ATE191141T1 - Behandlungsverfahren unter verwendung unilamellar-liposomaler arachiddonsäuremetabolit- formulierungen - Google Patents

Behandlungsverfahren unter verwendung unilamellar-liposomaler arachiddonsäuremetabolit- formulierungen

Info

Publication number: ATE191141T1
Authority: AT; Austria
Prior art keywords: arachiddonic; acid metabolite; treatment methods; unilamellar liposomal; formulations
Prior art date: 1993-11-04

Application number

AT95900504T

Other languages

English (en)

Inventor

Marc J Ostro

Andrew S Janoff

Sharma R Minchey

Original Assignee

Liposome Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-04

Filing date

1994-11-03

Publication date

2000-04-15

1994-11-03 Application filed by Liposome Co Inc filed Critical Liposome Co Inc

2000-04-15 Application granted granted Critical

2000-04-15 Publication of ATE191141T1 publication Critical patent/ATE191141T1/de

Links

239000000203 mixture Substances 0.000 title abstract 2
239000002253 acid Substances 0.000 title 1
239000002207 metabolite Substances 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical class CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 abstract 2
208000035475 disorder Diseases 0.000 abstract 2
229940094443 oxytocics prostaglandins Drugs 0.000 abstract 2
150000003180 prostaglandins Chemical class 0.000 abstract 2
GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 abstract 1
206010004053 Bacterial toxaemia Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
241001465754 Metazoa Species 0.000 abstract 1
208000013222 Toxemia Diseases 0.000 abstract 1
230000004913 activation Effects 0.000 abstract 1
229960000711 alprostadil Drugs 0.000 abstract 1
230000001668 ameliorated effect Effects 0.000 abstract 1
230000001413 cellular effect Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
150000002632 lipids Chemical class 0.000 abstract 1
239000002502 liposome Substances 0.000 abstract 1
GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A61K9/1278—Post-loading, e.g. by ion or pH gradient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Dispersion Chemistry (AREA)
Hematology (AREA)
Rheumatology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Physical Education & Sports Medicine (AREA)
Vascular Medicine (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Manufacturing Of Micro-Capsules (AREA)
Saccharide Compounds (AREA)
Detergent Compositions (AREA)

AT95900504T 1993-11-04 1994-11-03 Behandlungsverfahren unter verwendung unilamellar-liposomaler arachiddonsäuremetabolit- formulierungen ATE191141T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US14789893A	1993-11-04	1993-11-04
US15285293A	1993-11-16	1993-11-16
US18008994A	1994-01-11	1994-01-11
PCT/US1994/012579 WO1995012388A1 (en)	1993-11-04	1994-11-03	Methods of treatment using unilamellar liposomal arachidonic acid metabolite formulations

Publications (1)

Publication Number	Publication Date
ATE191141T1 true ATE191141T1 (de)	2000-04-15

Family

ID=27386612

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT95900504T ATE191141T1 (de)	1993-11-04	1994-11-03	Behandlungsverfahren unter verwendung unilamellar-liposomaler arachiddonsäuremetabolit- formulierungen
AT95900532T ATE184785T1 (de)	1993-11-04	1994-11-03	Multilamellare liposomformulierungen, die einen arachidsäuremetaboliten enthalten

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT95900532T ATE184785T1 (de)	1993-11-04	1994-11-03	Multilamellare liposomformulierungen, die einen arachidsäuremetaboliten enthalten

Country Status (13)

Country	Link
EP (2)	EP0726763B1 (de)
JP (2)	JPH09504793A (de)
KR (2)	KR100355246B1 (de)
AT (2)	ATE191141T1 (de)
AU (2)	AU687921B2 (de)
CA (2)	CA2175896A1 (de)
DE (2)	DE69423773T2 (de)
DK (2)	DK0726763T3 (de)
ES (2)	ES2144118T3 (de)
GR (2)	GR3032006T3 (de)
NO (2)	NO312809B1 (de)
PT (1)	PT726763E (de)
WO (2)	WO1995012388A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2179986A1 (en) *	1994-01-11	1995-07-13	Andrew S. Janoff	Treatment using arachidonic acid metabolite and particulate formulations
CA2260859A1 (en) *	1996-07-22	1998-01-29	Monsanto Company	Thiol sulfone metalloprotease inhibitors
US6747027B1 (en)	1996-07-22	2004-06-08	Pharmacia Corporation	Thiol sulfonamide metalloprotease inhibitors
US6362183B1 (en)	1997-03-04	2002-03-26	G. D. Searle & Company	Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds
WO1998039316A1 (en)	1997-03-04	1998-09-11	Monsanto Company	N-hydroxy 4-sulfonyl butanamide compounds
WO1998039315A1 (en)	1997-03-04	1998-09-11	Monsanto Company	Aromatic sulfonyl alpha-cycloamino hydroxamic acid compounds
US20010039287A1 (en)	1997-11-14	2001-11-08	Thomas E Barta	Aromatic sulfone hydroxamic acid metalloprotease inhibitor
US6750228B1 (en)	1997-11-14	2004-06-15	Pharmacia Corporation	Aromatic sulfone hydroxamic acid metalloprotease inhibitor
JP2001523662A (ja)	1997-11-14	2001-11-27	ジー・ディー・サール・アンド・カンパニー	芳香族スルホンヒドロキサム酸メタロプロテアーゼ阻害剤
AP2001002240A0 (en)	1999-02-08	2001-09-30	Searle & Co	Sufamato hydroxamic acid metalloprotease inhibitor.
US6583299B1 (en)	1999-05-20	2003-06-24	G.D. Searle & Co.	α-amino-β-sulfonyl hydroxamic acid compounds
US6683078B2 (en)	2001-07-19	2004-01-27	Pharmacia Corporation	Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors
JP2003342196A (ja) *	2002-05-31	2003-12-03	Mukku:Kk	静脈注射用組成物、その製造法およびその製剤
WO2013039851A1 (en)	2011-09-12	2013-03-21	Mallinckrodt Llc	Optical agents for imaging and visualization of matrix metalloproteinase enzymes
CN111053743B (zh) *	2018-10-16	2023-07-14	石药集团中奇制药技术（石家庄）有限公司	一种前列地尔脂质体及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1988009170A1 (en) *	1987-05-22	1988-12-01	The Liposome Company, Inc.	Prostaglandin-lipid formulations
US5262168A (en) *	1987-05-22	1993-11-16	The Liposome Company, Inc.	Prostaglandin-lipid formulations
JPH0395118A (ja) *	1989-09-07	1991-04-19	Green Cross Corp:The	プロスタグランジン含有脂肪小体製剤
JPH04356421A (ja) *	1991-03-06	1992-12-10	Green Cross Corp:The	プロスタグランジン類含有脂肪小体組成物
ATE176401T1 (de) *	1991-05-07	1999-02-15	Liposome Co Inc	Liposomale prostaglandinformulierungen
JPH05139977A (ja) *	1991-05-17	1993-06-08	Green Cross Corp:The	プロスタグランジン類リポソーム複合体を充填した注射器

1994
- 1994-11-03 EP EP95900504A patent/EP0726763B1/de not_active Expired - Lifetime
- 1994-11-03 JP JP7513436A patent/JPH09504793A/ja not_active Abandoned
- 1994-11-03 AU AU81326/94A patent/AU687921B2/en not_active Ceased
- 1994-11-03 AT AT95900504T patent/ATE191141T1/de not_active IP Right Cessation
- 1994-11-03 DE DE69423773T patent/DE69423773T2/de not_active Expired - Fee Related
- 1994-11-03 JP JP7513378A patent/JPH09511216A/ja active Pending
- 1994-11-03 ES ES95900504T patent/ES2144118T3/es not_active Expired - Lifetime
- 1994-11-03 DK DK95900504T patent/DK0726763T3/da active
- 1994-11-03 DK DK95900532T patent/DK0726764T3/da active
- 1994-11-03 CA CA002175896A patent/CA2175896A1/en not_active Abandoned
- 1994-11-03 WO PCT/US1994/012579 patent/WO1995012388A1/en not_active Ceased
- 1994-11-03 PT PT95900504T patent/PT726763E/pt unknown
- 1994-11-03 DE DE69420859T patent/DE69420859T2/de not_active Expired - Fee Related
- 1994-11-03 KR KR1019960702299A patent/KR100355246B1/ko not_active Expired - Fee Related
- 1994-11-03 KR KR1019960702298A patent/KR100355247B1/ko not_active Expired - Fee Related
- 1994-11-03 AU AU81308/94A patent/AU8130894A/en not_active Abandoned
- 1994-11-03 EP EP95900532A patent/EP0726764B1/de not_active Expired - Lifetime
- 1994-11-03 ES ES95900532T patent/ES2136271T3/es not_active Expired - Lifetime
- 1994-11-03 CA CA002175057A patent/CA2175057A1/en not_active Abandoned
- 1994-11-03 AT AT95900532T patent/ATE184785T1/de not_active IP Right Cessation
- 1994-11-03 WO PCT/US1994/012710 patent/WO1995012389A1/en not_active Ceased
1996
- 1996-05-02 NO NO19961778A patent/NO312809B1/no not_active IP Right Cessation
- 1996-05-02 NO NO19961779A patent/NO312810B1/no not_active IP Right Cessation
1999
- 1999-11-30 GR GR990403099T patent/GR3032006T3/el unknown
2000
- 2000-06-29 GR GR20000401517T patent/GR3033817T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK0726763T3 (da)	2000-07-10
KR100355247B1 (ko)	2003-01-24
JPH09511216A (ja)	1997-11-11
NO312809B1 (no)	2002-07-08
ES2136271T3 (es)	1999-11-16
KR100355246B1 (ko)	2003-01-06
NO961779L (no)	1996-05-02
DK0726764T3 (da)	1999-12-20
DE69423773D1 (de)	2000-05-04
EP0726763A1 (de)	1996-08-21
ATE184785T1 (de)	1999-10-15
NO312810B1 (no)	2002-07-08
EP0726764A1 (de)	1996-08-21
AU8130894A (en)	1995-05-23
KR960705543A (ko)	1996-11-08
NO961778L (no)	1996-06-25
CA2175896A1 (en)	1995-05-11
GR3033817T3 (en)	2000-10-31
AU687921B2 (en)	1998-03-05
DE69420859T2 (de)	2000-01-05
EP0726764B1 (de)	1999-09-22
NO961778D0 (no)	1996-05-02
CA2175057A1 (en)	1995-05-11
DE69420859D1 (de)	1999-10-28
WO1995012389A1 (en)	1995-05-11
DE69423773T2 (de)	2000-07-20
KR960705544A (ko)	1996-11-08
WO1995012388A1 (en)	1995-05-11
ES2144118T3 (es)	2000-06-01
NO961779D0 (no)	1996-05-02
PT726763E (pt)	2000-09-29
EP0726763B1 (de)	2000-03-29
JPH09504793A (ja)	1997-05-13
GR3032006T3 (en)	2000-03-31
AU8132694A (en)	1995-05-23

Legal Events

Date	Code	Title	Description
2000-08-15	UEP	Publication of translation of european patent specification
2006-08-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69423773D1 (de)	2000-05-04	Behandlungsverfahren unter verwendung unilamellar-liposomaler arachiddonsäuremetabolit-formulierungen
SV1995000007A (es)	1996-02-28	Derivados del acido micofenolico 5-substituidos.
ES2180635T3 (es)	2003-02-16	Metodo para reducir la grasa corporal en animales mediante la administracion de acido linoleico conjugado.
AR013488A1 (es)	2000-12-27	COMPOSICIoN GERMICIDA ACUOSA PARA EL TRATAMIENTO O PREVENCIoN DE ENFERMEDADES INFECCIOSAS DE LAS PEZUNAS DE ANIMALES, Y USO DE DICHA COMPOSICIoN
NO20030374D0 (no)	2003-01-24	Syklopentanoindoler, preparater som inneholder slike forbindelser og behandlingsfremgangsmåter
FI956113A7 (fi)	1995-12-19	Fungisidisia vaikuttavien aineiden yhdistelmiä
NO973017D0 (no)	1997-06-27	Nye trienoiske retinoid forbindelser og fremgangsmåter
BR9811094A (pt)	2000-07-18	Agente terapêutico para tumores linfáticos
ATE205401T1 (de)	2001-09-15	Lokale behandlung von psoriasis unter verwendung neutralisierender antikörper gegen il-8
ES2180164T3 (es)	2003-02-01	Agentes acuosos para el cuidado de la piel y del cabello.
ES2192669T3 (es)	2003-10-16	Uso de proteinas como agentes frente a enfermedades autoinmunes.
ES2141978T3 (es)	2000-04-01	Retinoides triciclicos, metodos para su produccion y uso.
ATE176397T1 (de)	1999-02-15	Arachidonsäuremetaboliten enthaltende interdigitations-fusions-liposomen
IT1195200B (it)	1988-10-12	Attrattivo per insetti composito,per i maschi della nottuella delle messi,e procedimento per la preparazione degli ingredienti attivi di esso
NO20023111D0 (no)	2002-06-27	Utvortes preparat for behandling av pruritus
AR019893A1 (es)	2002-03-20	Un metodo para reducir o evitar el mal olor
GT198804306A (es)	1989-12-07	Conversion de isomeros piretroidesen especies mas activas.
ATE286739T1 (de)	2005-01-15	Verwendung einer pollenextrakt-haltigen verbindung zur behandlung erkrankungsbedingter gewichtszunahme
DE69722178D1 (de)	2003-06-26	Therapeutischer wirkstoff für augenerkrankungen
PT980251E (pt)	2003-01-31	Factor de tecido para influenciar a formacao de vasos sanguineos
NO20032035D0 (no)	2003-05-06	Terapeutiske midler for heratokonjunktivitis sykdommer omfattende farnesyleddiksyre som aktiv ingrediens
ES2187963T3 (es)	2003-06-16	Sales farmaceuticamente aceptables de 3-sulfato de 3-hidroxi-estr-5(10)-en 17-ona activas con estrogenos.
ES2105973B1 (es)	1998-05-01	Composicion liposomal para la regeneracion celular de la piel.
CO4850559A1 (es)	1999-10-26	Metodo de reduccion o prevencion del mal olor
ECSP972162A (es)	1999-01-19	Formas solidas de dosificacion oral que contienen valsartan