ATE18562T1 - Zellspezifische glykopeptidliganden. - Google Patents
Zellspezifische glykopeptidliganden.Info
- Publication number
- ATE18562T1 ATE18562T1 AT82103247T AT82103247T ATE18562T1 AT E18562 T1 ATE18562 T1 AT E18562T1 AT 82103247 T AT82103247 T AT 82103247T AT 82103247 T AT82103247 T AT 82103247T AT E18562 T1 ATE18562 T1 AT E18562T1
- Authority
- AT
- Austria
- Prior art keywords
- cell
- mannopyranosylthio
- metabolizable
- propionyl
- lysine
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title abstract 3
- 102000002068 Glycopeptides Human genes 0.000 title abstract 2
- 108010015899 Glycopeptides Proteins 0.000 title abstract 2
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 230000000975 bioactive effect Effects 0.000 abstract 2
- 150000001720 carbohydrates Chemical class 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 208000015872 Gaucher disease Diseases 0.000 abstract 1
- 102000004547 Glucosylceramidase Human genes 0.000 abstract 1
- 108010017544 Glucosylceramidase Proteins 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract 1
- NVGBPTNZLWRQSY-UWVGGRQHSA-N Lys-Lys Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(O)=O)CCCCN NVGBPTNZLWRQSY-UWVGGRQHSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 abstract 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 abstract 1
- 229940124599 anti-inflammatory drug Drugs 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 abstract 1
- 229960003957 dexamethasone Drugs 0.000 abstract 1
- -1 dilysine Chemical compound 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000002641 enzyme replacement therapy Methods 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 210000001865 kupffer cell Anatomy 0.000 abstract 1
- 108010054155 lysyllysine Proteins 0.000 abstract 1
- 210000002540 macrophage Anatomy 0.000 abstract 1
- 229960003104 ornithine Drugs 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/255,416 US4386026A (en) | 1981-04-20 | 1981-04-20 | Cell-specific glycopeptide ligands |
| EP82103247A EP0063373B1 (de) | 1981-04-20 | 1982-04-19 | Zellspezifische Glykopeptidliganden |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE18562T1 true ATE18562T1 (de) | 1986-03-15 |
Family
ID=22968229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT82103247T ATE18562T1 (de) | 1981-04-20 | 1982-04-19 | Zellspezifische glykopeptidliganden. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4386026A (de) |
| EP (1) | EP0063373B1 (de) |
| JP (1) | JPS57181095A (de) |
| AT (1) | ATE18562T1 (de) |
| DE (1) | DE3269778D1 (de) |
| DK (1) | DK173282A (de) |
| ES (1) | ES511516A0 (de) |
| GR (1) | GR76475B (de) |
| IE (1) | IE52473B1 (de) |
| PT (1) | PT74747B (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4701521A (en) * | 1978-07-17 | 1987-10-20 | The Trustees Of Boston University | Method of effecting cellular uptake of molecules |
| US4466951A (en) * | 1982-11-12 | 1984-08-21 | University Of California | Intracellular trapping of therapeutics or tracer agents |
| FR2551442B1 (fr) * | 1983-09-05 | 1987-04-30 | Centre Nat Rech Scient | Nouveaux derives furaniques, leur preparation et leur application |
| US4873322A (en) * | 1986-01-24 | 1989-10-10 | Ciba-Geigy Corporation | Saccharide derivatives and processes for their manufacture |
| US4946675A (en) * | 1987-05-27 | 1990-08-07 | Xoma Corporation | Hepatic blocking agents |
| US5879680A (en) * | 1987-12-23 | 1999-03-09 | The United States Of America As Represented By The Department Of Health And Human Services | Cloned DNA for synthesizing unique glucocerebrosidase |
| ZA9010460B (en) * | 1989-12-29 | 1992-11-25 | Univ Technologies Int | Methods for modelling tertiary structures of biologically active ligands including agonists and antagonists thereto and novel synthetic antagonists based on angiotensin |
| US5432260A (en) * | 1991-05-03 | 1995-07-11 | Washington University | High affinity mannose receptor ligands |
| US5332575A (en) * | 1991-10-03 | 1994-07-26 | Parfums Christian Dior | Method of targeting melanocytes with a compound containing a fucose residue |
| AU4534593A (en) * | 1992-06-12 | 1994-01-04 | Affymax Technologies N.V. | Compositions and methods for enhanced drug delivery |
| TW263437B (de) * | 1992-09-24 | 1995-11-21 | Takeda Pharm Industry Co Ltd | |
| US5508387A (en) * | 1993-08-04 | 1996-04-16 | Glycomed Incorporated | Selectin binding glycopeptides |
| CA2173990A1 (en) * | 1993-10-12 | 1995-04-20 | Narasinga Rao | A library of glyco-peptides useful for identification of cell adhesion inhibitors |
| JP4256932B2 (ja) * | 1995-06-07 | 2009-04-22 | ジョエル ケイ． スワデッシュ | 抗原プロセシング細胞標的複合体 |
| US5965719A (en) * | 1996-11-15 | 1999-10-12 | Sunsorb Biotech, Inc. | Combinatorial synthesis of carbohydrate libraries |
| EP0953357A1 (de) * | 1997-01-17 | 1999-11-03 | Drug Delivery System Institute, Ltd. | Nephotropische Arzneien |
| US7033765B1 (en) | 1997-02-20 | 2006-04-25 | Toronto Research Chemicals, Inc. | Site-specific drug delivery |
| IL131445A0 (en) * | 1997-02-20 | 2001-01-28 | David S Dime | Site-specific drug delivery |
| EP0969873B1 (de) * | 1997-03-27 | 2006-06-07 | Institut Pasteur | Multiple,kohlenhydrathaltige glycopeptid-antigene, daraus entwickelte impfstoffe sowie deren verwendung |
| ATE287895T1 (de) * | 1997-08-08 | 2005-02-15 | Aventis Pharma Gmbh | Substituierte tetrahydropyranderivate sowie verfahren zu deren herstellung |
| EP1619210A1 (de) * | 1998-10-30 | 2006-01-25 | Daiichi Pharmaceutical Co., Ltd. | DDS-Verbindungen und Methoden ihrer Prüfung |
| AU1830200A (en) | 1998-11-25 | 2000-06-13 | Vanderbilt University | Cationic liposomes for gene transfer |
| WO2002010219A1 (en) * | 2000-07-26 | 2002-02-07 | Cho, Sung-Woo | Oligolysine transducing domain, oligolysine-cargo molecule complex and uses thereof |
| CA2497195C (en) | 2001-12-14 | 2014-07-08 | The University Of Wyoming | Methods and compositions for controlled release of drugs |
| CN103804458B (zh) * | 2014-02-25 | 2016-08-24 | 中国人民解放军第四军医大学 | 基于胆固醇的三种脂质材料的制备及其应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3226379A (en) * | 1964-01-14 | 1965-12-28 | Grace W R & Co | Novel 1,3-bis(polyhydroxyalkyl)-2-imidazolidinones and 1,3-bis(polyhydroxyalkyl)-imidazolidine-2-thiones |
| US3859337A (en) * | 1969-06-11 | 1975-01-07 | Stauffer Chemical Co | Ethylenediaminetetraacetic acid anhydride derivatives |
| US3953594A (en) * | 1971-08-13 | 1976-04-27 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Process for preparing bleomycin group antibiotics |
| IT1050366B (it) * | 1972-10-18 | 1981-03-10 | Chinos Ind Farmacobilologica S | Sali di amminoacidi con esteri polisolforici di glicopeptidi naturali e loro preparazione |
| US4195128A (en) * | 1976-05-03 | 1980-03-25 | Bayer Aktiengesellschaft | Polymeric carrier bound ligands |
| SE431758B (sv) * | 1977-03-04 | 1984-02-27 | Pharmacia Fine Chemicals Ab | Som tioleringsreagens eller berarmatris for enzymer anvendbart derivat av en sh-grupphaltig polymer |
| US4120953A (en) * | 1977-04-04 | 1978-10-17 | American Cyanamid Company | Novel 2,2', 2"-[s-phenenyltris(sulfonylimino)tris]-[2-deoxy-α-D-glucopyranose], dodecakis (H-sulfate) compounds and their salts |
| NL7906191A (nl) * | 1978-08-25 | 1980-02-27 | Tanabe Seiyaku Co | Nieuwe nitrosoureumderivaten en de bereidingswijze daarvan. |
| US4223013A (en) * | 1978-12-29 | 1980-09-16 | Syva Company | Amitriptyline conjugates to antigenic proteins and enzymes |
| US4267102A (en) * | 1979-03-05 | 1981-05-12 | Nippon Kayaku Kabushiki Kaisha | Bleomycin group antibiotics |
| JPS5646897A (en) * | 1979-09-26 | 1981-04-28 | Seiichi Shibata | Novel glycopeptide |
| US4259233A (en) * | 1979-10-23 | 1981-03-31 | Miles Laboratories, Inc. | β-Galactosyl-umbelliferone-labeled protein and polypeptide conjugates |
| CA1203532A (en) * | 1980-07-10 | 1986-04-22 | Chembiomed Ltd. | Synthesis of tumor antigenic determinant |
-
1981
- 1981-04-20 US US06/255,416 patent/US4386026A/en not_active Expired - Fee Related
-
1982
- 1982-04-13 GR GR67908A patent/GR76475B/el unknown
- 1982-04-14 PT PT74747A patent/PT74747B/pt not_active IP Right Cessation
- 1982-04-16 IE IE898/82A patent/IE52473B1/en not_active IP Right Cessation
- 1982-04-19 AT AT82103247T patent/ATE18562T1/de not_active IP Right Cessation
- 1982-04-19 DK DK173282A patent/DK173282A/da active IP Right Grant
- 1982-04-19 DE DE8282103247T patent/DE3269778D1/de not_active Expired
- 1982-04-19 ES ES511516A patent/ES511516A0/es active Granted
- 1982-04-19 EP EP82103247A patent/EP0063373B1/de not_active Expired
- 1982-04-20 JP JP57064870A patent/JPS57181095A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| PT74747A (en) | 1982-05-01 |
| ES8306162A1 (es) | 1983-05-01 |
| IE52473B1 (en) | 1987-11-11 |
| DK173282A (da) | 1982-10-21 |
| EP0063373B1 (de) | 1986-03-12 |
| GR76475B (de) | 1984-08-10 |
| DE3269778D1 (en) | 1986-04-17 |
| JPS57181095A (en) | 1982-11-08 |
| PT74747B (en) | 1985-01-08 |
| EP0063373A1 (de) | 1982-10-27 |
| ES511516A0 (es) | 1983-05-01 |
| US4386026A (en) | 1983-05-31 |
| IE820898L (en) | 1982-10-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE18562T1 (de) | Zellspezifische glykopeptidliganden. | |
| Kapas et al. | Somnogenic, pyrogenic, and anorectic activities of tumor necrosis factor-alpha and TNF-alpha fragments | |
| US5597578A (en) | TGF-β protein compositions for inhibition of cell proliferation | |
| KR100896945B1 (ko) | 당뇨병의 치료방법 | |
| Brew | Secretion of α-lactalbumin into milk and its relevance to the organization and control of lactose synthetase | |
| Ashwell et al. | Hepatic recognition and catabolism of serum glycoproteins | |
| CA2064689A1 (en) | Stabilized protein or peptide conjugates | |
| GB2246295B (en) | Continuous release pharmaceutical compositions | |
| DE69812727D1 (de) | Opioid-konjugate mit endogenen Trägerproteinen | |
| HUP0101545A1 (hu) | Peptideket időben elnyújtva kibocsátó gyógyászati készítmények és eljárás az előállításukra | |
| AU7479796A (en) | Preparation of peptide containing biodegradable microspheres by melt process | |
| AU637637B2 (en) | Estrogen-containing active substance plaster | |
| EP0552256A4 (de) | ||
| Poznansky et al. | Insulin: carrier potential for enzyme and drug therapy | |
| KR890000520A (ko) | 폴리펩티드 | |
| Melton et al. | Covalent linkage of carboxypeptidase G2 to soluble dextrans—II: in vivo distribution and fate of conjugates | |
| JPS57140725A (en) | Physiologically active substance having carcinostatic action | |
| CS151887A2 (en) | Method of sound, physiologically normal farming animal's mamma parenchyma's growth increase | |
| JPH0347114A (ja) | 直腸及び膣適用に適する、生物学的に活性なペプチド薬剤を製造する方法 | |
| Lin et al. | Granule proteins of the dental follicle and stellate reticulum inhibit tooth eruption and eyelid opening in postnatal rats | |
| Duncan et al. | Biological evaluation of soluble synthetic polymers as drug carriers | |
| CA2006106A1 (en) | Improved phase separation-microencapsulated pharmaceutical compositions useful for alleviating dental disease | |
| Shoham et al. | Feedback inhibition of thymic secretory activity in mice treated by the thymic extract TP-1 (thymostimulin) | |
| JPH06293631A (ja) | ケラチン加水分解物を担体として用いたドラッグデリバリーシステム | |
| SU651812A1 (ru) | Способ предупреждени образовани спаек |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |