DK0771200T3 - Anvendelse af raloxifen og dets analoger til fremstilling af et medikament til behandling af virale sygdomme - Google Patents

Anvendelse af raloxifen og dets analoger til fremstilling af et medikament til behandling af virale sygdomme

Info

Publication number: DK0771200T3
Authority: DK; Denmark
Prior art keywords: raloxifene; analogues; medicament; manufacture; treatment
Prior art date: 1994-08-22

Application number

DK95930863T

Other languages

Danish (da)

English (en)

Inventor

Andrew Lawrence Glasebrook

David Lynn Phillips

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-22

Filing date

1995-08-21

Publication date

2000-05-15

1995-08-21 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2000-05-15 Application granted granted Critical

2000-05-15 Publication of DK0771200T3 publication Critical patent/DK0771200T3/da

Links

201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
239000003814 drug Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
GZUITABIAKMVPG-UHFFFAOYSA-N raloxifene Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 GZUITABIAKMVPG-UHFFFAOYSA-N 0.000 title 1
229960004622 raloxifene Drugs 0.000 title 1
230000003612 virological effect Effects 0.000 title 1
RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Natural products C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
-1 hexamethyleneamino Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
230000029812 viral genome replication Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)

DK95930863T 1994-08-22 1995-08-21 Anvendelse af raloxifen og dets analoger til fremstilling af et medikament til behandling af virale sygdomme DK0771200T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/294,171 US5494920A (en)	1994-08-22	1994-08-22	Methods of inhibiting viral replication
PCT/US1995/010580 WO1996005830A1 (en)	1994-08-22	1995-08-21	Methods of inhibiting viral replication

Publications (1)

Publication Number	Publication Date
DK0771200T3 true DK0771200T3 (da)	2000-05-15

Family

ID=23132219

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95930863T DK0771200T3 (da)	1994-08-22	1995-08-21	Anvendelse af raloxifen og dets analoger til fremstilling af et medikament til behandling af virale sygdomme

Country Status (15)

Country	Link
US (1)	US5494920A (de)
EP (1)	EP0771200B1 (de)
JP (1)	JPH10504572A (de)
AT (1)	ATE189601T1 (de)
AU (1)	AU3408795A (de)
CA (1)	CA2198122A1 (de)
DE (1)	DE69515038T2 (de)
DK (1)	DK0771200T3 (de)
ES (1)	ES2141957T3 (de)
GR (1)	GR3033269T3 (de)
IL (1)	IL115014A0 (de)
MX (1)	MX9701329A (de)
PT (1)	PT771200E (de)
WO (1)	WO1996005830A1 (de)
ZA (1)	ZA956986B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6531314B1 (en)	1996-12-10	2003-03-11	Merck & Co., Inc.	Growth hormone secretagogue receptor family
US6242199B1 (en)	1995-12-13	2001-06-05	Merck & Co., Inc.	Assays for growth hormone secretagogue receptors
UA57596C2 (uk) *	1996-03-26	2003-06-16	Елі Ліллі Енд Компані	Похідне бензотіофену, фармацевтична лікарська форма, фармацевтична композиція, спосіб лікування остеопорозу та спосіб зниження рівнів ліпідів
US6458811B1 (en) *	1996-03-26	2002-10-01	Eli Lilly And Company	Benzothiophenes formulations containing same and methods
CZ20013912A3 (cs)	1999-05-04	2002-05-15	Strakan Limited	Androgen glykosid, sloučenina, testosteron-ß-D-glukosid, 5 alfa-Dihydrotestosteron- 17ß-D-glukosid, farmaceutický prostředek a pouľití sloučeniny
UA87854C2 (en)	2004-06-07	2009-08-25	Мерк Энд Ко., Инк.	N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
AU2005314089B2 (en) *	2004-12-08	2011-03-03	Cedars-Sinai Medical Center	Methods for diagnosis and treatment of Crohn's disease
WO2010048415A1 (en) *	2008-10-22	2010-04-29	Cedars-Sinai Medical Center	Methods of using jak3 genetic variants to diagnose and predict crohn's disease
US20100021917A1 (en) *	2007-02-14	2010-01-28	Cedars-Sinai Medical Center	Methods of using genes and genetic variants to predict or diagnose inflammatory bowel disease
US20100190162A1 (en) *	2007-02-26	2010-07-29	Cedars-Sinai Medical Center	Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease
WO2008137762A2 (en) *	2007-05-04	2008-11-13	Cedars-Sinai Medical Center	Methods of diagnosis and treatment of crohn's disease
WO2010039931A2 (en) *	2008-10-01	2010-04-08	Cedars-Sinai Medical Center	Methods of using il17rd and il23-il17 pathway genes to diagnose crohn's disease
US20100015156A1 (en) *	2007-03-06	2010-01-21	Cedars-Sinai Medical Center	Diagnosis of inflammatory bowel disease in children
US8486640B2 (en)	2007-03-21	2013-07-16	Cedars-Sinai Medical Center	Ileal pouch-anal anastomosis (IPAA) factors in the treatment of inflammatory bowel disease
WO2008134569A2 (en) *	2007-04-26	2008-11-06	Cedars-Sinai Medical Center	Diagnosis and treatment of inflammatory bowel disease in the puerto rican population
EP2155769B1 (de)	2007-05-04	2012-06-27	Katholieke Universiteit Leuven KU Leuven Research & Development	Schutz gegen gewebedegeneration
WO2010062960A2 (en)	2008-11-26	2010-06-03	Cedars-Sinai Medical Center	METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE
WO2010075579A2 (en)	2008-12-24	2010-07-01	Cedars-Sinai Medical Center	Methods of predicting medically refractive ulcerative colitis (mr-uc) requiring colectomy
WO2013190520A2 (en)	2012-06-22	2013-12-27	The General Hospital Corporation	Gh-releasing agents in the treatment of vascular stenosis and associated conditions
KR20230109779A (ko)	2013-03-27	2023-07-20	세다르스-신나이 메디칼 센터	Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한섬유증 및 염증의 완화 및 반전
EP4105236A1 (de)	2013-07-19	2022-12-21	Cedars-Sinai Medical Center	Anti-tl1a (tnfsf15) antikörper zur behandlung von entzündlichen darmerkrankungen
ES2864079T3 (es)	2014-05-30	2021-10-13	Pfizer	Derivados de carbonitrilo como moduladores selectivos del receptor de andrógenos
KR20180127416A (ko)	2016-03-17	2018-11-28	세다르스-신나이 메디칼 센터	Rnaset2를 통한 염증성 장 질환의 진단 방법
WO2023275715A1 (en)	2021-06-30	2023-01-05	Pfizer Inc.	Metabolites of selective androgen receptor modulators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4133814A (en) *	1975-10-28	1979-01-09	Eli Lilly And Company	2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4380635A (en) *	1981-04-03	1983-04-19	Eli Lilly And Company	Synthesis of acylated benzothiophenes
US4418068A (en) *	1981-04-03	1983-11-29	Eli Lilly And Company	Antiestrogenic and antiandrugenic benzothiophenes
US5395842A (en) *	1988-10-31	1995-03-07	Endorecherche Inc.	Anti-estrogenic compounds and compositions
JP3157882B2 (ja) *	1991-11-15	2001-04-16	帝国臓器製薬株式会社	新規なベンゾチオフエン誘導体

1994
- 1994-08-22 US US08/294,171 patent/US5494920A/en not_active Expired - Fee Related
1995
- 1995-08-21 DK DK95930863T patent/DK0771200T3/da active
- 1995-08-21 ZA ZA9506986A patent/ZA956986B/xx unknown
- 1995-08-21 IL IL11501495A patent/IL115014A0/xx unknown
- 1995-08-21 DE DE69515038T patent/DE69515038T2/de not_active Expired - Fee Related
- 1995-08-21 WO PCT/US1995/010580 patent/WO1996005830A1/en not_active Ceased
- 1995-08-21 AU AU34087/95A patent/AU3408795A/en not_active Abandoned
- 1995-08-21 EP EP95930863A patent/EP0771200B1/de not_active Expired - Lifetime
- 1995-08-21 JP JP8508230A patent/JPH10504572A/ja not_active Withdrawn
- 1995-08-21 CA CA002198122A patent/CA2198122A1/en not_active Abandoned
- 1995-08-21 MX MX9701329A patent/MX9701329A/es unknown
- 1995-08-21 ES ES95930863T patent/ES2141957T3/es not_active Expired - Lifetime
- 1995-08-21 AT AT95930863T patent/ATE189601T1/de not_active IP Right Cessation
- 1995-08-21 PT PT95930863T patent/PT771200E/pt unknown
2000
- 2000-04-19 GR GR20000400952T patent/GR3033269T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO1996005830A1 (en)	1996-02-29
EP0771200A1 (de)	1997-05-07
US5494920A (en)	1996-02-27
DE69515038T2 (de)	2000-06-29
DE69515038D1 (de)	2000-03-16
AU3408795A (en)	1996-03-14
MX9701329A (es)	1997-05-31
ATE189601T1 (de)	2000-02-15
ZA956986B (en)	1997-02-21
PT771200E (pt)	2000-07-31
EP0771200A4 (de)	1997-09-10
EP0771200B1 (de)	2000-02-09
JPH10504572A (ja)	1998-05-06
CA2198122A1 (en)	1996-02-29
ES2141957T3 (es)	2000-04-01
GR3033269T3 (en)	2000-09-29
IL115014A0 (en)	1995-12-08

Publication	Publication Date	Title
ATE189601T1 (de)	2000-02-15	Verwendung von raloxifen und dessen analogen zur herstellung eines medikaments zur behandlung viraler erkrankungen
NO971520L (no)	1997-04-03	Fremgangsmåte for hemming av tilstander forbundet med neuropeptid Y
MX9701360A (es)	1997-05-31	Metodos para la inhibicion de la desmielinizacion y las enfermedades de la dismielinizacion.
DK0651999T3 (da)	2002-06-17	Fremgangsmåder til inhibering af livmoderfibrose
IL111284A (en)	2000-02-29	2-phenyl-3-aroylbenzothiophenes for use as medicaments for inhibiting endometriosis
DK0652000T3 (da)	2001-11-12	Anvendelse af 2-phenyl-3-aroylbenzothiophener til fremstilling af et lægemiddel til inhibering af angiogenese og angiogene sygdomme
DK0659411T3 (da)	2001-09-24	Fremgangsmåde til forøgelse af libido hos kvinder efter menopausen
DK0652002T3 (da)	2001-04-17	Anvendelse af 2-phenyl-3-aroylebenzothiophener til fremstilling af et medikament til hæmning af brusknedbrydning
NO970786L (no)	1997-02-20	Fremgangsmåte for hemming av benprotesedegradering
DK0583271T3 (da)	1999-07-26	Arylmorpholin, fremstilling og anvendelse
EA199700136A1 (ru)	1997-12-30	Способы ингибирования экзогенных эстрогенов
DK0769945T3 (da)	2003-06-10	Brug af 2-phenyl-3-aroylbenzothiophenderivater til fremstilling af et medikament til behandling af knogler og knoglebrud
NO971794L (no)	1997-05-22	Fremgangsmåte for hemming av tilstander forbundet med bradykinin
MX9701333A (es)	1997-05-31	Metodos para inhibir el daño neuronal.
MY113757A (en)	2002-05-31	Methods of inhibiting endometrial cancer
DK0771201T3 (da)	2001-05-07	Anvendelse af 2-phenyl-3-aroylbenzothiophener til fremstilling af et medikament til inhibering af primær endometrisk hyperplasi
DK0772438T3 (da)	1999-11-01	Anvendelse af benzothiophener til fremstilling af et medikament til reduktion af ardannelse under sårheling
NO970784L (no)	1997-02-20	Fremgangsmåte for opprettholdelse av tenner og oralt ben
MX9709536A (es)	1998-03-29	Metodo para reducir el factor de transcripcion bef-1.
MX9709651A (es)	1998-03-29	Metodos para modulacion del factor de transcripcion nf-kb.
MX9706072A (es)	1997-10-31	Metodos de inhibicion de la adhesion celula-celula.