ATE186916T1 - Hochreactive estern von karboxylgruppen enthaltenden polysachariden und die daraus hergestellte carboxypolysaccharide - Google Patents

Hochreactive estern von karboxylgruppen enthaltenden polysachariden und die daraus hergestellte carboxypolysaccharide

Info

Publication number
ATE186916T1
ATE186916T1 AT95913099T AT95913099T ATE186916T1 AT E186916 T1 ATE186916 T1 AT E186916T1 AT 95913099 T AT95913099 T AT 95913099T AT 95913099 T AT95913099 T AT 95913099T AT E186916 T1 ATE186916 T1 AT E186916T1
Authority
AT
Austria
Prior art keywords
polysaccharides
carboxy
pct
modified
active esters
Prior art date
Application number
AT95913099T
Other languages
English (en)
Inventor
Zefferino Righetto
Davide Bellini
Original Assignee
Fidia Advanced Biopolymers Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Advanced Biopolymers Srl filed Critical Fidia Advanced Biopolymers Srl
Application granted granted Critical
Publication of ATE186916T1 publication Critical patent/ATE186916T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Polyesters Or Polycarbonates (AREA)
AT95913099T 1994-03-11 1995-03-13 Hochreactive estern von karboxylgruppen enthaltenden polysachariden und die daraus hergestellte carboxypolysaccharide ATE186916T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1994PD000043A IT1268955B1 (it) 1994-03-11 1994-03-11 Esteri attivi di polisaccaridi carbossilici

Publications (1)

Publication Number Publication Date
ATE186916T1 true ATE186916T1 (de) 1999-12-15

Family

ID=11390595

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95913099T ATE186916T1 (de) 1994-03-11 1995-03-13 Hochreactive estern von karboxylgruppen enthaltenden polysachariden und die daraus hergestellte carboxypolysaccharide

Country Status (11)

Country Link
US (1) US5856299A (de)
EP (1) EP0749446B1 (de)
AT (1) ATE186916T1 (de)
CA (1) CA2184899C (de)
DE (1) DE69513507T2 (de)
DK (1) DK0749446T3 (de)
ES (1) ES2141925T3 (de)
GR (1) GR3032589T3 (de)
IT (1) IT1268955B1 (de)
PT (1) PT749446E (de)
WO (1) WO1995024429A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1247472B (it) * 1991-05-31 1994-12-17 Fidia Spa Processo per la preparazione di microsfere contenenti componenti biologicamente attivi.
US6632802B2 (en) * 1996-08-29 2003-10-14 Fidia Advanced Biopolymers S.R.L. Hyaluronic acid esters, threads and biomaterials containing them, and their use in surgery
IT1287698B1 (it) * 1996-08-29 1998-08-18 Fidia Advanced Biopolymers Srl Fili da sutura essenzialmente costituiti da derivati esterei dello acido ialuronico
ATE413415T1 (de) 1996-09-19 2008-11-15 Univ Michigan Polymere enthaltend polysaccharide wie alginate oder modifizierte alginate
EP1806367A3 (de) * 1996-09-19 2007-11-28 The Regents Of The University Of Michigan Polysaccharide wie Alginate oder modifizierte Alginate enthaltende Polymere
ITPD980169A1 (it) * 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
IT1301994B1 (it) * 1998-08-05 2000-07-20 Jasper Ltd Liability Co Derivati dell'acido ialuronico.
US6630457B1 (en) * 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
US6517678B1 (en) 2000-01-20 2003-02-11 Kimberly-Clark Worldwide, Inc. Modified polysaccharides containing amphiphillic hydrocarbon moieties
US6398911B1 (en) 2000-01-21 2002-06-04 Kimberly-Clark Worldwide, Inc. Modified polysaccharides containing polysiloxane moieties
US6596126B1 (en) * 1999-01-25 2003-07-22 Kimberly-Clark Worldwide, Inc. Modified polysaccharides containing aliphatic hydrocarbon moieties
US6896769B2 (en) 1999-01-25 2005-05-24 Kimberly-Clark Worldwide, Inc. Modified condensation polymers containing azetidinium groups in conjunction with amphiphilic hydrocarbon moieties
US6465602B2 (en) 2000-01-20 2002-10-15 Kimberly-Clark Worldwide, Inc. Modified condensation polymers having azetidinium groups and containing polysiloxane moieties
IT1317091B1 (it) * 2000-02-08 2003-05-26 S F I R Societa Fondaria Ind R Gel di acido ialuronico cross-linked con l-amminoacidi ol-amminoesteri bifunzionali.
US20030049253A1 (en) * 2001-08-08 2003-03-13 Li Frank Q. Polymeric conjugates for delivery of MHC-recognized epitopes via peptide vaccines
US20040127416A1 (en) * 2002-11-15 2004-07-01 Massia Stephen P. Therapeutic bioconjugates
EP1595892A4 (de) 2003-02-21 2007-06-20 Terumo Corp Vernetzbares polysaccharidderivat, herstellungsverfahren dafür, vernetzbares polysaccharidderivat enthaltende zusammensetzung und material für die medizinische behandlung
US20050095219A1 (en) * 2003-10-29 2005-05-05 Shu-Ping Yang Compositions for promoting vaginal cell proliferation and maturation
US8313765B2 (en) * 2003-12-04 2012-11-20 Industrial Technology Research Institute Biodegradable hyaluronic acid derivative, biodegradable polymeric micelle composition and pharmaceutical or bioactive composition
GB2408741B (en) * 2003-12-04 2008-06-18 Ind Tech Res Inst Hyaluronic acid derivative with urethane linkage
ITMI20041373A1 (it) 2004-07-09 2004-10-09 Lima Lto S P A N-metil-ammidi di carbossimetilcellulosa acido alginico o carbossimetalamido
ITPD20050056A1 (it) 2005-03-02 2006-09-03 Fidia Farmaceutici Derivati ammidici del'acido ialuronico in osteoartrosi
EP2106263B1 (de) 2007-01-04 2016-12-21 Hepacore Ltd. Wasserlösliche und reaktive derivate von carboxy-polysacchariden und fibrinogen-konjugate daraus
WO2009133763A1 (ja) * 2008-05-01 2009-11-05 テルモ株式会社 視認性医療用処置材
ITMI20080981A1 (it) * 2008-05-27 2009-11-28 Fidia Advanced Biopolymers Srl Processo per la preparazione di microsfere di polimeri semi-sintetici
ITRM20080636A1 (it) 2008-11-28 2010-05-29 Univ Palermo Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli.
JP5604072B2 (ja) * 2009-09-28 2014-10-08 テルモ株式会社 活性エステル化多糖およびその製造方法
FR2966248B1 (fr) * 2010-10-18 2020-05-01 Centre National De La Recherche Scientifique (Cnrs) Procede de fonctionnalisation de surfaces pour la detection d'analytes
WO2012140650A2 (en) 2011-04-12 2012-10-18 Hepacore Ltd. Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof
TWI561535B (en) 2011-10-06 2016-12-11 Bvw Holding Ag Copolymers of hydrophobic and hydrophilic segments that reduce protein adsorption
FR3066386B1 (fr) * 2017-05-18 2020-08-28 Bioxis Pharmaceuticals Procede de preparation d'un gel aqueux d'acide hyaluronique

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2881161A (en) * 1955-03-25 1959-04-07 Henkel & Cie Gmbh Amides of alginic acid
DD121785A1 (de) * 1975-08-06 1976-08-20
US4732863A (en) * 1984-12-31 1988-03-22 University Of New Mexico PEG-modified antibody with reduced affinity for cell surface Fc receptors
US5202431A (en) * 1985-07-08 1993-04-13 Fidia, S.P.A. Partial esters of hyaluronic acid
IT1203814B (it) * 1986-06-30 1989-02-23 Fidia Farmaceutici Esteri dell'acido alginico
US6174999B1 (en) * 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
IT1219587B (it) * 1988-05-13 1990-05-18 Fidia Farmaceutici Polisaccaridi carbossiilici autoreticolati
IT1219942B (it) * 1988-05-13 1990-05-24 Fidia Farmaceutici Esteri polisaccaridici
US5332809A (en) * 1991-02-11 1994-07-26 Fidia S.P.A. Partial esters of gellan

Also Published As

Publication number Publication date
ITPD940043A1 (it) 1995-09-11
US5856299A (en) 1999-01-05
IT1268955B1 (it) 1997-03-18
DE69513507T2 (de) 2000-07-06
GR3032589T3 (en) 2000-05-31
ITPD940043A0 (it) 1994-03-11
ES2141925T3 (es) 2000-04-01
DK0749446T3 (da) 2000-05-08
CA2184899C (en) 2006-05-30
EP0749446A1 (de) 1996-12-27
PT749446E (pt) 2000-05-31
WO1995024429A1 (en) 1995-09-14
EP0749446B1 (de) 1999-11-24
CA2184899A1 (en) 1995-08-14
DE69513507D1 (de) 1999-12-30

Similar Documents

Publication Publication Date Title
ATE186916T1 (de) Hochreactive estern von karboxylgruppen enthaltenden polysachariden und die daraus hergestellte carboxypolysaccharide
HU893005D0 (en) Process for producing polysaccharidic esthers
ATE133336T1 (de) Verwendung von rapamycin zur herstellung eines arzneimittels zur behandlung von augenentzündungen
FR2642970B1 (fr) Produit cosmetique contenant des derives d'acides hyaluronique et ascorbique
HU9501953D0 (en) Pharmaceutically active pyridine derivatives and process for the preparation thereof
PT781281E (pt) Derivados de beta-carbolina agonistas da melatonina seu processo de preparacao e sua utilizacao a titulo de medicamento
EG20001A (en) Process for preparing of novel hydrox-amic acid and N-hydroxyurea derivatives and their use
DE69815122D1 (de) Saccharid-enthaltende zubereitungen zur behandlung von alzheimerschen erkrankung und von weiteren amyloidosen
ATE213164T1 (de) Verwendung von nona- und dekapeptiden zur herstellung eines arzneimittels zur bekämpfung von aids
JPH05503733A (ja) メチルピロリジノンキトーサン、その生産方法および使用
HU9201258D0 (en) Process for the production of medical preparations for treating hiv infections and of their active agents
ATE162804T1 (de) Selbstvernetztes gellangummi
ATE172117T1 (de) Verwendung von trospiumchlorid zur herstellung eines arzneimittels zur behandlung von blasenkrankheiten
DE3851941D1 (de) Polycyclische aromatische Ester von makroliden Antibiotika und linkosamiden Antibiotika, Verfahren zu ihrer Herstellung und die sie enthaltenden pharmazeutischen und kosmetischen Zusammensetzungen.
ATE162076T1 (de) Verwendung von nadh und nadph zur herstellung eines arzneimittels zur behandlung von morbus alzheimer
NO172043C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive n-2,3-butadienyl-triamioalkanderivater
AU5326098A (en) Benzofuranacrylic acid derivatives and their use as modulators of RXRS or RARS receptors
DE69528573T2 (de) Verwendung einer Zubereitung enthaltend einen Plasminogen-Aktivator für die Verbesserung der Wundheilung
ATE136465T1 (de) Verwendung von gibberellinen zur herstellung eines arzneimittels zur behandlung von prostatitis
DE69129563D1 (de) Epidermis-Wachstumsfaktor als Arzneimittel zur Wiederherstellung der Neuronen der Substantia nigra in der Behandlung nervenzerstörender Störungen
RU94000064A (ru) Новые 2-циано-3-гидроксипропенамиды, метод их получения и содержащие их фармацевтические композиции
RU94028944A (ru) Способ получения косметического средства для ухода за кожей
OA09665A (fr) Esters d'aminoacides de l'hydroquinone, leur procédé de préparation et compositions pharmaceutiques ou cosmétiques les contenant
DE3881484D1 (de) Optisch aktive produkte von 20,21-dinoreburnamenin-derivaten, verfahren zur herstellung, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zusammenstellungen.
ATE192650T1 (de) Verwendung von efaroxan und dessen derivaten zur herstellung eines arzneimittels zur behandlung parkinsonscher krankheit

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee