DK0770091T3 - Forbindelser til ophævelse af lægmiddelresistens - Google Patents

Forbindelser til ophævelse af lægmiddelresistens

Info

Publication number: DK0770091T3
Authority: DK; Denmark
Prior art keywords: obzl; glu; otbu; boc; trp
Prior art date: 1994-05-12

Application number

DK94915684T

Other languages

English (en)

Inventor

Imre Mezo

Istvan Palyi

Balazs Sarkadi

Janos Seprodi

Orsolya Csuka

Maria Magocsi

Istvan Teplan

Zsolt Vadasz

Borbola Vincze

Original Assignee

Imre Mezo

Istvan Palyi

Balazs Sarkadi

Janos Seprodi

Orsolya Csuka

Maria Magocsi

Istvan Teplan

Zsolt Vadasz

Borbola Vincze

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-12

Filing date

1994-05-12

Publication date

2000-08-14

1994-05-12 Application filed by Imre Mezo, Istvan Palyi, Balazs Sarkadi, Janos Seprodi, Orsolya Csuka, Maria Magocsi, Istvan Teplan, Zsolt Vadasz, Borbola Vincze filed Critical Imre Mezo

2000-08-14 Application granted granted Critical

2000-08-14 Publication of DK0770091T3 publication Critical patent/DK0770091T3/da

Links

206010059866 Drug resistance Diseases 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
OIOAKXPMBIZAHL-LURJTMIESA-N (2s)-2-azaniumyl-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoate Chemical compound CC(C)(C)OC(=O)CC[C@H](N)C(O)=O OIOAKXPMBIZAHL-LURJTMIESA-N 0.000 abstract 3
XBPCUCUWBYBCDP-UHFFFAOYSA-N Dicyclohexylamine Chemical compound C1CCCCC1NC1CCCCC1 XBPCUCUWBYBCDP-UHFFFAOYSA-N 0.000 abstract 3
SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 3
AVKNGPAMCBSNSO-UHFFFAOYSA-N cyclohexylmethanamine Chemical compound NCC1CCCCC1 AVKNGPAMCBSNSO-UHFFFAOYSA-N 0.000 abstract 3
VGALFAWDSNRXJK-VIFPVBQESA-N L-aspartic acid beta-benzyl ester Chemical compound OC(=O)[C@@H](N)CC(=O)OCC1=CC=CC=C1 VGALFAWDSNRXJK-VIFPVBQESA-N 0.000 abstract 2
KAFHLONDOVSENM-HNNXBMFYSA-N O-Benzyl-L-tyrosine Chemical compound C1=CC(C[C@H](N)C(O)=O)=CC=C1OCC1=CC=CC=C1 KAFHLONDOVSENM-HNNXBMFYSA-N 0.000 abstract 2
BHHGXPLMPWCGHP-UHFFFAOYSA-N Phenethylamine Chemical compound NCCC1=CC=CC=C1 BHHGXPLMPWCGHP-UHFFFAOYSA-N 0.000 abstract 2
229910001573 adamantine Inorganic materials 0.000 abstract 2
125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 2
150000002148 esters Chemical class 0.000 abstract 2
KCUNTYMNJVXYKZ-JTQLQIEISA-N methyl (2s)-2-amino-3-(1h-indol-3-yl)propanoate Chemical compound C1=CC=C2C(C[C@H](N)C(=O)OC)=CNC2=C1 KCUNTYMNJVXYKZ-JTQLQIEISA-N 0.000 abstract 2
UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 2
PVFCXMDXBIEMQG-JTQLQIEISA-N (2s)-2-(phenylmethoxycarbonylamino)pentanedioic acid Chemical compound OC(=O)CC[C@@H](C(O)=O)NC(=O)OCC1=CC=CC=C1 PVFCXMDXBIEMQG-JTQLQIEISA-N 0.000 abstract 1
VVQIIIAZJXTLRE-QMMMGPOBSA-N (2s)-2-amino-6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid Chemical compound CC(C)(C)OC(=O)NCCCC[C@H](N)C(O)=O VVQIIIAZJXTLRE-QMMMGPOBSA-N 0.000 abstract 1
CKGCFBNYQJDIGS-LBPRGKRZSA-N (2s)-2-azaniumyl-6-(phenylmethoxycarbonylamino)hexanoate Chemical compound [O-]C(=O)[C@@H]([NH3+])CCCCNC(=O)OCC1=CC=CC=C1 CKGCFBNYQJDIGS-LBPRGKRZSA-N 0.000 abstract 1
ONOURAAVVKGJNM-SCZZXKLOSA-N (2s,3r)-2-azaniumyl-3-phenylmethoxybutanoate Chemical compound [O-]C(=O)[C@@H]([NH3+])[C@@H](C)OCC1=CC=CC=C1 ONOURAAVVKGJNM-SCZZXKLOSA-N 0.000 abstract 1
QEMSHQQIJMBEMP-UHFFFAOYSA-N 2-chloro-n-(2-methylpropyl)aniline Chemical compound CC(C)CNC1=CC=CC=C1Cl QEMSHQQIJMBEMP-UHFFFAOYSA-N 0.000 abstract 1
125000004080 3-carboxypropanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C(O[H])=O 0.000 abstract 1
108010078791 Carrier Proteins Proteins 0.000 abstract 1
BWLUMTFWVZZZND-UHFFFAOYSA-N Dibenzylamine Chemical compound C=1C=CC=CC=1CNCC1=CC=CC=C1 BWLUMTFWVZZZND-UHFFFAOYSA-N 0.000 abstract 1
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 1
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
102100030306 TBC1 domain family member 9 Human genes 0.000 abstract 1
DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
VSDUZFOSJDMAFZ-VIFPVBQESA-N methyl L-phenylalaninate Chemical group COC(=O)[C@@H](N)CC1=CC=CC=C1 VSDUZFOSJDMAFZ-VIFPVBQESA-N 0.000 abstract 1
230000036457 multidrug resistance Effects 0.000 abstract 1
ZDAZUJBASMCUAK-UHFFFAOYSA-N n-[2-(1h-indol-3-yl)ethyl]pyridine-3-carboxamide Chemical compound C=1NC2=CC=CC=C2C=1CCNC(=O)C1=CC=CN=C1 ZDAZUJBASMCUAK-UHFFFAOYSA-N 0.000 abstract 1
-1 phenylethylarnide Chemical compound 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Indole Compounds (AREA)
Silicon Polymers (AREA)

DK94915684T 1994-05-12 1994-05-12 Forbindelser til ophævelse af lægmiddelresistens DK0770091T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/IB1994/000144 WO1995031474A1 (en)	1994-05-12	1994-05-12	Compounds for reversing drug resistance

Publications (1)

Publication Number	Publication Date
DK0770091T3 true DK0770091T3 (da)	2000-08-14

Family

ID=11004299

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94915684T DK0770091T3 (da)	1994-05-12	1994-05-12	Forbindelser til ophævelse af lægmiddelresistens

Country Status (8)

Country	Link
US (1)	US6297216B1 (da)
EP (1)	EP0770091B1 (da)
AT (1)	ATE190065T1 (da)
AU (1)	AU693791B2 (da)
DE (1)	DE69423243T2 (da)
DK (1)	DK0770091T3 (da)
ES (1)	ES2146651T3 (da)
WO (1)	WO1995031474A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6162616A (en) *	1997-04-16	2000-12-19	Millennium Pharmaceuticals, Inc.	Multidrug resistance-associated polypeptide
ATE323283T1 (de) *	1999-03-17	2006-04-15	Univ North Carolina	Screening-verfahren von kandidaten verbindungen für empfindlichkeit gegenüber gallenexkretion
US7601494B2 (en) *	1999-03-17	2009-10-13	The University Of North Carolina At Chapel Hill	Method of screening candidate compounds for susceptibility to biliary excretion
US7723303B2 (en) *	2000-08-24	2010-05-25	The Regents Of The University Of California	Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
US7199102B2 (en) *	2000-08-24	2007-04-03	The Regents Of The University Of California	Orally administered peptides synergize statin activity
US7148197B2 (en) *	2000-08-24	2006-12-12	The Regents Of The University Of California	Orally administered small peptides synergize statin activity
WO2003035685A1 (en) *	2001-10-24	2003-05-01	Solvo Biotechnology Inc.	Use of a half-transporter protein of the abcg-family for selecting cells and in gene therapy
WO2003041128A2 (en) *	2001-11-07	2003-05-15	Pharmacia Corporation	Methods of promoting uptake and nuclear accumulation of polyamides in eukaryotic cells
US8318724B2 (en) *	2004-05-14	2012-11-27	The Cleveland Clinic Foundation	Small molecule inhibitors of MRP1 and other multidrug transporters
AU2005287004B2 (en) *	2004-09-16	2011-03-17	The Regents Of The University Of California	G-type peptides and other agents to ameliorate atherosclerosis and other pathologies
KR20070089996A (ko)	2004-12-06	2007-09-04	더 리전트 오브 더 유니버시티 오브 캘리포니아	세동맥의 구조 및 기능의 개선 방법
US20080293639A1 (en) *	2005-04-29	2008-11-27	The Regents Of The University Of California	Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
FR2950888B1 (fr) *	2009-10-06	2011-12-09	Centre Nat Rech Scient	Modulateurs peptidiques et peptidomimetiques non competitifs specifiques de la glycoproteine p
FR3101709B1 (fr) *	2019-10-04	2024-08-30	Biomarqueurs	Méthode de détection, localisation et quantification de protéines MDR

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3862925A (en) *	1973-07-05	1975-01-28	American Home Prod	Preparation of somatotropin release inhibiting factor and intermediates therefor
US3882098A (en) *	1974-01-03	1975-05-06	American Home Prod	Synthesis of des-Ala{hu 1{b , Gly{hu 2{b , Asn{hu 5{b -SRIF and intermediates
US4028319A (en) *	1976-05-07	1977-06-07	G. D. Searle & Co.	2 and 3-substituted enkephalins
JPS5850213B2 (ja) *	1977-06-20	1983-11-09	株式会社第一ラジオアイソト−プ研究所	カルチトニンの定量法
JPS5828867B2 (ja) *	1979-07-13	1983-06-18	財団法人微生物化学研埋会	新テトラペプチド誘導体類
US4497801A (en) *	1982-09-17	1985-02-05	Fujisawa Pharmaceutical Co., Ltd.	New peptides, process for preparation thereof and use thereof
FR2559157B1 (fr) *	1984-02-07	1986-08-01	Inst Nat Sante Rech Med	Nouvel hexapeptide, son procede d'obtention et les compositions pharmaceutiques qui le contiennent
FR2567524B1 (fr) *	1984-07-10	1987-11-27	Sanofi Sa	Procede de synthese de la somatocrinine en phase liquide et peptides intermediaires
CA1309805C (en) *	1985-04-16	1992-11-03	Naoki Higuchi	Dipeptide derivative and synthesis and use thereof
EP0201743B1 (en) *	1985-04-16	1992-04-01	Suntory Limited	Dipeptide derivatives of fatty acids, process for preparing them, pharmaceutical composition and use
SU1544778A1 (ru) *	1987-10-26	1990-02-23	Институт элементоорганических соединений им.А.Н.Несмеянова	Способ получени пептидов

1994
- 1994-05-12 AT AT94915684T patent/ATE190065T1/de not_active IP Right Cessation
- 1994-05-12 DE DE69423243T patent/DE69423243T2/de not_active Expired - Fee Related
- 1994-05-12 ES ES94915684T patent/ES2146651T3/es not_active Expired - Lifetime
- 1994-05-12 EP EP94915684A patent/EP0770091B1/en not_active Expired - Lifetime
- 1994-05-12 WO PCT/IB1994/000144 patent/WO1995031474A1/en not_active Ceased
- 1994-05-12 AU AU67606/94A patent/AU693791B2/en not_active Ceased
- 1994-05-12 DK DK94915684T patent/DK0770091T3/da active
1995
- 1995-05-12 US US08/737,255 patent/US6297216B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0770091A1 (en)	1997-05-02
ES2146651T3 (es)	2000-08-16
DE69423243D1 (de)	2000-04-06
DE69423243T2 (de)	2000-11-02
EP0770091B1 (en)	2000-03-01
AU693791B2 (en)	1998-07-09
ATE190065T1 (de)	2000-03-15
WO1995031474A1 (en)	1995-11-23
US6297216B1 (en)	2001-10-02
AU6760694A (en)	1995-12-05

Publication	Publication Date	Title
DK0770091T3 (da)	2000-08-14	Forbindelser til ophævelse af lægmiddelresistens
PT695757E (pt)	2002-09-30	Amidas peptidicas inibidoras de cancro humano
CA2270289A1 (en)	1998-05-14	Proteins with enhanced levels of essential amino acids
DE69417252D1 (de)	1999-04-22	Verbesserte immunogene zusammensetzung gegen mensliches gastrin 17
TR199701718T1 (xx)	1998-05-21	Somatostatin Peptidler.
ATE321774T1 (de)	2006-04-15	An aminosaeure angereicherte speicherproteine, insbesondere an lysin angereicherte mais-gamma- zeine, und diese exprimierende pflanzen
CY1110927T1 (el)	2015-06-10	Αμινο-καταληκτικως διακλαδισμενη rantεs ως ανταγωνιστης των χημοκινων
MX9606536A (es)	1997-03-29	Proteinas n-terminalmente extendidas expresadas en levaduras.
EP0334244A3 (en)	1991-05-29	Bradykinin antagonist peptides
NO940299L (no)	1994-01-28	Peptid med organbeskyttende aktivitet
DE68920931D1 (de)	1995-03-16	Rekombinanter natürlicher Killerzellen-Aktivator.
ATE242202T1 (de)	2003-06-15	Peptide
IE800053L (en)	1980-07-12	Muraminyl polypeptides
ATE42308T1 (de)	1989-05-15	Pharmakologisch aktive peptide.
US9850274B2 (en)	2017-12-26	Peptide combination
ATE124955T1 (de)	1995-07-15	Substrat-peptide.
NZ273815A (en)	1999-05-28	Peptide compositions for treating protein allergies or autoimmune diseases containing at least two isolated and purified peptides
EP0717752A4 (en)	1997-08-20	THERAPEITIC INGREDIENTS
Francis et al.	1989	Terminology for fibrinogen γ-chains differing in carboxyl terminal amino acid sequence
FR2787454B1 (fr)	2002-02-15	Inhibiteur de la topoisomerase ii
Shin et al.	1992	Synthesis of four peptide derivatives to build the sequence corresponding to 31-53 of human epidermal growth factor (h-EGF)
YU64192A (sh)	1994-06-10	Analozi insulina
KONOPIŃSKA et al.	1984	Influence of the peptide chain length of new elongated tuftsin analogs on phagocytosis process
CA2247998A1 (en)	1997-09-04	Fragments of cr1 and their use
ITMI931627A0 (it)	1993-07-22	Analoghi di un polipeptide anti-trombinico e procedimento per la loro preparazione