ATE186273T1 - Verfahren und vorrichtung zum erzeugen eines aerosolnebels - Google Patents

Verfahren und vorrichtung zum erzeugen eines aerosolnebels

Info

Publication number
ATE186273T1
ATE186273T1 AT96912014T AT96912014T ATE186273T1 AT E186273 T1 ATE186273 T1 AT E186273T1 AT 96912014 T AT96912014 T AT 96912014T AT 96912014 T AT96912014 T AT 96912014T AT E186273 T1 ATE186273 T1 AT E186273T1
Authority
AT
Austria
Prior art keywords
high pressure
generating
aerosol mist
liquefied gas
aerosolized
Prior art date
Application number
AT96912014T
Other languages
English (en)
Inventor
Peter Gerard Hiscocks
David Laurence Gee
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE186273T1 publication Critical patent/ATE186273T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
    • B65D83/44—Valves specially adapted for the discharge of contents; Regulating devices
    • B65D83/52—Metering valves; Metering devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Otolaryngology (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Nozzles (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)
  • Catching Or Destruction (AREA)
  • Detergent Compositions (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Processing Of Stones Or Stones Resemblance Materials (AREA)
  • Ceramic Products (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pens And Brushes (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
AT96912014T 1995-04-13 1996-04-12 Verfahren und vorrichtung zum erzeugen eines aerosolnebels ATE186273T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9507768.1A GB9507768D0 (en) 1995-04-13 1995-04-13 Method of apparatus

Publications (1)

Publication Number Publication Date
ATE186273T1 true ATE186273T1 (de) 1999-11-15

Family

ID=10773079

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96912014T ATE186273T1 (de) 1995-04-13 1996-04-12 Verfahren und vorrichtung zum erzeugen eines aerosolnebels

Country Status (20)

Country Link
US (2) US6032836A (de)
EP (1) EP0820415B1 (de)
JP (1) JPH11503362A (de)
KR (1) KR19980703845A (de)
CN (1) CN1186474A (de)
AT (1) ATE186273T1 (de)
AU (1) AU709006B2 (de)
BR (1) BR9604916A (de)
CA (1) CA2217949A1 (de)
CZ (1) CZ321297A3 (de)
DE (1) DE69605028T2 (de)
EA (1) EA001229B1 (de)
ES (1) ES2139350T3 (de)
GB (1) GB9507768D0 (de)
HU (1) HUP9801701A3 (de)
NO (1) NO974707L (de)
NZ (1) NZ306449A (de)
PL (1) PL180486B1 (de)
TR (1) TR199701149T1 (de)
WO (1) WO1996032344A1 (de)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2324121A (en) * 1997-04-07 1998-10-14 Bespak Plc Seal arrangements for pressurised dispensing containers
GB2332712A (en) * 1997-07-29 1999-06-30 Glaxo Group Ltd Valve for aerosol container
GB9805938D0 (en) 1998-03-19 1998-05-13 Glaxo Group Ltd Valve for aerosol container
BR0008867A (pt) 1999-03-12 2002-01-02 Glaxo Group Ltd Válvula dosadora para um recipiente de aerossol, recipiente de aerossol, dispositivo de inalação para distribuir medicamento para um paciente, e, uso do mesmo
HK1049621A1 (zh) 1999-06-09 2003-05-23 罗伯特‧E‧希弗斯 超临界流体辅助的喷雾和鼓泡乾燥
AU2001263098A1 (en) * 2000-05-12 2001-11-26 Iep Pharmaceutical Devices, Inc. Powder/liquid metering valve
WO2001089557A2 (en) * 2000-05-24 2001-11-29 The United States Of America, As Represented By Secretary Of The Department Of Health & Human Services Methods for preventing strokes by inducing tolerance to e-selectin
US7897575B2 (en) * 2000-05-24 2011-03-01 The United States Of America As Represented By The Department Of Health And Human Services Treatment and prevention of vascular dementia
US6523860B1 (en) 2000-10-12 2003-02-25 Illinois Tool Works Inc. Fuel cell adapter system for combustion tools
US6796478B2 (en) 2000-10-12 2004-09-28 Illinois Tool Works Inc. Fuel cell adapter system for combustion tools
US6667344B2 (en) 2001-04-17 2003-12-23 Dey, L.P. Bronchodilating compositions and methods
AU2003215357A1 (en) * 2002-02-22 2003-09-09 Terrasimco Inc. Bladder-based apparatus and method for dispensing coatings
US6832699B2 (en) * 2002-02-22 2004-12-21 Terrasimco Inc. Direct pressure apparatus and method for dispensing coatings
JPWO2003097249A1 (ja) * 2002-05-16 2005-09-15 株式会社 バイオアクティス ガス噴射弁
CN100386247C (zh) 2002-08-13 2008-05-07 因斯蒂尔医学技术有限公司 用于储存和分配物质的容器及阀组件,以及相关方法
US6938810B2 (en) 2003-04-15 2005-09-06 Illinois Tool Works Inc. Fuel cell adapter system for combustion tools
TWI359675B (en) 2003-07-10 2012-03-11 Dey L P Bronchodilating β-agonist compositions
US8030362B2 (en) * 2003-12-12 2011-10-04 Otic Pharma Ltd. Compositions for treatment of ear disorders and methods of use thereof
US8940321B2 (en) 2003-12-12 2015-01-27 Otic Pharma Ltd. Compositions for treatment of ear disorders and methods of use thereof
US7934696B1 (en) 2006-02-21 2011-05-03 John Gruben Ether injection control valve
US20100204096A1 (en) * 2006-10-09 2010-08-12 Government Of The United States Of Americas As Rep Treatment of inflammation, demyelination and neuronal/axonal loss
US9010329B2 (en) * 2009-02-10 2015-04-21 Aerophase Electronically-controlled, high pressure flow control valve and method of use
AU2010253770B9 (en) 2009-05-29 2015-02-12 Pearl Therapeutics, Inc. Compositions for respiratory delivery of active agents and associated methods and systems
US8815258B2 (en) 2009-05-29 2014-08-26 Pearl Therapeutics, Inc. Compositions, methods and systems for respiratory delivery of two or more active agents
FR2952618B1 (fr) * 2009-11-17 2011-11-25 Serge Gandy Bouchon doseur pour recipient apte a contenir un fluide sous pression, et recipient muni d'un tel bouchon
BR112012024238A2 (pt) 2010-03-25 2019-09-24 New Injection Systems Ltd injetor
US8826525B2 (en) 2010-11-22 2014-09-09 Andrew Llc Laser weld coaxial connector and interconnection method
CN101983737B (zh) * 2010-11-30 2013-12-11 三峡大学第一临床医学院 呼吸机雾化装置
WO2013065051A1 (en) 2011-11-01 2013-05-10 Naveh Pharma (1996) Ltd. Formulation and device for treating ceruminosis
BR112015011084A2 (pt) * 2012-11-16 2017-07-11 New Injection Systems Ltd conjunto de seringa pré-preenchida portátil
CA2890764C (en) 2012-11-23 2021-05-04 New Injection Systems Ltd Auto-injector assembly
US20140275517A1 (en) 2013-03-15 2014-09-18 Pearl Therapeutics, Inc. Methods and systems for conditioning of particulate crystalline materials
US11554229B2 (en) 2013-03-26 2023-01-17 OptiNose Inc. Nasal administration
FR3006300B1 (fr) * 2013-06-04 2015-07-03 Aptar France Sas Valve doseuse et dispositif de distribution de produit fluide comportant une telle valve.
CA2938994A1 (en) 2014-02-10 2015-08-13 Patara Pharma, LLC Inhalable formulations of sodium cromolyn with improved bioavailability
CN106535889A (zh) 2014-02-10 2017-03-22 帕塔拉制药有限责任公司 用于治疗肺疾病的肥大细胞稳定剂
DE102015204153A1 (de) 2015-03-09 2016-09-15 Henkel Ag & Co. Kgaa Mittel und Verfahren zur temporären Verformung keratinhaltiger Fasern
US10265296B2 (en) 2015-08-07 2019-04-23 Respivant Sciences Gmbh Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders
EP3331522A1 (de) 2015-08-07 2018-06-13 Patara Pharma LLC Verfahren zur behandlung von mastzellbedingten erkrankungen mit mastzellstabilisatoren
EP3506893A4 (de) 2016-08-31 2020-01-22 Respivant Sciences GmbH Cromolynzusammensetzungen zur behandlung von chronischem husten aufgrund von idiopathischer pulmonaler fibrose
AU2017339366A1 (en) 2016-10-07 2019-04-11 Respivant Sciences Gmbh Cromolyn compositions for treatment of pulmonary fibrosis
DE102018219038A1 (de) 2018-11-08 2020-05-14 Continental Reifen Deutschland Gmbh Verteilervorrichtung zur Erzeugung eines Aerosols, System zum Abdichten und Aufpumpen von Fahrzeugluftreifen und ein Verfahren zum Abdichten von Fahrzeugluftreifen oder aufblasbaren technischen Gummiartikeln sowie die Verwendung einer Dosiereinheit zum Erzeugen eines Aerosols
WO2021101997A1 (en) 2019-11-22 2021-05-27 Kindeva Drug Delivery L.P. Carbon dioxide based metered dose inhaler
AU2021207583A1 (en) 2020-01-16 2022-09-01 Kindeva Drug Delivery L.P. Medicinal compositions for carbon dioxide based metered dose inhalers
GB2592376A (en) * 2020-02-25 2021-09-01 Aer Beatha Ltd Canister
USD998474S1 (en) 2020-11-25 2023-09-12 The Procter & Gamble Company Aerosol dispenser
KR102609936B1 (ko) * 2021-01-12 2023-12-06 에어그린 주식회사 분사 장치
US11827443B2 (en) 2021-05-03 2023-11-28 The Procter & Gamble Company Aerosol foam dispenser
USD1015881S1 (en) 2021-05-03 2024-02-27 The Procter & Gamble Company Aerosol foam dispenser
US12502339B2 (en) 2021-05-03 2025-12-23 The Procter & Gamble Company Foam compositions
EP4398880A1 (de) 2021-09-08 2024-07-17 Kindeva Drug Delivery L.P. Dosierinhalatoren und suspensionszusammensetzungen
EP4673151A1 (de) 2022-03-01 2026-01-07 Kindeva Drug Delivery L.P. Inhalatoren mit abgemessener dosis und suspensionen mit hoher dosis
JP2026507199A (ja) 2023-03-02 2026-02-27 キンデーバ ドラッグ デリバリー リミティド パートナーシップ 定量吸入器及びhfa-152a中にカンナビノイドを含む溶液
AU2024230822A1 (en) 2023-03-02 2025-10-16 Breath Of Life International Ltd Metered dose inhalers and solutions including cannabinoids in hfo-1234ze(e)
CN116115868B (zh) * 2023-03-31 2025-06-20 艾特美(苏州)医药科技有限公司 用于定量雾化装置的袋阀组件及定量雾化装置

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3176889A (en) * 1961-08-14 1965-04-06 Potapenko Gennady Pressurized dispenser with integral stem seal
US3190508A (en) * 1963-03-05 1965-06-22 Rexall Drug Chemical Metering valve for fluids under pressure
FR1458099A (fr) * 1965-01-08 1966-03-04 Perfectionnements aux dispositifs doseurs
DE2366186A1 (de) * 1973-05-26 1978-08-24
US3877618A (en) * 1974-03-25 1975-04-15 Olin Corp Lost motion fluid measuring valve assembly
US3966097A (en) * 1975-07-02 1976-06-29 Olin Corporation Fluid metering valve
CA1075854A (en) * 1976-08-16 1980-04-22 Charles W. Simons Aerosol propellants for personal products
DE2832252A1 (de) * 1978-07-22 1980-01-31 Hoechst Ag Impfpistole
BE887518A (fr) * 1980-02-15 1981-08-13 Glaxo Group Ltd Cartothioates d'androstanes
EP0037277A1 (de) 1980-04-01 1981-10-07 Interlake, Inc. Speicher- und Ausgabesystem mit Schwerkraftzuführung
FR2507304A1 (fr) 1981-06-03 1982-12-10 Lacroix E Dispositif lance-leurre infrarouge a mise en oeuvre rapide avec double securite
HU193144B (en) 1981-06-06 1987-08-28 Andras Tejfalussy Sprayer for testing agrochemical interaction of multifactor
US4506803A (en) * 1982-08-09 1985-03-26 Hoffmann-La Roche Inc. Metered aerosol dispenser and method of using the dispenser
ZW6584A1 (en) * 1983-04-18 1985-04-17 Glaxo Group Ltd Phenethanolamine derivatives
US4655959A (en) * 1983-06-28 1987-04-07 The Drackett Company Preparation of non-flammable aerosol propellant microemulsion system
FR2615124B1 (fr) 1987-05-12 1989-11-24 Valois Valve aerosol doseuse a propulseur, utilisable en position inversee
US5225183A (en) * 1988-12-06 1993-07-06 Riker Laboratories, Inc. Medicinal aerosol formulations
GB8828477D0 (en) * 1988-12-06 1989-01-05 Riker Laboratories Inc Medical aerosol formulations
GB8921222D0 (en) 1989-09-20 1989-11-08 Riker Laboratories Inc Medicinal aerosol formulations
IE67185B1 (en) * 1990-02-02 1996-03-06 Fisons Plc Propellant compositions
DE4003272A1 (de) * 1990-02-03 1991-08-08 Boehringer Ingelheim Kg Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen
CA2077354A1 (en) * 1990-03-23 1991-09-24 Minnesota Mining And Manufacturing Company Use of soluble fluorosurfactants for the preparation of metered-dose aerosol formulations
US5169433A (en) * 1990-07-18 1992-12-08 Formulogics, Inc. Method of preparing mixtures of active ingredients and excipients using liquid carbon dioxide
US5190029A (en) * 1991-02-14 1993-03-02 Virginia Commonwealth University Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
IL104068A (en) * 1991-12-12 1998-10-30 Glaxo Group Ltd Surfactant-free pharmaceutical aerosol formulation comprising 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoro-n- propane as propellant
US5301664A (en) * 1992-03-06 1994-04-12 Sievers Robert E Methods and apparatus for drug delivery using supercritical solutions
US5639441A (en) * 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
GB9305975D0 (en) * 1993-03-23 1993-05-12 Minnesota Mining & Mfg Metered-dose aerosol valves
US5474758A (en) * 1993-07-28 1995-12-12 Minnesota Mining And Manufacturing Company Seals for use in an aerosol delivery device
US5400920A (en) * 1993-07-29 1995-03-28 Minnesota Mining And Manufacturing Company One-time fill aerosol valve
JPH07241498A (ja) * 1994-03-07 1995-09-19 Nippon Tansan Gas Co Ltd 環境保全性液化ガスをプロペラントとしたエアロゾル発生方法
JP3472617B2 (ja) * 1994-04-01 2003-12-02 日本炭酸瓦斯株式会社 液化炭酸ガス用定量噴射弁及びこの弁を用いた噴射器と噴射装置
KR19980702911A (ko) * 1995-03-10 1998-09-05 테릴 케이. 퀄리 에어로졸 밸브
CA2234957C (en) * 1995-10-17 2006-12-19 Inge B. Henriksen Insoluble drug delivery
US5891420A (en) * 1997-04-21 1999-04-06 Aeropharm Technology Limited Environmentally safe triancinolone acetonide aerosol formulations for oral inhalation

Also Published As

Publication number Publication date
EA001229B1 (ru) 2000-12-25
KR19980703845A (ko) 1998-12-05
AU709006B2 (en) 1999-08-19
CZ321297A3 (cs) 1999-06-16
BR9604916A (pt) 1999-06-15
US6482390B1 (en) 2002-11-19
JPH11503362A (ja) 1999-03-26
CN1186474A (zh) 1998-07-01
WO1996032344A1 (en) 1996-10-17
HUP9801701A3 (en) 1998-12-28
DE69605028D1 (de) 1999-12-09
NO974707L (no) 1997-12-10
PL322746A1 (en) 1998-02-16
HUP9801701A2 (hu) 1998-10-28
EA199700224A1 (ru) 1998-04-30
NZ306449A (en) 1998-11-25
ES2139350T3 (es) 2000-02-01
AU5500696A (en) 1996-10-30
PL180486B1 (pl) 2001-02-28
DE69605028T2 (de) 2000-04-20
EP0820415A1 (de) 1998-01-28
TR199701149T1 (xx) 1998-01-21
NO974707D0 (no) 1997-10-10
CA2217949A1 (en) 1996-10-17
GB9507768D0 (en) 1995-05-31
US6032836A (en) 2000-03-07
EP0820415B1 (de) 1999-11-03

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