ATE187458T1 - Peptidverbindungen mit wachstumsfaktorähnlicher aktivität - Google Patents
Peptidverbindungen mit wachstumsfaktorähnlicher aktivitätInfo
- Publication number
- ATE187458T1 ATE187458T1 AT96913807T AT96913807T ATE187458T1 AT E187458 T1 ATE187458 T1 AT E187458T1 AT 96913807 T AT96913807 T AT 96913807T AT 96913807 T AT96913807 T AT 96913807T AT E187458 T1 ATE187458 T1 AT E187458T1
- Authority
- AT
- Austria
- Prior art keywords
- activity
- growth factor
- peptide compounds
- peptide
- cytomodulin
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title 1
- 230000010005 growth-factor like effect Effects 0.000 title 1
- 239000011159 matrix material Substances 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 1
- 230000003278 mimic effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 1
- 230000017423 tissue regeneration Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/431,954 US5661127A (en) | 1995-05-01 | 1995-05-01 | Peptide compositions with growth factor-like activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE187458T1 true ATE187458T1 (de) | 1999-12-15 |
Family
ID=23714154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96913807T ATE187458T1 (de) | 1995-05-01 | 1996-04-18 | Peptidverbindungen mit wachstumsfaktorähnlicher aktivität |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5661127A (de) |
| EP (1) | EP0824545B1 (de) |
| JP (1) | JPH11506427A (de) |
| KR (1) | KR19990008239A (de) |
| CN (1) | CN1183103A (de) |
| AT (1) | ATE187458T1 (de) |
| AU (1) | AU709197B2 (de) |
| CA (1) | CA2218161C (de) |
| DE (1) | DE69605544T2 (de) |
| ES (1) | ES2140082T3 (de) |
| NZ (1) | NZ307338A (de) |
| WO (1) | WO1996034881A1 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030077825A1 (en) * | 1994-07-22 | 2003-04-24 | Bhatnagar Rajendra S. | Structures useful for bone engineering and methods |
| US5786327A (en) | 1993-03-12 | 1998-07-28 | Gensci Regeneration Sciences Inc. | Bone stimulating factor, methods of isolating same, and methods of increasing bone growth comprising administering same |
| US6638912B2 (en) * | 1995-05-01 | 2003-10-28 | The Regents Of The University Of California | Peptide compositions mimicking TGF-β activity |
| US5780436A (en) * | 1995-05-01 | 1998-07-14 | The Regents Of The University Of California | Peptide compositions with growth factor-like activity |
| US6117839A (en) * | 1995-06-07 | 2000-09-12 | Gensci Regeneration Sciences, Inc. | Bone stimulating factor |
| US6352973B1 (en) | 1995-06-07 | 2002-03-05 | Osteopharm Inc. | Bone stimulating factor |
| US6693081B2 (en) | 1995-09-26 | 2004-02-17 | Osteopharm Inc. | Bone stimulating factor |
| MXPA00000009A (es) | 1998-06-22 | 2005-09-08 | Autologous Wound Therapy Inc | Solicitud para patente de utilidad para curativo de heridas mejorado enriquecido con plaquetas. |
| US20030229393A1 (en) * | 2001-03-15 | 2003-12-11 | Kutryk Michael J. B. | Medical device with coating that promotes cell adherence and differentiation |
| US8460367B2 (en) * | 2000-03-15 | 2013-06-11 | Orbusneich Medical, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
| US8088060B2 (en) | 2000-03-15 | 2012-01-03 | Orbusneich Medical, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
| US20070141107A1 (en) * | 2000-03-15 | 2007-06-21 | Orbusneich Medical, Inc. | Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device |
| EP1263484B1 (de) | 2000-03-15 | 2007-05-16 | OrbusNeich Medical, Inc. | Beschichtung welche ein anhaften von endothelzellen stimuliert |
| US20070055367A1 (en) * | 2000-03-15 | 2007-03-08 | Orbus Medical Technologies, Inc. | Medical device with coating that promotes endothelial cell adherence and differentiation |
| US9522217B2 (en) | 2000-03-15 | 2016-12-20 | Orbusneich Medical, Inc. | Medical device with coating for capturing genetically-altered cells and methods for using same |
| US7671018B2 (en) * | 2000-08-30 | 2010-03-02 | University Of Delaware | Delivery system for heparin-binding growth factors |
| US6509318B1 (en) * | 2000-09-29 | 2003-01-21 | The Regents Of The University Of California | TGF-B inhibitors and methods |
| US6815421B1 (en) * | 2001-03-22 | 2004-11-09 | Osteopharm Inc. | Polypeptides for use in ameliorating effects of aging in mammals |
| AU2003291871A1 (en) * | 2002-12-05 | 2004-06-23 | Osteopharm Inc. | Bone growth factor |
| WO2005107817A2 (en) * | 2004-04-30 | 2005-11-17 | Orbus Medical Technologies, Inc. | Medical device with coating for capturing genetically-altered cells and methods of using same |
| US8697139B2 (en) | 2004-09-21 | 2014-04-15 | Frank M. Phillips | Method of intervertebral disc treatment using articular chondrocyte cells |
| US20060293227A1 (en) * | 2005-06-24 | 2006-12-28 | Bhatnagar Rajendra S | Cosmetic compositions and methods using transforming growth factor-beta mimics |
| US20060293228A1 (en) * | 2005-06-24 | 2006-12-28 | Bhatnagar Rajendra S | Therapeutic compositions and methods using transforming growth factor-beta mimics |
| US8048443B2 (en) | 2005-12-16 | 2011-11-01 | Cerapedics, Inc. | Pliable medical device and method of use |
| EP2021014A1 (de) * | 2006-05-26 | 2009-02-11 | Brystol-Myers Squibb Company | Glp-1-rezeptor-modulatoren mit verzögerter freisetzung |
| ITRM20060409A1 (it) * | 2006-07-31 | 2008-02-01 | Cnr Consiglio Naz Delle Ric Er | Sequenza prptidica isolata nel dominio il tipo-immunoglobulina del recettore 1 del fattore di crescita dell'endotelio vascolare e legante l'integrina a5b1 ad attivita' proangiogenica |
| KR20110017371A (ko) | 2008-04-30 | 2011-02-21 | 가부시키가이샤 제노믹스 | 생체내 기능적 세포의 고효율 채취법 |
| KR20120135190A (ko) | 2009-10-28 | 2012-12-12 | 고꾸리쯔 다이가꾸 호우징 오사까 다이가꾸 | 골수 간엽계 및/또는 다능성 줄기세포의 혈중 동원(動員)에 의한 조직 재생 촉진제 |
| CN103687946B (zh) | 2011-04-26 | 2017-05-03 | 吉诺米克斯股份有限公司 | 用于诱导组织再生的肽及其应用 |
| FR2992555A1 (fr) * | 2012-06-28 | 2014-01-03 | Svr Rech | Combinaison dermocosmetique depigmentante et eclaircissante |
| CN104955470B (zh) | 2012-10-25 | 2017-06-16 | 吉诺米克斯股份有限公司 | 利用了hmgb1片段的针对脊髄损伤的新型治疗方法 |
| PL2913058T3 (pl) * | 2012-10-25 | 2018-04-30 | Genomix Co., Ltd. | Nowy sposób leczenia zawału mięśnia sercowego przy użyciu fragmentu HMGB1 |
| US20160000682A1 (en) | 2014-07-02 | 2016-01-07 | Geoffrey Brooks Consultants Llc | Peptide-Based Compositions and Methods of Use |
| WO2016049580A2 (en) | 2014-09-26 | 2016-03-31 | Rajendra Sahai Bhatnagar | Inhibitors of nf kappa-b activity for treatment of diseases and disorders |
| US9943566B2 (en) * | 2016-03-16 | 2018-04-17 | Geoffrey Brooks Consultants, Llc | NF-κB inhibitor composition for skin health |
| BR112019014921A2 (pt) | 2017-01-27 | 2020-03-31 | StemRIM Inc. | Agente terapêutico para miocardiopatia, infarto antigo do miocárdio e insuficiência cardíaca crônica |
| US12421498B2 (en) | 2017-12-01 | 2025-09-23 | StemRIM Inc. | Ectodermal mesenchymal stem cells and method for producing same |
| JPWO2019107530A1 (ja) | 2017-12-01 | 2020-11-26 | 株式会社ステムリム | 炎症性腸疾患の治療薬 |
| WO2019156137A1 (ja) | 2018-02-08 | 2019-08-15 | 株式会社ステムリム | 乾癬の治療薬 |
| US12304933B2 (en) | 2018-10-05 | 2025-05-20 | StemRIM Inc. | Disease treatment drug based on mesenchymal-stem-cell mobilization |
| EP4377328A4 (de) | 2021-07-29 | 2025-10-08 | Univ Northwestern | Selbstanordnende peptidamphiphile mit einem mimetischen epitop des transformierenden wachstumsfaktors beta 1 (tgf-beta1) |
| WO2025081123A1 (en) | 2023-10-12 | 2025-04-17 | Fred Hutchinson Cancer Center | Methods and compositions for improving t cell immunotherapy |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5240912A (en) * | 1983-05-09 | 1993-08-31 | Todaro George J | Transforming growth factor (TGF) peptides |
| US5284763A (en) * | 1985-03-22 | 1994-02-08 | Genentech, Inc. | Nucleic acid encoding TGF-β and its uses |
| IL76079A (en) * | 1985-08-13 | 1991-03-10 | Univ Ramot | Collagen implants |
| US4975526A (en) * | 1989-02-23 | 1990-12-04 | Creative Biomolecules, Inc. | Bone collagen matrix for zenogenic implants |
| US5178845A (en) * | 1988-04-20 | 1993-01-12 | Norian Corporation | Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite |
| US5055447A (en) * | 1988-07-28 | 1991-10-08 | Genentech, Inc. | Method and compositions for the treatment and prevention of septic shock |
| US5236905A (en) * | 1988-08-25 | 1993-08-17 | Oncogen | In vitro method of inhibition of HIV using transforming growth factor-.beta. |
| US5258029A (en) * | 1988-09-29 | 1993-11-02 | Collagen Corporation | Method for improving implant fixation |
| US5268455A (en) * | 1989-05-25 | 1993-12-07 | Genentech, Inc. | Process for making biologically active polypeptides based on transforming growth factor-βsequences |
| US5324519A (en) * | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
| US5158934A (en) * | 1989-09-01 | 1992-10-27 | Genentech, Inc. | Method of inducing bone growth using TGF-β |
| US5364839A (en) * | 1990-06-18 | 1994-11-15 | Genetics Institute, Inc. | Osteoinductive pharmaceutical formulations |
| US5206023A (en) * | 1991-01-31 | 1993-04-27 | Robert F. Shaw | Method and compositions for the treatment and repair of defects or lesions in cartilage |
| US5208219A (en) * | 1991-02-14 | 1993-05-04 | Celtrix Pharmaceuticals Inc. | Method for inducing bone growth |
| US5270300A (en) * | 1991-09-06 | 1993-12-14 | Robert Francis Shaw | Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone |
| CA2122491A1 (en) * | 1991-10-31 | 1993-05-13 | Herbert Y. Lin | Tgf-.beta. type receptor cdnas and uses therefor |
| DE69233022T2 (de) * | 1991-11-04 | 2004-02-12 | Genetics Institute, LLC, Cambridge | Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung |
| US5322933A (en) * | 1992-05-07 | 1994-06-21 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Crystal structure of TGF-β-2 |
| US5420243A (en) * | 1993-01-26 | 1995-05-30 | Celtrix Pharmaceuticals, Inc. | Biologically active TGF-β2 peptides |
| US6040431A (en) * | 1995-06-07 | 2000-03-21 | Stryker Corporation | Single chain analogs of the TGF-β superfamily (morphons) |
-
1995
- 1995-05-01 US US08/431,954 patent/US5661127A/en not_active Expired - Fee Related
-
1996
- 1996-04-18 DE DE69605544T patent/DE69605544T2/de not_active Expired - Fee Related
- 1996-04-18 KR KR1019970707765A patent/KR19990008239A/ko not_active Withdrawn
- 1996-04-18 AU AU56650/96A patent/AU709197B2/en not_active Ceased
- 1996-04-18 AT AT96913807T patent/ATE187458T1/de not_active IP Right Cessation
- 1996-04-18 NZ NZ307338A patent/NZ307338A/en unknown
- 1996-04-18 CN CN96193633A patent/CN1183103A/zh active Pending
- 1996-04-18 JP JP8533330A patent/JPH11506427A/ja not_active Withdrawn
- 1996-04-18 ES ES96913807T patent/ES2140082T3/es not_active Expired - Lifetime
- 1996-04-18 CA CA002218161A patent/CA2218161C/en not_active Expired - Fee Related
- 1996-04-18 WO PCT/US1996/005374 patent/WO1996034881A1/en not_active Ceased
- 1996-04-18 EP EP96913807A patent/EP0824545B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU709197B2 (en) | 1999-08-26 |
| AU5665096A (en) | 1996-11-21 |
| DE69605544T2 (de) | 2000-05-31 |
| EP0824545A1 (de) | 1998-02-25 |
| US5661127A (en) | 1997-08-26 |
| EP0824545A4 (de) | 1998-05-20 |
| ES2140082T3 (es) | 2000-02-16 |
| CN1183103A (zh) | 1998-05-27 |
| NZ307338A (en) | 1998-06-26 |
| EP0824545B1 (de) | 1999-12-08 |
| CA2218161C (en) | 2008-02-05 |
| JPH11506427A (ja) | 1999-06-08 |
| KR19990008239A (ko) | 1999-01-25 |
| WO1996034881A1 (en) | 1996-11-07 |
| DE69605544D1 (de) | 2000-01-13 |
| CA2218161A1 (en) | 1996-11-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |