ATE199253T1 - Antidepressiv wirkende 3-halophenylpiperazinyl- propylderivate von substituierten triazolonen und triazoldionen - Google Patents

Antidepressiv wirkende 3-halophenylpiperazinyl- propylderivate von substituierten triazolonen und triazoldionen

Info

Publication number
ATE199253T1
ATE199253T1 AT93401083T AT93401083T ATE199253T1 AT E199253 T1 ATE199253 T1 AT E199253T1 AT 93401083 T AT93401083 T AT 93401083T AT 93401083 T AT93401083 T AT 93401083T AT E199253 T1 ATE199253 T1 AT E199253T1
Authority
AT
Austria
Prior art keywords
triazolones
halophenylpiperazinyl
antidepressant
substituted
trifluoromethyl
Prior art date
Application number
AT93401083T
Other languages
English (en)
Inventor
Robert F Mayol
George M Luke
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ATE199253T1 publication Critical patent/ATE199253T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT93401083T 1992-04-28 1993-04-26 Antidepressiv wirkende 3-halophenylpiperazinyl- propylderivate von substituierten triazolonen und triazoldionen ATE199253T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/875,044 US5256664A (en) 1992-04-28 1992-04-28 Antidepressant 3-halophenylpiperazinylpropyl derivatives of substituted triazolones and triazoldiones

Publications (1)

Publication Number Publication Date
ATE199253T1 true ATE199253T1 (de) 2001-03-15

Family

ID=25365103

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93401083T ATE199253T1 (de) 1992-04-28 1993-04-26 Antidepressiv wirkende 3-halophenylpiperazinyl- propylderivate von substituierten triazolonen und triazoldionen

Country Status (10)

Country Link
US (1) US5256664A (de)
EP (1) EP0568437B1 (de)
JP (1) JPH0641095A (de)
AT (1) ATE199253T1 (de)
CA (1) CA2094890C (de)
DE (1) DE69329942T2 (de)
DK (1) DK0568437T3 (de)
ES (1) ES2154644T3 (de)
GR (1) GR3035809T3 (de)
PT (1) PT568437E (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4425144A1 (de) * 1994-07-15 1996-01-18 Basf Ag Triazolverbindungen und deren Verwendung
US6403593B1 (en) 1995-07-14 2002-06-11 Abbott Laboratories Triazole compounds and the use thereof
DE19728996A1 (de) 1997-07-07 1999-01-14 Basf Ag Triazolverbindungen und deren Verwendung
ES2152860B1 (es) * 1998-10-23 2001-08-16 Finaf 92 Sa Forma cristalina de la nefazodona y procedimiento para su preparacion.
EP1171133B1 (de) * 1999-04-09 2006-06-21 Sepracor Inc. R-hydroxynefazodon
JP2002541192A (ja) 1999-04-09 2002-12-03 セプラコール， インク． Ｓ−ヒドロキシネファゾドン
US6586437B2 (en) 1999-04-09 2003-07-01 Sepracor Inc. (S)-hydroxynefazodone antipsychotic therapy
US6469008B2 (en) 1999-04-09 2002-10-22 Sepracor Inc. (R)-hydroxynefazodone antipsychotic therapy
JP3850224B2 (ja) 2001-03-26 2006-11-29 株式会社ジェイテクト 研削加工方法及び数値制御研削盤
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
CA2356450C (en) * 2001-09-10 2003-11-25 Brantford Chemicals Inc. An improved process for the preparation of nefazodone hydrochloride
CN102379684B (zh) 2005-04-28 2014-11-19 普罗透斯数字保健公司 药物信息系统
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
EP2398500B1 (de) 2009-02-20 2019-03-13 2-BBB Medicines B.V. Arzneiabgabesystem auf glutathion-basis
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
CN104402842A (zh) * 2014-11-19 2015-03-11 苏州乔纳森新材料科技有限公司 一种哌嗪类药物中间体的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487773A (en) * 1981-03-16 1984-12-11 Mead Johnson & Company 1,2,4-Triazol-3-one antidepressants
US4338317A (en) * 1981-03-16 1982-07-06 Mead Johnson & Company Phenoxyethyl-1,2,4,-triazol-3-one antidepressants
US4386091A (en) * 1982-02-24 1983-05-31 Mead Johnson & Company 2-Phenoxyalkyl-1,2,4-triazol-3-one antidepressants
US4613600A (en) * 1983-09-30 1986-09-23 Mead Johnson & Company Antidepressant 1,2,4-triazolone compounds
US5116852A (en) * 1990-12-03 1992-05-26 Bristol-Myers Squibb Co. Treatment of sleep disorders

Also Published As

Publication number Publication date
US5256664A (en) 1993-10-26
EP0568437B1 (de) 2001-02-21
DE69329942T2 (de) 2001-08-16
JPH0641095A (ja) 1994-02-15
DE69329942D1 (de) 2001-03-29
DK0568437T3 (da) 2001-04-30
PT568437E (pt) 2001-06-29
GR3035809T3 (en) 2001-07-31
CA2094890A1 (en) 1993-10-29
ES2154644T3 (es) 2001-04-16
EP0568437A1 (de) 1993-11-03
CA2094890C (en) 2000-04-11

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee