ATE187172T1 - Chinolin-2-on derivate als serotonin antagonisten - Google Patents

Chinolin-2-on derivate als serotonin antagonisten

Info

Publication number: ATE187172T1
Authority: AT; Austria
Prior art keywords: quinolin; derivatives; serotonin antagonists; serotonin; antagonists
Prior art date: 1995-09-15

Application number

AT96931112T

Other languages

English (en)

Inventor

Cort Gary Mc

Christian Hoornaert

Genevieve Dellac

Michel Aletru

Original Assignee

Sanofi Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-15

Filing date

1996-09-12

Publication date

1999-12-15

1995-09-15 Priority claimed from FR9510815A external-priority patent/FR2738822B1/fr

1995-09-21 Priority claimed from FR9511083A external-priority patent/FR2739100B1/fr

1996-09-12 Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo

1999-12-15 Application granted granted Critical

1999-12-15 Publication of ATE187172T1 publication Critical patent/ATE187172T1/de

Links

229940082988 antihypertensives serotonin antagonists Drugs 0.000 title 1
239000003420 antiserotonin agent Substances 0.000 title 1
LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Epidemiology (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AT96931112T 1995-09-15 1996-09-12 Chinolin-2-on derivate als serotonin antagonisten ATE187172T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9510815A FR2738822B1 (fr)	1995-09-15	1995-09-15	Derives de 4-(omega-(4-(thieno(3,2-c)pyridin-4-yl)piperazin- 1-yl)alkyl)quinolein-2(1h)-one, leur preparation et leur application en therapeutique
FR9511083A FR2739100B1 (fr)	1995-09-21	1995-09-21	Derives de 4-(omega-(4-(4-fluorobenzoyl)piperidin-1-yl)- alkyl)quinolein-2(1h)-one, leur preparation et leur application en therapeutique

Publications (1)

Publication Number	Publication Date
ATE187172T1 true ATE187172T1 (de)	1999-12-15

Family

ID=26232206

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96931112T ATE187172T1 (de)	1995-09-15	1996-09-12	Chinolin-2-on derivate als serotonin antagonisten

Country Status (29)

Country	Link
US (1)	US5958924A (de)
EP (1)	EP0850235B1 (de)
JP (1)	JP3335362B2 (de)
KR (1)	KR100422850B1 (de)
CN (1)	CN1094490C (de)
AR (1)	AR003996A1 (de)
AT (1)	ATE187172T1 (de)
AU (1)	AU715879B2 (de)
BG (1)	BG63779B1 (de)
BR (1)	BR9610579A (de)
CA (1)	CA2228038C (de)
CO (1)	CO4750663A1 (de)
CZ (1)	CZ288149B6 (de)
DE (1)	DE69605430T2 (de)
DK (1)	DK0850235T3 (de)
EE (1)	EE04116B1 (de)
ES (1)	ES2142089T3 (de)
GR (1)	GR3032618T3 (de)
HU (1)	HU222745B1 (de)
IL (1)	IL123600A (de)
NO (1)	NO323841B1 (de)
NZ (1)	NZ318436A (de)
PL (1)	PL184808B1 (de)
RU (1)	RU2167874C2 (de)
SI (1)	SI0850235T1 (de)
SK (1)	SK282222B6 (de)
TR (1)	TR199800464T1 (de)
UA (1)	UA44332C2 (de)
WO (1)	WO1997010238A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
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BR9610579A (pt) *	1995-09-15	1999-07-06	Sanofi Synthelabo	Derivados de quinolein-2(1H)-ona como antagonistas da serotonina
FR2761067B1 (fr) *	1997-03-20	1999-04-23	Synthelabo	Derives de quinolein-2-(1h)-one, leur preparation et leur application en therapeutique
FR2761071B1 (fr) *	1997-03-20	1999-12-03	Synthelabo	Derives de quinolein-2(1h)-one et de dihydroquinolein-2(1h)- one, leur preparation et leur application en therapeutique
FR2797874B1 (fr) *	1999-08-27	2002-03-29	Adir	Nouveaux derives de la pyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2001053288A1 (en) *	2000-01-20	2001-07-26	Eisai Co., Ltd.	Novel piperidine compounds and drugs containing the same
FR2812548B1 (fr) *	2000-08-01	2002-09-20	Sanofi Synthelabo	Utilisation de derives de quinolein-2(1h)-one ou un de leurs sels pharmaceutiquement acceptable pour la preparation d'un medicament destine au traitement de l'insuffisance renale
RU2267485C2 (ru) *	2003-10-07	2006-01-10	Общество С Ограниченной Ответственностью "Асинэкс Медхим"	Производные 3-аминометилхинолона-2 в качестве ингибиторов no-синтетазы и способ их получения, биологически активные соединения и фармацевтическая композиция на их основе
RU2284325C2 (ru) *	2003-12-17	2006-09-27	Общество С Ограниченной Ответственностью "Асинэкс Медхим"	Производные фенил-3-аминометил-хинолона-2 в качестве ингибиторов no-синтетазы, способ их получения, биологически активные соединения и фармацевтическая композиция на их основе
GB0420722D0 (en)	2004-09-17	2004-10-20	Addex Pharmaceuticals Sa	Novel allosteric modulators
TWI320783B (en)	2005-04-14	2010-02-21	Otsuka Pharma Co Ltd	Heterocyclic compound
AR059898A1 (es)	2006-03-15	2008-05-07	Janssen Pharmaceutica Nv	Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
FR2909670B1 (fr) *	2006-12-12	2010-07-30	Sanofi Aventis	Derive fluore de quinoleine-2(1h)-one,son procede de preparation et son utilisation comme intermediaire de synthese
TW200845978A (en)	2007-03-07	2008-12-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en)	2007-03-07	2009-01-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
BRPI0817101A2 (pt)	2007-09-14	2017-05-09	Addex Pharmaceuticals Sa	4-(aril-x-fenil)-1h-piridin-2-onas 1,3-dissubstituídas
SI2203439T1 (sl)	2007-09-14	2011-05-31	Ortho Mcneil Janssen Pharm	1',3'-disubstituirani 4-fenil-3,4,5,6-tetrahidro-2H-1'H-(1,4')bipiridinil-2'-oni
ES2439291T3 (es)	2008-09-02	2014-01-22	Janssen Pharmaceuticals, Inc.	Derivados de 3-azabiciclo[3.1.0]hexilo como moduladores de receptores de glutamato metabotrópicos
PL2344471T3 (pl) *	2008-10-02	2013-12-31	Taisho Pharmaceutical Co Ltd	Pochodna 7-piperydynoalkilo-3,4-dihydrochinolonu
ES2401691T3 (es)	2008-11-28	2013-04-23	Ortho-Mcneil-Janssen Pharmaceuticals, Inc.	Derivados de indol y de benzoxacina como moduladores de los receptores metabotrópicos de glutamato
SG176018A1 (en)	2009-05-12	2011-12-29	Janssen Pharmaceuticals Inc	1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
ES2440001T3 (es)	2009-05-12	2014-01-27	Janssen Pharmaceuticals, Inc.	Derivados de 1,2,4-triazolo[4,3-A]piridina y su uso para el tratamiento o prevención de trastornos neurológicos y psiquiátricos
MY153913A (en)	2009-05-12	2015-04-15	Janssen Pharmaceuticals Inc	7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
ES2552455T3 (es)	2010-11-08	2015-11-30	Janssen Pharmaceuticals, Inc.	Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
CA2814998C (en)	2010-11-08	2019-10-29	Janssen Pharmaceuticals, Inc.	1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CN103298809B (zh)	2010-11-08	2016-08-31	杨森制药公司	1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
JO3368B1 (ar)	2013-06-04	2019-03-13	Janssen Pharmaceutica Nv	مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar)	2013-09-06	2019-03-13	Janssen Pharmaceutica Nv	مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
US10537573B2 (en)	2014-01-21	2020-01-21	Janssen Pharmaceutica Nv	Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
IL279202B2 (en)	2014-01-21	2023-09-01	Janssen Pharmaceutica Nv	Combinations containing positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic subtype 2 receptor and their use
IL287136B2 (en)	2016-02-05	2023-09-01	Denali Therapeutics Inc	Receptor inhibitors - interacting with protein kinase 1
HUE058802T2 (hu)	2016-12-09	2022-09-28	Denali Therapeutics Inc	RIPK1 inhibitorokként alkalmas vegyületek
CN108707109A (zh) *	2018-08-29	2018-10-26	常州沃腾化工科技有限公司	一种2-甲氧基-4-三氟甲基吡啶-3-磺酰氯的制备方法
US11999750B2 (en)	2022-01-12	2024-06-04	Denali Therapeutics Inc.	Crystalline forms of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido [3,2-B][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide

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DE2345422C2 (de) *	1973-09-08	1983-12-22	Dr. Karl Thomae Gmbh, 7950 Biberach	Substituierte Isochinolyl-arylpiperazine diese enthaltende Arzneimittel sowie Verfahren zu deren Herstellung
NL8001369A (nl) *	1980-03-06	1981-10-01	Acf Chemiefarma Nv	Nieuwe chinolinederivaten en farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werkwijze voor het bereiden van deze verbindingen.
IT1155357B (it) *	1982-07-06	1987-01-28	Ravizza Spa	Processo per la preparazione della kentanserina
CA1278792C (en) *	1985-05-06	1991-01-08	Joseph P. Yevich	Antipsychotic fused-ring pyridinylpiperazine derivatives
KR910006138B1 (ko) *	1986-09-30	1991-08-16	에자이 가부시끼가이샤	환상아민 유도체
FR2644786B1 (fr) *	1989-03-21	1993-12-31	Adir Cie	Nouveaux derives fluoro-4 benzoiques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
RU1774624C (ru) *	1990-11-11	1995-02-09	Украинская фармацевтическая академия	Диэтиламиноэтиламида 1-пропил-2-оксо-4-гидроксихинолин-3-карбоновой кислоты гидрохлорид, проявляющий анестезирующую, противоаритмическую, антиоксидантную, антимикробную и фунгицидную активность
US5457099A (en) *	1992-07-02	1995-10-10	Sawai Pharmaceutical Co., Ltd.	Carbostyril derivatives and antiallergic agent
BR9610579A (pt) *	1995-09-15	1999-07-06	Sanofi Synthelabo	Derivados de quinolein-2(1H)-ona como antagonistas da serotonina

1996
- 1996-09-12 BR BR9610579A patent/BR9610579A/pt not_active Application Discontinuation
- 1996-09-12 CA CA002228038A patent/CA2228038C/en not_active Expired - Fee Related
- 1996-09-12 ES ES96931112T patent/ES2142089T3/es not_active Expired - Lifetime
- 1996-09-12 HU HU9802940A patent/HU222745B1/hu not_active IP Right Cessation
- 1996-09-12 DK DK96931112T patent/DK0850235T3/da active
- 1996-09-12 US US09/011,482 patent/US5958924A/en not_active Expired - Lifetime
- 1996-09-12 WO PCT/FR1996/001401 patent/WO1997010238A1/fr not_active Ceased
- 1996-09-12 SI SI9630151T patent/SI0850235T1/xx unknown
- 1996-09-12 UA UA98031235A patent/UA44332C2/uk unknown
- 1996-09-12 CZ CZ1998786A patent/CZ288149B6/cs not_active IP Right Cessation
- 1996-09-12 AU AU69919/96A patent/AU715879B2/en not_active Ceased
- 1996-09-12 EE EE9800089A patent/EE04116B1/xx not_active IP Right Cessation
- 1996-09-12 EP EP96931112A patent/EP0850235B1/de not_active Expired - Lifetime
- 1996-09-12 AR ARP960104322A patent/AR003996A1/es active IP Right Grant
- 1996-09-12 NZ NZ318436A patent/NZ318436A/xx not_active IP Right Cessation
- 1996-09-12 PL PL96325467A patent/PL184808B1/pl not_active IP Right Cessation
- 1996-09-12 SK SK346-98A patent/SK282222B6/sk not_active IP Right Cessation
- 1996-09-12 KR KR10-1998-0701920A patent/KR100422850B1/ko not_active Expired - Fee Related
- 1996-09-12 RU RU98106501/04A patent/RU2167874C2/ru not_active IP Right Cessation
- 1996-09-12 CN CN96198333A patent/CN1094490C/zh not_active Expired - Fee Related
- 1996-09-12 TR TR1998/00464T patent/TR199800464T1/xx unknown
- 1996-09-12 AT AT96931112T patent/ATE187172T1/de active
- 1996-09-12 DE DE69605430T patent/DE69605430T2/de not_active Expired - Lifetime
- 1996-09-12 IL IL12360096A patent/IL123600A/en not_active IP Right Cessation
- 1996-09-12 JP JP51170797A patent/JP3335362B2/ja not_active Expired - Fee Related
- 1996-09-12 CO CO96048698A patent/CO4750663A1/es unknown
1998
- 1998-03-11 BG BG102316A patent/BG63779B1/bg unknown
- 1998-03-13 NO NO19981141A patent/NO323841B1/no not_active IP Right Cessation
2000
- 2000-02-09 GR GR20000400317T patent/GR3032618T3/el unknown

Also Published As

Publication number	Publication date
AU6991996A (en)	1997-04-01
EE04116B1 (et)	2003-08-15
JPH11514982A (ja)	1999-12-21
CZ78698A3 (cs)	1998-06-17
KR100422850B1 (ko)	2004-07-23
CN1202168A (zh)	1998-12-16
CZ288149B6 (en)	2001-05-16
AR003996A1 (es)	1998-09-30
US5958924A (en)	1999-09-28
IL123600A (en)	2001-05-20
NZ318436A (en)	1999-02-25
CN1094490C (zh)	2002-11-20
SK282222B6 (sk)	2001-12-03
NO981141L (no)	1998-05-15
IL123600A0 (en)	1998-10-30
HUP9802940A3 (en)	2001-11-28
SI0850235T1 (en)	2000-04-30
KR19990044666A (ko)	1999-06-25
PL325467A1 (en)	1998-07-20
DK0850235T3 (da)	2000-05-29
CO4750663A1 (es)	1999-03-31
AU715879B2 (en)	2000-02-10
JP3335362B2 (ja)	2002-10-15
SK34698A3 (en)	1998-08-05
NO323841B1 (no)	2007-07-09
MX9802028A (es)	1998-09-30
EE9800089A (et)	1998-10-15
TR199800464T1 (xx)	1998-05-21
GR3032618T3 (en)	2000-05-31
NO981141D0 (no)	1998-03-13
HU222745B1 (hu)	2003-09-29
HUP9802940A2 (hu)	1999-05-28
BG102316A (en)	1999-03-31
PL184808B1 (pl)	2002-12-31
BG63779B1 (bg)	2002-12-29
DE69605430T2 (de)	2000-07-13
EP0850235A1 (de)	1998-07-01
UA44332C2 (uk)	2002-02-15
RU2167874C2 (ru)	2001-05-27
HK1014868A1 (en)	1999-10-08
BR9610579A (pt)	1999-07-06
WO1997010238A1 (fr)	1997-03-20
ES2142089T3 (es)	2000-04-01
EP0850235B1 (de)	1999-12-01
DE69605430D1 (de)	2000-01-05
CA2228038C (en)	2009-04-21
CA2228038A1 (en)	1997-03-20

Legal Events

Date	Code	Title	Description
2000-05-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
ATE187172T1 (de)	1999-12-15	Chinolin-2-on derivate als serotonin antagonisten
ATE216999T1 (de)	2002-05-15	Pyrimidin-4-on derivate als pestizidesmittel
ATE149163T1 (de)	1997-03-15	Indolin derivate als 5ht2c antagonisten
ATE321037T1 (de)	2006-04-15	Als antikrebsmittel verwendbare alkinyl- substituierte chinolin-2-on-derivate
DE69628334D1 (de)	2003-06-26	Chinolin derivate als nk3 antagoniste
FI970310L (fi)	1997-01-24	4-indolijohdannaiset serotoniinin vaikuttaja- ja vastavaikuttaja-aineina
DE69533408D1 (de)	2004-09-23	Chinolinderivate als Tachykinin NK3 Rezeptor Antagonisten
FI944734A7 (fi)	1994-10-07	Kinoliinijohdannaiset leukotrieeniantagonisteina
ATE197300T1 (de)	2000-11-15	Indolderivate als 5-ht rezeptorantagoniste
DE69325167D1 (de)	1999-07-08	Kondensierte indol-derivate als 5-ht4-rezeptor-antagonisten
DE69613368D1 (de)	2001-07-19	Chinazolin derivate
DE69613369D1 (de)	2001-07-19	Chinazolin derivate
DE69613367D1 (de)	2001-07-19	Chinazolin derivate
DE69634416D1 (de)	2005-04-07	Chinolin-derivate
DE69714265D1 (de)	2002-08-29	Tetrahydrochinolinderivate als eaa antagonisten
NO974043L (no)	1997-11-03	Indolderivater som EAA-antagonister
ATE254621T1 (de)	2003-12-15	Thienoisoxazolyl- und thienylpyrazolyl-phenoxy substituierte propyl derivate als d4 antagonisten
DE69703242D1 (de)	2000-11-09	Indolin-derivate verwendbar als 5-ht-2c rezeptor-antagonisten
ATE325118T1 (de)	2006-06-15	Piperazinoderivate als neurokinin-antagonisten
DE69717449D1 (de)	2003-01-09	Indolin-derivate verwendbar als 5-ht-2c rezeptor-antagonisten
DE69617010D1 (de)	2001-12-20	Isazole derivate als fibrinogen-rezeptor-antagonisten
DE69709869D1 (de)	2002-02-28	BENZO[g]CHINOLIN DERIVATE
FI970143A7 (fi)	1997-01-14	Kinoliinijohdannaiset leukotrieeniantagonisteina
KR950700884A (ko)	1995-02-20	루코트리엔 길항제로서의 퀴놀린 유도체(Quinoline derivatives as leukotriene antagonists)
FI963463L (fi)	1996-09-04	Indolijohdannaiset CCK-reseptoriantagonisteina