ATE187062T1 - Formulierungen zum suspendieren: von proteine und peptiden - Google Patents
Formulierungen zum suspendieren: von proteine und peptidenInfo
- Publication number
- ATE187062T1 ATE187062T1 AT96920358T AT96920358T ATE187062T1 AT E187062 T1 ATE187062 T1 AT E187062T1 AT 96920358 T AT96920358 T AT 96920358T AT 96920358 T AT96920358 T AT 96920358T AT E187062 T1 ATE187062 T1 AT E187062T1
- Authority
- AT
- Austria
- Prior art keywords
- peptides
- proteins
- beneficial agent
- suspension formulations
- suspension
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/475,238 US5904935A (en) | 1995-06-07 | 1995-06-07 | Peptide/protein suspending formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE187062T1 true ATE187062T1 (de) | 1999-12-15 |
Family
ID=23886776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96920358T ATE187062T1 (de) | 1995-06-07 | 1996-05-22 | Formulierungen zum suspendieren: von proteine und peptiden |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US5904935A (de) |
| EP (1) | EP0831773B1 (de) |
| JP (2) | JPH11506730A (de) |
| KR (1) | KR100460653B1 (de) |
| CN (1) | CN1138528C (de) |
| AT (1) | ATE187062T1 (de) |
| AU (1) | AU706318B2 (de) |
| CA (1) | CA2220871C (de) |
| DE (1) | DE69605417T2 (de) |
| DK (1) | DK0831773T3 (de) |
| ES (1) | ES2139360T3 (de) |
| FI (1) | FI119464B (de) |
| NZ (1) | NZ308843A (de) |
| WO (1) | WO1996040049A1 (de) |
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6063910A (en) * | 1991-11-14 | 2000-05-16 | The Trustees Of Princeton University | Preparation of protein microparticles by supercritical fluid precipitation |
| CZ286632B6 (cs) | 1992-09-29 | 2000-05-17 | Inhale Therapeutic Systems | Farmaceutický prostředek |
| EP1462096B1 (de) | 1994-03-07 | 2008-12-10 | Nektar Therapeutics | Verfahren und Zusammensetzung für die pulmonale Darreichung von Insulin |
| US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| MY125870A (en) * | 1997-07-25 | 2006-08-30 | Alza Corp | Osmotic delivery system flow modulator apparatus and method |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US6309623B1 (en) | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| WO1999055310A1 (en) | 1998-04-27 | 1999-11-04 | Altus Biologics Inc. | Stabilized protein crystals, formulations containing them and methods of making them |
| US8052982B2 (en) | 1998-07-20 | 2011-11-08 | Peptech Animal Health Pty Limited | Bioimplant formulation comprising lecithin and stearin |
| HK1038508B (en) * | 1998-09-09 | 2006-06-30 | Alza Corporation | Dosage form comprising liquid formulation |
| US6194006B1 (en) | 1998-12-30 | 2001-02-27 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of microparticles having a selected release profile |
| US7258869B1 (en) | 1999-02-08 | 2007-08-21 | Alza Corporation | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle |
| US7919109B2 (en) | 1999-02-08 | 2011-04-05 | Intarcia Therapeutics, Inc. | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles |
| CA2361424C (en) * | 1999-02-08 | 2009-04-28 | Intarcia Therapeutics, Inc. | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles |
| KR20080011353A (ko) | 2000-02-24 | 2008-02-01 | 몬산토 테크놀로지 엘엘씨 | 소마토트로핀의 지속적인 방출을 위한 비수성 주사제제들 |
| US6992065B2 (en) | 2000-04-19 | 2006-01-31 | Genentech, Inc. | Sustained release formulations |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| US6264987B1 (en) | 2000-05-19 | 2001-07-24 | Alkermes Controlled Therapeutics Inc. Ii | Method for preparing microparticles having a selected polymer molecular weight |
| US6495164B1 (en) | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
| MXPA03000073A (es) * | 2000-06-26 | 2003-09-25 | Monsanto Technology Llc | Formulaciones que contienen agente tensioactivo no acuoso para la liberacion prolongada de somatrotopina. |
| US6664234B1 (en) * | 2000-06-30 | 2003-12-16 | Monsanto Technology Llc | Non-aqueous injectable formulation preparation with pH adjusted for extended release of somatotropin |
| US6824822B2 (en) | 2001-08-31 | 2004-11-30 | Alkermes Controlled Therapeutics Inc. Ii | Residual solvent extraction method and microparticles produced thereby |
| US6471995B1 (en) | 2000-09-27 | 2002-10-29 | Alkermes Controlled Therapeutics, Inc. Ii | Apparatus and method for preparing microparticles using liquid-liquid extraction |
| US20020114843A1 (en) | 2000-12-27 | 2002-08-22 | Ramstack J. Michael | Preparation of microparticles having improved flowability |
| NZ526720A (en) * | 2000-12-28 | 2007-11-30 | Altus Pharmaceuticals Inc | Crystallisation of whole antibodies or fragments thereof, on a large scale and a process allowing an alternative route for delivery of therapeutic antibodies |
| AU2002242231B2 (en) * | 2001-02-23 | 2007-09-06 | Genentech, Inc. | Erodible polymers for injection |
| CA2448218C (en) * | 2001-06-21 | 2012-05-29 | Genentech, Inc. | Sustained release formulation |
| CA2451185A1 (en) * | 2001-06-21 | 2003-01-03 | Altus Biologics, Inc. | Spherical protein particles and methods of making and using them |
| WO2003053411A1 (en) | 2001-12-19 | 2003-07-03 | Nektar Therapeutics | Pulmonary delivery of aminoglycosides |
| NZ537136A (en) * | 2002-06-17 | 2007-07-27 | Alza Corp | Osmotic delivery system with early zero order push power engine comprising an osmotic agent dispersed in the fluid vehicle |
| CA2508124A1 (en) * | 2002-12-19 | 2004-07-08 | Alza Corporation | Stable, non-aqueous, single-phase gels and formulations thereof for delivery from an implantable device |
| US7731947B2 (en) * | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| CA2520766A1 (en) * | 2003-03-31 | 2004-10-21 | Alza Corporation | Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems |
| DE602004012081T2 (de) * | 2003-03-31 | 2009-03-19 | Intarcia Therapeutics, Inc., Emeryville | Osmotische pumpe mit mitteln zum ableiten des innendrucks |
| CA2530136C (en) | 2003-06-26 | 2012-10-16 | Control Delivery Systems, Inc. | In-situ gelling drug delivery system |
| CA2530113C (en) | 2003-06-26 | 2013-08-13 | Control Delivery Systems, Inc. | Bioerodible sustained release drug delivery systems |
| US7459021B2 (en) | 2003-09-03 | 2008-12-02 | Shmuel Bukshpan | Methods and apparatus for rapid crystallization of biomolecules |
| MXPA06002030A (es) * | 2003-10-31 | 2006-05-17 | Alza Corp | Bomba osmotica con tapon de membrana de auto-retencion, de rapido inicio. |
| JP2007526792A (ja) * | 2003-11-06 | 2007-09-20 | アルザ・コーポレーシヨン | 移植可能な浸透ポンプと一緒の使用のためのモジュール型の吸入速度低下器 |
| KR101040415B1 (ko) | 2004-04-15 | 2011-06-09 | 알케르메스,인코포레이티드 | 중합체 기재 지속적 방출 방법 |
| US20050266087A1 (en) * | 2004-05-25 | 2005-12-01 | Gunjan Junnarkar | Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium |
| US7772182B2 (en) * | 2004-08-05 | 2010-08-10 | Alza Corporation | Stable suspension formulations of erythropoietin receptor agonists |
| US20060029551A1 (en) * | 2004-08-05 | 2006-02-09 | Kui Liu | Stable particle formulations of erythropoietin receptor agonists |
| US20060045891A1 (en) * | 2004-08-24 | 2006-03-02 | Lovalenti Phillip M | Density-matched suspension vehicles and pharmaceutical suspensions |
| US7655254B2 (en) * | 2005-02-03 | 2010-02-02 | Intarcia Therapeutics, Inc. | Implantable device for continuous delivery of interferon |
| US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
| WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
| US7759312B2 (en) | 2005-03-11 | 2010-07-20 | Endo Pharmaceuticals Solutions Inc. | Delivery of dry formulations of octreotide |
| EP2457564A1 (de) * | 2005-03-11 | 2012-05-30 | Endo Pharmaceuticals Solutions Inc. | Octreotid-Formulierungen mit kontrollierter Freisetzung |
| US7959938B2 (en) | 2005-03-15 | 2011-06-14 | Intarcia Therapeutics, Inc. | Polyoxaester suspending vehicles for use with implantable delivery systems |
| AU2007266475B2 (en) | 2006-05-30 | 2009-12-03 | Intarcia Therapeutics, Inc. | Two-piece, internal-channel osmotic delivery system flow modulator |
| NZ573174A (en) * | 2006-06-01 | 2012-01-12 | Msd Consumer Care Inc | Sustained release pharmaceutical dosage form containing phenylephrine |
| JP5048773B2 (ja) * | 2006-08-09 | 2012-10-17 | インターシア セラピューティクス,インコーポレイティド | 浸透圧式デリバリーシステム及びピストンアセンブリー |
| AU2008244523B2 (en) | 2007-04-23 | 2012-02-16 | Intarcia Therapeutics, Inc. | Suspension formulations of insulinotropic peptides and uses thereof |
| RU2463079C2 (ru) | 2007-04-27 | 2012-10-10 | Эндо Фармасьютикалз Солюшнз Инк. | Разделительные агенты для имплантируемого устройства и способы их применения |
| CN101674812B (zh) * | 2007-04-30 | 2013-12-11 | 诺沃-诺迪斯克有限公司 | 干燥蛋白组合物的方法、干燥的蛋白组合物和包含干燥的蛋白的药物组合物 |
| DK2170283T3 (en) | 2007-06-22 | 2019-04-15 | Univ Texas | CREATION OF STABLE SUBMICRON Peptide OR PROTEIN PARTICLES BY THIN FILM FREEZING |
| DK2240155T3 (da) | 2008-02-13 | 2012-09-17 | Intarcia Therapeutics Inc | Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler |
| WO2009158412A2 (en) | 2008-06-25 | 2009-12-30 | Endo Pharmaceuticals Solutions Inc. | Sustained delivery of exenatide and other polypeptides |
| EP2317975B1 (de) | 2008-06-25 | 2016-04-13 | Endo Pharmaceuticals Solutions Inc. | Octreotid-implantat mit freisetzungsmittel |
| KR20170138580A (ko) | 2008-08-15 | 2017-12-15 | 아이언우드 파마슈티컬스, 인코포레이티드 | 경구 투여를 위한 리나클로타이드-함유 제형 |
| AU2009303905B2 (en) * | 2008-10-15 | 2015-01-22 | Intarcia Therapeutics, Inc. | Highly concentrated drug particles, formulations, suspensions and uses thereof |
| JP5711138B2 (ja) | 2008-11-16 | 2015-04-30 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 高濃度の低粘度懸濁液 |
| EP3466438A1 (de) | 2009-08-03 | 2019-04-10 | Incube Labs, Llc | Schluckbare kapsel und verfahren zur stimulation der inkretinproduktion innerhalb des darmtrakts |
| CA2770077A1 (en) | 2009-08-06 | 2011-02-10 | Ironwood Pharmaceuticals, Inc. | Formulations comprising linaclotide |
| SMT201700583T1 (it) | 2009-09-28 | 2018-01-11 | Intarcia Therapeutics Inc | Instaurazione e/o terminazione rapida di erogazione di farmaci in modo sostanzialmente stazionario |
| US8562589B2 (en) | 2009-12-24 | 2013-10-22 | Rani Therapeutics, Llc | Swallowable drug delivery device and method of delivery |
| UA108636C2 (xx) | 2010-02-17 | 2015-05-25 | Пептид | |
| US9072668B2 (en) | 2010-03-09 | 2015-07-07 | Janssen Biotech, Inc. | Non-aqueous high concentration reduced viscosity suspension formulations of antibodies |
| LT2603232T (lt) | 2010-08-11 | 2020-01-27 | Ironwood Pharmaceuticals, Inc. | Stabilios linaklotido vaisto formos |
| US8969293B2 (en) | 2010-12-23 | 2015-03-03 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising exenatide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8980822B2 (en) | 2010-12-23 | 2015-03-17 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising pramlintide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US10639272B2 (en) | 2010-12-23 | 2020-05-05 | Rani Therapeutics, Llc | Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9402806B2 (en) | 2010-12-23 | 2016-08-02 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8809269B2 (en) | 2010-12-23 | 2014-08-19 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising insulin for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9402807B2 (en) | 2010-12-23 | 2016-08-02 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8809271B2 (en) | 2010-12-23 | 2014-08-19 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising liraglutide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9283179B2 (en) | 2010-12-23 | 2016-03-15 | Rani Therapeutics, Llc | GnRH preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9259386B2 (en) | 2010-12-23 | 2016-02-16 | Rani Therapeutics, Llc | Therapeutic preparation comprising somatostatin or somatostatin analogoue for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8734429B2 (en) | 2010-12-23 | 2014-05-27 | Rani Therapeutics, Llc | Device, system and methods for the oral delivery of therapeutic compounds |
| US9861683B2 (en) | 2010-12-23 | 2018-01-09 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9284367B2 (en) | 2010-12-23 | 2016-03-15 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9415004B2 (en) | 2010-12-23 | 2016-08-16 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8846040B2 (en) | 2010-12-23 | 2014-09-30 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising etanercept for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9149617B2 (en) | 2010-12-23 | 2015-10-06 | Rani Therapeutics, Llc | Device, system and methods for the oral delivery of therapeutic compounds |
| US8764733B2 (en) | 2010-12-23 | 2014-07-01 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9629799B2 (en) | 2010-12-23 | 2017-04-25 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| ES2614864T3 (es) | 2011-08-17 | 2017-06-02 | Ironwood Pharmaceuticals, Inc. | Tratamientos para trastornos gastrointestinales |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| US10925639B2 (en) | 2015-06-03 | 2021-02-23 | Intarcia Therapeutics, Inc. | Implant placement and removal systems |
| KR20240037175A (ko) | 2016-05-16 | 2024-03-21 | 인타르시아 세라퓨틱스 인코포레이티드 | 글루카곤-수용체 선택적 폴리펩티드 및 이들의 이용 방법 |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| MX2019008006A (es) | 2017-01-03 | 2019-08-29 | Intarcia Therapeutics Inc | Metodos que comprenden la administracion continua de un agonista del receptor de glp-1 y la co-administracion de un farmaco. |
| USD933219S1 (en) | 2018-07-13 | 2021-10-12 | Intarcia Therapeutics, Inc. | Implant removal tool and assembly |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3732865A (en) * | 1971-01-13 | 1973-05-15 | Alza Corp | Osmotic dispenser |
| US3833725A (en) * | 1972-12-08 | 1974-09-03 | Syntex Corp | Dialkylated glycol compositions and medicament preparations containing same |
| US4036954A (en) * | 1973-11-02 | 1977-07-19 | Yamanouchi Pharmaceutical Co., Ltd. | Stable prostaglandin E group-containing formulation |
| US4180560A (en) * | 1976-10-26 | 1979-12-25 | Syntex Corporation | Inert core implant pellet |
| US4215691A (en) * | 1978-10-11 | 1980-08-05 | Alza Corporation | Vaginal contraceptive system made from block copolymer |
| US4237885A (en) * | 1978-10-23 | 1980-12-09 | Alza Corporation | Delivery system with mated members for storing and releasing a plurality of beneficial agents |
| US4389414A (en) * | 1981-05-11 | 1983-06-21 | Syntex (U.S.A.) Inc. | Prostaglandin compositions |
| US4507281A (en) * | 1981-10-13 | 1985-03-26 | Exovir, Inc. | Interferon-containing compositions |
| US4475916A (en) * | 1982-03-18 | 1984-10-09 | Merck & Co., Inc. | Osmotic drug delivery system |
| ATE37983T1 (de) * | 1982-04-22 | 1988-11-15 | Ici Plc | Mittel mit verzoegerter freigabe. |
| US4483849A (en) * | 1983-01-07 | 1984-11-20 | Carter William A | Stabilization and purification of interferon with propylene glycol, resulting in a non-toxic product |
| JPS60501759A (ja) * | 1983-07-01 | 1985-10-17 | バテル メモリアル インステイチユ−ト | 生物分解性ポリペプチド及び薬剤の緩慢な放出のためのその使用 |
| US4855134A (en) * | 1983-10-14 | 1989-08-08 | Sumitomo Pharmaceuticals Company, Limited | Sustained-release preparation |
| GB2155889B (en) * | 1984-03-21 | 1988-03-02 | Alza Corp | Dispenser-capsule |
| US5032572A (en) * | 1984-07-18 | 1991-07-16 | Medical College Of Ohio | Polymers containing cross-linked azo bonds, which polymers are useful for releasing therapeutic agents into the lower gastrointestinal tract |
| US4847079A (en) * | 1985-07-29 | 1989-07-11 | Schering Corporation | Biologically stable interferon compositions comprising thimerosal |
| GB8613688D0 (en) * | 1986-06-05 | 1986-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| US4853218A (en) * | 1987-02-24 | 1989-08-01 | Schering Corporation | Zinc-protamine-alpha interferon complex |
| JPS63281299A (ja) * | 1987-05-13 | 1988-11-17 | Hitachi Ltd | 連想メモリ装置 |
| EP0294160A1 (de) * | 1987-06-02 | 1988-12-07 | Schering Corporation | Behandlung von chronischer Hepatitis B mit einer Mischung menschlicher rekombinanter Alpha- und Gamma-Interferone |
| US4871538A (en) * | 1987-07-13 | 1989-10-03 | Schering Corporation | Insoluble copper-alpha interferon complex |
| IT1222734B (it) * | 1987-09-25 | 1990-09-12 | Scalvo S P A | Formulaziopne farmaceutiche e forme di dosaggio per la somminaistarzione rettale di calcitonina |
| US4855141A (en) * | 1988-03-25 | 1989-08-08 | Alza Corporation | Device comprising means for protecting and dispensing fluid sensitive medicament |
| HU201567B (en) * | 1988-07-21 | 1990-11-28 | Gyogyszerkutato Intezet | Process for production of intravenous medical compositions containing cyclosphorin |
| US5342625A (en) * | 1988-09-16 | 1994-08-30 | Sandoz Ltd. | Pharmaceutical compositions comprising cyclosporins |
| US5034229A (en) * | 1988-12-13 | 1991-07-23 | Alza Corporation | Dispenser for increasing feed conversion of hog |
| US5110596A (en) * | 1988-12-13 | 1992-05-05 | Alza Corporation | Delivery system comprising means for delivering agent to livestock |
| US5057318A (en) * | 1988-12-13 | 1991-10-15 | Alza Corporation | Delivery system for beneficial agent over a broad range of rates |
| EP0374120A3 (de) * | 1988-12-13 | 1991-07-31 | Monsanto Company | Zusammensetzung mit kontrollierter Wirkstoffabgabe von Polypeptiden |
| IT8920486A0 (it) * | 1989-05-12 | 1989-05-12 | Isf Spa | Composizioni farmaceutiche. |
| JP2514249B2 (ja) * | 1989-05-23 | 1996-07-10 | 帝人株式会社 | 安定化されたカルシトニン類医薬組成物 |
| US5100392A (en) * | 1989-12-08 | 1992-03-31 | Biosynthesis, Inc. | Implantable device for administration of drugs or other liquid solutions |
| IT1242642B (it) * | 1990-04-17 | 1994-05-16 | Alfa Wassermann Spa | Formulazioni iniettabili contenenti naproxen sale sodico. |
| FR2663223B1 (fr) * | 1990-06-14 | 1994-12-02 | Af Aplicaciones Far Lab | Forme galenique parenterale. |
| US5137727A (en) * | 1991-06-12 | 1992-08-11 | Alza Corporation | Delivery device providing beneficial agent stability |
| US5236707A (en) * | 1991-11-08 | 1993-08-17 | Dallas Biotherapeutics, Inc. | Stabilization of human interferon |
| JP3730667B2 (ja) * | 1991-12-27 | 2006-01-05 | 武田薬品工業株式会社 | 注射用組成物 |
| US5223265A (en) * | 1992-01-10 | 1993-06-29 | Alza Corporation | Osmotic device with delayed activation of drug delivery |
| US5221278A (en) * | 1992-03-12 | 1993-06-22 | Alza Corporation | Osmotically driven delivery device with expandable orifice for pulsatile delivery effect |
| US5614487A (en) * | 1993-05-28 | 1997-03-25 | Genentech, Inc. | Sustained release pharmaceutical composition |
| WO1995010989A1 (en) * | 1993-10-19 | 1995-04-27 | Scimed Life Systems, Inc. | Intravascular stent pump |
| DK0768867T3 (da) * | 1994-06-13 | 2002-10-28 | Alza Corp | Doseringsform til indgivelse af lægemiddel i væskeformig formulering |
| WO1999008832A1 (de) * | 1997-08-20 | 1999-02-25 | Mikron Sa Agno | Vorrichtung zum bewegen und positionieren eines gegenstandes in einer ebene |
-
1995
- 1995-06-07 US US08/475,238 patent/US5904935A/en not_active Expired - Lifetime
-
1996
- 1996-05-22 CN CNB961944943A patent/CN1138528C/zh not_active Expired - Fee Related
- 1996-05-22 NZ NZ308843A patent/NZ308843A/xx not_active IP Right Cessation
- 1996-05-22 AT AT96920358T patent/ATE187062T1/de not_active IP Right Cessation
- 1996-05-22 ES ES96920358T patent/ES2139360T3/es not_active Expired - Lifetime
- 1996-05-22 AU AU58694/96A patent/AU706318B2/en not_active Ceased
- 1996-05-22 JP JP9500644A patent/JPH11506730A/ja not_active Withdrawn
- 1996-05-22 WO PCT/US1996/007377 patent/WO1996040049A1/en not_active Ceased
- 1996-05-22 DE DE69605417T patent/DE69605417T2/de not_active Expired - Lifetime
- 1996-05-22 CA CA2220871A patent/CA2220871C/en not_active Expired - Fee Related
- 1996-05-22 KR KR1019970708967A patent/KR100460653B1/ko not_active Expired - Fee Related
- 1996-05-22 EP EP96920358A patent/EP0831773B1/de not_active Expired - Lifetime
- 1996-05-22 DK DK96920358T patent/DK0831773T3/da active
-
1997
- 1997-12-05 FI FI974429A patent/FI119464B/fi active IP Right Grant
-
1999
- 1999-01-28 US US09/238,159 patent/US5972370A/en not_active Expired - Lifetime
-
2008
- 2008-10-22 JP JP2008271657A patent/JP2009057389A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2220871C (en) | 2011-02-08 |
| EP0831773B1 (de) | 1999-12-01 |
| FI119464B (fi) | 2008-11-28 |
| US5972370A (en) | 1999-10-26 |
| KR19990022486A (ko) | 1999-03-25 |
| CN1138528C (zh) | 2004-02-18 |
| JP2009057389A (ja) | 2009-03-19 |
| WO1996040049A1 (en) | 1996-12-19 |
| CN1187119A (zh) | 1998-07-08 |
| DE69605417T2 (de) | 2000-03-23 |
| DK0831773T3 (da) | 2000-05-08 |
| ES2139360T3 (es) | 2000-02-01 |
| CA2220871A1 (en) | 1996-12-19 |
| AU5869496A (en) | 1996-12-30 |
| AU706318B2 (en) | 1999-06-17 |
| FI974429A0 (fi) | 1997-12-05 |
| FI974429L (fi) | 1997-12-05 |
| KR100460653B1 (ko) | 2005-08-05 |
| NZ308843A (en) | 2000-01-28 |
| EP0831773A1 (de) | 1998-04-01 |
| US5904935A (en) | 1999-05-18 |
| JPH11506730A (ja) | 1999-06-15 |
| DE69605417D1 (de) | 2000-01-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |