ES2144642T3 - Proceso de preparacion de la furosemida. - Google Patents

Proceso de preparacion de la furosemida.

Info

Publication number
ES2144642T3
ES2144642T3 ES95937826T ES95937826T ES2144642T3 ES 2144642 T3 ES2144642 T3 ES 2144642T3 ES 95937826 T ES95937826 T ES 95937826T ES 95937826 T ES95937826 T ES 95937826T ES 2144642 T3 ES2144642 T3 ES 2144642T3
Authority
ES
Spain
Prior art keywords
preparation process
furosemide
fluoro
chloro
furosemide preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95937826T
Other languages
English (en)
Inventor
Angelo Signor
Alfredo Guerrato
Giovanni Signor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Proteos SRL
Original Assignee
Proteos SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proteos SRL filed Critical Proteos SRL
Application granted granted Critical
Publication of ES2144642T3 publication Critical patent/ES2144642T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C07C17/14—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the side-chain of aromatic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Furan Compounds (AREA)

Abstract

SE DESCRIBE UN NUEVO PROCEDIMIENTO DE PREPARACION DE FUROSEMIDA [ACIDO 4-CLORO-N-(2-FURILMETIL)-5-SULFAMOIL-ANTRANILICO], QUE COMPRENDE LA FOTOCLORACION DE 4-CLORO-2-FLUORO-TOLUENO, PARA PRODUCIR 4-CLORO-2-FLUORO-BENZOTRICLORURO, LA AMINOSULFONILACION DEL MISMO, Y LA ULTERIOR CONDENSACION CON FURFURILAMINA.
ES95937826T 1994-10-24 1995-10-23 Proceso de preparacion de la furosemida. Expired - Lifetime ES2144642T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI942171A IT1271035B (it) 1994-10-24 1994-10-24 Procedimento per la preparazione della furosemide

Publications (1)

Publication Number Publication Date
ES2144642T3 true ES2144642T3 (es) 2000-06-16

Family

ID=11369760

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95937826T Expired - Lifetime ES2144642T3 (es) 1994-10-24 1995-10-23 Proceso de preparacion de la furosemida.

Country Status (8)

Country Link
US (1) US5739361A (es)
EP (1) EP0788494B1 (es)
AT (1) ATE189677T1 (es)
AU (1) AU3868895A (es)
DE (1) DE69515053T2 (es)
ES (1) ES2144642T3 (es)
IT (1) IT1271035B (es)
WO (1) WO1996012714A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8168674B1 (en) 2002-02-22 2012-05-01 Microdose Therapeutx, Inc. Method for treating bronchial diseases
CN105906589A (zh) * 2015-10-22 2016-08-31 菏泽市方明制药有限公司 一种呋赛米的制备方法
CN106117168B (zh) * 2016-06-30 2018-09-18 东北制药集团股份有限公司 一种呋塞米的制备方法
CN113219084A (zh) * 2021-03-26 2021-08-06 天圣制药集团股份有限公司 一种呋塞米及其制剂中2-呋喃甲胺及其缩合反应杂质的hplc检测方法
CN116410161A (zh) * 2021-12-29 2023-07-11 北京济美堂医药研究有限公司 一种精制呋塞米的方法
CN117510444B (zh) * 2024-01-06 2024-03-08 成都瑞尔医药科技有限公司 一种呋塞米的精制工艺
CN118290370A (zh) * 2024-03-07 2024-07-05 台山市新宁制药有限公司 一种呋塞米的生产工艺及其纯化方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3058882A (en) * 1959-12-28 1962-10-16 Hoechst Ag N'-substituted-3-carboxy-6-halo-sulfanilamide and derivatives thereof
NL126738C (es) * 1963-04-13
DE1220436B (de) * 1964-10-21 1966-07-07 Hoechst Ag Verfahren zur Herstellung von Sulfamylanthranilsaeuren
DE3217619A1 (de) * 1982-05-11 1983-11-17 Bayer Ag, 5090 Leverkusen 2,4-dihalogenbenzoyl-(thio)harnstoffe, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel

Also Published As

Publication number Publication date
DE69515053T2 (de) 2000-08-03
ATE189677T1 (de) 2000-02-15
AU3868895A (en) 1996-05-15
EP0788494B1 (en) 2000-02-09
US5739361A (en) 1998-04-14
EP0788494A1 (en) 1997-08-13
ITMI942171A1 (it) 1996-04-24
IT1271035B (it) 1997-05-26
DE69515053D1 (de) 2000-03-16
ITMI942171A0 (it) 1994-10-24
WO1996012714A1 (en) 1996-05-02

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