ATE188736T1 - Endothelin-dna und verwendung davon - Google Patents

Endothelin-dna und verwendung davon

Info

Publication number: ATE188736T1
Authority: AT; Austria
Prior art keywords: endothelin; dna; human; sequence containing; segment coding
Prior art date: 1988-10-25

Application number

AT92120602T

Other languages

English (en)

Inventor

Tomoh Masaki

Masashi Yanagisawa

Akihiro Inoue

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-25

Filing date

1989-10-20

Publication date

2000-01-15

1989-10-20 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

2000-01-15 Application granted granted Critical

2000-01-15 Publication of ATE188736T1 publication Critical patent/ATE188736T1/de

Links

102000002045 Endothelin Human genes 0.000 title 1
108050009340 Endothelin Proteins 0.000 title 1
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1
102000007055 Endothelin-3 Human genes 0.000 abstract 4
108010072844 Endothelin-3 Proteins 0.000 abstract 4
ZGOVYTPSWMLYOF-QEADGSHQSA-N chembl1790180 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CC=3C=CC=CC=3)C(=O)N[C@H](C(=O)N[C@H](CCC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)[C@H](C)O)=O)NC(=O)[C@@H]([C@@H](C)O)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZGOVYTPSWMLYOF-QEADGSHQSA-N 0.000 abstract 4
OQGZWNZGVYLIFX-JQWUVQPESA-N 117399-93-6 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CSSC[C@@H](C(N[C@@H](CC=3C=CC=CC=3)C(=O)N[C@H](C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)[C@@H](C)O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](N)CSSC1)C1=CN=CN1 OQGZWNZGVYLIFX-JQWUVQPESA-N 0.000 abstract 3
108020004414 DNA Proteins 0.000 abstract 3
101000841213 Homo sapiens Endothelin-3 Proteins 0.000 abstract 3
102000043615 human EDN3 Human genes 0.000 abstract 3
108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
102000004169 proteins and genes Human genes 0.000 abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 2
241000282412 Homo Species 0.000 abstract 1
208000001953 Hypotension Diseases 0.000 abstract 1
241001465754 Metazoa Species 0.000 abstract 1
238000012258 culturing Methods 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000001963 growth medium Substances 0.000 abstract 1
230000036543 hypotension Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1
239000005526 vasoconstrictor agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Vascular Medicine (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT92120602T 1988-10-25 1989-10-20 Endothelin-dna und verwendung davon ATE188736T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP26714988		1988-10-25
JP13270589		1989-05-29

Publications (1)

Publication Number	Publication Date
ATE188736T1 true ATE188736T1 (de)	2000-01-15

Family

ID=26467225

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92120602T ATE188736T1 (de)	1988-10-25	1989-10-20	Endothelin-dna und verwendung davon

Country Status (5)

Country	Link
US (4)	US5231166A (de)
EP (2)	EP0543425B1 (de)
AT (1)	ATE188736T1 (de)
CA (1)	CA2001303C (de)
DE (2)	DE68914582T2 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5962490A (en)	1987-09-25	1999-10-05	Texas Biotechnology Corporation	Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
JP2807474B2 (ja) *	1987-11-02	1998-10-08	武田薬品工業株式会社	Ｄｎａおよびその用途
US5231166A (en) *	1988-10-25	1993-07-27	Takeda Chemical Industries, Ltd.	Endothelin
CA2026468A1 (en) *	1989-09-30	1991-03-31	Takeda Chemical Industries, Ltd.	Human endothelin-3 cdna and use thereof
WO1991013089A1 (en) *	1990-02-26	1991-09-05	Takeda Chemical Industries, Ltd.	Peptide derivatives and production thereof
JP2999579B2 (ja) *	1990-07-18	2000-01-17	武田薬品工業株式会社	Ｄｎａおよびその用途
JPH05271286A (ja) *	1990-10-19	1993-10-19	General Hospital Corp	エンドテリン前駆体、その遺伝子および受容体
EP0574530A4 (en) *	1991-03-08	1996-04-03	Res Corp Technologies Inc	Endothelin antagonists
WO1993023404A1 (en) *	1992-05-19	1993-11-25	Immunopharmaceutics, Inc.	Compounds that modulate endothelin activity
US5767310A (en) *	1993-03-19	1998-06-16	Merck & Co., Inc.	Phenoxyphenylacetic acid derivatives
CA2142985A1 (en) *	1993-06-25	1995-01-05	Kenji Shibata	Endothelin-antagonizing peptide
WO1995005366A1 (en) *	1993-08-19	1995-02-23	Janssen Pharmaceutica N.V.	Vasoconstrictive substituted aryloxyalkyl diamines
US5688640A (en) *	1994-08-10	1997-11-18	Board Of Regents, The University Of Texas System	Methods of screening of effectors of endothelin converting enzyme-1
US5538991A (en) *	1994-09-14	1996-07-23	Merck & Co., Inc.	Endothelin antagonists bearing 5-membered heterocyclic amides
US5559135A (en) *	1994-09-14	1996-09-24	Merck & Co., Inc.	Endothelin antagonists bearing pyridyl amides
US5736376A (en) *	1995-12-19	1998-04-07	Board Of Regents, The University Of Texas System	Recombinant endothelin converting enzyme-2 and its use in ECE inhibitor screening
US5804585A (en)	1996-04-15	1998-09-08	Texas Biotechnology Corporation	Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
CA2396495A1 (en)	2000-01-25	2001-08-02	Cellomics, Inc.	Method and system for automated inference creation of physico-chemical interaction knowledge from databases of co-occurrence data
US6768982B1 (en)	2000-09-06	2004-07-27	Cellomics, Inc.	Method and system for creating and using knowledge patterns
CA2490409A1 (en)	2002-06-28	2004-01-08	Centocor, Inc.	Mammalian ch1 deleted mimetibodies, compositions, methods and uses
AU2007230887A1 (en) *	2006-03-23	2007-10-04	Amylin Pharmaceuticals, Inc.	Endothelin and endothelin receptor agonists in the treatment of metabolic diseases
US7838250B1 (en)	2006-04-04	2010-11-23	Singulex, Inc.	Highly sensitive system and methods for analysis of troponin
JP5308328B2 (ja)	2006-04-04	2013-10-09	シングレックス，インコーポレイテッド	トロポニンの分析のための高感度のシステムおよび方法
WO2009039982A2 (en) *	2007-09-11	2009-04-02	Mondobiotech Laboratories Ag	Use of a peptide as a therapeutic agent
KR20100061481A (ko) *	2007-09-11	2010-06-07	몬도바이오테크 래보래토리즈 아게	치료제로서의 미니가스트린
WO2010144358A1 (en)	2009-06-08	2010-12-16	Singulex, Inc.	Highly sensitive biomarker panels

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4675297A (en) *	1981-02-23	1987-06-23	The Regents Of The University Of California	Genes encoding bovine prolactin
DE3881467T2 (de) *	1987-10-09	1993-10-21	Agency Ind Science Techn	Vasokonstriktor-Peptid.
JP2807474B2 (ja) *	1987-11-02	1998-10-08	武田薬品工業株式会社	Ｄｎａおよびその用途
US5231166A (en) *	1988-10-25	1993-07-27	Takeda Chemical Industries, Ltd.	Endothelin

1989
- 1989-10-16 US US07/422,132 patent/US5231166A/en not_active Expired - Lifetime
- 1989-10-20 DE DE68914582T patent/DE68914582T2/de not_active Expired - Lifetime
- 1989-10-20 DE DE68929134T patent/DE68929134T2/de not_active Expired - Lifetime
- 1989-10-20 EP EP92120602A patent/EP0543425B1/de not_active Expired - Lifetime
- 1989-10-20 EP EP89119505A patent/EP0366016B1/de not_active Expired - Lifetime
- 1989-10-20 AT AT92120602T patent/ATE188736T1/de not_active IP Right Cessation
- 1989-10-24 CA CA002001303A patent/CA2001303C/en not_active Expired - Lifetime
1993
- 1993-01-27 US US08/009,764 patent/US5294569A/en not_active Expired - Lifetime
- 1993-12-06 US US08/163,030 patent/US5548061A/en not_active Expired - Lifetime
1996
- 1996-05-14 US US08/645,771 patent/US5811263A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2001303C (en)	2000-06-20
EP0366016A2 (de)	1990-05-02
EP0366016B1 (de)	1994-04-13
US5231166A (en)	1993-07-27
EP0543425A1 (de)	1993-05-26
DE68914582D1 (de)	1994-05-19
US5294569A (en)	1994-03-15
DE68914582T2 (de)	1994-08-25
US5548061A (en)	1996-08-20
EP0366016A3 (en)	1990-08-01
DE68929134T2 (de)	2000-07-13
CA2001303A1 (en)	1990-04-25
EP0543425B1 (de)	2000-01-12
US5811263A (en)	1998-09-22
DE68929134D1 (de)	2000-02-17

Legal Events

Date	Code	Title	Description
2000-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE68929134D1 (de)	2000-02-17	Endothelin-DNA und Verwendung davon
ATE142691T1 (de)	1996-09-15	Proteine mit faktor-viii-aktivität, verfahren zu deren herstellung unter verwendung von genetisch modifizierten zellen und diese enthaltende pharmazeutische zusammensetzungen
DE69027961D1 (de)	1996-09-05	Protein, DNA und ihre Verwendung
DE69019609D1 (de)	1995-06-29	Proteine und deren Herstellung.
HUT47635A (en)	1989-03-28	Process for producing new forms of colony stimulant factor-1
DE69130981D1 (de)	1999-04-15	Expression von makrophagen-induzierbaren proteinen (mips) in hefezellen
ATE149524T1 (de)	1997-03-15	Dns, die ein menschliches, gefässverengendes peptid kodiert, und dessen verwendung
DE3650538D1 (de)	1996-08-08	Interleukin-4 protein mit bcgf- und tcgf-aktivität gegenüber menschlichen zellen (menschliches interleukin-4)
ATE127844T1 (de)	1995-09-15	Dns und ihre verwendung.
DE69131069D1 (de)	1999-05-06	Plasmid das für die aminosäuresequenz von tcf-ii kodierende dns enthalt, transformierte zelle und produktion einer physiologisch aktiven substanz mit ihrer verwendung
ATE69241T1 (de)	1991-11-15	Herstellung von polypeptiden mit humangammainterferon-aktivitaet.
IT1238348B (it)	1993-07-13	Processo per la preparazione di costrutti genetici per l'espressione del fattore di crescita nervoso in cellule eucariote.
DE69012377D1 (de)	1994-10-20	Polypeptid und dessen Herstellung.
EP0315118A3 (de)	1990-09-19	Endothelin kodierendes DNA und dessen Verwendung
ATE66251T1 (de)	1991-08-15	Expressionsplasmide fuer die herstellung eines heterologen proteins in bakterien.
DE68924222D1 (de)	1995-10-19	Megakaryocytopoietin, seine Herstellung und Benutzung.
ATE103989T1 (de)	1994-04-15	Monoklonale antikoerper gegen e7-protein des humanen papillomvirus typ 16, verfahren zu ihrer herstellung sowie ihre verwendung.
DE69027466D1 (de)	1996-07-25	Achromobacter-Protease-I-Gen sowie Genprodukt
ATE119938T1 (de)	1995-04-15	Produktion von menschlichen nervenwachstumsfaktoren.
DE69131393D1 (de)	1999-08-05	Menschlicher Rezeptor für luteinisierendes Hormon und Choriongonadotropin
DE69032471D1 (de)	1998-08-13	Proteine mit onkostatin-m-aktivität und verfahren zu ihrer herstellung
EP0390327A3 (de)	1990-11-14	Verfahren zur Züchtung von Gewebekulturen
IL84629A0 (en)	1988-04-29	Process and device for the cultivation of mammalian cells in a suspension culture,and their use for the preparation of proteins