ATE189771T1 - Zubereitung mit kontrollierter freisetzung, die ein morphinsalz enthält - Google Patents

Zubereitung mit kontrollierter freisetzung, die ein morphinsalz enthält

Info

Publication number: ATE189771T1
Authority: AT; Austria
Prior art keywords: morphine; controlled release; preparations; manufacture; preparation containing
Prior art date: 1993-03-30

Application number

AT94912116T

Other languages

English (en)

Inventor

Birgitta Olsson

Maritta Anneli Chefrad

Gert Ragnarsson

Original Assignee

Pharmacia & Upjohn Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-30

Filing date

1994-03-24

Publication date

2000-03-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20389415&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE189771(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1994-03-24 Application filed by Pharmacia & Upjohn Ab filed Critical Pharmacia & Upjohn Ab

2000-03-15 Application granted granted Critical

2000-03-15 Publication of ATE189771T1 publication Critical patent/ATE189771T1/de

Links

BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical class O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title abstract 9
239000003405 delayed action preparation Substances 0.000 title 1
229960005181 morphine Drugs 0.000 abstract 4
238000002360 preparation method Methods 0.000 abstract 3
238000004519 manufacturing process Methods 0.000 abstract 2
210000002966 serum Anatomy 0.000 abstract 2
230000000202 analgesic effect Effects 0.000 abstract 1
230000004888 barrier function Effects 0.000 abstract 1
239000002775 capsule Substances 0.000 abstract 1
238000013270 controlled release Methods 0.000 abstract 1
239000012528 membrane Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000002245 particle Substances 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
230000036470 plasma concentration Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

AT94912116T 1993-03-30 1994-03-24 Zubereitung mit kontrollierter freisetzung, die ein morphinsalz enthält ATE189771T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9301057A SE9301057L (sv)	1993-03-30	1993-03-30	Beredning med kontrollerad frisättning
PCT/SE1994/000264 WO1994022431A1 (en)	1993-03-30	1994-03-24	Controlled release preparation containing a salt of morphine

Publications (1)

Publication Number	Publication Date
ATE189771T1 true ATE189771T1 (de)	2000-03-15

Family

ID=20389415

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94912116T ATE189771T1 (de)	1993-03-30	1994-03-24	Zubereitung mit kontrollierter freisetzung, die ein morphinsalz enthält

Country Status (25)

Country	Link
US (1)	US5614218A (de)
EP (1)	EP0642335B2 (de)
JP (1)	JP4107678B2 (de)
KR (1)	KR100316206B1 (de)
CN (1)	CN1104891C (de)
AT (1)	ATE189771T1 (de)
AU (1)	AU680891C (de)
CA (1)	CA2135639C (de)
CZ (1)	CZ284924B6 (de)
DE (1)	DE69423028T3 (de)
DK (1)	DK0642335T4 (de)
EE (1)	EE03147B1 (de)
ES (1)	ES2144516T5 (de)
FI (1)	FI113743B (de)
GR (1)	GR3033325T3 (de)
HU (1)	HU227344B1 (de)
LV (1)	LV10684B (de)
NO (1)	NO310015B1 (de)
NZ (1)	NZ263632A (de)
PL (1)	PL175326B1 (de)
PT (1)	PT642335E (de)
RU (1)	RU2136283C1 (de)
SE (1)	SE9301057L (de)
SK (1)	SK280362B6 (de)
WO (1)	WO1994022431A1 (de)

Families Citing this family (68)

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US5266331A (en) *	1991-11-27	1993-11-30	Euroceltique, S.A.	Controlled release oxycodone compositions
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AU735113C (en) *	1991-12-24	2007-06-14	Mundipharma Medical Gmbh	Opioid formulations for treating pain
US5472712A (en) *	1991-12-24	1995-12-05	Euroceltique, S.A.	Controlled-release formulations coated with aqueous dispersions of ethylcellulose
US5958459A (en) *	1991-12-24	1999-09-28	Purdue Pharma L.P.	Opioid formulations having extended controlled released
US5478577A (en) *	1993-11-23	1995-12-26	Euroceltique, S.A.	Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US20080075781A1 (en) *	1992-11-25	2008-03-27	Purdue Pharma Lp	Controlled release oxycodone compositions
NZ260408A (en) *	1993-05-10	1996-05-28	Euro Celtique Sa	Controlled release preparation comprising tramadol
US20070275062A1 (en) *	1993-06-18	2007-11-29	Benjamin Oshlack	Controlled release oxycodone compositions
IL109944A (en) †	1993-07-01	1998-12-06	Euro Celtique Sa	Sustained release dosage unit forms containing morphine and a method of preparing these sustained release dosage unit forms
US7740881B1 (en)	1993-07-01	2010-06-22	Purdue Pharma Lp	Method of treating humans with opioid formulations having extended controlled release
IL110014A (en) *	1993-07-01	1999-11-30	Euro Celtique Sa	Solid controlled-release oral dosage forms of opioid analgesics
US5879705A (en) *	1993-07-27	1999-03-09	Euro-Celtique S.A.	Sustained release compositions of morphine and a method of preparing pharmaceutical compositions
US5891471A (en) *	1993-11-23	1999-04-06	Euro-Celtique, S.A.	Pharmaceutical multiparticulates
US20020006438A1 (en) *	1998-09-25	2002-01-17	Benjamin Oshlack	Sustained release hydromorphone formulations exhibiting bimodal characteristics
US5965161A (en)	1994-11-04	1999-10-12	Euro-Celtique, S.A.	Extruded multi-particulates
GB9519363D0 (en)	1995-09-22	1995-11-22	Euro Celtique Sa	Pharmaceutical formulation
DE19607395C2 (de) *	1996-02-28	2002-11-21	Lohmann Therapie Syst Lts	Salze aus einem kationischen narkotischen Analgetikum mit einem anionischen nichtnarkotischen Analgetikum, Verfahren zu deren Herstellung und die diese Salze enthaltenden pharmazeutischen Präparate
US6245351B1 (en)	1996-03-07	2001-06-12	Takeda Chemical Industries, Ltd.	Controlled-release composition
US5891474A (en)	1997-01-29	1999-04-06	Poli Industria Chimica, S.P.A.	Time-specific controlled release dosage formulations and method of preparing same
US6066339A (en) *	1997-10-17	2000-05-23	Elan Corporation, Plc	Oral morphine multiparticulate formulation
US6806294B2 (en)	1998-10-15	2004-10-19	Euro-Celtique S.A.	Opioid analgesic
DE19901683B4 (de) *	1999-01-18	2005-07-21	Grünenthal GmbH	Analgetikum mit kontrollierter Wirkstofffreisetzung
FR2794646B1 (fr)	1999-06-09	2001-09-21	Ethypharm Lab Prod Ethiques	Microgranules de sulfate de morphine, procede de preparation et composition les contenant
US10179130B2 (en)	1999-10-29	2019-01-15	Purdue Pharma L.P.	Controlled release hydrocodone formulations
ATE526950T1 (de)	1999-10-29	2011-10-15	Euro Celtique Sa	Hydrocodon-formulierungen mit gesteuerter freisetzung
EP2283829A1 (de)	2000-10-30	2011-02-16	Euro-Celtique S.A.	Hydrocodon-Formulierungen mit gesteuerter Freisetzung
UA81224C2 (uk) *	2001-05-02	2007-12-25	Euro Celtic S A	Дозована форма оксикодону та її застосування
US20110104214A1 (en)	2004-04-15	2011-05-05	Purdue Pharma L.P.	Once-a-day oxycodone formulations
US20030072731A1 (en) *	2001-05-15	2003-04-17	Cynthia Gulian	Dip coating compositions containing starch or dextrin
AU4061702A (en) *	2001-05-15	2003-04-03	Mcneil-Ppc, Inc.	Dip coating compositions containing starch or dextrin
US20030070584A1 (en) *	2001-05-15	2003-04-17	Cynthia Gulian	Dip coating compositions containing cellulose ethers
WO2003024430A1 (en)	2001-09-21	2003-03-27	Egalet A/S	Morphine polymer release system
EP1429739A1 (de)	2001-09-21	2004-06-23	Egalet A/S	Polymer-freigabe-system
US8309118B2 (en) *	2001-09-28	2012-11-13	Mcneil-Ppc, Inc.	Film forming compositions containing sucralose
CA2479350A1 (en) *	2002-03-15	2003-09-25	Cypress Bioscience, Inc.	Ne and 5-ht reuptake inhibitors for treating visceral pain syndromes
US7429619B2 (en) *	2002-08-02	2008-09-30	Mcneil Consumer Healthcare	Polyacrylic film forming compositions
DK1551372T3 (en) *	2002-09-20	2018-07-23	Alpharma Pharmaceuticals Llc	SEQUERATION SUBSTANCES AND RELATED COMPOSITIONS AND PROCEDURES
EP1545468A4 (de) *	2002-09-20	2007-06-20	Alpharma Inc	Opioid-formulierungen mit verz gerter freisetzung und anwendungsverfahren
EP1546120A4 (de) *	2002-10-04	2006-11-22	Pharmacia Corp	Pharmazeutische zusammensetzung zur behandlung von parkinson-krankheit
US20060003004A1 (en) *	2002-10-25	2006-01-05	Collegium Pharmaceutical, Inc.	Pulsatile release compositions of milnacipran
US20040132826A1 (en) *	2002-10-25	2004-07-08	Collegium Pharmaceutical, Inc.	Modified release compositions of milnacipran
JP2006515008A (ja) *	2003-01-28	2006-05-18	コレギウムファーマシューティカル，インコーポレイテッド	経口投与のためのミルナシプランの多粒子状組成物
EP1610767B1 (de)	2003-03-26	2011-01-19	Egalet A/S	Morphin-system mit kontrollierter freisetzung
TWI347201B (en)	2003-04-21	2011-08-21	Euro Celtique Sa	Pharmaceutical products,uses thereof and methods for preparing the same
KR101087464B1 (ko) *	2003-08-08	2011-11-25	밸리언트 인터내셔널(바베이도스) 에스알엘	부프로피온 히드로클로라이드의 개질 방출형 정제
EP1810678A1 (de)	2006-01-19	2007-07-25	Holger Lars Hermann	Verwendung einer Kombination von Morphin und Naloxon zur Drogensubstitution
US20070190141A1 (en) *	2006-02-16	2007-08-16	Aaron Dely	Extended release opiate composition
US20080069891A1 (en) *	2006-09-15	2008-03-20	Cima Labs, Inc.	Abuse resistant drug formulation
US20080075768A1 (en) *	2006-07-21	2008-03-27	Vaughn Jason M	Hydrophobic opioid abuse deterrent delivery system using opioid antagonists
US8445018B2 (en)	2006-09-15	2013-05-21	Cima Labs Inc.	Abuse resistant drug formulation
AU2008258596B2 (en)	2007-06-04	2013-02-14	Egalet Ltd	Controlled release pharmaceutical compositions for prolonged effect
CA2923102C (en) *	2007-08-13	2019-10-15	Omeho Life Sciences Inc.	Abuse resistant drugs, method of use and method of making
GB2460915B (en) *	2008-06-16	2011-05-25	Biovascular Inc	Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor
NZ594207A (en)	2009-02-06	2013-03-28	Egalet Ltd	Immediate release composition resistant to abuse by intake of alcohol
DK3045043T3 (da)	2009-02-26	2020-08-03	Relmada Therapeutics Inc	Orale farmaceutiske sammensætninger af 3-hydroxy-n-methylmorphinan med forlænget frigivelse og fremgangsmåde til anvendelse
WO2010149169A2 (en)	2009-06-24	2010-12-29	Egalet A/S	Controlled release formulations
CA2798702A1 (en)	2010-05-11	2011-11-17	Cima Labs Inc.	Alcoholresistant metoprolol-containing extended-release oral dosage forms
EP2590636A1 (de)	2010-07-06	2013-05-15	Grünenthal GmbH	Neue gastroretentive dosierungsformen mit einem gaba-analog und einem opioid
US9549899B2 (en)	2012-07-06	2017-01-24	Egalet Ltd.	Abuse deterrent pharmaceutical compositions for controlled release
WO2014146093A2 (en)	2013-03-15	2014-09-18	Inspirion Delivery Technologies, Llc	Abuse deterrent compositions and methods of use
AU2014306759B2 (en)	2013-08-12	2018-04-26	Pharmaceutical Manufacturing Research Services, Inc.	Extruded immediate release abuse deterrent pill
US10172797B2 (en)	2013-12-17	2019-01-08	Pharmaceutical Manufacturing Research Services, Inc.	Extruded extended release abuse deterrent pill
US9492444B2 (en)	2013-12-17	2016-11-15	Pharmaceutical Manufacturing Research Services, Inc.	Extruded extended release abuse deterrent pill
EP3169315B1 (de)	2014-07-17	2020-06-24	Pharmaceutical Manufacturing Research Services, Inc.	Missbrauchssichere flüssigkeitsfülldosierform mit unmittelbarer freisetzung
US10729685B2 (en)	2014-09-15	2020-08-04	Ohemo Life Sciences Inc.	Orally administrable compositions and methods of deterring abuse by intranasal administration
US20160106737A1 (en)	2014-10-20	2016-04-21	Pharmaceutical Manufacturing Research Services, Inc.	Extended Release Abuse Deterrent Liquid Fill Dosage Form
KR102810926B1 (ko)	2017-12-20	2025-05-22	퍼듀 퍼머 엘피	남용 억제 황산모르핀 제형

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DK150008C (da) *	1981-11-20	1987-05-25	Benzon As Alfred	Fremgangsmaade til fremstilling af et farmaceutisk oralt polydepotpraeparat
US4443428A (en) *	1982-06-21	1984-04-17	Euroceltique, S.A.	Extended action controlled release compositions
CA2007181C (en) *	1989-01-06	1998-11-24	Angelo Mario Morella	Sustained release pharmaceutical composition
SE8902699D0 (sv) *	1989-08-09	1989-08-09	Lejus Medical Ab	Diltiazem containing pharmaceutical compositios
DE4105480A1 (de) *	1991-02-21	1992-08-27	Boehringer Mannheim Gmbh	Verbesserte aktivierung von rekombinanten proteinen
US5273760A (en) †	1991-12-24	1993-12-28	Euroceltigue, S.A.	Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
US5478577A (en) †	1993-11-23	1995-12-26	Euroceltique, S.A.	Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
SE9202250D0 (sv) *	1992-07-29	1992-07-29	Gacell Lab Ab	Controlled release morphine preparation

1993
- 1993-03-30 SE SE9301057A patent/SE9301057L/xx not_active Application Discontinuation
1994
- 1994-03-16 US US08/213,518 patent/US5614218A/en not_active Expired - Lifetime
- 1994-03-24 PL PL94306421A patent/PL175326B1/pl unknown
- 1994-03-24 AT AT94912116T patent/ATE189771T1/de active
- 1994-03-24 HU HU9403437A patent/HU227344B1/hu unknown
- 1994-03-24 SK SK1437-94A patent/SK280362B6/sk not_active IP Right Cessation
- 1994-03-24 JP JP52197694A patent/JP4107678B2/ja not_active Expired - Lifetime
- 1994-03-24 DE DE69423028T patent/DE69423028T3/de not_active Expired - Lifetime
- 1994-03-24 NZ NZ263632A patent/NZ263632A/en not_active IP Right Cessation
- 1994-03-24 ES ES94912116T patent/ES2144516T5/es not_active Expired - Lifetime
- 1994-03-24 DK DK94912116T patent/DK0642335T4/da active
- 1994-03-24 KR KR1019940704397A patent/KR100316206B1/ko not_active Expired - Lifetime
- 1994-03-24 CN CN94190160A patent/CN1104891C/zh not_active Expired - Lifetime
- 1994-03-24 AU AU64393/94A patent/AU680891C/en not_active Expired
- 1994-03-24 PT PT94912116T patent/PT642335E/pt unknown
- 1994-03-24 CZ CZ942986A patent/CZ284924B6/cs not_active IP Right Cessation
- 1994-03-24 CA CA002135639A patent/CA2135639C/en not_active Expired - Lifetime
- 1994-03-24 RU RU94046147A patent/RU2136283C1/ru active
- 1994-03-24 EP EP94912116A patent/EP0642335B2/de not_active Expired - Lifetime
- 1994-03-24 WO PCT/SE1994/000264 patent/WO1994022431A1/en not_active Ceased
- 1994-11-16 EE EE9400376A patent/EE03147B1/xx unknown
- 1994-11-29 NO NO944565A patent/NO310015B1/no not_active IP Right Cessation
- 1994-11-29 FI FI945621A patent/FI113743B/fi not_active IP Right Cessation
- 1994-11-30 LV LVP-94-228A patent/LV10684B/xx unknown
2000
- 2000-04-26 GR GR20000401009T patent/GR3033325T3/el unknown

Also Published As

Publication number	Publication date
EP0642335B2 (de)	2005-01-19
HUT71417A (en)	1995-11-28
RU94046147A (ru)	1996-11-10
CN1104891C (zh)	2003-04-09
LV10684B (en)	1996-02-20
CA2135639A1 (en)	1994-10-13
EP0642335A1 (de)	1995-03-15
DE69423028T3 (de)	2006-07-20
KR100316206B1 (ko)	2002-11-09
ES2144516T5 (es)	2005-07-01
DK0642335T3 (da)	2000-07-24
EP0642335B1 (de)	2000-02-16
PL175326B1 (pl)	1998-12-31
AU6439394A (en)	1994-10-24
FI945621L (fi)	1994-11-29
LV10684A (lv)	1995-06-20
NO944565D0 (no)	1994-11-29
US5614218A (en)	1997-03-25
AU680891C (en)	2002-01-03
HU227344B1 (en)	2011-04-28
CN1106608A (zh)	1995-08-09
FI113743B (fi)	2004-06-15
NO944565L (no)	1994-11-29
ES2144516T3 (es)	2000-06-16
NZ263632A (en)	1997-06-24
CA2135639C (en)	2006-02-07
DE69423028D1 (de)	2000-03-23
EE03147B1 (et)	1999-02-15
DE69423028T2 (de)	2001-01-18
SE9301057L (sv)	1994-10-01
AU680891B2 (en)	1997-08-14
SE9301057D0 (sv)	1993-03-30
RU2136283C1 (ru)	1999-09-10
JPH08501319A (ja)	1996-02-13
WO1994022431A1 (en)	1994-10-13
CZ284924B6 (cs)	1999-04-14
DK0642335T4 (da)	2005-05-23
PT642335E (pt)	2000-08-31
FI945621A0 (fi)	1994-11-29
PL306421A1 (en)	1995-04-03
HU9403437D0 (en)	1995-02-28
JP4107678B2 (ja)	2008-06-25
SK280362B6 (sk)	1999-12-10
SK143794A3 (en)	1995-06-07
GR3033325T3 (en)	2000-09-29
CZ298694A3 (en)	1995-05-17
NO310015B1 (no)	2001-05-07

Legal Events

Date

Code

Title

Description

2000-08-15

UEP

Publication of translation of european patent specification

2005-06-15

EEFA

Change of the company name

2005-10-15

UEP