ATE190493T1 - Verwendung von 4-(4-chlorophenyl- sulphonylcarbamoyl) benzoyl - l - valyl - l - proline 1(rs) - (1-trifluoroacetyl-2- methylpropyl)amide zur herstellung eines medikaments für die behandlung von gefässkrankheiten - Google Patents

Verwendung von 4-(4-chlorophenyl- sulphonylcarbamoyl) benzoyl - l - valyl - l - proline 1(rs) - (1-trifluoroacetyl-2- methylpropyl)amide zur herstellung eines medikaments für die behandlung von gefässkrankheiten

Info

Publication number: ATE190493T1
Authority: AT; Austria
Prior art keywords: valyl; trifluoroacetyl; methylpropyl; chlorophenyl; proline
Prior art date: 1991-06-18

Application number

AT92911644T

Other languages

English (en)

Inventor

Jawehar Lal Mehta

Tom Gustave Per Saldeen

Wilmer Wayne Nichols

Original Assignee

Zeneca Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-06-18

Filing date

1992-06-17

Publication date

2000-04-15

1992-06-17 Application filed by Zeneca Ltd filed Critical Zeneca Ltd

2000-04-15 Application granted granted Critical

2000-04-15 Publication of ATE190493T1 publication Critical patent/ATE190493T1/de

Links

208000019553 vascular disease Diseases 0.000 title abstract 2
-1 4-(4-CHLOROPHENYL-SULPHONYLCARBAMOYL) BENZOYL Chemical class 0.000 title 1
229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
229940122858 Elastase inhibitor Drugs 0.000 abstract 1
206010022562 Intermittent claudication Diseases 0.000 abstract 1
208000018262 Peripheral vascular disease Diseases 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
208000026106 cerebrovascular disease Diseases 0.000 abstract 1
239000003602 elastase inhibitor Substances 0.000 abstract 1
230000001771 impaired effect Effects 0.000 abstract 1
208000021156 intermittent vascular claudication Diseases 0.000 abstract 1
208000031225 myocardial ischemia Diseases 0.000 abstract 1
210000000440 neutrophil Anatomy 0.000 abstract 1
230000010410 reperfusion Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000007631 vascular surgery Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Radar Systems Or Details Thereof (AREA)

AT92911644T 1991-06-18 1992-06-17 Verwendung von 4-(4-chlorophenyl- sulphonylcarbamoyl) benzoyl - l - valyl - l - proline 1(rs) - (1-trifluoroacetyl-2- methylpropyl)amide zur herstellung eines medikaments für die behandlung von gefässkrankheiten ATE190493T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB919113164A GB9113164D0 (en)	1991-06-18	1991-06-18	Pharmaceutical agent
PCT/GB1992/001087 WO1992022309A1 (en)	1991-06-18	1992-06-17	Use of 4-(4-chlorophenyl-sulphonylcarbamoyl) benzoyl-l-valyl-l-proline 1(rs)-(1-trifluoroacetyl-2-methylpropyl) amide in the treatment of vascular diseases

Publications (1)

Publication Number	Publication Date
ATE190493T1 true ATE190493T1 (de)	2000-04-15

Family

ID=10696898

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92911644T ATE190493T1 (de)	1991-06-18	1992-06-17	Verwendung von 4-(4-chlorophenyl- sulphonylcarbamoyl) benzoyl - l - valyl - l - proline 1(rs) - (1-trifluoroacetyl-2- methylpropyl)amide zur herstellung eines medikaments für die behandlung von gefässkrankheiten

Country Status (12)

Country	Link
EP (1)	EP0589937B1 (de)
JP (1)	JPH06508826A (de)
AT (1)	ATE190493T1 (de)
AU (1)	AU667307B2 (de)
CA (1)	CA2111846A1 (de)
DE (1)	DE69230792T2 (de)
DK (1)	DK0589937T3 (de)
ES (1)	ES2142825T3 (de)
GB (1)	GB9113164D0 (de)
GR (1)	GR3032825T3 (de)
NO (1)	NO934689D0 (de)
WO (1)	WO1992022309A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2002161051A (ja) *	1996-12-24	2002-06-04	Fujisawa Pharmaceut Co Ltd	脳虚血性疾患等の治療剤
AT406120B (de)	1997-08-28	2000-02-25	Immuno Ag	Gewebekleber
US6903244B1 (en)	1999-02-26	2005-06-07	University Of Utah Research Foundation	Mice which are +/− or −/− for the elastin gene as models for vascular disease
CA2368937A1 (en) *	1999-04-13	2000-10-19	North Shore-Long Island Jewish Research Institute	Prevention of brain damage in stroke
IL148924A (en) *	2002-03-26	2015-06-30	Mor Research Applic Ltd	Use of substances that inhibit intracellular elastase activity in the preparation of a drug for the treatment and / or prevention of necrosis of cells and related diseases
EP3600333A4 (de)	2017-03-21	2020-11-25	The Scripps Research Institute	Cu- und ni-katalysierte decarboxylative borylierungsreaktionen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8600263D0 (en) *	1985-01-22	1986-02-12	Ici America Inc	Peptide derivatives
IE911697A1 (en) *	1990-05-24	1991-12-04	Zeneca Ltd	Therapeutic agent
US5162348A (en) *	1990-05-24	1992-11-10	Imperial Chemical Industries Plc	Treatment of cystic fibrosis
ES2129401T3 (es) *	1990-05-24	1999-06-16	Zeneca Ltd	Uso de un compuesto terapeutico para el tratamiento de bronquitis.
GB9014132D0 (en) *	1990-06-25	1990-08-15	Ici Plc	Agent for therapy

1991
- 1991-06-18 GB GB919113164A patent/GB9113164D0/en active Pending
1992
- 1992-06-17 JP JP4510795A patent/JPH06508826A/ja active Pending
- 1992-06-17 WO PCT/GB1992/001087 patent/WO1992022309A1/en not_active Ceased
- 1992-06-17 AT AT92911644T patent/ATE190493T1/de not_active IP Right Cessation
- 1992-06-17 AU AU19007/92A patent/AU667307B2/en not_active Ceased
- 1992-06-17 DE DE69230792T patent/DE69230792T2/de not_active Expired - Fee Related
- 1992-06-17 EP EP92911644A patent/EP0589937B1/de not_active Expired - Lifetime
- 1992-06-17 DK DK92911644T patent/DK0589937T3/da active
- 1992-06-17 CA CA002111846A patent/CA2111846A1/en not_active Abandoned
- 1992-06-17 ES ES92911644T patent/ES2142825T3/es not_active Expired - Lifetime
1993
- 1993-12-17 NO NO934689A patent/NO934689D0/no not_active Application Discontinuation
2000
- 2000-03-16 GR GR20000400462T patent/GR3032825T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69230792D1 (de)	2000-04-20
JPH06508826A (ja)	1994-10-06
NO934689L (no)	1993-12-17
DE69230792T2 (de)	2000-06-29
CA2111846A1 (en)	1992-12-23
GB9113164D0 (en)	1991-08-07
AU667307B2 (en)	1996-03-21
AU1900792A (en)	1993-01-12
ES2142825T3 (es)	2000-05-01
NO934689D0 (no)	1993-12-17
EP0589937A1 (de)	1994-04-06
EP0589937B1 (de)	2000-03-15
DK0589937T3 (da)	2000-07-31
GR3032825T3 (en)	2000-06-30
WO1992022309A1 (en)	1992-12-23

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Legal Events

Date	Code	Title	Description
2003-03-15	REN	Ceased due to non-payment of the annual fee