ATE190065T1 - Stoffe zur aufhebung von arzneimittelresistenzen - Google Patents

Stoffe zur aufhebung von arzneimittelresistenzen

Info

Publication number: ATE190065T1
Authority: AT; Austria
Prior art keywords: obzl; glu; otbu; boc; trp
Prior art date: 1994-05-12

Application number

AT94915684T

Other languages

English (en)

Inventor

Balazs Sarkadi

Janos Seprodi

Orsolya Csuka

Maria Magocsi

Imre Mezo

Istvan Teplan

Zsolt Vadasz

Borbala Vincze

Istvan Palyi

Original Assignee

Balazs Sarkadi

Janos Seprodi

Orsolya Csuka

Maria Magocsi

Imre Mezo

Istvan Teplan

Zsolt Vadasz

Borbala Vincze

Istvan Palyi

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-12

Filing date

1994-05-12

Publication date

2000-03-15

1994-05-12 Application filed by Balazs Sarkadi, Janos Seprodi, Orsolya Csuka, Maria Magocsi, Imre Mezo, Istvan Teplan, Zsolt Vadasz, Borbala Vincze, Istvan Palyi filed Critical Balazs Sarkadi

2000-03-15 Application granted granted Critical

2000-03-15 Publication of ATE190065T1 publication Critical patent/ATE190065T1/de

Links

206010059866 Drug resistance Diseases 0.000 title 1
239000000126 substance Substances 0.000 title 1
OIOAKXPMBIZAHL-LURJTMIESA-N (2s)-2-azaniumyl-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoate Chemical compound CC(C)(C)OC(=O)CC[C@H](N)C(O)=O OIOAKXPMBIZAHL-LURJTMIESA-N 0.000 abstract 3
XBPCUCUWBYBCDP-UHFFFAOYSA-N Dicyclohexylamine Chemical compound C1CCCCC1NC1CCCCC1 XBPCUCUWBYBCDP-UHFFFAOYSA-N 0.000 abstract 3
SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 3
AVKNGPAMCBSNSO-UHFFFAOYSA-N cyclohexylmethanamine Chemical compound NCC1CCCCC1 AVKNGPAMCBSNSO-UHFFFAOYSA-N 0.000 abstract 3
VGALFAWDSNRXJK-VIFPVBQESA-N L-aspartic acid beta-benzyl ester Chemical compound OC(=O)[C@@H](N)CC(=O)OCC1=CC=CC=C1 VGALFAWDSNRXJK-VIFPVBQESA-N 0.000 abstract 2
KAFHLONDOVSENM-HNNXBMFYSA-N O-Benzyl-L-tyrosine Chemical compound C1=CC(C[C@H](N)C(O)=O)=CC=C1OCC1=CC=CC=C1 KAFHLONDOVSENM-HNNXBMFYSA-N 0.000 abstract 2
BHHGXPLMPWCGHP-UHFFFAOYSA-N Phenethylamine Chemical compound NCCC1=CC=CC=C1 BHHGXPLMPWCGHP-UHFFFAOYSA-N 0.000 abstract 2
229910001573 adamantine Inorganic materials 0.000 abstract 2
125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 2
150000002148 esters Chemical class 0.000 abstract 2
KCUNTYMNJVXYKZ-JTQLQIEISA-N methyl (2s)-2-amino-3-(1h-indol-3-yl)propanoate Chemical compound C1=CC=C2C(C[C@H](N)C(=O)OC)=CNC2=C1 KCUNTYMNJVXYKZ-JTQLQIEISA-N 0.000 abstract 2
UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 2
PVFCXMDXBIEMQG-JTQLQIEISA-N (2s)-2-(phenylmethoxycarbonylamino)pentanedioic acid Chemical compound OC(=O)CC[C@@H](C(O)=O)NC(=O)OCC1=CC=CC=C1 PVFCXMDXBIEMQG-JTQLQIEISA-N 0.000 abstract 1
VVQIIIAZJXTLRE-QMMMGPOBSA-N (2s)-2-amino-6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid Chemical compound CC(C)(C)OC(=O)NCCCC[C@H](N)C(O)=O VVQIIIAZJXTLRE-QMMMGPOBSA-N 0.000 abstract 1
CKGCFBNYQJDIGS-LBPRGKRZSA-N (2s)-2-azaniumyl-6-(phenylmethoxycarbonylamino)hexanoate Chemical compound [O-]C(=O)[C@@H]([NH3+])CCCCNC(=O)OCC1=CC=CC=C1 CKGCFBNYQJDIGS-LBPRGKRZSA-N 0.000 abstract 1
ONOURAAVVKGJNM-SCZZXKLOSA-N (2s,3r)-2-azaniumyl-3-phenylmethoxybutanoate Chemical compound [O-]C(=O)[C@@H]([NH3+])[C@@H](C)OCC1=CC=CC=C1 ONOURAAVVKGJNM-SCZZXKLOSA-N 0.000 abstract 1
QEMSHQQIJMBEMP-UHFFFAOYSA-N 2-chloro-n-(2-methylpropyl)aniline Chemical compound CC(C)CNC1=CC=CC=C1Cl QEMSHQQIJMBEMP-UHFFFAOYSA-N 0.000 abstract 1
125000004080 3-carboxypropanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C(O[H])=O 0.000 abstract 1
108010078791 Carrier Proteins Proteins 0.000 abstract 1
BWLUMTFWVZZZND-UHFFFAOYSA-N Dibenzylamine Chemical compound C=1C=CC=CC=1CNCC1=CC=CC=C1 BWLUMTFWVZZZND-UHFFFAOYSA-N 0.000 abstract 1
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 1
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
102100030306 TBC1 domain family member 9 Human genes 0.000 abstract 1
DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
VSDUZFOSJDMAFZ-VIFPVBQESA-N methyl L-phenylalaninate Chemical group COC(=O)[C@@H](N)CC1=CC=CC=C1 VSDUZFOSJDMAFZ-VIFPVBQESA-N 0.000 abstract 1
230000036457 multidrug resistance Effects 0.000 abstract 1
ZDAZUJBASMCUAK-UHFFFAOYSA-N n-[2-(1h-indol-3-yl)ethyl]pyridine-3-carboxamide Chemical compound C=1NC2=CC=CC=C2C=1CCNC(=O)C1=CC=CN=C1 ZDAZUJBASMCUAK-UHFFFAOYSA-N 0.000 abstract 1
-1 phenylethylarnide Chemical compound 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Indole Compounds (AREA)
Silicon Polymers (AREA)

AT94915684T 1994-05-12 1994-05-12 Stoffe zur aufhebung von arzneimittelresistenzen ATE190065T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/IB1994/000144 WO1995031474A1 (en)	1994-05-12	1994-05-12	Compounds for reversing drug resistance

Publications (1)

Publication Number	Publication Date
ATE190065T1 true ATE190065T1 (de)	2000-03-15

Family

ID=11004299

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94915684T ATE190065T1 (de)	1994-05-12	1994-05-12	Stoffe zur aufhebung von arzneimittelresistenzen

Country Status (8)

Country	Link
US (1)	US6297216B1 (de)
EP (1)	EP0770091B1 (de)
AT (1)	ATE190065T1 (de)
AU (1)	AU693791B2 (de)
DE (1)	DE69423243T2 (de)
DK (1)	DK0770091T3 (de)
ES (1)	ES2146651T3 (de)
WO (1)	WO1995031474A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6162616A (en) *	1997-04-16	2000-12-19	Millennium Pharmaceuticals, Inc.	Multidrug resistance-associated polypeptide
ATE323283T1 (de) *	1999-03-17	2006-04-15	Univ North Carolina	Screening-verfahren von kandidaten verbindungen für empfindlichkeit gegenüber gallenexkretion
US7601494B2 (en) *	1999-03-17	2009-10-13	The University Of North Carolina At Chapel Hill	Method of screening candidate compounds for susceptibility to biliary excretion
US7723303B2 (en) *	2000-08-24	2010-05-25	The Regents Of The University Of California	Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
US7199102B2 (en) *	2000-08-24	2007-04-03	The Regents Of The University Of California	Orally administered peptides synergize statin activity
US7148197B2 (en) *	2000-08-24	2006-12-12	The Regents Of The University Of California	Orally administered small peptides synergize statin activity
WO2003035685A1 (en) *	2001-10-24	2003-05-01	Solvo Biotechnology Inc.	Use of a half-transporter protein of the abcg-family for selecting cells and in gene therapy
WO2003041128A2 (en) *	2001-11-07	2003-05-15	Pharmacia Corporation	Methods of promoting uptake and nuclear accumulation of polyamides in eukaryotic cells
US8318724B2 (en) *	2004-05-14	2012-11-27	The Cleveland Clinic Foundation	Small molecule inhibitors of MRP1 and other multidrug transporters
AU2005287004B2 (en) *	2004-09-16	2011-03-17	The Regents Of The University Of California	G-type peptides and other agents to ameliorate atherosclerosis and other pathologies
KR20070089996A (ko)	2004-12-06	2007-09-04	더 리전트 오브 더 유니버시티 오브 캘리포니아	세동맥의 구조 및 기능의 개선 방법
US20080293639A1 (en) *	2005-04-29	2008-11-27	The Regents Of The University Of California	Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
FR2950888B1 (fr) *	2009-10-06	2011-12-09	Centre Nat Rech Scient	Modulateurs peptidiques et peptidomimetiques non competitifs specifiques de la glycoproteine p
FR3101709B1 (fr) *	2019-10-04	2024-08-30	Biomarqueurs	Méthode de détection, localisation et quantification de protéines MDR

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3862925A (en) *	1973-07-05	1975-01-28	American Home Prod	Preparation of somatotropin release inhibiting factor and intermediates therefor
US3882098A (en) *	1974-01-03	1975-05-06	American Home Prod	Synthesis of des-Ala{hu 1{b , Gly{hu 2{b , Asn{hu 5{b -SRIF and intermediates
US4028319A (en) *	1976-05-07	1977-06-07	G. D. Searle & Co.	2 and 3-substituted enkephalins
JPS5850213B2 (ja) *	1977-06-20	1983-11-09	株式会社第一ラジオアイソト−プ研究所	カルチトニンの定量法
JPS5828867B2 (ja) *	1979-07-13	1983-06-18	財団法人微生物化学研埋会	新テトラペプチド誘導体類
US4497801A (en) *	1982-09-17	1985-02-05	Fujisawa Pharmaceutical Co., Ltd.	New peptides, process for preparation thereof and use thereof
FR2559157B1 (fr) *	1984-02-07	1986-08-01	Inst Nat Sante Rech Med	Nouvel hexapeptide, son procede d'obtention et les compositions pharmaceutiques qui le contiennent
FR2567524B1 (fr) *	1984-07-10	1987-11-27	Sanofi Sa	Procede de synthese de la somatocrinine en phase liquide et peptides intermediaires
CA1309805C (en) *	1985-04-16	1992-11-03	Naoki Higuchi	Dipeptide derivative and synthesis and use thereof
EP0201743B1 (de) *	1985-04-16	1992-04-01	Suntory Limited	Dipeptid-Derivate von Fettsäure, Verfahren zu ihrer Herstellung, Heilmittel, das sie enthält und Anwendung
SU1544778A1 (ru) *	1987-10-26	1990-02-23	Институт элементоорганических соединений им.А.Н.Несмеянова	Способ получени пептидов

1994
- 1994-05-12 AT AT94915684T patent/ATE190065T1/de not_active IP Right Cessation
- 1994-05-12 DE DE69423243T patent/DE69423243T2/de not_active Expired - Fee Related
- 1994-05-12 ES ES94915684T patent/ES2146651T3/es not_active Expired - Lifetime
- 1994-05-12 EP EP94915684A patent/EP0770091B1/de not_active Expired - Lifetime
- 1994-05-12 WO PCT/IB1994/000144 patent/WO1995031474A1/en not_active Ceased
- 1994-05-12 AU AU67606/94A patent/AU693791B2/en not_active Ceased
- 1994-05-12 DK DK94915684T patent/DK0770091T3/da active
1995
- 1995-05-12 US US08/737,255 patent/US6297216B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0770091A1 (de)	1997-05-02
ES2146651T3 (es)	2000-08-16
DE69423243D1 (de)	2000-04-06
DE69423243T2 (de)	2000-11-02
EP0770091B1 (de)	2000-03-01
AU693791B2 (en)	1998-07-09
WO1995031474A1 (en)	1995-11-23
US6297216B1 (en)	2001-10-02
DK0770091T3 (da)	2000-08-14
AU6760694A (en)	1995-12-05

Legal Events

Date	Code	Title	Description
2000-09-15	UEP	Publication of translation of european patent specification
2005-02-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE190065T1 (de)	2000-03-15	Stoffe zur aufhebung von arzneimittelresistenzen
Lauer et al.	1995	Sequence dependence of aspartimide formation during 9-fluorenylmethoxycarbonyl solid-phase peptide synthesis
MX9606536A (es)	1997-03-29	Proteinas n-terminalmente extendidas expresadas en levaduras.
PT695757E (pt)	2002-09-30	Amidas peptidicas inibidoras de cancro humano
ES2063350T3 (es)	1995-01-01	Nuevas proteinas con efecto inhibidor del tnf y su produccion.
CA2270289A1 (en)	1998-05-14	Proteins with enhanced levels of essential amino acids
EP0307592A3 (de)	1990-06-06	Varianten des pankreatischen Rinder-Trypsininhibitors, deren Herstellung und Verwendung
Sabsay et al.	1991	Domain structure and sequence distribution in dentin phosphophoryn
ES2112255T3 (es)	1998-04-01	Complejos proteicos que tienen actividad del factor viii:c y su produccion.
Tosteson et al.	1987	Solid-phase synthesis of melittin: purification and functional characterization
GB9311454D0 (en)	1993-07-21	Pharmaceutical compositions
MY113407A (en)	2002-02-28	Tri-, tetra-, penta-, and polypeptides and their therapeutic use as an antidepressant agent
IE800053L (en)	1980-07-12	Muraminyl polypeptides
US9850274B2 (en)	2017-12-26	Peptide combination
ATE42308T1 (de)	1989-05-15	Pharmakologisch aktive peptide.
NZ273815A (en)	1999-05-28	Peptide compositions for treating protein allergies or autoimmune diseases containing at least two isolated and purified peptides
ATE124955T1 (de)	1995-07-15	Substrat-peptide.
Mihara et al.	1993	Synthesis of the 60 amino acid homeo domain and smaller fragments of the Drosophila gene regulatory protein Antennapedia by a segment synthesis-condensation approach
Régnier	1981	The purification of protease IV of E. coli and the demonstration that it is an endoproteolytic enzyme
Yeung et al.	1978	SYNTHESIS AND OPIATE ACTIVITY OF HUMAN β‐ENDORPHIN ANALOGS WITH VARIOUS CHAIN LENGTHS
Peruffo et al.	1985	Isolation and partial characterisation of γ-Gliadins 40 and 43· 5 associated with quality in common wheat
EP0717752A4 (de)	1997-08-20	Therapeitische inhaltsstoffe
SHINODA	1973	Amino Acid Sequence of a Human Kappa Type Bence-Jones Protein I. Tryptic Peptides of Protein Ni
Benoiton et al.	1981	The relative susceptibility to racemization of L-and D-residues in peptide synthesis
Francis et al.	1989	Terminology for fibrinogen γ-chains differing in carboxyl terminal amino acid sequence