi column chromatography system
US6730228B2 (en) * 2001-08-28 2004-05-04 Symyx Technologies, Inc. Methods and apparatus for characterization of polymers using multi-dimensional liquid chromatography with regular second-dimension sampling
US6780315B2 (en) 2002-12-09 2004-08-24 Waters Investments Limited Backflow prevention for high pressure gradient systems
JP3823092B2 (ja) * 2003-03-11 2006-09-20 株式会社日立ハイテクノロジーズ 分離分析装置
US6977143B1 (en) 2003-09-08 2005-12-20 Quest Diagnostics Investments Incorporated Determination of testosterone by mass spectrometry
JP4377761B2 (ja) * 2004-07-01 2009-12-02 株式会社日立ハイテクノロジーズ 液体クロマトグラフ装置
JP4399304B2 (ja) * 2004-03-29 2010-01-13 富士フイルム株式会社 自動核酸分離精製方法およびその装置
US20060169640A1 (en) * 2005-02-01 2006-08-03 Hubert Quinn High throughput screening, purification and recovery system for large and small molecules
US7745226B2 (en) 2005-04-06 2010-06-29 Quest Diagnostics Investments Incorporated Methods for detecting vitamin D metabolites
US7972867B2 (en) 2005-04-06 2011-07-05 Quest Diagnostics Investments Incorporated Methods for detecting vitamin D metabolites by mass spectrometry
CA2820957A1 (en) * 2006-05-26 2007-12-06 Laboratory Corporation Of America Holdings Liquid chromatography with tandem mass spectrometry of estrone, estradiol and free thyroxine
US8877051B2 (en) * 2006-07-21 2014-11-04 Waters Technologies Corporation Time delay for sample collection in chromatography systems
US8017015B2 (en) 2006-10-20 2011-09-13 Quest Diagnostics Investments Incorporated Monolithic column chromatography
WO2008150488A1 (en) * 2007-06-01 2008-12-11 Laboratory Corporation Of America Holdings Methods and systems for quantification of peptides and other analytes
US8017403B2 (en) 2007-06-14 2011-09-13 Quest Diagnostics Investments Incorporated Mass spectrometry method for measuring vitamin B6 in body fluid
US20090134325A1 (en) * 2007-11-27 2009-05-28 Goldman Mildred M Methods for detecting estradiol by mass spectrometry
US7972868B2 (en) * 2007-11-28 2011-07-05 Quest Diagnostics Investments Incorporated Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry
US8916385B2 (en) * 2007-12-13 2014-12-23 Quest Diagnostics Investments, Inc. Methods for detecting estrone by mass spectrometry
TW200933195A (en) * 2008-01-28 2009-08-01 Ind Tech Res Inst Autostereoscopic display
US7834313B2 (en) 2008-08-08 2010-11-16 Quest Diagnostics Investments Incorporated Mass spectrometry assay for plasma-renin
US7893399B2 (en) * 2008-09-09 2011-02-22 Quest Diagnostics Investments Incorporated Methods for detecting dehydroepiandrosterone by mass spectrometry
US7804063B2 (en) * 2008-10-06 2010-09-28 Quest Diagnostics Investments Incorporated Methods for detecting dihydrotestosterone by mass spectrometry
US7952067B2 (en) * 2008-10-06 2011-05-31 Quest Diagnostics Investments Incorporated Methods for detecting vitamin C by mass spectrometry
US8039794B2 (en) 2008-12-16 2011-10-18 Quest Diagnostics Investments Incorporated Mass spectrometry assay for thiopurine-S-methyl transferase activity and products generated thereby
US7952068B2 (en) 2008-12-16 2011-05-31 Quest Diagnostics Investments Incorporated Methods for detecting catecholamines by mass spectrometry
US8399829B2 (en) 2008-12-18 2013-03-19 Quest Diagnostics Investments Incorporated Vitamin B2 detection by mass spectrometry
WO2010075175A1 (en) 2008-12-23 2010-07-01 Quest Diagnostics Investments Incorporated Mass spectrometry assay for estrogenic compounds
EP2384437B1 (en) 2008-12-24 2018-12-12 Quest Diagnostics Investments Incorporated Mass spectrometry assay for pregnenolone and 17-hydroxypregnenolone
CN102596230B (zh) 2009-11-05 2015-08-05 奎斯特诊断投资公司 用高分辨率质谱法量化胰岛素样生长因子-i和胰岛素样生长因子-ii
US7977117B2 (en) 2009-12-03 2011-07-12 Quest Diagnostics Investments Incorprated Vitamin D metabolite determination utilizing mass spectrometry following derivatization
US8034627B2 (en) 2009-12-03 2011-10-11 Quest Diagnostics Investments Incorporated Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry
US20120025067A1 (en) 2009-12-11 2012-02-02 Quest Diagnostics Investments Incorporated Mass spectrometric determination of non-derivatized, non-metabolized vitamin d
EP4711765A2 (en) 2009-12-11 2026-03-18 Quest Diagnostics Investments Incorporated Mass spectrometry of steroidal compounds in multiplex samples
WO2011084751A1 (en) 2009-12-21 2011-07-14 Quest Diagnostics Investments Incorporated Glucagon detection and quantitation by mass spectrometry
US10837972B2 (en) 2010-06-09 2020-11-17 Quest Diagnostics Investments Incorporated Mass spectrometric determination of derivatized methylmalonic acid
US10215765B2 (en) 2010-09-15 2019-02-26 Quest Diagnostics Investments Incorporated Detection of vitamins A and E by tandem mass spectrometry
WO2012037365A1 (en) 2010-09-16 2012-03-22 Quest Diagnostics Investments Incorporated Mass spectrometric determination of eicosapentaenoic acid and docosahexaenoic acid
WO2012058614A1 (en) 2010-10-29 2012-05-03 Cohesive Technologies Inc. Lc-ms separation and detection of vitamin d metabolites
US9625429B2 (en) 2010-10-29 2017-04-18 Cohesive Technologies Inc. LC-MS configuration for purification and detection of analytes having a broad range of hydrophobicites
US9012835B2 (en) 2010-11-08 2015-04-21 Georgetown University Methods for simultaneous quantification of thyroid hormones and metabolites thereof by mass spectrometry
CA2823324C (en) 2010-12-28 2019-12-31 Quest Diagnostics Investments Incorporated Quantitation of insulin by mass spectrometry
US9177766B2 (en) 2010-12-30 2015-11-03 Quest Diagnostics Investments Incorporated Mass spectrometric quantitation assay for metabolites of leflunomide
US8728824B2 (en) 2011-06-22 2014-05-20 Quest Diagnostics Investments Inc. Mass spectrometric determination of fatty acids
JP6444736B2 (ja) 2011-11-23 2018-12-26 クエスト ダイアグノスティックス インヴェストメンツ インコーポレイテッド タンデム質量分析によるキスペプチン−５４の検出
US8669519B2 (en) 2011-12-05 2014-03-11 Quest Diagnostics Investments, Inc. Methods for detecting reverse triiodothyronine by mass spectrometry
US8779355B2 (en) 2011-12-28 2014-07-15 Quest Diagnostics Investments, Inc. Methods for detecting lacosamide by mass spectrometry
EP2680005A1 (en) 2012-06-28 2014-01-01 Rheinische Friedrich-Wilhelms-Universität Bonn Lipid analysis
US9594074B2 (en) 2012-12-26 2017-03-14 Quest Diagnostics Investments Incorporated C peptide detection by mass spectrometry
US9966243B2 (en) 2013-01-29 2018-05-08 Georgetown University Apparatus and methods for plasma-assisted reaction chemical ionization (PARCI) mass spectrometry
CN105431853B (zh) 2013-05-23 2018-12-28 艾弗诺泰普有限责任公司 表型整合的社会研究数据库和方法
EP3097414A4 (en) * 2014-01-24 2017-10-11 DH Technologies Development PTE. Ltd. Systems and methods for delivering liquid to an ion source
CN121016264A (zh) 2014-05-30 2025-11-28 帝肯样品制备股份有限公司 分析物的提取、衍生化和定量
US10324082B2 (en) 2015-03-03 2019-06-18 Quest Diagnostics Investments Llc Methods for quantitation of insulin levels by mass spectrometry
EP3118619A1 (en) 2015-07-14 2017-01-18 Vrije Universiteit Brussel High-performance liquid chromatography with a vortex flow inducer
US11360098B2 (en) 2015-09-28 2022-06-14 Quest Diagnostics Investments Llc Amyloid beta detection by mass spectrometry
US10564062B2 (en) * 2016-10-19 2020-02-18 Honeywell International Inc. Human-machine interface for gas valve
CN118883748A (zh) 2017-03-31 2024-11-01 奎斯特诊断投资有限公司 用于定量胰岛素和c-肽的方法
WO2019028080A1 (en) 2017-07-31 2019-02-07 Quest Diagnostics Investments Llc DETECTION OF THE ISOTYPE OF APOLIPOPROTEIN E BY MASS SPECTROMETRY
US11860141B2 (en) 2017-08-14 2024-01-02 Quest Diagnostics Investments Llc Detection and quantitation of guanidinoacetate, creatine, and creatinine by mass spectrometry
GB201802123D0 (en) 2018-02-09 2018-03-28 Metabolomic Diagnostics Ltd A method of processomg a biological sample
JP7273865B2 (ja) 2018-03-16 2023-05-15 クエスト ダイアグノスティックス インヴェストメンツ エルエルシー マススペクトロメトリーによるクロモグラニンａの検出方法
WO2019217899A2 (en) 2018-05-11 2019-11-14 Laboratory Corporation Of America Holdings Compositions and methods to detect kidney fibrosis
JP7109596B2 (ja) 2018-06-01 2022-07-29 ラボラトリー コーポレイション オブ アメリカ ホールディングス Ｌｃ－ｍｓ／ｍｓプロテオーム遺伝子型解析のための方法およびシステム
JP7378469B2 (ja) 2018-10-03 2023-11-13 ラボラトリー コーポレイション オブ アメリカ ホールディングス アスコルビン酸を測定するための方法およびシステム
EP3956669A1 (en) 2019-04-16 2022-02-23 Laboratory Corporation of America Holdings Methods and systems for the detection of 11-oxo androgens by lc-ms/ms
WO2022056282A1 (en) 2020-09-10 2022-03-17 Laboratory Corporation Of America Holdings Methods and systems for detecting prostaglandins by lc-ms/ms
WO2022196275A1 (ja) 2021-03-17 2022-09-22 日本水産株式会社 精製の方法および精製された製品
CN118140145A (zh) 2021-10-27 2024-06-04 美国控股实验室公司 用于测量孕酮代谢物的方法和系统
CN115236217B (zh) * 2022-06-17 2023-07-21 北京科技大学 一种三轴围压煤体氧化升温特性测定装置及方法
KR20250156182A (ko) 2023-03-17 2025-10-31 퀘스트 다이아그노스틱스 인베스트먼츠 엘엘씨 질량 분광측정법에 의한 다중화 샘플 내의 테스토스테론의 정량 개선
EP4689669A1 (en) 2023-03-31 2026-02-11 Quest Diagnostics Investments LLC Methods for quantitation of adiponectin by mass spectrometry
WO2025106989A1 (en) 2023-11-16 2025-05-22 Laboratory Corporation Of America Holdings Methods and systems for using isotopically labeled analytes for calibration for quantification of analytes in dried samples
WO2025255166A2 (en) 2024-06-04 2025-12-11 Laboratory Corporation Of America Holdings Methods and systems for detecting protein biomarkers of rheumatoid arthritis in a biological sample using lc-ms/ms

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208284A (en) * 1965-05-11 1980-06-17 Hahn Hans H Apparatus for distribution separation processes
GB1148662A (en) * 1965-05-11 1969-04-16 Pretorius Victor Chromatographic process and apparatus therefor
US3869067A (en) * 1972-06-26 1975-03-04 Du Pont Apparatus for gradient elution
GB1526065A (en) * 1974-10-16 1978-09-27 Asahi Chemical Ind Process for separation of hydrocarbon mixture
US3997298A (en) * 1975-02-27 1976-12-14 Cornell Research Foundation, Inc. Liquid chromatography-mass spectrometry system and method
SE434312B (sv) * 1975-10-22 1984-07-16 Atomic Energy Authority Uk Porosgel, sett for dess framstellning samt anvendning av densamma for framstellning av ett keramiskt katalysatormaterial
US4032445A (en) * 1975-11-10 1977-06-28 Varian Associates Liquid chromatography pumping system with compensation means for liquid compressibility
US4311586A (en) * 1980-04-22 1982-01-19 Tracor, Inc. Solvent mixing in HPLC using low pressure solvent metering pumps
US4454043A (en) * 1980-11-17 1984-06-12 Monsanto Company Column switching procedure
US4512897A (en) * 1981-07-28 1985-04-23 Amf Incorporated Molecular separation column and use thereof
US4446105A (en) * 1982-10-29 1984-05-01 The United States Of America As Represented By The United States Department Of Energy System for analyzing coal liquefaction products
SE464816B (sv) * 1985-10-15 1991-06-17 Nilsson Kjell Makroporoesa partiklar, foerfarande foer dess framstaellning och dess anvaendning
JPS62218861A (ja) * 1986-03-20 1987-09-26 Minoru Koga 回転式多流路試料導入バルブ
JPH0669521B2 (ja) * 1986-12-23 1994-09-07 三菱化成エンジニアリング株式会社 クロマト分離法
GB2223692A (en) * 1988-09-16 1990-04-18 Philips Nv Liquid chromatography
US5019270A (en) * 1989-07-06 1991-05-28 Perseptive Biosystems, Inc. Perfusive chromatography
WO1991003298A1 (en) * 1989-08-31 1991-03-21 Union Oil Company Of California Continuous high performance liquid chromatography
US5164090A (en) * 1989-11-06 1992-11-17 E. R. Squibb & Sons, Inc. Process for the direct chromatographic analysis of drugs and metabolites in whole blood samples using internal surface reverse phase technology
US5328603A (en) * 1990-03-20 1994-07-12 The Center For Innovative Technology Lignocellulosic and cellulosic beads for use in affinity and immunoaffinity chromatography of high molecular weight proteins
DE4018778A1 (de) * 1990-06-12 1991-12-19 Braun Melsungen Ag Adsorptionsmaterial zur selektiven entfernung von ldl- oder/und vldl
DE4018928C2 (de) * 1990-06-13 1996-03-28 Bodenseewerk Perkin Elmer Co Vorrichtung zur Eingabe von flüssigen Proben in einen Trägerflüssigkeitsstrom
US5256298A (en) * 1992-04-22 1993-10-26 Powell Paul E Continuous-belt separator/reactor and method
US5268097A (en) * 1992-06-19 1993-12-07 Sepracor Inc. Passivated and stabilized porous mineral oxide supports and method for the preparation and use of same
US5478924A (en) * 1994-02-16 1995-12-26 Cramer; Steven M. Displacement chromatography of proteins using low molecular weight displacers
US5503933A (en) * 1994-02-25 1996-04-02 Purdue Research Foundation Covalently bonded coatings
US5567307A (en) * 1994-09-30 1996-10-22 Lachat Instruments System and a method for using a small suppressor column in performing liquid chromatography
US5772874A (en) * 1995-11-02 1998-06-30 Cohesive Technologies, Inc. High performance liquid chromatography method and apparatus

Also Published As

Publication number Publication date
DE69700523D1 (de) 1999-10-21
ATE184702T1 (de) 1999-10-15
DK0840893T3 (da) 2000-04-03
WO1997026532A1 (en) 1997-07-24
CA2242885C (en) 2006-08-15
US5968367A (en) 1999-10-19
DE69700523T2 (de) 2000-04-27
EP0840893B1 (en) 1999-09-15
PL327920A1 (en) 1999-01-04
NZ330867A (en) 1998-11-25
JP3452936B2 (ja) 2003-10-06
CA2242885A1 (en) 1997-07-24
US5795469A (en) 1998-08-18
AU712735B2 (en) 1999-11-11
AU1753797A (en) 1997-08-11
EP0840893A1 (en) 1998-05-13
JP2000504414A (ja) 2000-04-11

Similar Documents

Publication Publication Date Title
ES2140209T3 (es) Procedimiento y dispositivo de cromatografia de liquidos de alto rendimiento.
ES2130857T3 (es) Cromatografia liquida de alto rendimiento, procedimiento y aparato.
CA2082013A1 (en) Mechanical Gas Chromatography Injection Valves and Column Multiplexing Techniques
DE3170534D1 (en) A device for vaporization injection in a gas-chromatographic column
Golshan-Shirazi et al. Analytical solution for the ideal model of chromatography in the case of a pulse of a binary mixture with competitive Langmuir isotherm
ATE227107T1 (de) Methode, eine gasübersättigte flüssigkeit zu einem gasarmen ort zu leiten und ihre anwendung
ES8505483A1 (es) Sistema y su correspondiente metodo de circulacion continua para la mezcla de segmentos fluidos en su trayecto.
NO941604D0 (no) Injektor for flotasjonsinnretning
Scott et al. The design of column connection tubes for liquid chromatography
GB1106093A (en) Chromatography of complex mixtures
CA2059491A1 (en) Process and apparatus for mass transfer between liquid and gaseous media
DK0865300T3 (da) System til at afgive en blanding af to væskekomponenter
Helfferich Travel of molecules and disturbances in chromatographic columns: A paradox and its resolution
SE8802126D0 (sv) Apparatus for flow field flow fractionation
ES2140665T3 (es) Procedimiento y dispositivo para introducir un fluido de tratamiento liquido o gaseoso en una corriente de gases de humos.
US3444722A (en) Device for supplying carrier gas to transport eluted portion of sample and to backflush chromatographic column
JPS57110919A (en) Method of and apparatus for primarily measuring flow rate of fluid passing through nozzle with pitot tube
IT7823050U1 (it) Apparecchiatura per l'alimentazione di gas vettore a portata costante per iniettore diretto in colonna (on-column injector) utilizzato con colonne capillari e microimpaccate.
BE813809A (fr) Procede a dispositif d'injection d'echantillons liquides dans un systeme de separation chromatographique en phase gazeuse
SU997618A3 (ru) Устройство дл линейной тонкослойной хроматографии под давлением
CN208255154U (zh) 高效液相色谱仪
Wang et al. Soil science society of America
IT8019005A0 (it) Valvola di controllo del passaggio di iniezione per un iniettore diretto in colonna gas-cromatografica e procedimentodi iniezione utilizzante tale valvola.
Novák et al. Fundamental concepts
Whittle The use of HRGC in water quality control

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 840893

Country of ref document: ES