ATE254621T1 - Thienoisoxazolyl- und thienylpyrazolyl-phenoxy substituierte propyl derivate als d4 antagonisten - Google Patents

Thienoisoxazolyl- und thienylpyrazolyl-phenoxy substituierte propyl derivate als d4 antagonisten

Info

Publication number
ATE254621T1
ATE254621T1 AT00964969T AT00964969T ATE254621T1 AT E254621 T1 ATE254621 T1 AT E254621T1 AT 00964969 T AT00964969 T AT 00964969T AT 00964969 T AT00964969 T AT 00964969T AT E254621 T1 ATE254621 T1 AT E254621T1
Authority
AT
Austria
Prior art keywords
thienoisoxazolyl
thienylpyrazolyl
antagonists
phenoxy substituted
substituted propyl
Prior art date
Application number
AT00964969T
Other languages
English (en)
Inventor
David M Fink
Brian S Freed
Nicholas J Hrib
Raymond W Kosley Jr
George E Lee
Gregory H Merriman
Barbara S Rauckman
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Application granted granted Critical
Publication of ATE254621T1 publication Critical patent/ATE254621T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT00964969T 1999-09-14 2000-09-13 Thienoisoxazolyl- und thienylpyrazolyl-phenoxy substituierte propyl derivate als d4 antagonisten ATE254621T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39608199A 1999-09-14 1999-09-14
PCT/US2000/024962 WO2001019833A1 (en) 1999-09-14 2000-09-13 Thienoisoxazolyl- and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as d4 antagonists

Publications (1)

Publication Number Publication Date
ATE254621T1 true ATE254621T1 (de) 2003-12-15

Family

ID=23565772

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00964969T ATE254621T1 (de) 1999-09-14 2000-09-13 Thienoisoxazolyl- und thienylpyrazolyl-phenoxy substituierte propyl derivate als d4 antagonisten

Country Status (26)

Country Link
EP (1) EP1216250B1 (de)
JP (1) JP4847662B2 (de)
KR (1) KR20020027647A (de)
AR (1) AR032134A1 (de)
AT (1) ATE254621T1 (de)
AU (1) AU7577400A (de)
BR (1) BR0014515A (de)
CA (1) CA2383340C (de)
CY (1) CY1101692T1 (de)
CZ (1) CZ2002897A3 (de)
DE (1) DE60006699T2 (de)
DK (1) DK1216250T3 (de)
EA (1) EA200200355A1 (de)
EE (1) EE200200135A (de)
ES (1) ES2209995T3 (de)
HR (1) HRP20020220A2 (de)
HU (1) HUP0203526A3 (de)
IL (1) IL148623A0 (de)
MX (1) MXPA02002695A (de)
NO (1) NO20021251L (de)
PL (1) PL354515A1 (de)
PT (1) PT1216250E (de)
SK (1) SK3512002A3 (de)
TW (1) TW530060B (de)
WO (1) WO2001019833A1 (de)
ZA (1) ZA200201762B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
US7253165B2 (en) 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
JP4497815B2 (ja) * 2001-02-16 2010-07-07 アベンティス・ファーマスーティカルズ・インコーポレイテツド 新規な複素環式アミド誘導体およびドーパミンｄ３受容体リガンドとしてのその使用
CN1300116C (zh) 2001-04-16 2007-02-14 卫材株式会社 1h－吲唑化合物
KR20040020457A (ko) * 2002-08-30 2004-03-09 주식회사 대웅 3-｛2-[4-(6-플루오로벤조[ｄ]이속사졸-3-일)피페리디노]에틸｝-2-메틸-6,7,8,9-테트라하이드로-4Ｈ-피리도[1,2-ａ]피리미딘-4-온 또는 그 산부가염의 제조방법
KR20050092424A (ko) * 2003-01-17 2005-09-21 씨브이 쎄러퓨틱스, 인코포레이티드 심혈관 질환의 치료에 유용한 치환된 헤테로고리 화합물
JP2007297321A (ja) * 2006-04-28 2007-11-15 Daiso Co Ltd アリール２−メチルグリシジルエーテル類の製造法
JP2007297330A (ja) * 2006-04-28 2007-11-15 Daiso Co Ltd ２−メチルグリシジル誘導体の製造法
CA2894126A1 (en) * 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
DK2935222T3 (en) 2012-12-21 2019-01-07 Epizyme Inc PRMT5 INHIBITORS AND APPLICATIONS THEREOF
JP2016505597A (ja) 2012-12-21 2016-02-25 エピザイム，インコーポレイティド Ｐｒｍｔ５阻害剤およびその使用
CA2899363A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
US9745291B2 (en) 2012-12-21 2017-08-29 Epizyme, Inc. PRMT5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof
US20170198006A1 (en) * 2014-06-25 2017-07-13 Epizyme, Inc. Prmt5 inhibitors and uses thereof
WO2016022605A1 (en) 2014-08-04 2016-02-11 Epizyme, Inc. Prmt5 inhibitors and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4728651A (en) * 1985-10-24 1988-03-01 Hoechst-Roussel Pharmaceuticals Inc. Antihypertensive thieno-isoxazoles and -pyrazoles
US6187774B1 (en) * 1996-03-04 2001-02-13 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and pharmaceutical applications thereof
HUP9603001A3 (en) * 1996-10-30 1999-07-28 Richter Gedeon Vegyeszet Heterocycle compounds comprising nitrogen, process for producing them and pharmaceutical compositions containing the same
JP4627882B2 (ja) * 1998-02-09 2011-02-09 デユフアー・インターナシヨナル・リサーチ・ベー・ブイ Ｄ４−アンタゴニスト活性を有するベンズイソキサゾール誘導体

Also Published As

Publication number Publication date
CA2383340C (en) 2010-06-15
ES2209995T3 (es) 2004-07-01
EE200200135A (et) 2003-04-15
TW530060B (en) 2003-05-01
NO20021251L (no) 2002-05-10
BR0014515A (pt) 2002-06-25
CZ2002897A3 (cs) 2002-07-17
DE60006699D1 (en) 2003-12-24
PL354515A1 (en) 2004-01-26
IL148623A0 (en) 2002-09-12
JP2003509432A (ja) 2003-03-11
KR20020027647A (ko) 2002-04-13
HRP20020220A2 (en) 2004-02-29
PT1216250E (pt) 2004-04-30
CA2383340A1 (en) 2001-03-22
JP4847662B2 (ja) 2011-12-28
ZA200201762B (en) 2003-08-27
DE60006699T2 (de) 2004-09-30
HUP0203526A3 (en) 2004-12-28
HUP0203526A2 (hu) 2003-01-28
WO2001019833A1 (en) 2001-03-22
CY1101692T1 (el) 2010-07-28
SK3512002A3 (en) 2003-03-04
EP1216250A1 (de) 2002-06-26
AU7577400A (en) 2001-04-17
DK1216250T3 (da) 2004-02-23
EA200200355A1 (ru) 2002-10-31
MXPA02002695A (es) 2002-07-30
EP1216250B1 (de) 2003-11-19
NO20021251D0 (no) 2002-03-13
AR032134A1 (es) 2003-10-29

Similar Documents

Publication Publication Date Title
DE60032601D1 (de) Als antikrebsmittel verwendbare heterocyklische derivate
DE60020812D1 (de) Heteroaryl-substituierte chinolin-2-on derivate verwendbar als antikrebsmittel
DE60009147T2 (de) Admantan derivate
DE60036803D1 (de) Arylmethyl-carbonylamino-thiazolderivate und ihre verwendung als antitumormittel
ATE359275T1 (de) Substituierte bizyclische derivate verwendbar als antitumor mittel
DE69920009D1 (de) Isothiazole derivate verwendbar als antikrebsmittel
DE69930518D1 (de) Als antikrebsmittel verwendbare alkinyl-substituierte chinolin-2-on-derivate
ATE330954T1 (de) Quinazolin-derivate als vegf-hemmer
DE60222647D1 (de) Urea derivate als integrin alpha 4 antagonisten
DE69605430D1 (de) Chinolin-2-on derivate als serotonin antagonisten
DE60013127D1 (de) 5-phenyl-pyrimidine derivate
ATE273980T1 (de) 6-phenylpyrrolopyrimidindion derivate
DE50013404D1 (de) Substituierte 2-dialkylaminoalkylbiphenyl-derivate
ATE254621T1 (de) Thienoisoxazolyl- und thienylpyrazolyl-phenoxy substituierte propyl derivate als d4 antagonisten
ATE221052T1 (de) Tetrahydrochinolinderivate als eaa antagonisten
ATE309225T1 (de) Substituierte chinazoline derivate
DE60025918D1 (de) 4-phenyl-pyrimidine derivate
DE60003072D1 (de) Thiazolidindion-derivate als antidiabetika
DE60012953D1 (de) 3-amino-2-phenylpiperidinderivate als substanz p antagonisten
DE60143905D1 (de) Phtalazinon derivate
DE69838303D1 (de) Hydroxyprolin derivate
ATE260259T1 (de) Substituierte isochinolinderivate und ihre verwendung als anticonvulsiva
EP1124552A4 (de) Chrysen-derivate als antitumormittel
EE200200133A (et) Asendamata tienoisoksasoolfenoksüetüül- ja propüülderivaadid ning nende kasutamine D4 antagonistidena
ATE269316T1 (de) 2-phenylpyran-4-on derivate

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1216250

Country of ref document: EP

REN Ceased due to non-payment of the annual fee