ES2091126T3 - Nuevos compuestos biciclicos de pirimidina, su procedimiento de preparacion y composiciones farmaceuticas que los contienen. - Google Patents

Nuevos compuestos biciclicos de pirimidina, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2091126T3
ES2091126T3 ES94902003T ES94902003T ES2091126T3 ES 2091126 T3 ES2091126 T3 ES 2091126T3 ES 94902003 T ES94902003 T ES 94902003T ES 94902003 T ES94902003 T ES 94902003T ES 2091126 T3 ES2091126 T3 ES 2091126T3
Authority
ES
Spain
Prior art keywords
pct
pirimidine
contain
pharmaceutical compositions
preparation procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94902003T
Other languages
English (en)
Inventor
Gilbert Regnier
Alain Dhainaut
Ghanem Atassi
Alain Pierre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Servier de Medecine Translationnelle SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2091126T3 publication Critical patent/ES2091126T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

NUEVOS COMPUESTOS BICICLICOS DE PIRIMIDINA UTILIZABLES COMO MEDICAMENTOS Y QUE RESPONDEN A LA FORMULA (I). ESTOS NUEVOS COMPUESTOS Y SUS SALES FISIOLOGICAMENTE TOLERABLES PUEDEN UTILIZARSE EN TERAPIA, PARTICULARMENTE PARA SUPRIMIR LA RESISTENCIA DE LAS CELULAS TUMORALES A LOS AGENTES ANTICANCEROSOS.
ES94902003T 1992-12-11 1993-12-09 Nuevos compuestos biciclicos de pirimidina, su procedimiento de preparacion y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2091126T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9214913A FR2699176B1 (fr) 1992-12-11 1992-12-11 Nouveaux composés bicycliques de pyrimidine, leur procédé de préparation et les compositions pharmaceutiques les renfermant.

Publications (1)

Publication Number Publication Date
ES2091126T3 true ES2091126T3 (es) 1996-10-16

Family

ID=9436453

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94902003T Expired - Lifetime ES2091126T3 (es) 1992-12-11 1993-12-09 Nuevos compuestos biciclicos de pirimidina, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.

Country Status (13)

Country Link
US (1) US5508277A (es)
EP (1) EP0673376B1 (es)
JP (1) JPH08504426A (es)
AT (1) ATE138380T1 (es)
AU (1) AU666422B2 (es)
CA (1) CA2117462A1 (es)
DE (1) DE69302829T2 (es)
DK (1) DK0673376T3 (es)
ES (1) ES2091126T3 (es)
FR (1) FR2699176B1 (es)
GR (1) GR3020330T3 (es)
NZ (1) NZ258595A (es)
WO (1) WO1994013668A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE9110772U1 (de) * 1991-08-30 1991-11-14 Wolf - Geräte GmbH Vertriebsgesellschaft KG, 5240 Betzdorf Gartenschere
FR2699176B1 (fr) * 1992-12-11 1995-03-03 Adir Nouveaux composés bicycliques de pyrimidine, leur procédé de préparation et les compositions pharmaceutiques les renfermant.
US6794390B2 (en) * 1996-08-02 2004-09-21 Cv Therapeutics, Inc. Purine inhibitors of cyclin dependent kinase 2 & ikappabalpha
US5866702A (en) * 1996-08-02 1999-02-02 Cv Therapeutics, Incorporation Purine inhibitors of cyclin dependent kinase 2
CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
EP2671508B1 (en) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-informatics system
US7932257B2 (en) 2005-07-22 2011-04-26 Sunesis Pharmaceuticals, Inc. Substituted pyrazolo[4,3-d]pyrimidines as aurora kinase inhibitors
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
EP2414361A1 (en) 2009-03-31 2012-02-08 ArQule, Inc. Substituted heterocyclic compounds
KR20180114970A (ko) 2009-05-06 2018-10-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
WO2023192941A2 (en) * 2022-04-01 2023-10-05 Drexel University Treating cancer with small molecules that inhibit acss-2

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1544419A (en) * 1975-11-19 1979-04-19 Science Union & Cie Purines and pyrazolo-pyrimidines a process for their preparation and pharmaceutical compositions containing them
DE2804416A1 (de) * 1978-02-02 1979-08-09 Boehringer Mannheim Gmbh Neue purin-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
US5204353A (en) * 1987-04-07 1993-04-20 Ciba-Geigy Corporation 3-benzyl-3H-1,2,3-triazolo[4,5-d]pyrimidines, compositions thereof, and method of treating epilepsy therewith
US4999363A (en) * 1988-06-09 1991-03-12 Kyowa Hakko Kogyo Co., Ltd. Tricyclic compounds
EP0363320A3 (de) * 1988-10-06 1991-11-21 Ciba-Geigy Ag Substituierte 9H-Purine
FR2643373B1 (fr) * 1989-01-10 1993-12-31 Adir Cie Nouveaux derives des bisarylalcenes, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
US5256650A (en) * 1989-03-29 1993-10-26 Merrell Dow Pharmaceuticals Inc. Selective adenosine receptor agents
AU641183B2 (en) * 1989-09-19 1993-09-16 Teijin Limited Pyrrolo(2,3-d)pyrimidine derivative, process for preparing the same, and pharmaceutical preparation comprising the derivative as active ingredient
KR0155955B1 (ko) * 1989-10-11 1998-11-16 이따가끼 히로시 2 환성 피리미딘 유도체, 그의 제조방법 및 그를 유효성분으로 하는 의약제제
US5397782A (en) * 1990-06-13 1995-03-14 Janssen Pharmaceutica N.V. Method of treating addiction to alcohol
US5217980A (en) * 1990-07-19 1993-06-08 Janssen Pharmaceutica N.V. Oxazolyl and piperidinyl substituted benimidazolyl compounds
KR0168404B1 (ko) * 1990-12-06 1999-03-20 오오가 노리오 피드백 클램프 회로
FR2699176B1 (fr) * 1992-12-11 1995-03-03 Adir Nouveaux composés bicycliques de pyrimidine, leur procédé de préparation et les compositions pharmaceutiques les renfermant.

Also Published As

Publication number Publication date
EP0673376B1 (fr) 1996-05-22
DE69302829D1 (de) 1996-06-27
AU5653594A (en) 1994-07-04
AU666422B2 (en) 1996-02-08
EP0673376A1 (fr) 1995-09-27
WO1994013668A1 (fr) 1994-06-23
ATE138380T1 (de) 1996-06-15
GR3020330T3 (en) 1996-09-30
NZ258595A (en) 1996-04-26
DE69302829T2 (de) 1996-11-28
CA2117462A1 (fr) 1994-06-23
FR2699176B1 (fr) 1995-03-03
US5508277A (en) 1996-04-16
JPH08504426A (ja) 1996-05-14
FR2699176A1 (fr) 1994-06-17
DK0673376T3 (da) 1996-10-07

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