ATE190493T1 - Verwendung von 4-(4-chlorophenyl- sulphonylcarbamoyl) benzoyl - l - valyl - l - proline 1(rs) - (1-trifluoroacetyl-2- methylpropyl)amide zur herstellung eines medikaments für die behandlung von gefässkrankheiten - Google Patents
Verwendung von 4-(4-chlorophenyl- sulphonylcarbamoyl) benzoyl - l - valyl - l - proline 1(rs) - (1-trifluoroacetyl-2- methylpropyl)amide zur herstellung eines medikaments für die behandlung von gefässkrankheitenInfo
- Publication number
- ATE190493T1 ATE190493T1 AT92911644T AT92911644T ATE190493T1 AT E190493 T1 ATE190493 T1 AT E190493T1 AT 92911644 T AT92911644 T AT 92911644T AT 92911644 T AT92911644 T AT 92911644T AT E190493 T1 ATE190493 T1 AT E190493T1
- Authority
- AT
- Austria
- Prior art keywords
- valyl
- trifluoroacetyl
- methylpropyl
- chlorophenyl
- proline
- Prior art date
Links
- 208000019553 vascular disease Diseases 0.000 title abstract 2
- -1 4-(4-CHLOROPHENYL-SULPHONYLCARBAMOYL) BENZOYL Chemical class 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 229940122858 Elastase inhibitor Drugs 0.000 abstract 1
- 206010022562 Intermittent claudication Diseases 0.000 abstract 1
- 208000018262 Peripheral vascular disease Diseases 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 239000003602 elastase inhibitor Substances 0.000 abstract 1
- 230000001771 impaired effect Effects 0.000 abstract 1
- 208000021156 intermittent vascular claudication Diseases 0.000 abstract 1
- 208000031225 myocardial ischemia Diseases 0.000 abstract 1
- 210000000440 neutrophil Anatomy 0.000 abstract 1
- 230000010410 reperfusion Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000007631 vascular surgery Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Radar Systems Or Details Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919113164A GB9113164D0 (en) | 1991-06-18 | 1991-06-18 | Pharmaceutical agent |
| PCT/GB1992/001087 WO1992022309A1 (en) | 1991-06-18 | 1992-06-17 | Use of 4-(4-chlorophenyl-sulphonylcarbamoyl) benzoyl-l-valyl-l-proline 1(rs)-(1-trifluoroacetyl-2-methylpropyl) amide in the treatment of vascular diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE190493T1 true ATE190493T1 (de) | 2000-04-15 |
Family
ID=10696898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92911644T ATE190493T1 (de) | 1991-06-18 | 1992-06-17 | Verwendung von 4-(4-chlorophenyl- sulphonylcarbamoyl) benzoyl - l - valyl - l - proline 1(rs) - (1-trifluoroacetyl-2- methylpropyl)amide zur herstellung eines medikaments für die behandlung von gefässkrankheiten |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0589937B1 (de) |
| JP (1) | JPH06508826A (de) |
| AT (1) | ATE190493T1 (de) |
| AU (1) | AU667307B2 (de) |
| CA (1) | CA2111846A1 (de) |
| DE (1) | DE69230792T2 (de) |
| DK (1) | DK0589937T3 (de) |
| ES (1) | ES2142825T3 (de) |
| GB (1) | GB9113164D0 (de) |
| GR (1) | GR3032825T3 (de) |
| NO (1) | NO934689L (de) |
| WO (1) | WO1992022309A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002161051A (ja) * | 1996-12-24 | 2002-06-04 | Fujisawa Pharmaceut Co Ltd | 脳虚血性疾患等の治療剤 |
| AT406120B (de) | 1997-08-28 | 2000-02-25 | Immuno Ag | Gewebekleber |
| US6903244B1 (en) | 1999-02-26 | 2005-06-07 | University Of Utah Research Foundation | Mice which are +/− or −/− for the elastin gene as models for vascular disease |
| EP1191845A4 (de) * | 1999-04-13 | 2002-07-17 | Long Island Jewish Res Inst | Prävention von durch ischämie ausgelösten hirnschädigungen |
| IL148924A (en) * | 2002-03-26 | 2015-06-30 | Mor Research Applic Ltd | Use of substances that inhibit intracellular elastase activity in the preparation of a drug for the treatment and / or prevention of necrosis of cells and related diseases |
| WO2018175173A1 (en) * | 2017-03-21 | 2018-09-27 | The Scripps Research Institute | Cu-and ni-catalyzed decarboxylative borylation reactions |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8600263D0 (en) * | 1985-01-22 | 1986-02-12 | Ici America Inc | Peptide derivatives |
| ES2129401T3 (es) * | 1990-05-24 | 1999-06-16 | Zeneca Ltd | Uso de un compuesto terapeutico para el tratamiento de bronquitis. |
| US5162348A (en) * | 1990-05-24 | 1992-11-10 | Imperial Chemical Industries Plc | Treatment of cystic fibrosis |
| IE911697A1 (en) * | 1990-05-24 | 1991-12-04 | Zeneca Ltd | Therapeutic agent |
| GB9014132D0 (en) * | 1990-06-25 | 1990-08-15 | Ici Plc | Agent for therapy |
-
1991
- 1991-06-18 GB GB919113164A patent/GB9113164D0/en active Pending
-
1992
- 1992-06-17 AU AU19007/92A patent/AU667307B2/en not_active Ceased
- 1992-06-17 JP JP4510795A patent/JPH06508826A/ja active Pending
- 1992-06-17 DE DE69230792T patent/DE69230792T2/de not_active Expired - Fee Related
- 1992-06-17 ES ES92911644T patent/ES2142825T3/es not_active Expired - Lifetime
- 1992-06-17 EP EP92911644A patent/EP0589937B1/de not_active Expired - Lifetime
- 1992-06-17 CA CA002111846A patent/CA2111846A1/en not_active Abandoned
- 1992-06-17 WO PCT/GB1992/001087 patent/WO1992022309A1/en not_active Ceased
- 1992-06-17 AT AT92911644T patent/ATE190493T1/de not_active IP Right Cessation
- 1992-06-17 DK DK92911644T patent/DK0589937T3/da active
-
1993
- 1993-12-17 NO NO934689A patent/NO934689L/no not_active Application Discontinuation
-
2000
- 2000-03-16 GR GR20000400462T patent/GR3032825T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU1900792A (en) | 1993-01-12 |
| DE69230792D1 (de) | 2000-04-20 |
| GB9113164D0 (en) | 1991-08-07 |
| NO934689D0 (no) | 1993-12-17 |
| GR3032825T3 (en) | 2000-06-30 |
| WO1992022309A1 (en) | 1992-12-23 |
| DE69230792T2 (de) | 2000-06-29 |
| DK0589937T3 (da) | 2000-07-31 |
| EP0589937B1 (de) | 2000-03-15 |
| JPH06508826A (ja) | 1994-10-06 |
| CA2111846A1 (en) | 1992-12-23 |
| AU667307B2 (en) | 1996-03-21 |
| ES2142825T3 (es) | 2000-05-01 |
| EP0589937A1 (de) | 1994-04-06 |
| NO934689L (no) | 1993-12-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |