ATE186721T1 - Vitamin d3 derivat und verfahren zu dessen herstellung - Google Patents
Vitamin d3 derivat und verfahren zu dessen herstellungInfo
- Publication number
- ATE186721T1 ATE186721T1 AT95921131T AT95921131T ATE186721T1 AT E186721 T1 ATE186721 T1 AT E186721T1 AT 95921131 T AT95921131 T AT 95921131T AT 95921131 T AT95921131 T AT 95921131T AT E186721 T1 ATE186721 T1 AT E186721T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- vitamin
- derivative
- production
- group
- Prior art date
Links
- 150000003704 vitamin D3 derivatives Chemical class 0.000 title 1
- 229930003316 Vitamin D Natural products 0.000 abstract 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 235000019166 vitamin D Nutrition 0.000 abstract 1
- 239000011710 vitamin D Substances 0.000 abstract 1
- 150000003710 vitamin D derivatives Chemical class 0.000 abstract 1
- 229940046008 vitamin d Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12514494 | 1994-06-07 | ||
| JP22018594 | 1994-09-14 | ||
| JP22322994 | 1994-09-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE186721T1 true ATE186721T1 (de) | 1999-12-15 |
Family
ID=27315056
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98101653T ATE201397T1 (de) | 1994-06-07 | 1995-06-07 | Vitamin d3 derivate und ein verfahren zu ihrer herstellung |
| AT98101654T ATE205190T1 (de) | 1994-06-07 | 1995-06-07 | Vitamin d3-derivate und ein verfahren zu ihrer herstellung |
| AT95921131T ATE186721T1 (de) | 1994-06-07 | 1995-06-07 | Vitamin d3 derivat und verfahren zu dessen herstellung |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98101653T ATE201397T1 (de) | 1994-06-07 | 1995-06-07 | Vitamin d3 derivate und ein verfahren zu ihrer herstellung |
| AT98101654T ATE205190T1 (de) | 1994-06-07 | 1995-06-07 | Vitamin d3-derivate und ein verfahren zu ihrer herstellung |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US5719297A (de) |
| EP (3) | EP0712843B1 (de) |
| AT (3) | ATE201397T1 (de) |
| DE (3) | DE69513367T2 (de) |
| ES (1) | ES2138212T3 (de) |
| WO (1) | WO1995033716A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE201397T1 (de) * | 1994-06-07 | 2001-06-15 | Teijin Ltd | Vitamin d3 derivate und ein verfahren zu ihrer herstellung |
| DE19619036A1 (de) | 1996-04-30 | 1997-11-13 | Schering Ag | Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| GB2321244B (en) * | 1997-01-20 | 2000-11-22 | Pharmacia & Upjohn Spa | Vitamin D3 analogues,process for preparing them,and their use as antiproliferative and antitumour agents |
| ATE290526T1 (de) * | 1997-06-25 | 2005-03-15 | Teijin Ltd | Vitamin-d3?-derivate und aus diesen hergestellte heilmittel gegen entzündliche erkrankungen der atemwege |
| WO2000024712A1 (en) | 1998-10-23 | 2000-05-04 | Teijin Limited | Vitamin d3 derivatives and remedies for inflammatory respiratory diseases containing the same |
| DE19935771A1 (de) * | 1999-07-23 | 2001-02-01 | Schering Ag | Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| WO2001091794A2 (en) | 2000-05-30 | 2001-12-06 | Virginia Commonwealth University | Vitamin d3 analogs as radiosensitizers for the treatment of cancer |
| CA2420759A1 (en) * | 2000-08-30 | 2003-02-27 | Daishiro Miura | Parathyroid hormone production inhibitors containing vitamin d3 derivatives |
| AU2008202109B2 (en) * | 2001-06-13 | 2012-02-02 | Magnachem International Laboratories, Inc | Lactone formulations and method of use |
| US6900242B2 (en) * | 2001-06-13 | 2005-05-31 | Magnachem International Laboratories, Inc. | Lactone formulations and method of use |
| AU2003211496A1 (en) * | 2002-02-20 | 2003-09-09 | Teijin Limited | Vitamin d3 derivatives and remedies using the same |
| EP1342796A3 (de) * | 2002-02-22 | 2004-01-02 | Teijin Limited | Verbindung zur Behandlung der Paget Knochenkrankheit |
| US8188145B2 (en) | 2002-06-12 | 2012-05-29 | Magnachem International Laboratories, Inc. | Synthetic lactone formulations and method of use |
| CN102579427A (zh) | 2002-11-05 | 2012-07-18 | 马格纳化学国际实验室公司 | 合成的内酯制剂及其使用方法 |
| CN1771239B (zh) * | 2003-01-30 | 2010-06-09 | 帝人制药株式会社 | 维生素d3内酯衍生物 |
| AU2004207720A1 (en) * | 2003-01-31 | 2004-08-12 | Teijin Pharma Limited | Crystal of (23S)-1alpha-hydroxy-27-nor-25-methylenevitamin D3-26,23-lactone and process for producing the same |
| CA2741526A1 (en) | 2008-10-24 | 2010-04-29 | Magnachem International Laboratories, Inc. | Method for screening for compounds selectively interacting with rad9 |
| JPWO2010053165A1 (ja) | 2008-11-04 | 2012-04-05 | 帝人ファーマ株式会社 | ビタミンｄ３ラクタム誘導体 |
| KR101666255B1 (ko) * | 2013-01-08 | 2016-10-13 | 삼성에스디아이 주식회사 | 이차 전지 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58118516A (ja) * | 1981-12-29 | 1983-07-14 | Teijin Ltd | １α，２５−ジヒドロキシビタミンＤ↓３−２６，２３−ラクトンを含有するカルシユウム調節剤 |
| JPS58210011A (ja) * | 1982-05-31 | 1983-12-07 | Kureha Chem Ind Co Ltd | 抗腫瘍剤 |
| JPS60185715A (ja) * | 1984-03-05 | 1985-09-21 | Teijin Ltd | 骨形成促進剤 |
| DE69403541T2 (de) * | 1993-02-05 | 1997-09-25 | Teijin Ltd | Lacton-Verbindung und Verfahren zu ihrer Herstellung |
| ATE201397T1 (de) * | 1994-06-07 | 2001-06-15 | Teijin Ltd | Vitamin d3 derivate und ein verfahren zu ihrer herstellung |
-
1995
- 1995-06-07 AT AT98101653T patent/ATE201397T1/de active
- 1995-06-07 AT AT98101654T patent/ATE205190T1/de active
- 1995-06-07 AT AT95921131T patent/ATE186721T1/de active
- 1995-06-07 DE DE69513367T patent/DE69513367T2/de not_active Expired - Lifetime
- 1995-06-07 WO PCT/JP1995/001145 patent/WO1995033716A1/ja not_active Ceased
- 1995-06-07 EP EP95921131A patent/EP0712843B1/de not_active Expired - Lifetime
- 1995-06-07 DE DE69521065T patent/DE69521065T2/de not_active Expired - Lifetime
- 1995-06-07 ES ES95921131T patent/ES2138212T3/es not_active Expired - Lifetime
- 1995-06-07 US US08/591,547 patent/US5719297A/en not_active Expired - Lifetime
- 1995-06-07 EP EP98101653A patent/EP0854138B1/de not_active Expired - Lifetime
- 1995-06-07 DE DE69522589T patent/DE69522589T2/de not_active Expired - Lifetime
- 1995-06-07 EP EP98101654A patent/EP0854139B1/de not_active Expired - Lifetime
-
1997
- 1997-11-14 US US08/971,201 patent/US5986112A/en not_active Expired - Lifetime
-
1999
- 1999-06-08 US US09/327,489 patent/US6177586B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0854138A2 (de) | 1998-07-22 |
| DE69522589D1 (de) | 2001-10-11 |
| EP0854139A3 (de) | 1998-09-23 |
| DE69521065T2 (de) | 2001-10-25 |
| EP0854139B1 (de) | 2001-09-05 |
| EP0854138B1 (de) | 2001-05-23 |
| EP0712843B1 (de) | 1999-11-17 |
| EP0854139A2 (de) | 1998-07-22 |
| DE69513367D1 (de) | 1999-12-23 |
| ATE205190T1 (de) | 2001-09-15 |
| EP0712843A1 (de) | 1996-05-22 |
| DE69521065D1 (de) | 2001-06-28 |
| EP0854138A3 (de) | 1998-09-23 |
| DE69513367T2 (de) | 2000-06-08 |
| US5986112A (en) | 1999-11-16 |
| ES2138212T3 (es) | 2000-01-01 |
| DE69522589T2 (de) | 2002-04-18 |
| US6177586B1 (en) | 2001-01-23 |
| WO1995033716A1 (en) | 1995-12-14 |
| ATE201397T1 (de) | 2001-06-15 |
| EP0712843A4 (de) | 1996-11-13 |
| US5719297A (en) | 1998-02-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |