ATE190610T1 - Benzothiazolone-derivate - Google Patents

Benzothiazolone-derivate

Info

Publication number
ATE190610T1
ATE190610T1 AT96930256T AT96930256T ATE190610T1 AT E190610 T1 ATE190610 T1 AT E190610T1 AT 96930256 T AT96930256 T AT 96930256T AT 96930256 T AT96930256 T AT 96930256T AT E190610 T1 ATE190610 T1 AT E190610T1
Authority
AT
Austria
Prior art keywords
benzothiazolone derivatives
benzothiazolone
derivatives
Prior art date
Application number
AT96930256T
Other languages
English (en)
Inventor
Roger Victor Bonnert
Roger Charles Brown
Peter Alan Cage
Francis Ince
Garry Pairaudeau
Original Assignee
Astra Pharma Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9518952.8A external-priority patent/GB9518952D0/en
Priority claimed from GBGB9614346.6A external-priority patent/GB9614346D0/en
Application filed by Astra Pharma Prod filed Critical Astra Pharma Prod
Application granted granted Critical
Publication of ATE190610T1 publication Critical patent/ATE190610T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C311/04—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/24—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT96930256T 1995-09-15 1996-09-12 Benzothiazolone-derivate ATE190610T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9518952.8A GB9518952D0 (en) 1995-09-15 1995-09-15 Compounds
GBGB9614346.6A GB9614346D0 (en) 1996-07-10 1996-07-10 Benzothiazolone derivatives
PCT/GB1996/002247 WO1997010227A1 (en) 1995-09-15 1996-09-12 Benzothiazolone derivatives

Publications (1)

Publication Number Publication Date
ATE190610T1 true ATE190610T1 (de) 2000-04-15

Family

ID=26307771

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96930256T ATE190610T1 (de) 1995-09-15 1996-09-12 Benzothiazolone-derivate

Country Status (28)

Country Link
US (5) US5846989A (de)
EP (1) EP0850232B1 (de)
JP (1) JP3213327B2 (de)
KR (1) KR19990044674A (de)
CN (2) CN1073098C (de)
AR (1) AR004512A1 (de)
AT (1) ATE190610T1 (de)
AU (1) AU706094B2 (de)
BR (1) BR9610316A (de)
CA (1) CA2231003A1 (de)
CY (1) CY2227B1 (de)
CZ (1) CZ74098A3 (de)
DE (1) DE69607183T2 (de)
EE (1) EE03395B1 (de)
ES (1) ES2146901T3 (de)
GR (1) GR3033681T3 (de)
HU (1) HUP9802393A3 (de)
IL (4) IL141956A0 (de)
IS (1) IS4679A (de)
MY (1) MY113518A (de)
NO (1) NO310721B1 (de)
NZ (4) NZ318007A (de)
PL (1) PL325517A1 (de)
PT (1) PT850232E (de)
SK (1) SK282394B6 (de)
TR (1) TR199800457T2 (de)
TW (1) TW356468B (de)
WO (1) WO1997010227A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2238770T5 (es) * 1997-10-17 2012-01-17 Ark Therapeutics Limited Utilización de inhibidores del sistema renina-angiotensina para el tratamiento de la hipoxia o de la disminución de la función metabólica.
SE0004750D0 (sv) * 2000-12-19 2000-12-19 Astrazeneca Ab Novel formulation
AR040962A1 (es) * 2002-08-09 2005-04-27 Novartis Ag Compuestos derivados de tiazol 1,3-2-ona, composicion farmaceutica y proceso de preparacion del compuesto
GB0218629D0 (en) * 2002-08-09 2002-09-18 Novartis Ag Organic compounds
ES2329586T3 (es) * 2003-11-21 2009-11-27 Theravance, Inc. Compuestos que tienen actividad agonista del receptor beta2 adrenergico y antagonista del receptor muscarino.
GB0426164D0 (en) 2004-11-29 2004-12-29 Novartis Ag Organic compounds
UA94235C2 (en) * 2005-08-09 2011-04-26 Астразенека Аб Novel benzothiazolone derivatives
TW200738658A (en) 2005-08-09 2007-10-16 Astrazeneca Ab Novel compounds
RU2415136C2 (ru) * 2005-08-09 2011-03-27 Астразенека Аб Новые производные бензотиазолона
TW200740781A (en) * 2005-08-29 2007-11-01 Astrazeneca Ab Novel compounds
TW200745067A (en) 2006-03-14 2007-12-16 Astrazeneca Ab Novel compounds
US20120142646A1 (en) * 2006-12-20 2012-06-07 Lilian Alcaraz Novel Compounds 621
TW200833670A (en) * 2006-12-20 2008-08-16 Astrazeneca Ab Novel compounds 569
GB0702458D0 (en) 2007-02-08 2007-03-21 Astrazeneca Ab Salts 668
JP2011524896A (ja) 2008-06-18 2011-09-08 アストラゼネカ・アクチエボラーグ 呼吸器障害の処置用のベータ2−アドレナリン受容体アゴニストとして作用するベンズオキサジノン誘導体
WO2009154562A1 (en) * 2008-06-20 2009-12-23 Astrazeneca Ab Pharmaceutical composition comprising a 4-hydroxy-2-oxo-2, 3- dihydro-1, 3-benzothiazol-7-yl compound for modulation of beta2-adrenoreceptor activity

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4314944A (en) * 1980-08-22 1982-02-09 Smithkline Corporation 4-Aminoalkyl-7-hydroxy-2(3H)-indolones
US4452808A (en) * 1982-12-07 1984-06-05 Smithkline Beckman Corporation 4-Aminoalkyl-2(3H)-indolones
GB8426200D0 (en) * 1984-10-17 1984-11-21 Glaxo Holdings Ltd Chemical compounds
US4554284A (en) * 1984-09-12 1985-11-19 Smithkline Beckman Corporation 7-(2-Aminoethyl)-1,3-benzthia- or oxa-zol-2(3H)-ones
US4554287A (en) * 1984-09-12 1985-11-19 Smithkline Beckman Corporation Antihypertensive 7-[2-(dialkylamino)ethyl]-4-hydroxy-1,3-benzimidazol-2-ones
EP0180994A3 (de) * 1984-11-08 1987-09-23 Syntex (U.S.A.) Inc. Antihypertensive Dialkylaminoethylanilinderivate
DE3728695A1 (de) * 1987-08-25 1989-03-09 Schering Ag Neue benzimidazol-derivate
GB9024208D0 (en) * 1990-11-07 1990-12-19 Salutar Inc Compounds
IE914003A1 (en) * 1990-11-20 1992-05-20 Astra Pharma Prod Biologically Active Amines
GB9210632D0 (en) * 1992-05-19 1992-07-01 Fisons Plc Compounds
GB9211172D0 (en) * 1992-05-27 1992-07-08 Fisons Plc Compounds

Also Published As

Publication number Publication date
AU6937196A (en) 1997-04-01
IL141954A0 (en) 2002-03-10
IL141955A0 (en) 2002-03-10
ES2146901T3 (es) 2000-08-16
US5973167A (en) 1999-10-26
SK29598A3 (en) 1999-01-11
EP0850232B1 (de) 2000-03-15
MX9801963A (es) 1998-08-30
CY2227B1 (en) 2003-04-18
HUP9802393A3 (en) 2000-01-28
NO981104L (no) 1998-05-14
US6008365A (en) 1999-12-28
NZ332397A (en) 1999-02-25
CN1356323A (zh) 2002-07-03
NZ332396A (en) 1999-02-25
AU706094B2 (en) 1999-06-10
NO981104D0 (no) 1998-03-12
GR3033681T3 (en) 2000-10-31
IL123639A (en) 2002-04-21
US5977384A (en) 1999-11-02
TR199800457T2 (xx) 1998-07-21
DE69607183T2 (de) 2000-11-23
NO310721B1 (no) 2001-08-20
EE03395B1 (et) 2001-04-16
PT850232E (pt) 2000-08-31
CA2231003A1 (en) 1997-03-20
AR004512A1 (es) 1998-12-16
DE69607183D1 (de) 2000-04-20
NZ332395A (en) 1999-02-25
BR9610316A (pt) 1999-07-06
MY113518A (en) 2002-03-30
EE9800069A (et) 1998-10-15
IS4679A (is) 1998-03-04
SK282394B6 (sk) 2002-01-07
NZ318007A (en) 1999-07-29
IL123639A0 (en) 1998-10-30
US6080869A (en) 2000-06-27
JPH11512422A (ja) 1999-10-26
WO1997010227A1 (en) 1997-03-20
EP0850232A1 (de) 1998-07-01
HUP9802393A2 (hu) 1999-04-28
US5846989A (en) 1998-12-08
IL141956A0 (en) 2002-03-10
CN1202163A (zh) 1998-12-16
KR19990044674A (ko) 1999-06-25
TW356468B (en) 1999-04-21
HK1008781A1 (en) 1999-05-21
CN1073098C (zh) 2001-10-17
CZ74098A3 (cs) 1998-08-12
JP3213327B2 (ja) 2001-10-02
PL325517A1 (en) 1998-08-03

Similar Documents

Publication Publication Date Title
DE69522717D1 (de) Chinazolinderivate
DE69611361D1 (de) Chinazolin-derivate
NO974103L (no) Arylsulfonylaminohydroksamsyre-derivater
DE69610698D1 (de) Chinazolin-derivate
PT833828E (pt) Derivados de rapamicina
BR9611834A (pt) Derivados de oximetóxi-3-aril-pirona
ATE199150T1 (de) Diphenylmethylenpiperidin-derivate
NO964667D0 (no) Purin-6-on-derivater
ATE440854T1 (de) 5-deoxy-cytidin-derivate
DE69607183D1 (de) Benzothiazolone-derivate
BR9509793A (pt) Derivados de tiofeneno
DE69601527D1 (de) Pyrrolylbenzimidazol-Derivate
ATA100695A (de) Prothrombin-derivate
PT856007E (pt) Derivados de ciclopeptidos
DE69627830D1 (de) Pyrazol-derivate
DE69628200D1 (de) Diarylalkenylamin-derivate
ATE202093T1 (de) 4-amino-benzoylguanidin-derivate
DE59610106D1 (de) Fluorbenzylether-Derivate
ATE177102T1 (de) Chromanderivate
DE69624122D1 (de) Aza-anthracyclinone-derivate
BR9603508A (pt) Derivados de alquenil-benzoilguanidina
BR9506618A (pt) Derivados de difeniloxazolinas
FI955026A7 (fi) Alkyyli-5-metyylisulfonyylibentsoyyliguanidiinijohdannaisia
ATE202088T1 (de) 4-mercapto-benzoylguanidin-derivate
DE69620514D1 (de) 5-aminoflavon-derivate

Legal Events

Date Code Title Description
EEIH Change in the person of patent owner
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee