ATE187455T1 - Methotrexatderivate mit antirheumatischer aktivität - Google Patents

Methotrexatderivate mit antirheumatischer aktivität

Info

Publication number: ATE187455T1
Authority: AT; Austria
Prior art keywords: methotrexate derivatives; antirheumatic; antirheumatic activity; activity; ch2so
Prior art date: 1990-08-14

Application number

AT91914615T

Other languages

English (en)

Inventor

Nobuhiro Ohi

Hiroharu Matsuoka

Katsuhito Miyamoto

Hiroshi Suzuki

Nobuaki Kato

Keiichiro Tsuji

Yasuhisa Takeda

Masahiko Mihara

Hiromichi Nishina

Shin Shimaoka

Kenichi Akamatsu

Original Assignee

Chugai Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-14

Filing date

1991-08-14

Publication date

1999-12-15

1991-05-30 Priority claimed from JP3228158A external-priority patent/JPH04352785A/ja

1991-06-12 Priority claimed from JP3247141A external-priority patent/JPH04368385A/ja

1991-08-14 Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd

1999-12-15 Application granted granted Critical

1999-12-15 Publication of ATE187455T1 publication Critical patent/ATE187455T1/de

Links

230000003356 anti-rheumatic effect Effects 0.000 title abstract 2
FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical class C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 title 1
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 1
DBTDEFJAFBUGPP-UHFFFAOYSA-N Methanethial Chemical compound S=C DBTDEFJAFBUGPP-UHFFFAOYSA-N 0.000 abstract 1
229910018828 PO3H2 Inorganic materials 0.000 abstract 1
201000004681 Psoriasis Diseases 0.000 abstract 1
229910006069 SO3H Inorganic materials 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000001093 anti-cancer Effects 0.000 abstract 1
239000003435 antirheumatic agent Substances 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
235000019256 formaldehyde Nutrition 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
230000001988 toxicity Effects 0.000 abstract 1
231100000419 toxicity Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT91914615T 1990-08-14 1991-08-14 Methotrexatderivate mit antirheumatischer aktivität ATE187455T1 (de)

Applications Claiming Priority (11)

Application Number	Priority Date	Filing Date	Title
JP21469190		1990-08-14
JP21563990		1990-08-15
JP25346690		1990-09-21
JP29310790		1990-10-30
JP33184590		1990-11-29
JP18062691		1991-04-19
JP18594391		1991-04-23
JP3228158A JPH04352785A (ja)	1991-05-30	1991-05-30	新規メトトレキセート誘導体
JP3247141A JPH04368385A (ja)	1991-06-12	1991-06-12	新規メトトレキセート誘導体
JP25830191		1991-07-03
JP27904791		1991-07-30

Publications (1)

Publication Number	Publication Date
ATE187455T1 true ATE187455T1 (de)	1999-12-15

Family

ID=27582227

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91914615T ATE187455T1 (de)	1990-08-14	1991-08-14	Methotrexatderivate mit antirheumatischer aktivität

Country Status (13)

Country	Link
US (1)	US5354753A (de)
EP (1)	EP0543997B1 (de)
CN (1)	CN1032858C (de)
AT (1)	ATE187455T1 (de)
AU (1)	AU8333291A (de)
CA (1)	CA2088665C (de)
DE (1)	DE69131835T2 (de)
DK (1)	DK0543997T3 (de)
ES (1)	ES2141710T3 (de)
GR (1)	GR3032704T3 (de)
HU (2)	HU223948B1 (de)
SG (1)	SG49917A1 (de)
WO (1)	WO1992003436A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69330639T2 (de) *	1992-01-27	2002-07-04	Chugai Seiyaku K.K., Tokio/Tokyo	Methotrexat-derivate
CN1037771C (zh) *	1992-12-25	1998-03-18	中外制药株式会社	甲氨喋呤衍生物
US5958928A (en) *	1995-03-27	1999-09-28	Chugai Seiyaku Kabushiki Kaisha	Pharmaceutical agents containing methotrexate derivative
KR100343409B1 (ko) *	1996-03-19	2002-08-22	쥬가이 세이야쿠 가부시키가이샤	포도막염치료제
US20030229113A1 (en) *	2000-03-24	2003-12-11	Koji Hashimoto	Keratinocyte growth inhibitors and hydroxamic acid derivatives
US7229986B2 (en)	2000-05-16	2007-06-12	Takeda Pharmaceutical Company Ltd.	Melanin-concentrating hormone antagonist
CN102014919B (zh)	2008-03-03	2015-02-25	托斯克公司	减少毒性的甲氨蝶呤佐剂及其使用方法
WO2009137081A2 (en) *	2008-05-07	2009-11-12	Massachusetts Institute Of Technology	Small molecule inhibitors of plasmodium falciparum dihydroorotate dehydrogenase
EP2551262A4 (de) *	2010-03-24	2014-01-15	Ajinomoto Kk	Glutamatderivate oder salze davon

1991
- 1991-08-14 HU HU9300264A patent/HU223948B1/hu not_active IP Right Cessation
- 1991-08-14 US US07/971,773 patent/US5354753A/en not_active Expired - Fee Related
- 1991-08-14 SG SG1996009165A patent/SG49917A1/en unknown
- 1991-08-14 EP EP91914615A patent/EP0543997B1/de not_active Expired - Lifetime
- 1991-08-14 DE DE69131835T patent/DE69131835T2/de not_active Expired - Fee Related
- 1991-08-14 CA CA002088665A patent/CA2088665C/en not_active Expired - Fee Related
- 1991-08-14 ES ES91914615T patent/ES2141710T3/es not_active Expired - Lifetime
- 1991-08-14 AU AU83332/91A patent/AU8333291A/en not_active Abandoned
- 1991-08-14 CN CN91105803A patent/CN1032858C/zh not_active Expired - Fee Related
- 1991-08-14 AT AT91914615T patent/ATE187455T1/de not_active IP Right Cessation
- 1991-08-14 DK DK91914615T patent/DK0543997T3/da active
- 1991-08-14 WO PCT/JP1991/001078 patent/WO1992003436A1/ja not_active Ceased
1995
- 1995-06-29 HU HU95P/P00529P patent/HU211481A9/hu unknown
2000
- 2000-02-18 GR GR20000400402T patent/GR3032704T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
US5354753A (en)	1994-10-11
HU211481A9 (en)	1995-11-28
GR3032704T3 (en)	2000-06-30
WO1992003436A1 (fr)	1992-03-05
CN1032858C (zh)	1996-09-25
EP0543997B1 (de)	1999-12-08
AU8333291A (en)	1992-03-17
SG49917A1 (en)	1998-06-15
HU223948B1 (hu)	2005-03-29
DE69131835T2 (de)	2000-06-15
CN1059725A (zh)	1992-03-25
HU9300264D0 (en)	1993-04-28
CA2088665C (en)	2001-05-01
EP0543997A1 (de)	1993-06-02
DK0543997T3 (da)	2000-04-10
HUT64974A (en)	1994-03-28
DE69131835D1 (de)	2000-01-13
ES2141710T3 (es)	2000-04-01
EP0543997A4 (en)	1993-12-29
CA2088665A1 (en)	1992-02-15

Legal Events

Date	Code	Title	Description
2000-04-15	UEP	Publication of translation of european patent specification
2005-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
LV10864A (lv)	1995-10-20	Triazinu atvasinajumi to iegusanas panemiens un herbicids kas tos iesledz sevi ka aktivu ingredientu
AU680704B2 (en)	1997-08-07	Cyclic amide derivatives
DE68910441D1 (de)	1993-12-09	Spiro-Verbindungen.
FI943561A0 (fi)	1994-07-29	Uudet ainekoostumukset
ATE122038T1 (de)	1995-05-15	N-phenylpyrazolderivate als insektizide.
DE69131835D1 (de)	2000-01-13	Methotrexatderivate mit antirheumatischer aktivität
DK0459505T3 (da)	1996-11-18	Imidazonaphthyridinderivater
ATE109770T1 (de)	1994-08-15	Derivate der coffeinsäure und pharmazeutische zusammensetzungen, die sie enthalten.
DE69013528D1 (de)	1994-12-01	Eine Perfluoralkylgruppe enthaltende Verbindung.
MX170732B (es)	1993-09-10	Composicion de derivados de succinimida y su uso
ATE159930T1 (de)	1997-11-15	Carbonsäurederivate
DE69423339D1 (de)	2000-04-13	Epoxycyclohexendionderivat
ATE69605T1 (de)	1991-12-15	Azolylpropenyl- und azolylmethyloxiran-derivate und diese enthaltende fungizide.
DE69018335D1 (de)	1995-05-11	Imidazochinolonderivate.
EP0292870A3 (en)	1989-10-18	Antidiabetic composition comprising 7-thiaprostaglandin e1 or its derivative
ATE110384T1 (de)	1994-09-15	Makrolid-derivate.
JPS55111492A (en)	1980-08-28	Thiazole derivative and its manufacture
FI901046A0 (fi)	1990-03-01	Stabilisering av polyprenylfoereningen.