ATE149524T1 - Dns, die ein menschliches, gefässverengendes peptid kodiert, und dessen verwendung - Google Patents

Dns, die ein menschliches, gefässverengendes peptid kodiert, und dessen verwendung

Info

Publication number
ATE149524T1
ATE149524T1 AT91111815T AT91111815T ATE149524T1 AT E149524 T1 ATE149524 T1 AT E149524T1 AT 91111815 T AT91111815 T AT 91111815T AT 91111815 T AT91111815 T AT 91111815T AT E149524 T1 ATE149524 T1 AT E149524T1
Authority
AT
Austria
Prior art keywords
human
human endothelin
vasocontracting
peptide
dna encoding
Prior art date
Application number
AT91111815T
Other languages
English (en)
Inventor
Haruo Onda
Shoichi Ohkubo
Takuo Kosaka
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ATE149524T1 publication Critical patent/ATE149524T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT91111815T 1990-07-18 1991-07-16 Dns, die ein menschliches, gefässverengendes peptid kodiert, und dessen verwendung ATE149524T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP18796090 1990-07-18
JP145191 1991-01-10
JP3143127A JP2999579B2 (ja) 1990-07-18 1991-06-14 Ｄｎａおよびその用途

Publications (1)

Publication Number Publication Date
ATE149524T1 true ATE149524T1 (de) 1997-03-15

Family

ID=27274926

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91111815T ATE149524T1 (de) 1990-07-18 1991-07-16 Dns, die ein menschliches, gefässverengendes peptid kodiert, und dessen verwendung

Country Status (6)

Country Link
US (2) US6365725B1 (de)
EP (1) EP0468337B1 (de)
JP (1) JP2999579B2 (de)
AT (1) ATE149524T1 (de)
CA (1) CA2046754A1 (de)
DE (1) DE69124857T2 (de)

Families Citing this family (39)

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JPH05271286A (ja) * 1990-10-19 1993-10-19 General Hospital Corp エンドテリン前駆体、その遺伝子および受容体
US5756295A (en) * 1994-12-05 1998-05-26 Takeda Chemical Industries, Ltd. DNA primer and a method for screening DNAS
IL145712A0 (en) 1999-04-01 2002-07-25 Esperion Therapeutics Inc Ether compounds, compositions, and uses thereof
AU2002211666A1 (en) 2000-10-11 2002-04-22 Esperion Therapeutics, Inc. Sulfide and disulfide compounds and compositions for cholesterol management and related uses
US20040122091A1 (en) * 2000-10-11 2004-06-24 Esperion Therapeutics, Inc. Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
US6713507B2 (en) 2000-10-11 2004-03-30 Esperion Therapeutics, Inc. Ether compounds and compositions for cholesterol management and related uses
CA2425311C (en) 2000-10-11 2011-06-14 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
IL155246A0 (en) 2000-10-11 2003-11-23 Esperion Therapeutics Inc Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
US7304093B2 (en) * 2000-10-11 2007-12-04 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
US20040192771A1 (en) * 2001-10-11 2004-09-30 Dasseux Jean-Louis Henri Ether compounds and compositions for cholesterol management and related uses
US20040204502A1 (en) * 2001-10-11 2004-10-14 Dasseux Jean-Louis Henri Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
US20050020694A1 (en) * 2001-10-11 2005-01-27 Dasseux Jean-Louis Henri Sulfide and disulfide compounds and compositions for cholesterol management and related uses
EP1495034A2 (de) * 2002-04-10 2005-01-12 Esperion Therapeutics, Inc. Acyl-coenzym-a nachahmer aus pantolacton und pantothensäurederivaten, deren zusammensetzungen und verfahren zur cholesterinkontrolle sowie verwandte verwendungen davon
BR0312426A (pt) * 2002-07-03 2005-12-06 Esperion Therapeutics Inc Composição farmacêutica, métodos para tratar, prevenir ou controlar um colesterol, dislipidemia ou distúrbio relacionado, para reduzir ou evitar um efeito adverso associado com monoterapia de pantetina e para reduzir ou evitar um efeito adverso associado com monoterapia de segundo agente ativo, e, kit
CA2513660C (en) * 2003-01-23 2012-05-08 Esperion Therapeutics, Inc. Hydroxyl compounds and compositions for cholesterol management and related uses
US7390504B2 (en) * 2003-11-07 2008-06-24 Jj Pharma, Inc. HDL-boosting combination therapy complexes
WO2005068412A1 (en) 2003-12-24 2005-07-28 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
US20060075861A1 (en) * 2004-10-07 2006-04-13 Flooding Daniel L Film cutter
CA2584485C (en) * 2004-10-20 2013-12-31 Resverlogix Corp. Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
JP5368792B2 (ja) * 2005-07-29 2013-12-18 レスバーロジックス コーポレイション 複合疾患の予防および処置のための薬学的組成物および挿入可能な医療用デバイスによるその送達
JP2010513973A (ja) * 2006-12-19 2010-04-30 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ レンズ構造体及び製造方法並びに成形ポリマー品の製造
DK2118074T3 (en) * 2007-02-01 2014-03-10 Resverlogix Corp Compounds for the prevention and treatment of cardiovascular diseases
PL2167069T3 (pl) 2007-05-23 2012-04-30 Amcol International Corp Krzemiany warstwowe oddziałujące z cholesterolem oraz sposoby zmniejszania hipercholesterolemii u ssaka
AU2008303941A1 (en) * 2007-09-11 2009-04-02 Mondobiotech Laboratories Ag Use of the peptide Pro-Gly-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys as a therapeutic agent
KR101629356B1 (ko) 2008-06-26 2016-06-13 리스버로직스 코퍼레이션 퀴나졸리논 유도체의 제조방법
NZ594332A (en) 2009-01-08 2013-09-27 Resverlogix Corp Compounds for the prevention and treatment of cardiovascular disease
KR101709492B1 (ko) 2009-03-18 2017-02-23 리스버로직스 코퍼레이션 신규한 소염제
US9757368B2 (en) 2009-04-22 2017-09-12 Resverlogix Corp. Anti-inflammatory agents
DK2473605T3 (en) 2009-09-03 2018-05-28 Pfizer Vaccines Llc PCSK9-VACCINE
WO2012131504A1 (en) 2011-03-02 2012-10-04 Pfizer Inc. Pcsk9 vaccine
RU2640115C2 (ru) 2011-11-01 2017-12-26 Ресверлоджикс Корп. Фармацевтические композиции замещенных хиназолинонов
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
US9271978B2 (en) 2012-12-21 2016-03-01 Zenith Epigenetics Corp. Heterocyclic compounds as bromodomain inhibitors
WO2015123291A1 (en) 2014-02-11 2015-08-20 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Pcsk9 vaccine and methods of using the same
CN107530307A (zh) 2015-03-13 2018-01-02 艾斯柏伦治疗公司 包含etc1002和依泽替米贝的固定剂量组合和制剂以及治疗心血管疾病或降低心血管疾病风险的方法
US10111885B2 (en) 2015-03-13 2018-10-30 Resverlogix Corp. Compositions and therapeutic methods for the treatment of complement-associated diseases
MA41793A (fr) 2015-03-16 2018-01-23 Esperion Therapeutics Inc Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire
EP4438114A3 (de) 2019-06-21 2024-12-25 Esperion Therapeutics, Inc. Verfahren zur herstellung von bempedosäure und zusammensetzungen davon

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2807474B2 (ja) 1987-11-02 1998-10-08 武田薬品工業株式会社 Ｄｎａおよびその用途
US5231166A (en) 1988-10-25 1993-07-27 Takeda Chemical Industries, Ltd. Endothelin

Also Published As

Publication number Publication date
CA2046754A1 (en) 1992-01-19
US5756344A (en) 1998-05-26
US6365725B1 (en) 2002-04-02
DE69124857D1 (de) 1997-04-10
JPH04281790A (ja) 1992-10-07
JP2999579B2 (ja) 2000-01-17
EP0468337B1 (de) 1997-03-05
EP0468337A1 (de) 1992-01-29
DE69124857T2 (de) 1997-07-24

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