ATE186302T1 - Etoposidanaloge - Google Patents

Etoposidanaloge

Info

Publication number: ATE186302T1
Authority: AT; Austria
Prior art keywords: beta; nhch2ch; alpha; etoposide analogues; etoposide
Prior art date: 1989-02-23

Application number

AT90903699T

Other languages

English (en)

Inventor

Kuo-Hsiung Lee

Zhe Qing Wang

Yung-Chi Cheng

Su-Ying Liu

Yasuhiro Imakura

Mitsumasa - Shirotauchi Haruna

Scott A Beers

Lee S Thurston

Hua-Juan Room A- Dai

Chung-Hsiung Chen

Phillip J Bowen

Dora M Schnur

Yao Haur Chinese Culture U Kuo

Masami - Inui Higaghiazai Mori

Original Assignee

Univ North Carolina

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-23

Filing date

1990-02-23

Publication date

1999-11-15

1989-09-12 Priority claimed from US07/406,330 external-priority patent/US5132322A/en

1990-02-23 Application filed by Univ North Carolina filed Critical Univ North Carolina

1999-11-15 Application granted granted Critical

1999-11-15 Publication of ATE186302T1 publication Critical patent/ATE186302T1/de

Links

VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical class COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
230000000259 anti-tumor effect Effects 0.000 abstract 1
229960005420 etoposide Drugs 0.000 abstract 1
CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Steroid Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT90903699T 1989-02-23 1990-02-23 Etoposidanaloge ATE186302T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US31382689A	1989-02-23	1989-02-23
US07/406,330 US5132322A (en)	1989-02-23	1989-09-12	Etoposide analogues

Publications (1)

Publication Number	Publication Date
ATE186302T1 true ATE186302T1 (de)	1999-11-15

Family

ID=26979072

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90903699T ATE186302T1 (de)	1989-02-23	1990-02-23	Etoposidanaloge

Country Status (6)

Country	Link
EP (1)	EP0461141B1 (de)
JP (1)	JP3043802B2 (de)
AT (1)	ATE186302T1 (de)
AU (1)	AU632796B2 (de)
DE (1)	DE69033342T2 (de)
WO (1)	WO1990009788A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5300500A (en) *	1989-02-23	1994-04-05	The University Of North Carolina At Chapel Hill	4 beta-amino podophyllotoxin analog compounds and methods
TW221441B (de) *	1991-01-25	1994-03-01	Taiho Pharmaceutical Co Ltd
AU4113693A (en) *	1992-04-24	1993-11-29	University Of North Carolina At Chapel Hill, The	4-beta-amino podophyllotoxin derivatives antitumor agents
US5338867A (en) *	1992-04-24	1994-08-16	Genelabs Technologies, Inc.	Preparation of 4β- amino podophyllotoxin compounds
FR2742439B1 (fr) *	1995-12-14	1998-03-06	Pf Medicament	Procede de preparation de la 4'-demethylepipodophyllotoxine a partir de la podophyllotoxine
JPH1135454A (ja) *	1997-07-22	1999-02-09	Meiji Milk Prod Co Ltd	抗腫瘍剤
FR2859208B1 (fr) *	2003-09-02	2006-01-21	Servier Lab	Nouveaux derives de 9-amino-podophyllotoxine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN103613600B (zh) *	2013-11-15	2017-01-04	湖北工业大学	具抗肿瘤活性的苯胺基鬼臼类衍生物及其制备方法和用途
CN103601732A (zh) *	2013-11-15	2014-02-26	湖北工业大学	具抗肿瘤活性的氮取代鬼臼类衍生物及其制备方法和用途
CN105732651B (zh) *	2016-03-17	2018-07-20	重庆药友制药有限责任公司	一种小分子肺靶向药物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH361293A (de) *	1957-06-03	1962-04-15	Sandoz Ag	Verfahren zur Herstellung von Podophyllsäure- und Pikropodophyllsäure-Derivaten
US2984674A (en) *	1958-06-02	1961-05-16	Sandoz Ag	Amides of podophyllic acid and picropodophyllic acid
CH459257A (de) *	1965-09-21	1968-07-15	Sandoz Ag	Verfahren zur Herstellung von 4'-Demethyl-epipodophyllotoxin
NL6613143A (de) *	1965-09-21	1967-03-22
FR2316939A1 (fr) *	1975-07-08	1977-02-04	Troponwerke Dinklage & Co	Derives de 2-benzopyranone et leur application comme medicaments
US4122092A (en) *	1977-08-25	1978-10-24	University Of Rochester	Total synthesis of (±)-picropodophyllone and (±)-4'-demethylpicropodophyllone
US4567253A (en) *	1984-02-03	1986-01-28	Tony Durst	2-Substituted derivatives of podophyllotoxin and etoposide
US4788216A (en) *	1984-12-28	1988-11-29	Conpharm Ab	Medicinal uses for podophyllotoxins
JPS6310789A (ja) *	1986-07-01	1988-01-18	Nippon Kayaku Co Ltd	新規ポドフイロトキシン誘導体
JPS6323884A (ja) *	1986-07-17	1988-02-01	Nippon Kayaku Co Ltd	新規ポドフイロトキシン誘導体
US4753935A (en) *	1987-01-30	1988-06-28	Syntex (U.S.A.) Inc.	Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions
JPH07116197B2 (ja) *	1987-05-14	1995-12-13	財団法人微生物化学研究会	４′−０−デメチル−１−エピポドフィロトキシン誘導体
JPH01117885A (ja) *	1987-10-30	1989-05-10	Dai Ichi Seiyaku Co Ltd	新規ボドフィロトキシン誘導体及びその製造法

1990
- 1990-02-23 DE DE69033342T patent/DE69033342T2/de not_active Expired - Fee Related
- 1990-02-23 EP EP90903699A patent/EP0461141B1/de not_active Expired - Lifetime
- 1990-02-23 JP JP2503787A patent/JP3043802B2/ja not_active Expired - Fee Related
- 1990-02-23 AU AU51571/90A patent/AU632796B2/en not_active Ceased
- 1990-02-23 AT AT90903699T patent/ATE186302T1/de not_active IP Right Cessation
- 1990-02-23 WO PCT/US1990/000842 patent/WO1990009788A1/en not_active Ceased

Also Published As

Publication number	Publication date
JP3043802B2 (ja)	2000-05-22
DE69033342T2 (de)	2000-05-11
AU5157190A (en)	1990-09-26
EP0461141B1 (de)	1999-11-03
DE69033342D1 (de)	1999-12-09
AU632796B2 (en)	1993-01-14
EP0461141A4 (en)	1992-07-01
WO1990009788A1 (en)	1990-09-07
EP0461141A1 (de)	1991-12-18

Similar Documents

Publication	Publication Date	Title
BR1100853A (pt)	1999-12-07	Composto, composição farmacêutica, e composição veterinária
ATE129697T1 (de)	1995-11-15	9-amino-7-substituierte-6-desmethyl-6- desoxytetracyclin.
FI931708A0 (fi)	1993-04-15	Herbicida substituerade aryl-haloalkylpyrazoler
BR9609653A (pt)	1999-12-21	Compostos e composições farmacêuticas contendo os mesmos
FI904851A0 (fi)	1990-10-02	Radiomaerkta antikoagulantpeptider.
FI73969B (fi)	1987-08-31	Foerfarande foer framstaellning av terapeutiskt aktiva trans-4-aminometylcyklohexankarboxylsyraderivat.
ATE186302T1 (de)	1999-11-15	Etoposidanaloge
AR228559A1 (es)	1983-03-30	Compuestos derivados de n'-(4(fenetiloxi sustituido)fenil)-n-metil-m-metoxi-ureas
SE9004060L (sv)	1992-06-20	Bensazepin- och bensotiazepin-derivat
FI935318A0 (fi)	1993-11-29	15-deoxispergualinanaloger, foerfarande foer deras framstaellning samt deras anvaendning i terapi
DE68916850D1 (de)	1994-08-25	Antikoagulierende Peptid-Alkohole.
FI830096A0 (fi)	1983-01-11	Foerfarande foer framstaellning av 2-acyl-1,3,4,6,7,11b-hexahydro-2h-pyrazino /2,1-a/-4-isokinolino och mellanprodukter
NO914375L (no)	1992-05-11	7-acyl-3-(substituerte carbamoyloxy)cefem-forbindelser ogfremgangsmaate for fremstilling av disse
DK0545582T3 (da)	1996-09-16	Forbedret fiskeproduktion
FI892681A0 (fi)	1989-06-01	Nya jodade icke-joniska trijodbenzenfoereningar och dessa innehaollande kontrastmedel.
DK0538314T3 (da)	1997-10-13	Indano-pyrrolidincarbamater
FI901277A0 (fi)	1990-03-14	2,5,6,7-tetranor-4,8-inter-m-fenylen pg1z-derivativ.
FR2391223A1 (fr)	1978-12-15	Composes anti-tumeur analogues a la septacidine
ATE117692T1 (de)	1995-02-15	Organozinnverbindungen mit antitumoraktivität und zusammensetzungen mit antitumorwirkung.
ES2096559T3 (es)	1997-03-16	Interferon gamma humano, procedimiento para la preparacion de dicho interferon gamma humano, y su uso.
FI853506A0 (fi)	1985-09-13	Nya antibioter, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska kompositioner.
JPS5543095A (en)	1980-03-26	Selectively protected 466diiooaminoglycosyl* 1*33diaminocyclitol and its mamufacture
DE59002172D1 (de)	1993-09-09	Neue 1,3-oxazine.
GB2002349A (en)	1979-02-21	Prostane derivatives
PT81690A (de)	1986-01-01	Neue 13alpha-alkyl-17beta-(3-acyloxypropyl)-gonane

Legal Events

Date	Code	Title	Description
2000-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties