ATE189677T1 - Verfahren zur herstellung von furosemide - Google Patents

Verfahren zur herstellung von furosemide

Info

Publication number: ATE189677T1
Authority: AT; Austria
Prior art keywords: pct; furosemide; chloro; producing; fluoro
Prior art date: 1994-10-24

Application number

AT95937826T

Other languages

English (en)

Inventor

Angelo Signor

Alfredo Guerrato

Giovanni Signor

Original Assignee

Proteos Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-24

Filing date

1995-10-23

Publication date

2000-02-15

1995-10-23 Application filed by Proteos Srl filed Critical Proteos Srl

2000-02-15 Application granted granted Critical

2000-02-15 Publication of ATE189677T1 publication Critical patent/ATE189677T1/de

Links

ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 title abstract 3
229960003883 furosemide Drugs 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
ACYJYVSUQNUQDV-UHFFFAOYSA-N 4-chloro-2-fluoro-1-(trichloromethyl)benzene Chemical compound FC1=CC(Cl)=CC=C1C(Cl)(Cl)Cl ACYJYVSUQNUQDV-UHFFFAOYSA-N 0.000 abstract 1
MKFCYQTVSDCXAQ-UHFFFAOYSA-N 4-chloro-2-fluoro-1-methylbenzene Chemical compound CC1=CC=C(Cl)C=C1F MKFCYQTVSDCXAQ-UHFFFAOYSA-N 0.000 abstract 1
238000009833 condensation Methods 0.000 abstract 1
230000005494 condensation Effects 0.000 abstract 1
DDRPCXLAQZKBJP-UHFFFAOYSA-N furfurylamine Chemical compound NCC1=CC=CO1 DDRPCXLAQZKBJP-UHFFFAOYSA-N 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
- C07C17/14—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the side-chain of aromatic compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Compounds Of Unknown Constitution (AREA)
Medicines Containing Plant Substances (AREA)
Furan Compounds (AREA)

AT95937826T 1994-10-24 1995-10-23 Verfahren zur herstellung von furosemide ATE189677T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ITMI942171A IT1271035B (it)	1994-10-24	1994-10-24	Procedimento per la preparazione della furosemide
PCT/EP1995/004153 WO1996012714A1 (en)	1994-10-24	1995-10-23	Process for the preparation of furosemide

Publications (1)

Publication Number	Publication Date
ATE189677T1 true ATE189677T1 (de)	2000-02-15

Family

ID=11369760

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95937826T ATE189677T1 (de)	1994-10-24	1995-10-23	Verfahren zur herstellung von furosemide

Country Status (8)

Country	Link
US (1)	US5739361A (de)
EP (1)	EP0788494B1 (de)
AT (1)	ATE189677T1 (de)
AU (1)	AU3868895A (de)
DE (1)	DE69515053T2 (de)
ES (1)	ES2144642T3 (de)
IT (1)	IT1271035B (de)
WO (1)	WO1996012714A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8168674B1 (en)	2002-02-22	2012-05-01	Microdose Therapeutx, Inc.	Method for treating bronchial diseases
CN105906589A (zh) *	2015-10-22	2016-08-31	菏泽市方明制药有限公司	一种呋赛米的制备方法
CN106117168B (zh) *	2016-06-30	2018-09-18	东北制药集团股份有限公司	一种呋塞米的制备方法
CN113219084A (zh) *	2021-03-26	2021-08-06	天圣制药集团股份有限公司	一种呋塞米及其制剂中2-呋喃甲胺及其缩合反应杂质的hplc检测方法
CN116410161A (zh) *	2021-12-29	2023-07-11	北京济美堂医药研究有限公司	一种精制呋塞米的方法
CN117510444B (zh) *	2024-01-06	2024-03-08	成都瑞尔医药科技有限公司	一种呋塞米的精制工艺
CN118290370A (zh) *	2024-03-07	2024-07-05	台山市新宁制药有限公司	一种呋塞米的生产工艺及其纯化方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3058882A (en) *	1959-12-28	1962-10-16	Hoechst Ag	N'-substituted-3-carboxy-6-halo-sulfanilamide and derivatives thereof
NL126738C (de) *	1963-04-13
DE1220436B (de) *	1964-10-21	1966-07-07	Hoechst Ag	Verfahren zur Herstellung von Sulfamylanthranilsaeuren
DE3217619A1 (de) *	1982-05-11	1983-11-17	Bayer Ag, 5090 Leverkusen	2,4-dihalogenbenzoyl-(thio)harnstoffe, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel

1994
- 1994-10-24 IT ITMI942171A patent/IT1271035B/it active IP Right Grant
1995
- 1995-10-23 DE DE69515053T patent/DE69515053T2/de not_active Expired - Fee Related
- 1995-10-23 AU AU38688/95A patent/AU3868895A/en not_active Abandoned
- 1995-10-23 ES ES95937826T patent/ES2144642T3/es not_active Expired - Lifetime
- 1995-10-23 US US08/817,569 patent/US5739361A/en not_active Expired - Fee Related
- 1995-10-23 AT AT95937826T patent/ATE189677T1/de not_active IP Right Cessation
- 1995-10-23 WO PCT/EP1995/004153 patent/WO1996012714A1/en not_active Ceased
- 1995-10-23 EP EP95937826A patent/EP0788494B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IT1271035B (it)	1997-05-26
DE69515053D1 (de)	2000-03-16
AU3868895A (en)	1996-05-15
EP0788494A1 (de)	1997-08-13
WO1996012714A1 (en)	1996-05-02
US5739361A (en)	1998-04-14
EP0788494B1 (de)	2000-02-09
ITMI942171A0 (it)	1994-10-24
ES2144642T3 (es)	2000-06-16
ITMI942171A1 (it)	1996-04-24
DE69515053T2 (de)	2000-08-03

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Legal Events

Date	Code	Title	Description
2000-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties