ATE191219T1 - Zwischenprodukte und ihre anwendung für die herstellung von n,n'-überbrückten bisindolylmaleimiden - Google Patents

Zwischenprodukte und ihre anwendung für die herstellung von n,n'-überbrückten bisindolylmaleimiden

Info

Publication number
ATE191219T1
ATE191219T1 AT96308317T AT96308317T ATE191219T1 AT E191219 T1 ATE191219 T1 AT E191219T1 AT 96308317 T AT96308317 T AT 96308317T AT 96308317 T AT96308317 T AT 96308317T AT E191219 T1 ATE191219 T1 AT E191219T1
Authority
AT
Austria
Prior art keywords
production
application
intermediate products
bridged bisindolylmaleimides
bisindolylmaleimides
Prior art date
Application number
AT96308317T
Other languages
English (en)
Inventor
Margaret Mary Faul
Christine Ann Krumrich
Leonard Larry Winneroski Jr
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21725638&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE191219(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE191219T1 publication Critical patent/ATE191219T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
AT96308317T 1995-11-20 1996-11-18 Zwischenprodukte und ihre anwendung für die herstellung von n,n'-überbrückten bisindolylmaleimiden ATE191219T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US734595P 1995-11-20 1995-11-20

Publications (1)

Publication Number Publication Date
ATE191219T1 true ATE191219T1 (de) 2000-04-15

Family

ID=21725638

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96308317T ATE191219T1 (de) 1995-11-20 1996-11-18 Zwischenprodukte und ihre anwendung für die herstellung von n,n'-überbrückten bisindolylmaleimiden

Country Status (31)

Country Link
EP (1) EP0776899B1 (de)
JP (2) JP4100708B2 (de)
KR (1) KR100342142B1 (de)
CN (1) CN1066734C (de)
AR (2) AR004718A1 (de)
AT (1) ATE191219T1 (de)
AU (1) AU701659B2 (de)
BR (1) BR9611709A (de)
CA (1) CA2237401C (de)
CO (1) CO4750824A1 (de)
CZ (1) CZ150398A3 (de)
DE (1) DE69607443T2 (de)
DK (1) DK0776899T3 (de)
EA (1) EA000639B1 (de)
ES (1) ES2145978T3 (de)
GR (1) GR3033729T3 (de)
HU (1) HU225716B1 (de)
IL (1) IL124415A (de)
MX (1) MX9803791A (de)
MY (1) MY118946A (de)
NO (1) NO310195B1 (de)
NZ (1) NZ323282A (de)
PE (1) PE17998A1 (de)
PL (1) PL184728B1 (de)
PT (1) PT776899E (de)
TR (1) TR199800876T2 (de)
TW (1) TW371661B (de)
UA (1) UA56145C2 (de)
WO (1) WO1997019080A1 (de)
YU (1) YU49316B (de)
ZA (1) ZA969645B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2245029A1 (en) 1998-03-13 1999-09-13 University Of British Columbia Granulatimide compounds as g2 checkpoint inhibitors
ATE251624T1 (de) * 1998-03-13 2003-10-15 Univ British Columbia Granulatimide-derivate zur behandlung von krebs
US6127401A (en) 1998-06-05 2000-10-03 Cephalon, Inc. Bridged indenopyrrolocarbazoles
US6300106B1 (en) 2000-11-22 2001-10-09 Ppg Industries Ohio, Inc. Method of preparing 3-[2-{(Methylsulfonyl)oxy}-ethoxy ]-4-(triphenylmethoxy)-1-butanol, methane sulfonate
EP2181999A1 (de) 2008-11-03 2010-05-05 Zentiva, A.S. Verfahren zur Herstellung von Ruboxistaurin
EP4504178A1 (de) * 2022-03-31 2025-02-12 4M Therapeutics Inc. N-desmethyl-ruboxistaurin als kinaseinhibitor
EP4654966A1 (de) * 2023-01-27 2025-12-03 Mellicell, Inc. Verfahren und zusammensetzungen zur behandlung von adipositas und erkrankungen im zusammenhang mit fettzellenvergrösserung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94274A0 (en) * 1989-05-05 1991-03-10 Goedecke Ag Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
PL182124B1 (pl) * 1993-12-07 2001-11-30 Lilly Co Eli Nowe zwiazki oraz srodek farmaceutyczny przeznaczony do leczenia powiklan cukrzycowych lub do leczenia nowotworów PL PL PL PL PL PL PL PL
US5559228A (en) * 1995-03-30 1996-09-24 Eli Lilly And Company Synthesis of bisindolylmaleimides

Also Published As

Publication number Publication date
EP0776899A1 (de) 1997-06-04
ZA969645B (en) 1998-05-18
NO982105L (no) 1998-05-08
JP2008138006A (ja) 2008-06-19
TR199800876T2 (xx) 1998-08-21
NO310195B1 (no) 2001-06-05
PL184728B1 (pl) 2002-12-31
IL124415A0 (en) 1998-12-06
ES2145978T3 (es) 2000-07-16
EA000639B1 (ru) 1999-12-29
YU61096A (sh) 1999-03-04
HUP9901975A3 (en) 2000-01-28
NZ323282A (en) 1999-01-28
KR19990067600A (ko) 1999-08-25
KR100342142B1 (ko) 2002-08-22
HU225716B1 (en) 2007-07-30
JP2000500496A (ja) 2000-01-18
AU701659B2 (en) 1999-02-04
JP4100708B2 (ja) 2008-06-11
EP0776899B1 (de) 2000-03-29
DE69607443D1 (de) 2000-05-04
PL326753A1 (en) 1998-10-26
DE69607443T2 (de) 2000-08-10
CN1207740A (zh) 1999-02-10
BR9611709A (pt) 1999-02-23
MY118946A (en) 2005-02-28
UA56145C2 (uk) 2003-05-15
CA2237401A1 (en) 1997-05-29
DK0776899T3 (da) 2000-07-10
HUP9901975A2 (hu) 1999-11-29
CZ150398A3 (cs) 1998-12-16
AU7738896A (en) 1997-06-11
PE17998A1 (es) 1998-04-20
TW371661B (en) 1999-10-11
PT776899E (pt) 2000-08-31
EA199800368A1 (ru) 1998-12-24
IL124415A (en) 2003-11-23
MX9803791A (es) 1998-09-30
NO982105D0 (no) 1998-05-08
GR3033729T3 (en) 2000-10-31
CN1066734C (zh) 2001-06-06
AR004719A1 (es) 1999-03-10
WO1997019080A1 (en) 1997-05-29
AR004718A1 (es) 1999-03-10
CO4750824A1 (es) 1999-03-31
CA2237401C (en) 2003-10-21
YU49316B (sh) 2005-06-10

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee