ATE189814T1 - Hydroxypyridin-derivate, ihre herstellung und ihre pharmazeutische verwendung - Google Patents
Hydroxypyridin-derivate, ihre herstellung und ihre pharmazeutische verwendungInfo
- Publication number
- ATE189814T1 ATE189814T1 AT97106079T AT97106079T ATE189814T1 AT E189814 T1 ATE189814 T1 AT E189814T1 AT 97106079 T AT97106079 T AT 97106079T AT 97106079 T AT97106079 T AT 97106079T AT E189814 T1 ATE189814 T1 AT E189814T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- substituted
- alkyl group
- halogen
- hydrogen atom
- Prior art date
Links
- 150000004806 hydroxypyridines Chemical class 0.000 title abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 102000004257 Potassium Channel Human genes 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 108020001213 potassium channel Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9290496 | 1996-04-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE189814T1 true ATE189814T1 (de) | 2000-03-15 |
Family
ID=14067477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97106079T ATE189814T1 (de) | 1996-04-15 | 1997-04-14 | Hydroxypyridin-derivate, ihre herstellung und ihre pharmazeutische verwendung |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5891895A (fr) |
| EP (1) | EP0802187B1 (fr) |
| AT (1) | ATE189814T1 (fr) |
| CA (1) | CA2202578A1 (fr) |
| DE (1) | DE69701298T2 (fr) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7329670B1 (en) | 1997-12-22 | 2008-02-12 | Bayer Pharmaceuticals Corporation | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas |
| US7517880B2 (en) | 1997-12-22 | 2009-04-14 | Bayer Pharmaceuticals Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
| US20080300281A1 (en) * | 1997-12-22 | 2008-12-04 | Jacques Dumas | Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas |
| US20080269265A1 (en) * | 1998-12-22 | 2008-10-30 | Scott Miller | Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas |
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| EP1140840B1 (fr) * | 1999-01-13 | 2006-03-22 | Bayer Pharmaceuticals Corp. | Diphenylurees a substituants -g(v)-carboxyaryles, inhibitrices de kinase raf |
| ME00275B (fr) | 1999-01-13 | 2011-02-10 | Bayer Corp | DIPHENYLUREES A SUBSTITUANTS ω-CARBOXYARYLES, INHIBITRICES DE KINASE RAF |
| US7928239B2 (en) | 1999-01-13 | 2011-04-19 | Bayer Healthcare Llc | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas |
| EP1158985B1 (fr) | 1999-01-13 | 2011-12-28 | Bayer HealthCare LLC | DIPHENYLE UREES A SUBSTITUTION OMEGA-CARBOXY ARYLE EN TANT QU'INHIBITEURS DE LA KINASE p38 |
| US7235576B1 (en) | 2001-01-12 | 2007-06-26 | Bayer Pharmaceuticals Corporation | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| US7371763B2 (en) * | 2001-04-20 | 2008-05-13 | Bayer Pharmaceuticals Corporation | Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas |
| WO2003047579A1 (fr) * | 2001-12-03 | 2003-06-12 | Bayer Pharmaceuticals Corporation | Composes de type uree aryle combines a d'autres agents cytostatiques ou cytotoxiques et servant a traiter des cancers humains |
| ATE529406T1 (de) * | 2002-02-11 | 2011-11-15 | Bayer Healthcare Llc | Aryl-harnstoffe als kinase inhibitoren |
| US20040023961A1 (en) * | 2002-02-11 | 2004-02-05 | Bayer Corporation | Aryl ureas with raf kinase and angiogenisis inhibiting activity |
| WO2003068229A1 (fr) | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | N-oxydes de pyridine, de quinoline, et d'isoquinoline en tant qu'inhibiteurs de kinase |
| SI1478358T1 (sl) | 2002-02-11 | 2013-09-30 | Bayer Healthcare Llc | Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi |
| US7557129B2 (en) | 2003-02-28 | 2009-07-07 | Bayer Healthcare Llc | Cyanopyridine derivatives useful in the treatment of cancer and other disorders |
| EP1636585B2 (fr) | 2003-05-20 | 2012-06-13 | Bayer HealthCare LLC | Diaryl-urees presentant une activite d'inhibition des kinases |
| WO2005000835A1 (fr) * | 2003-06-26 | 2005-01-06 | Novartis Ag | Procede de preparation d'intermediaires servant a preparer certaines n-formyle hydroxylamines antibacteriennes |
| EP1663978B1 (fr) * | 2003-07-23 | 2007-11-28 | Bayer Pharmaceuticals Corporation | Omega-carboxyaryldiphenyluree fluoro-subtituee pour le traitement et la prevention de maladies et d'etats pathologiques |
| EP2295426A1 (fr) * | 2004-04-30 | 2011-03-16 | Bayer HealthCare, LLC | Derives de pyrazolyl uree substitues utiles dans le traitement du cancer |
| US7709533B2 (en) | 2005-02-01 | 2010-05-04 | Icagen, Inc. | Imines as ion channel modulators |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH350461A (de) * | 1957-12-06 | 1960-11-30 | Ciba Geigy | Verwendung von Oxyketonen zum Schutze gegen ultraviolette Strahlung |
| JPS49119718A (fr) * | 1973-03-23 | 1974-11-15 | ||
| CH609980A5 (en) * | 1974-08-30 | 1979-03-30 | Ciba Geigy Ag | Process for the preparation of novel piperidine derivatives |
| US4297359A (en) * | 1978-07-25 | 1981-10-27 | Acf Chemiefarma Nv | Anti-ulcer compositions containing certain pyridyl oxime ethers |
| US4798841A (en) * | 1987-03-31 | 1989-01-17 | Warner-Lambert Company | Tetrahydropyridine oxime cholinergic agents and method of treatment |
| DK270488D0 (da) * | 1988-05-18 | 1988-05-18 | Novo Industri As | Hidtil ukendte o-substituerede ketoximer |
| JP2765876B2 (ja) * | 1988-10-24 | 1998-06-18 | 科研製薬株式会社 | ピリジルケトオキシムエーテル誘導体 |
| EP0388682A1 (fr) * | 1989-03-15 | 1990-09-26 | Bayer Ag | Hétéroarylphényléthers substitués, procédés pour leur préparation et leur utilisation comme insecticides |
| FR2644456B1 (fr) * | 1989-03-17 | 1991-07-05 | Rhone Poulenc Sante | Nouveaux derives du 1h, 3h-pyrrolo(1,2-c)thiazolecarboxamide-7, leur preparation et les compositions pharmaceutiques qui les contiennent |
| JPH0499767A (ja) * | 1990-08-20 | 1992-03-31 | Nippon Bayeragrochem Kk | ３―ベンゾイルピリジン０―ベンジルオキシム類の除草剤としての利用 |
| ATE195716T1 (de) * | 1992-04-22 | 2000-09-15 | Ligand Pharm Inc | Retinoid-x rezeptor selektive verbindungen |
| TW266206B (fr) * | 1993-04-28 | 1995-12-21 | Takeda Pharm Industry Co Ltd | |
| JPH08175994A (ja) * | 1994-10-27 | 1996-07-09 | Takeda Chem Ind Ltd | 脂質代謝改善剤 |
-
1997
- 1997-04-14 AT AT97106079T patent/ATE189814T1/de not_active IP Right Cessation
- 1997-04-14 US US08/834,123 patent/US5891895A/en not_active Expired - Fee Related
- 1997-04-14 DE DE69701298T patent/DE69701298T2/de not_active Expired - Fee Related
- 1997-04-14 CA CA002202578A patent/CA2202578A1/fr not_active Abandoned
- 1997-04-14 EP EP97106079A patent/EP0802187B1/fr not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69701298D1 (de) | 2000-03-23 |
| DE69701298T2 (de) | 2000-10-05 |
| EP0802187A1 (fr) | 1997-10-22 |
| US5891895A (en) | 1999-04-06 |
| EP0802187B1 (fr) | 2000-02-16 |
| CA2202578A1 (fr) | 1997-10-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |