ATE201397T1 - Vitamin d3 derivate und ein verfahren zu ihrer herstellung - Google Patents

Vitamin d3 derivate und ein verfahren zu ihrer herstellung

Info

Publication number
ATE201397T1
ATE201397T1 AT98101653T AT98101653T ATE201397T1 AT E201397 T1 ATE201397 T1 AT E201397T1 AT 98101653 T AT98101653 T AT 98101653T AT 98101653 T AT98101653 T AT 98101653T AT E201397 T1 ATE201397 T1 AT E201397T1
Authority
AT
Austria
Prior art keywords
sub
vitamin
derivatives
production
group
Prior art date
Application number
AT98101653T
Other languages
English (en)
Inventor
Masayasu Tabe
Atsuo Hazato
Kenji Manabe
Quingzhi Gao
Hiroko Tanaka
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Application granted granted Critical
Publication of ATE201397T1 publication Critical patent/ATE201397T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
AT98101653T 1994-06-07 1995-06-07 Vitamin d3 derivate und ein verfahren zu ihrer herstellung ATE201397T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP12514494 1994-06-07
JP22018594 1994-09-14
JP22322994 1994-09-19

Publications (1)

Publication Number Publication Date
ATE201397T1 true ATE201397T1 (de) 2001-06-15

Family

ID=27315056

Family Applications (3)

Application Number Title Priority Date Filing Date
AT95921131T ATE186721T1 (de) 1994-06-07 1995-06-07 Vitamin d3 derivat und verfahren zu dessen herstellung
AT98101654T ATE205190T1 (de) 1994-06-07 1995-06-07 Vitamin d3-derivate und ein verfahren zu ihrer herstellung
AT98101653T ATE201397T1 (de) 1994-06-07 1995-06-07 Vitamin d3 derivate und ein verfahren zu ihrer herstellung

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT95921131T ATE186721T1 (de) 1994-06-07 1995-06-07 Vitamin d3 derivat und verfahren zu dessen herstellung
AT98101654T ATE205190T1 (de) 1994-06-07 1995-06-07 Vitamin d3-derivate und ein verfahren zu ihrer herstellung

Country Status (6)

Country Link
US (3) US5719297A (de)
EP (3) EP0712843B1 (de)
AT (3) ATE186721T1 (de)
DE (3) DE69522589T2 (de)
ES (1) ES2138212T3 (de)
WO (1) WO1995033716A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69522589T2 (de) * 1994-06-07 2002-04-18 Teijin Ltd., Osaka Vitamin D3-Derivate und ein Verfahren zu ihrer Herstellung
DE19619036A1 (de) 1996-04-30 1997-11-13 Schering Ag Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
GB2321244B (en) * 1997-01-20 2000-11-22 Pharmacia & Upjohn Spa Vitamin D3 analogues,process for preparing them,and their use as antiproliferative and antitumour agents
EP0970948B1 (de) * 1997-06-25 2005-03-09 Teijin Limited Vitamin-d3?-derivate und aus diesen hergestellte heilmittel gegen entzündliche erkrankungen der atemwege
US6531460B1 (en) 1998-10-23 2003-03-11 Teijin Limited Vitamin D, derivatives and remedies for inflammatory respiratory diseases containing the same
DE19935771A1 (de) * 1999-07-23 2001-02-01 Schering Ag Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
US20020137731A1 (en) 2000-05-30 2002-09-26 Gewirtz David A. Combination of radiation and vitamin D3 analogs for the treatment of cancer
EP1321141A4 (de) * 2000-08-30 2004-02-18 Teijin Ltd Vitamin d3-enthaltende inhibitoren der parathyroidhormonproduktion
EP1406895B1 (de) 2001-06-13 2008-08-27 Magnachem International Laboratories, Inc. Lactonformulierungen und verfahren zur anwendung
AU2008202109B2 (en) * 2001-06-13 2012-02-02 Magnachem International Laboratories, Inc Lactone formulations and method of use
JPWO2003070716A1 (ja) * 2002-02-20 2005-06-09 帝人株式会社 ビタミンｄ３誘導体およびそれを用いる治療剤
US7163933B2 (en) * 2002-02-22 2007-01-16 Teijin Limited Treating agent for Paget's disease of bone
WO2004041217A2 (en) 2002-11-05 2004-05-21 Magnachem International Laboratories, Inc. Synthetic lactone formulations and method of use
JP4361528B2 (ja) * 2003-01-30 2009-11-11 帝人ファーマ株式会社 ビタミンｄ３ラクトン誘導体
AU2004207720A1 (en) * 2003-01-31 2004-08-12 Teijin Pharma Limited Crystal of (23S)-1alpha-hydroxy-27-nor-25-methylenevitamin D3-26,23-lactone and process for producing the same
WO2005102315A1 (en) 2004-04-23 2005-11-03 Magnachem International Laboratories, Inc. Synthetic lactone formulations for pain control
AU2009308423B2 (en) 2008-10-24 2013-08-29 Magnachem International Laboratories, Inc. Method for screening for compounds selectively interacting with Rad9
EP2363390A4 (de) 2008-11-04 2012-06-13 Teijin Pharma Ltd Abgeleitetes lactam von vitamine d3
KR101666255B1 (ko) * 2013-01-08 2016-10-13 삼성에스디아이 주식회사 이차 전지

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58118516A (ja) * 1981-12-29 1983-07-14 Teijin Ltd １α，２５−ジヒドロキシビタミンＤ↓３−２６，２３−ラクトンを含有するカルシユウム調節剤
JPS58210011A (ja) * 1982-05-31 1983-12-07 Kureha Chem Ind Co Ltd 抗腫瘍剤
JPS60185715A (ja) * 1984-03-05 1985-09-21 Teijin Ltd 骨形成促進剤
CA2114830C (en) * 1993-02-05 2000-06-06 Masayasu Tabe Lactone compound and process of production thereof
DE69522589T2 (de) * 1994-06-07 2002-04-18 Teijin Ltd., Osaka Vitamin D3-Derivate und ein Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
EP0854139A2 (de) 1998-07-22
EP0854138A2 (de) 1998-07-22
DE69522589T2 (de) 2002-04-18
ES2138212T3 (es) 2000-01-01
DE69521065T2 (de) 2001-10-25
DE69522589D1 (de) 2001-10-11
US6177586B1 (en) 2001-01-23
DE69513367D1 (de) 1999-12-23
EP0854138B1 (de) 2001-05-23
US5719297A (en) 1998-02-17
EP0854138A3 (de) 1998-09-23
ATE205190T1 (de) 2001-09-15
EP0854139B1 (de) 2001-09-05
DE69521065D1 (de) 2001-06-28
WO1995033716A1 (en) 1995-12-14
EP0712843A4 (de) 1996-11-13
EP0854139A3 (de) 1998-09-23
ATE186721T1 (de) 1999-12-15
EP0712843B1 (de) 1999-11-17
US5986112A (en) 1999-11-16
DE69513367T2 (de) 2000-06-08
EP0712843A1 (de) 1996-05-22

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