ES2140082T3 - Composiciones peptidicas con actividad de tipo factor de crecimiento. - Google Patents

Composiciones peptidicas con actividad de tipo factor de crecimiento.

Info

Publication number
ES2140082T3
ES2140082T3 ES96913807T ES96913807T ES2140082T3 ES 2140082 T3 ES2140082 T3 ES 2140082T3 ES 96913807 T ES96913807 T ES 96913807T ES 96913807 T ES96913807 T ES 96913807T ES 2140082 T3 ES2140082 T3 ES 2140082T3
Authority
ES
Spain
Prior art keywords
activity
growth factor
peptide compositions
factor type
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96913807T
Other languages
English (en)
Inventor
Rajendra S Bhatnagar
Jing Jing Qian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California Berkeley
University of California San Diego UCSD
Original Assignee
University of California Berkeley
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California Berkeley, University of California San Diego UCSD filed Critical University of California Berkeley
Application granted granted Critical
Publication of ES2140082T3 publication Critical patent/ES2140082T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE HA SINTETIZADO UN PEPTIDO CON LA SECUENCIA ANVAENA (SEC ID N :1). ESTE PEPTIDO, DENOMINADO CITOMODULINA , ES CAPAZ DE IMITAR UNA AMPLIA GAMA DE ACTIVIDADES DE TGF OS TIPOS CELULARES. SE DESCRIBEN COMPOSICIONES PARA APLICACIONES TALES COMO LA REPARACION DE TEJIDOS, QUE INCLUYEN UNA MATRIZ BIOCOMPATIBLE QUE PRESENTA CITOMODULINA MEZCLADA CON LA MATRIZ, O PORTADA POR ESTA.
ES96913807T 1995-05-01 1996-04-18 Composiciones peptidicas con actividad de tipo factor de crecimiento. Expired - Lifetime ES2140082T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/431,954 US5661127A (en) 1995-05-01 1995-05-01 Peptide compositions with growth factor-like activity

Publications (1)

Publication Number Publication Date
ES2140082T3 true ES2140082T3 (es) 2000-02-16

Family

ID=23714154

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96913807T Expired - Lifetime ES2140082T3 (es) 1995-05-01 1996-04-18 Composiciones peptidicas con actividad de tipo factor de crecimiento.

Country Status (12)

Country Link
US (1) US5661127A (es)
EP (1) EP0824545B1 (es)
JP (1) JPH11506427A (es)
KR (1) KR19990008239A (es)
CN (1) CN1183103A (es)
AT (1) ATE187458T1 (es)
AU (1) AU709197B2 (es)
CA (1) CA2218161C (es)
DE (1) DE69605544T2 (es)
ES (1) ES2140082T3 (es)
NZ (1) NZ307338A (es)
WO (1) WO1996034881A1 (es)

Families Citing this family (42)

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US20030077825A1 (en) * 1994-07-22 2003-04-24 Bhatnagar Rajendra S. Structures useful for bone engineering and methods
US5786327A (en) 1993-03-12 1998-07-28 Gensci Regeneration Sciences Inc. Bone stimulating factor, methods of isolating same, and methods of increasing bone growth comprising administering same
US6638912B2 (en) * 1995-05-01 2003-10-28 The Regents Of The University Of California Peptide compositions mimicking TGF-β activity
US5780436A (en) * 1995-05-01 1998-07-14 The Regents Of The University Of California Peptide compositions with growth factor-like activity
US6352973B1 (en) 1995-06-07 2002-03-05 Osteopharm Inc. Bone stimulating factor
US6117839A (en) * 1995-06-07 2000-09-12 Gensci Regeneration Sciences, Inc. Bone stimulating factor
US6693081B2 (en) 1995-09-26 2004-02-17 Osteopharm Inc. Bone stimulating factor
WO1999066797A1 (en) 1998-06-22 1999-12-29 Worden Charles E Enriched platelet wound healant
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US8460367B2 (en) * 2000-03-15 2013-06-11 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
JP5859179B2 (ja) 2000-03-15 2016-02-10 オーバスネイチ メディカル、インコーポレイテッド 内皮細胞接着を促進するコーティング
US20030229393A1 (en) * 2001-03-15 2003-12-11 Kutryk Michael J. B. Medical device with coating that promotes cell adherence and differentiation
US20070055367A1 (en) * 2000-03-15 2007-03-08 Orbus Medical Technologies, Inc. Medical device with coating that promotes endothelial cell adherence and differentiation
US20070141107A1 (en) * 2000-03-15 2007-06-21 Orbusneich Medical, Inc. Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device
WO2002017955A1 (en) * 2000-08-30 2002-03-07 University Of Delaware Delivery system for heparin-binding growth factors
US6509318B1 (en) * 2000-09-29 2003-01-21 The Regents Of The University Of California TGF-B inhibitors and methods
US6815421B1 (en) * 2001-03-22 2004-11-09 Osteopharm Inc. Polypeptides for use in ameliorating effects of aging in mammals
US20060052307A1 (en) * 2002-12-05 2006-03-09 Tam Cherk S Bone growth factor
CA2563329C (en) * 2004-04-30 2016-01-26 Orbus Medical Technologies, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
US20060293228A1 (en) * 2005-06-24 2006-12-28 Bhatnagar Rajendra S Therapeutic compositions and methods using transforming growth factor-beta mimics
US20060293227A1 (en) * 2005-06-24 2006-12-28 Bhatnagar Rajendra S Cosmetic compositions and methods using transforming growth factor-beta mimics
US8048443B2 (en) 2005-12-16 2011-11-01 Cerapedics, Inc. Pliable medical device and method of use
WO2007139589A1 (en) * 2006-05-26 2007-12-06 Bristol-Myers Squibb Company Sustained release glp-1 receptor modulators
ITRM20060409A1 (it) * 2006-07-31 2008-02-01 Cnr Consiglio Naz Delle Ric Er Sequenza prptidica isolata nel dominio il tipo-immunoglobulina del recettore 1 del fattore di crescita dell'endotelio vascolare e legante l'integrina a5b1 ad attivita' proangiogenica
KR20110017371A (ko) 2008-04-30 2011-02-21 가부시키가이샤 제노믹스 생체내 기능적 세포의 고효율 채취법
KR20120135190A (ko) 2009-10-28 2012-12-12 고꾸리쯔 다이가꾸 호우징 오사까 다이가꾸 골수 간엽계 및/또는 다능성 줄기세포의 혈중 동원(動員)에 의한 조직 재생 촉진제
KR102113809B1 (ko) 2011-04-26 2020-05-21 가부시키가이샤 스템림 조직 재생을 유도하기 위한 펩티드 및 그의 이용
FR2992555A1 (fr) * 2012-06-28 2014-01-03 Svr Rech Combinaison dermocosmetique depigmentante et eclaircissante
CA2889275C (en) * 2012-10-25 2021-06-15 Katsuto Tamai Novel method for treating cardiac infarction using hmgb1 fragment
ES2673861T3 (es) 2012-10-25 2018-06-26 Genomix Co., Ltd. Método novedoso para tratar el daño a la médula espinal utilizando el fragmento de hmgb1
US20160000682A1 (en) 2014-07-02 2016-01-07 Geoffrey Brooks Consultants Llc Peptide-Based Compositions and Methods of Use
CA2999711A1 (en) 2014-09-26 2016-03-31 Rajendra Sahai Bhatnagar Inhibitors of nf kappa-b activity for treatment of diseases and disorders
US9943566B2 (en) * 2016-03-16 2018-04-17 Geoffrey Brooks Consultants, Llc NF-κB inhibitor composition for skin health
PL3556378T3 (pl) 2017-01-27 2025-06-09 StemRIM Inc. Środek do leczenia kardiomiopatii, starego zawału mięśnia sercowego i przewlekłej niewydolności serca
CN118460462A (zh) 2017-12-01 2024-08-09 斯特姆里姆有限公司 外胚层间充质干细胞及其产生方法
US11298403B2 (en) 2017-12-01 2022-04-12 StemRIM Inc. Therapeutic agent for inflammatory bowel disease
WO2019156137A1 (ja) 2018-02-08 2019-08-15 株式会社ステムリム 乾癬の治療薬
US12304933B2 (en) 2018-10-05 2025-05-20 StemRIM Inc. Disease treatment drug based on mesenchymal-stem-cell mobilization
US12570709B2 (en) 2021-07-29 2026-03-10 Northwestern University Self-assembling peptide amphiphiles displaying a transforming growth factor beta 1 (TGF-ß1) mimetic epitope
WO2025081123A1 (en) 2023-10-12 2025-04-17 Fred Hutchinson Cancer Center Methods and compositions for improving t cell immunotherapy

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Publication number Priority date Publication date Assignee Title
US5240912A (en) * 1983-05-09 1993-08-31 Todaro George J Transforming growth factor (TGF) peptides
US5284763A (en) * 1985-03-22 1994-02-08 Genentech, Inc. Nucleic acid encoding TGF-β and its uses
IL76079A (en) * 1985-08-13 1991-03-10 Univ Ramot Collagen implants
US4975526A (en) * 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
US5178845A (en) * 1988-04-20 1993-01-12 Norian Corporation Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite
US5055447A (en) * 1988-07-28 1991-10-08 Genentech, Inc. Method and compositions for the treatment and prevention of septic shock
US5236905A (en) * 1988-08-25 1993-08-17 Oncogen In vitro method of inhibition of HIV using transforming growth factor-.beta.
US5258029A (en) * 1988-09-29 1993-11-02 Collagen Corporation Method for improving implant fixation
US5268455A (en) * 1989-05-25 1993-12-07 Genentech, Inc. Process for making biologically active polypeptides based on transforming growth factor-βsequences
US5324519A (en) * 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5158934A (en) * 1989-09-01 1992-10-27 Genentech, Inc. Method of inducing bone growth using TGF-β
US5364839A (en) * 1990-06-18 1994-11-15 Genetics Institute, Inc. Osteoinductive pharmaceutical formulations
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
US5208219A (en) * 1991-02-14 1993-05-04 Celtrix Pharmaceuticals Inc. Method for inducing bone growth
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
CA2122491A1 (en) * 1991-10-31 1993-05-13 Herbert Y. Lin Tgf-.beta. type receptor cdnas and uses therefor
DE69233022T2 (de) * 1991-11-04 2004-02-12 Genetics Institute, LLC, Cambridge Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung
US5322933A (en) * 1992-05-07 1994-06-21 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Crystal structure of TGF-β-2
US5420243A (en) * 1993-01-26 1995-05-30 Celtrix Pharmaceuticals, Inc. Biologically active TGF-β2 peptides
US6040431A (en) * 1995-06-07 2000-03-21 Stryker Corporation Single chain analogs of the TGF-β superfamily (morphons)

Also Published As

Publication number Publication date
CA2218161A1 (en) 1996-11-07
CN1183103A (zh) 1998-05-27
JPH11506427A (ja) 1999-06-08
EP0824545B1 (en) 1999-12-08
WO1996034881A1 (en) 1996-11-07
ATE187458T1 (de) 1999-12-15
EP0824545A1 (en) 1998-02-25
AU5665096A (en) 1996-11-21
US5661127A (en) 1997-08-26
CA2218161C (en) 2008-02-05
DE69605544D1 (de) 2000-01-13
AU709197B2 (en) 1999-08-26
NZ307338A (en) 1998-06-26
DE69605544T2 (de) 2000-05-31
KR19990008239A (ko) 1999-01-25
EP0824545A4 (en) 1998-05-20

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