ATE189601T1 - Verwendung von raloxifen und dessen analogen zur herstellung eines medikaments zur behandlung viraler erkrankungen - Google Patents

Verwendung von raloxifen und dessen analogen zur herstellung eines medikaments zur behandlung viraler erkrankungen

Info

Publication number: ATE189601T1
Authority: AT; Austria
Prior art keywords: raloxifene; analogues; medication; producing; treatment
Prior art date: 1994-08-22

Application number

AT95930863T

Other languages

English (en)

Inventor

Andrew Lawrence Glasebrook

David Lynn Phillips

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-22

Filing date

1995-08-21

Publication date

2000-02-15

1995-08-21 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2000-02-15 Application granted granted Critical

2000-02-15 Publication of ATE189601T1 publication Critical patent/ATE189601T1/de

Links

201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
GZUITABIAKMVPG-UHFFFAOYSA-N raloxifene Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 GZUITABIAKMVPG-UHFFFAOYSA-N 0.000 title 1
229960004622 raloxifene Drugs 0.000 title 1
230000003612 virological effect Effects 0.000 title 1
RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Natural products C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
-1 hexamethyleneamino Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
230000029812 viral genome replication Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)

AT95930863T 1994-08-22 1995-08-21 Verwendung von raloxifen und dessen analogen zur herstellung eines medikaments zur behandlung viraler erkrankungen ATE189601T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/294,171 US5494920A (en)	1994-08-22	1994-08-22	Methods of inhibiting viral replication
PCT/US1995/010580 WO1996005830A1 (en)	1994-08-22	1995-08-21	Methods of inhibiting viral replication

Publications (1)

Publication Number	Publication Date
ATE189601T1 true ATE189601T1 (de)	2000-02-15

Family

ID=23132219

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95930863T ATE189601T1 (de)	1994-08-22	1995-08-21	Verwendung von raloxifen und dessen analogen zur herstellung eines medikaments zur behandlung viraler erkrankungen

Country Status (15)

Country	Link
US (1)	US5494920A (de)
EP (1)	EP0771200B1 (de)
JP (1)	JPH10504572A (de)
AT (1)	ATE189601T1 (de)
AU (1)	AU3408795A (de)
CA (1)	CA2198122A1 (de)
DE (1)	DE69515038T2 (de)
DK (1)	DK0771200T3 (de)
ES (1)	ES2141957T3 (de)
GR (1)	GR3033269T3 (de)
IL (1)	IL115014A0 (de)
MX (1)	MX9701329A (de)
PT (1)	PT771200E (de)
WO (1)	WO1996005830A1 (de)
ZA (1)	ZA956986B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1997022004A1 (en)	1995-12-13	1997-06-19	Merck & Co., Inc.	Assays for growth hormone secretagogue receptors
US6531314B1 (en)	1996-12-10	2003-03-11	Merck & Co., Inc.	Growth hormone secretagogue receptor family
US6458811B1 (en) *	1996-03-26	2002-10-01	Eli Lilly And Company	Benzothiophenes formulations containing same and methods
DE69739855D1 (de) *	1996-03-26	2010-06-02	Lilly Co Eli	Benzothiophene und denen enthaltende zusammensetzungen
IL146284A0 (en)	1999-05-04	2002-07-25	Strakan Ltd	Androgen glycosides and pharmaceutical compositions containing the same
UA87854C2 (en)	2004-06-07	2009-08-25	Мерк Энд Ко., Инк.	N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
AU2005314089B2 (en) *	2004-12-08	2011-03-03	Cedars-Sinai Medical Center	Methods for diagnosis and treatment of Crohn's disease
US20100021917A1 (en) *	2007-02-14	2010-01-28	Cedars-Sinai Medical Center	Methods of using genes and genetic variants to predict or diagnose inflammatory bowel disease
US20100190162A1 (en) *	2007-02-26	2010-07-29	Cedars-Sinai Medical Center	Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease
US20100015156A1 (en) *	2007-03-06	2010-01-21	Cedars-Sinai Medical Center	Diagnosis of inflammatory bowel disease in children
US8486640B2 (en)	2007-03-21	2013-07-16	Cedars-Sinai Medical Center	Ileal pouch-anal anastomosis (IPAA) factors in the treatment of inflammatory bowel disease
WO2008134569A2 (en) *	2007-04-26	2008-11-06	Cedars-Sinai Medical Center	Diagnosis and treatment of inflammatory bowel disease in the puerto rican population
US20100144903A1 (en) *	2007-05-04	2010-06-10	Cedars-Sinai Medical Center	Methods of diagnosis and treatment of crohn's disease
WO2008134828A2 (en)	2007-05-04	2008-11-13	Katholieke Universiteit Leuven	Tissue degeneration protection
US20110177969A1 (en) *	2008-10-01	2011-07-21	Cedars-Sinai Medical Center	The role of il17rd and the il23-1l17 pathway in crohn's disease
US20110189685A1 (en) *	2008-10-22	2011-08-04	Cedars-Sinai Medical Center	Methods of using jak3 genetic variants to diagnose and predict crohn's disease
US20110229471A1 (en) *	2008-11-26	2011-09-22	Cedars-Sinai Medical Center	Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease
US9580752B2 (en)	2008-12-24	2017-02-28	Cedars-Sinai Medical Center	Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy
WO2013190520A2 (en)	2012-06-22	2013-12-27	The General Hospital Corporation	Gh-releasing agents in the treatment of vascular stenosis and associated conditions
KR20240122922A (ko)	2013-03-27	2024-08-13	세다르스-신나이 메디칼 센터	Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전
EP4105236A1 (de)	2013-07-19	2022-12-21	Cedars-Sinai Medical Center	Anti-tl1a (tnfsf15) antikörper zur behandlung von entzündlichen darmerkrankungen
ES2864079T3 (es)	2014-05-30	2021-10-13	Pfizer	Derivados de carbonitrilo como moduladores selectivos del receptor de andrógenos
CN109462996A (zh)	2016-03-17	2019-03-12	西达-赛奈医疗中心	通过rnaset2诊断炎性肠病的方法
WO2023275715A1 (en)	2021-06-30	2023-01-05	Pfizer Inc.	Metabolites of selective androgen receptor modulators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4133814A (en) *	1975-10-28	1979-01-09	Eli Lilly And Company	2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4380635A (en) *	1981-04-03	1983-04-19	Eli Lilly And Company	Synthesis of acylated benzothiophenes
US4418068A (en) *	1981-04-03	1983-11-29	Eli Lilly And Company	Antiestrogenic and antiandrugenic benzothiophenes
US5395842A (en) *	1988-10-31	1995-03-07	Endorecherche Inc.	Anti-estrogenic compounds and compositions
JP3157882B2 (ja) *	1991-11-15	2001-04-16	帝国臓器製薬株式会社	新規なベンゾチオフエン誘導体

1994
- 1994-08-22 US US08/294,171 patent/US5494920A/en not_active Expired - Fee Related
1995
- 1995-08-21 DK DK95930863T patent/DK0771200T3/da active
- 1995-08-21 IL IL11501495A patent/IL115014A0/xx unknown
- 1995-08-21 AU AU34087/95A patent/AU3408795A/en not_active Abandoned
- 1995-08-21 AT AT95930863T patent/ATE189601T1/de not_active IP Right Cessation
- 1995-08-21 JP JP8508230A patent/JPH10504572A/ja not_active Withdrawn
- 1995-08-21 DE DE69515038T patent/DE69515038T2/de not_active Expired - Fee Related
- 1995-08-21 ES ES95930863T patent/ES2141957T3/es not_active Expired - Lifetime
- 1995-08-21 WO PCT/US1995/010580 patent/WO1996005830A1/en not_active Ceased
- 1995-08-21 ZA ZA9506986A patent/ZA956986B/xx unknown
- 1995-08-21 MX MX9701329A patent/MX9701329A/es unknown
- 1995-08-21 CA CA002198122A patent/CA2198122A1/en not_active Abandoned
- 1995-08-21 EP EP95930863A patent/EP0771200B1/de not_active Expired - Lifetime
- 1995-08-21 PT PT95930863T patent/PT771200E/pt unknown
2000
- 2000-04-19 GR GR20000400952T patent/GR3033269T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0771200A4 (de)	1997-09-10
ZA956986B (en)	1997-02-21
EP0771200B1 (de)	2000-02-09
DE69515038T2 (de)	2000-06-29
AU3408795A (en)	1996-03-14
DE69515038D1 (de)	2000-03-16
CA2198122A1 (en)	1996-02-29
IL115014A0 (en)	1995-12-08
JPH10504572A (ja)	1998-05-06
DK0771200T3 (da)	2000-05-15
GR3033269T3 (en)	2000-09-29
MX9701329A (es)	1997-05-31
EP0771200A1 (de)	1997-05-07
PT771200E (pt)	2000-07-31
US5494920A (en)	1996-02-27
ES2141957T3 (es)	2000-04-01
WO1996005830A1 (en)	1996-02-29

Legal Events

Date	Code	Title	Description
2000-08-15	UEP	Publication of translation of european patent specification
2003-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE189601T1 (de)	2000-02-15	Verwendung von raloxifen und dessen analogen zur herstellung eines medikaments zur behandlung viraler erkrankungen
HU9403675D0 (en)	1995-02-28	Methods of inhibiting thrombin
MX9701360A (es)	1997-05-31	Metodos para la inhibicion de la desmielinizacion y las enfermedades de la dismielinizacion.
DE69428325D1 (de)	2001-10-25	Verwendung von 2-phenyl-3-aroylbenzothiophen Derivaten zur Herstellung eines Medikaments zur Hemmung der Angiogenese und angiogene Krankheiten
MX9701325A (es)	1997-05-31	Metodos para inhibir la mucositis ulcerativa.
ATE199642T1 (de)	2001-03-15	Verwendung von 2-phenyl-3-aroylbenzothiophen derivaten zur herstellung eines medikaments zur hemmung des knorpelabbaus
NO970786L (no)	1997-02-20	Fremgangsmåte for hemming av benprotesedegradering
ATE173252T1 (de)	1998-11-15	Arylmorpholine, herstellung und verwendung
EA199700136A1 (ru)	1997-12-30	Способы ингибирования экзогенных эстрогенов
ATE240101T1 (de)	2003-05-15	Verwendung von 2-phenyl-3- aroylbenzothiophenderivaten zur herstellung eines medikaments zur knochen- und bruchheilung
MX9701333A (es)	1997-05-31	Metodos para inhibir el daño neuronal.
ATE200623T1 (de)	2001-05-15	Verwendung von 2-phenyl-3-aroylbenzothiophen derivaten zur herstellung eines medikaments zur hemmung der primären endometriumhyperplasie
ATE179890T1 (de)	1999-05-15	Verwendung von benzothiophenen zur herstellung eines medikaments zur verminderung der narbenbildung bei der wundheilung
MX9709536A (es)	1998-03-29	Metodo para reducir el factor de transcripcion bef-1.
MX9709651A (es)	1998-03-29	Metodos para modulacion del factor de transcripcion nf-kb.
MX9706072A (es)	1997-10-31	Metodos de inhibicion de la adhesion celula-celula.
MX9705697A (es)	1997-10-31	Metodos para reducir los niveles de calcio del suero.