ATE189459T1 - Peptide mit endothelin antagonistischer aktivitaet. deren herstellung und pharmazeutische zusammensetzungen - Google Patents
Peptide mit endothelin antagonistischer aktivitaet. deren herstellung und pharmazeutische zusammensetzungenInfo
- Publication number
- ATE189459T1 ATE189459T1 AT94918587T AT94918587T ATE189459T1 AT E189459 T1 ATE189459 T1 AT E189459T1 AT 94918587 T AT94918587 T AT 94918587T AT 94918587 T AT94918587 T AT 94918587T AT E189459 T1 ATE189459 T1 AT E189459T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- optionally substituted
- pct
- substituted heterocyclic
- peptides
- Prior art date
Links
- 102000002045 Endothelin Human genes 0.000 title 1
- 108050009340 Endothelin Proteins 0.000 title 1
- 230000003042 antagnostic effect Effects 0.000 title 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 15
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000002308 endothelin receptor antagonist Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Crystallography & Structural Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939313330A GB9313330D0 (en) | 1993-06-28 | 1993-06-28 | New compound and its preparation |
| PCT/JP1994/001042 WO1995000537A1 (en) | 1993-06-28 | 1994-06-28 | New compound and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE189459T1 true ATE189459T1 (de) | 2000-02-15 |
Family
ID=10737937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94918587T ATE189459T1 (de) | 1993-06-28 | 1994-06-28 | Peptide mit endothelin antagonistischer aktivitaet. deren herstellung und pharmazeutische zusammensetzungen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5888972A (de) |
| EP (1) | EP0706532B1 (de) |
| JP (1) | JPH08511798A (de) |
| KR (1) | KR960703135A (de) |
| CN (1) | CN1129000A (de) |
| AT (1) | ATE189459T1 (de) |
| CA (1) | CA2165790A1 (de) |
| DE (1) | DE69422923T2 (de) |
| ES (1) | ES2141827T3 (de) |
| GB (1) | GB9313330D0 (de) |
| WO (1) | WO1995000537A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5811416A (en) * | 1994-06-06 | 1998-09-22 | Board Of Regents The University Of Texas System | Endothelin antagonist and/or endothelin synthase inhibitor in combination with a progestin, an estrogen, a cyclooxygenase inhibitor, or a nitric acid donor or substrate |
| US5863902A (en) * | 1995-01-06 | 1999-01-26 | Sibia Neurosciences, Inc. | Methods of treating neurodegenerative disorders using protease inhibitors |
| US5804560A (en) * | 1995-01-06 | 1998-09-08 | Sibia Neurosciences, Inc. | Peptide and peptide analog protease inhibitors |
| US5789442A (en) * | 1996-01-18 | 1998-08-04 | Schering Aktiengesellschaft | Treatment of urinary incontinence with nitric oxide synthase substrates and/or nitric oxide donors alone or in combination with estrogen or progesterone and/or other agents |
| US5906987A (en) * | 1997-03-10 | 1999-05-25 | Schering Aktiengesellschaft And Board Of Regents | Treatment of male climacteric disorders with nitric oxide synthase substrates and/or donors, in combination with androgens and/or aromatase inhibitors |
| DE19745146A1 (de) | 1997-10-14 | 1999-04-15 | Basf Ag | Neue pharmazeutisch wirksame Verbindungen, ihre Herstellung und Verwendung |
| EP1250935A1 (de) * | 2000-01-25 | 2002-10-23 | Meiji Seika Kaisha Ltd. | Heilmittel mit einem integrin-alpha-beta antagonist zur behandlung von reperfusionsschäden |
| DE10163239A1 (de) * | 2001-12-21 | 2003-07-10 | Aventis Pharma Gmbh | Substituierte Imidazolidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie enthaltendes Medikament |
| DE60309019T2 (de) * | 2002-05-03 | 2007-05-16 | Avecia Ltd., Blackley | Verfahren zur herstellung von peptidamiden durch seitenkettenanknüpfung an einer festphase |
| JP4838537B2 (ja) * | 2005-05-25 | 2011-12-14 | 株式会社 資生堂 | 不全角化抑制剤、毛穴縮小剤又は肌荒れ防止・改善剤及び皮膚外用組成物 |
| DE102005028862A1 (de) * | 2005-06-22 | 2007-01-11 | Sanofi-Aventis Deutschland Gmbh | Substituierte Heterocyclen, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| WO2007119214A2 (en) * | 2006-04-13 | 2007-10-25 | Actelion Pharmaceuticals Ltd | Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8707412D0 (en) * | 1987-03-27 | 1987-04-29 | Fujisawa Pharmaceutical Co | Peptide compounds |
| US4921855A (en) * | 1987-06-22 | 1990-05-01 | Fujisawa Pharmaceutical Co., Ltd. | New Histidyl amino acid derivatives, and pharmaceutical composition comprising the same |
| US5223489A (en) * | 1987-06-22 | 1993-06-29 | Ujisawa Pharmaceutical Co., Ltd. | Amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same |
| US5284828A (en) * | 1990-05-14 | 1994-02-08 | Fujisawa Pharmaceutical Co. Ltd. | Peptide compound and its preparation |
| US5430022A (en) * | 1990-05-14 | 1995-07-04 | Fujisawa Pharmaceutical Co., Ltd. | Peptide compound and its preparation |
| CA2043741C (en) * | 1990-06-07 | 2003-04-01 | Kiyofumi Ishikawa | Endothelin antagonistic peptide derivatives |
| IL99389A0 (en) * | 1990-09-17 | 1992-08-18 | Fujisawa Pharmaceutical Co | Amino acid derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
-
1993
- 1993-06-28 GB GB939313330A patent/GB9313330D0/en active Pending
-
1994
- 1994-06-28 US US08/564,271 patent/US5888972A/en not_active Expired - Fee Related
- 1994-06-28 AT AT94918587T patent/ATE189459T1/de not_active IP Right Cessation
- 1994-06-28 DE DE69422923T patent/DE69422923T2/de not_active Expired - Fee Related
- 1994-06-28 ES ES94918587T patent/ES2141827T3/es not_active Expired - Lifetime
- 1994-06-28 CA CA002165790A patent/CA2165790A1/en not_active Abandoned
- 1994-06-28 CN CN94193046A patent/CN1129000A/zh active Pending
- 1994-06-28 WO PCT/JP1994/001042 patent/WO1995000537A1/en not_active Ceased
- 1994-06-28 KR KR1019950705622A patent/KR960703135A/ko not_active Withdrawn
- 1994-06-28 EP EP94918587A patent/EP0706532B1/de not_active Expired - Lifetime
- 1994-06-28 JP JP7502656A patent/JPH08511798A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN1129000A (zh) | 1996-08-14 |
| DE69422923T2 (de) | 2000-06-15 |
| WO1995000537A1 (en) | 1995-01-05 |
| KR960703135A (ko) | 1996-06-19 |
| JPH08511798A (ja) | 1996-12-10 |
| EP0706532B1 (de) | 2000-02-02 |
| EP0706532A1 (de) | 1996-04-17 |
| US5888972A (en) | 1999-03-30 |
| DE69422923D1 (de) | 2000-03-09 |
| GB9313330D0 (en) | 1993-08-11 |
| CA2165790A1 (en) | 1995-01-05 |
| ES2141827T3 (es) | 2000-04-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX9401408A (es) | Nuevos derivados heterociclicos. | |
| DE69422923D1 (de) | Peptide mit endothelin antagonistischer aktivitaet. deren herstellung und pharmazeutische zusammensetzungen | |
| MY127537A (en) | Novel amidine deirvatives,their preparation and applicantion as medicines and pharmaceutical compositions | |
| FI954746A0 (fi) | Urea- ja amidijohdannaisia ja niiden käyttö solukalvojen kaliumkanavien säätelyyn | |
| NO952321D0 (no) | Polypeptid, samt anti-HIV-preparat fremstilt fra dette | |
| PL315636A1 (en) | Cosmetic or pharmaceutic compositions containing magnipherine or its derivatives | |
| MX9801716A (es) | Derivados de meta-guanidina, urea, tiourea o acido aminobenzoico azaciclico, como antagonistas de integrina. | |
| IL100015A0 (en) | Mono-n-substituted 1,4,7,10-tetraazacyclododecane derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same | |
| DE69425431D1 (en) | 1-amdinophenyl-pyrrolidone/piperidinone als blutblättchen-aggregations inhibitoren | |
| NO971470L (no) | Nye pyrimidon-derivater med fungicid aktivitet | |
| DE59406938D1 (de) | Pharmazeutische zubereitungen mit einem wirkstoff, der modifizierte amidingruppen enthält | |
| HUP0105204A2 (hu) | Helyettesített fenetil-amin-származékok és ezeket tartalmazó gyógyászati készítmények | |
| ES2091359T3 (es) | Nuevo compuesto peptidico y un procedimiento para su preparacion. | |
| DE69630699D1 (de) | Heterocyclische verbindungen als bradykinin antagonisten | |
| ES2083708T3 (es) | Nuevas piperazinilalcoil-3 dihidro-2,3,4h-benzoxazina-1,3 onas-4 sustituidas, su preparacion y su aplicacion en terapeutica. | |
| BG103958A (en) | Pharmaceutical compositions of thioxanide and nitazoxanide | |
| AR044175A1 (es) | Compuestos de cefemo | |
| ES2091126T3 (es) | Nuevos compuestos biciclicos de pirimidina, su procedimiento de preparacion y composiciones farmaceuticas que los contienen. | |
| ATE161178T1 (de) | Pyrazolpyridine für die behandlung der anämie | |
| IL114968A (en) | 1,4-dihydropyridine compounds and pharmaceutical compositions containing them | |
| DK0667864T3 (da) | Tricykliske forbindelser med farmaceutisk virkning | |
| GEP19991869B (en) | Amino Acid Derivatives of Substituted Quinoxaline 2,3-Dione Derivatives as Glutamate Receptor Antagonists | |
| MY110004A (en) | Biologically active ureido derivatives useful as antimetastatic agents. | |
| BR9306870A (pt) | Derivados farmacologicamente ativos de (aminometila terciária) - benzenometanol |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |