ES8306162A1 - Un procedimiento para la preparacion de glicopeptidos. - Google Patents

Un procedimiento para la preparacion de glicopeptidos.

Info

Publication number
ES8306162A1
ES8306162A1 ES511516A ES511516A ES8306162A1 ES 8306162 A1 ES8306162 A1 ES 8306162A1 ES 511516 A ES511516 A ES 511516A ES 511516 A ES511516 A ES 511516A ES 8306162 A1 ES8306162 A1 ES 8306162A1
Authority
ES
Spain
Prior art keywords
mannopyranosylthio
metabolizable
propionyl
lysine
peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES511516A
Other languages
English (en)
Other versions
ES511516A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES8306162A1 publication Critical patent/ES8306162A1/es
Publication of ES511516A0 publication Critical patent/ES511516A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE GLICOPEPTIDOS DE FORMULA _[SA N-BN- BA N, DONDE SA ES UN SACARIDO DE 1-4 UNIDADES MONOSACARIDO; B ES UN ESQUELETO Y BRAZO SEPARADOR POLIFUNCIONAL; N VALE 1-4; Y BA ES HIDROGENO O UNA SUSTANCIA BIOLOGICAMENTE ACTIVA. CONSISTE EN LA REACCION DE HIDROLISIS SUAVE DE LOS CORRESPONDIENTES COMPUESTOS EN LOS QUE LOS GRUPOS HIDROXILO DE LOS RADICALES SACARIDOS ESTAN COMPLETAMENTE ACETILADOS. LA HIDROLISIS SE LLEVA A CABO EN LA MEZCLA METANOL-AGUA-TRIETILAMINA 5:4:1, A LA TEMPERATURA AMBIENTE. DESPUES DE EVAPORACION A VACIO SE SEPARA EN UNA COLUMNA DE GEL DE SILICE, ELUYENDO CON CLOROFORMO-METANOL-AGUA. ESTOS COMPUESTOS TIENEN APLICACIONES PARA EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS Y LA ENFERMEDAD DE GAUCHER.
ES511516A 1981-04-20 1982-04-19 Un procedimiento para la preparacion de glicopeptidos. Granted ES511516A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/255,416 US4386026A (en) 1981-04-20 1981-04-20 Cell-specific glycopeptide ligands

Publications (2)

Publication Number Publication Date
ES8306162A1 true ES8306162A1 (es) 1983-05-01
ES511516A0 ES511516A0 (es) 1983-05-01

Family

ID=22968229

Family Applications (1)

Application Number Title Priority Date Filing Date
ES511516A Granted ES511516A0 (es) 1981-04-20 1982-04-19 Un procedimiento para la preparacion de glicopeptidos.

Country Status (10)

Country Link
US (1) US4386026A (es)
EP (1) EP0063373B1 (es)
JP (1) JPS57181095A (es)
AT (1) ATE18562T1 (es)
DE (1) DE3269778D1 (es)
DK (1) DK173282A (es)
ES (1) ES511516A0 (es)
GR (1) GR76475B (es)
IE (1) IE52473B1 (es)
PT (1) PT74747B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4701521A (en) * 1978-07-17 1987-10-20 The Trustees Of Boston University Method of effecting cellular uptake of molecules
US4466951A (en) * 1982-11-12 1984-08-21 University Of California Intracellular trapping of therapeutics or tracer agents
FR2551442B1 (fr) * 1983-09-05 1987-04-30 Centre Nat Rech Scient Nouveaux derives furaniques, leur preparation et leur application
US4873322A (en) * 1986-01-24 1989-10-10 Ciba-Geigy Corporation Saccharide derivatives and processes for their manufacture
US4946675A (en) * 1987-05-27 1990-08-07 Xoma Corporation Hepatic blocking agents
US5879680A (en) * 1987-12-23 1999-03-09 The United States Of America As Represented By The Department Of Health And Human Services Cloned DNA for synthesizing unique glucocerebrosidase
JPH05503691A (ja) * 1989-12-29 1993-06-17 ユニバーシティ・テクノロジーズ・インターナショナル・インコーポレイテッド アゴニストおよびアンタゴニストを含む生物学的に活性なリガンドの３次構造モデルの設計方法およびアンギオテンシンに基づいた新規合成アンタゴニスト
US5432260A (en) * 1991-05-03 1995-07-11 Washington University High affinity mannose receptor ligands
US5332575A (en) * 1991-10-03 1994-07-26 Parfums Christian Dior Method of targeting melanocytes with a compound containing a fucose residue
WO1993025197A1 (en) * 1992-06-12 1993-12-23 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
TW263437B (es) * 1992-09-24 1995-11-21 Takeda Pharm Industry Co Ltd
US5508387A (en) * 1993-08-04 1996-04-16 Glycomed Incorporated Selectin binding glycopeptides
CA2173990A1 (en) * 1993-10-12 1995-04-20 Narasinga Rao A library of glyco-peptides useful for identification of cell adhesion inhibitors
EP0831817B1 (en) * 1995-06-07 2001-03-14 Joel K. Swadesh Antigen-processing cell-targeted conjugates comprising a polyamino acid backbone and a non-steroidal anti-inflammatory agent
US5965719A (en) * 1996-11-15 1999-10-12 Sunsorb Biotech, Inc. Combinatorial synthesis of carbohydrate libraries
WO1998031392A1 (en) * 1997-01-17 1998-07-23 Drug Delivery System Institute, Ltd. Nephrotropic drugs
DE69830305T2 (de) * 1997-02-20 2006-02-02 Dime, David S., Toronto Ortsspezifische arzneimittel verabreichung
US7033765B1 (en) 1997-02-20 2006-04-25 Toronto Research Chemicals, Inc. Site-specific drug delivery
DE69834808T2 (de) * 1997-03-27 2007-06-06 Institut Pasteur Multiple,kohlenhydrathaltige glycopeptid-antigene, daraus entwickelte impfstoffe sowie deren verwendung
AU9258798A (en) * 1997-08-08 1999-03-01 Hoechst Marion Roussel Deutschland Gmbh Substituted tetrahydropyrane derivatives, method for producing same, the ir use as medicine or diagnostic agent, as well as medicine containing same
ID29943A (id) * 1998-10-30 2001-10-25 Daiichi Seiyaku Co Senyawa dds dan metode pengukurannya
US6656498B1 (en) 1998-11-25 2003-12-02 Vanderbilt University Cationic liposomes for gene transfer
US20040058856A1 (en) * 2000-07-26 2004-03-25 Soo-Young Choi Oligolysine transducing domain, oligolysine-cargo molecule complex and uses thereof
CA2822457C (en) 2001-12-14 2016-03-08 The University Of Wyoming Methods and compositions for controlled resease of drugs
CN103804458B (zh) * 2014-02-25 2016-08-24 中国人民解放军第四军医大学 基于胆固醇的三种脂质材料的制备及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3226379A (en) * 1964-01-14 1965-12-28 Grace W R & Co Novel 1,3-bis(polyhydroxyalkyl)-2-imidazolidinones and 1,3-bis(polyhydroxyalkyl)-imidazolidine-2-thiones
US3859337A (en) * 1969-06-11 1975-01-07 Stauffer Chemical Co Ethylenediaminetetraacetic acid anhydride derivatives
US3953594A (en) * 1971-08-13 1976-04-27 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Process for preparing bleomycin group antibiotics
IT1050366B (it) * 1972-10-18 1981-03-10 Chinos Ind Farmacobilologica S Sali di amminoacidi con esteri polisolforici di glicopeptidi naturali e loro preparazione
US4195128A (en) * 1976-05-03 1980-03-25 Bayer Aktiengesellschaft Polymeric carrier bound ligands
SE431758B (sv) * 1977-03-04 1984-02-27 Pharmacia Fine Chemicals Ab Som tioleringsreagens eller berarmatris for enzymer anvendbart derivat av en sh-grupphaltig polymer
US4120953A (en) * 1977-04-04 1978-10-17 American Cyanamid Company Novel 2,2', 2"-[s-phenenyltris(sulfonylimino)tris]-[2-deoxy-α-D-glucopyranose], dodecakis (H-sulfate) compounds and their salts
US4241053A (en) * 1978-08-25 1980-12-23 Tanabe Seiyaku Co., Ltd. Novel nitrosourea compounds and process for preparing the same
US4223013A (en) * 1978-12-29 1980-09-16 Syva Company Amitriptyline conjugates to antigenic proteins and enzymes
GB2044262B (en) * 1979-03-05 1983-01-26 Nippon Kayaku Kk Bleomycin group antibiotics
JPS5646897A (en) * 1979-09-26 1981-04-28 Seiichi Shibata Novel glycopeptide
US4259233A (en) * 1979-10-23 1981-03-31 Miles Laboratories, Inc. β-Galactosyl-umbelliferone-labeled protein and polypeptide conjugates
CA1203532A (en) * 1980-07-10 1986-04-22 Chembiomed Ltd. Synthesis of tumor antigenic determinant

Also Published As

Publication number Publication date
EP0063373B1 (en) 1986-03-12
DE3269778D1 (en) 1986-04-17
DK173282A (da) 1982-10-21
ATE18562T1 (de) 1986-03-15
IE52473B1 (en) 1987-11-11
EP0063373A1 (en) 1982-10-27
US4386026A (en) 1983-05-31
GR76475B (es) 1984-08-10
ES511516A0 (es) 1983-05-01
PT74747B (en) 1985-01-08
JPS57181095A (en) 1982-11-08
IE820898L (en) 1982-10-20
PT74747A (en) 1982-05-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401