ATE191509T1 - Enantio- und regioselektive synthesen von organischen verbindungen mit enolestern als irreversibele transacylierungs-reagenzien - Google Patents

Enantio- und regioselektive synthesen von organischen verbindungen mit enolestern als irreversibele transacylierungs-reagenzien

Info

Publication number
ATE191509T1
ATE191509T1 AT93107522T AT93107522T ATE191509T1 AT E191509 T1 ATE191509 T1 AT E191509T1 AT 93107522 T AT93107522 T AT 93107522T AT 93107522 T AT93107522 T AT 93107522T AT E191509 T1 ATE191509 T1 AT E191509T1
Authority
AT
Austria
Prior art keywords
irreversible
reagents
transacylation
enantio
organic compounds
Prior art date
Application number
AT93107522T
Other languages
English (en)
Inventor
Chi-Huey Wong
Yi-Fong Wang
William J Hennen
Kevin Anthony Babiak
John H Dygos
John S Ng
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of ATE191509T1 publication Critical patent/ATE191509T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/02—Monosaccharides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
AT93107522T 1988-08-30 1989-08-30 Enantio- und regioselektive synthesen von organischen verbindungen mit enolestern als irreversibele transacylierungs-reagenzien ATE191509T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23835888A 1988-08-30 1988-08-30
US07/396,723 US5106750A (en) 1988-08-30 1989-08-24 Enantio- and regioselective synthesis of organic compounds using enol esters as irreversible transacylation reagents

Publications (1)

Publication Number Publication Date
ATE191509T1 true ATE191509T1 (de) 2000-04-15

Family

ID=26931593

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93107522T ATE191509T1 (de) 1988-08-30 1989-08-30 Enantio- und regioselektive synthesen von organischen verbindungen mit enolestern als irreversibele transacylierungs-reagenzien

Country Status (8)

Country Link
US (1) US5106750A (de)
EP (2) EP0560408B1 (de)
JP (1) JP2843606B2 (de)
KR (1) KR910004809A (de)
AT (1) ATE191509T1 (de)
CA (1) CA1341217C (de)
DE (2) DE68929190T2 (de)
ES (2) ES2145017T3 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585252A (en) * 1988-08-30 1996-12-17 G. D. Searle & Co. Enantio- and regioselective synthesis of organic compounds using enol esters as irreversible transacylation reagents
US5914331A (en) * 1990-02-01 1999-06-22 Emory University Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
US5728575A (en) 1990-02-01 1998-03-17 Emory University Method of resolution of 1,3-oxathiolane nucleoside enantiomers
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
US5191109A (en) * 1990-02-02 1993-03-02 Sumitomo Chemical Company, Limited Process for preparing optically active cyclopentenones
CA2039857A1 (en) * 1990-04-26 1991-10-27 Wilfred Po-Sum Shum Process for producing epoxyalcohols of high optical purity
JP3027442B2 (ja) * 1990-10-30 2000-04-04 日東電工株式会社 光学活性エポキシアルコールの製法
DK0492497T3 (da) * 1990-12-24 1997-01-06 Hoechst Ag Fremgangsmåde til acylering af alkoholer med en immobiliseret pseudomonas-lipase
JP3097145B2 (ja) * 1991-02-27 2000-10-10 日産化学工業株式会社 コーリーラクトンジオールの光学分割方法
US5986095A (en) * 1992-01-06 1999-11-16 E.R. Squibb & Sons, Inc. Enantioselective preparation of halophenyl alcohols and acylates
US5447865A (en) * 1992-06-10 1995-09-05 Amprost Pharmaceutical, Inc. Method of resolution of hydroxy substituted cyclopentanone enantiomers using lipase and lithium salt complexation
DE4329293A1 (de) * 1993-08-31 1995-03-02 Basf Ag Lipase katalysierte Acylierung von Alkoholen mit Diketenen
AT401385B (de) * 1994-03-30 1996-08-26 Chemie Linz Gmbh Enzymatische racematspaltung asymmetrischer alkohole mittels vinylestern mehrbasiger carbonsäuren
DE4414273A1 (de) * 1994-04-23 1995-10-26 Chemie Linz Deutschland Enzymatische Racematspaltung asymmetrischer Alkohole mittels Vinylestern mehrbasiger Carbonsäuren
ES2216495T3 (es) 1998-02-17 2004-10-16 G.D. SEARLE & CO. Procedimiento para la resolucion enzimatica de lactamas.
US5989900A (en) * 1998-08-19 1999-11-23 Development Center Of Biotechnology Process for preparing optically active allylic alcohol derivatives
ES2159231B1 (es) * 1999-04-09 2002-05-16 Smithkline Beecham Sa Procedimiento de resolucion de mezclas enantiomericas de alcoholes catalizada por lipasas.
ES2225149T3 (es) * 1999-05-05 2005-03-16 COGNIS DEUTSCHLAND GMBH & CO. KG Procedimiento para la esterificacion selectiva de polioles.
DE60124616T2 (de) * 2000-05-08 2007-09-13 Pfizer Products Inc., Groton Enzymatische Spaltung von selektiven Modulatoren des Östrogenrezeptors
CN100413972C (zh) 2001-09-25 2008-08-27 弗·哈夫曼-拉罗切有限公司 制备取代的2-氨基-3-(2-氨基-苯硫基)-丙酸的酶催化方法
EP1620398A1 (de) * 2003-03-13 2006-02-01 Ciba SC Holding AG Verfahren zur herstellung von indolderivaten durch enzymatische acylierung
EP1813679A4 (de) * 2004-11-16 2011-08-31 Takasago Perfumery Co Ltd Verfahren zur herstellung einer optisch aktiven verbindung
EP1811037B1 (de) * 2006-01-18 2011-02-23 Shih-Yi Wei Optisch aktiven Cyclopentenonen zur Herstellung von Prostaglandinen
US8546114B2 (en) 2006-01-18 2013-10-01 Chirogate International Inc. Processes for the preparation of optically active cyclopentenones and cyclopentenones prepared therefrom
AR071312A1 (es) * 2008-04-09 2010-06-09 Scinopharm Taiwan Ltd Proceso para la preparacion de analogos de prostaglandina y sus intermediarios
ES2574606T3 (es) * 2009-11-26 2016-06-21 National Taiwan University Una sustancia activa contra el cáncer de Antrodia camphorata, método de preparación de la misma y uso de la misma
ES2554563B2 (es) * 2014-05-05 2016-08-16 Universidad De Sevilla Cepas bacterianas y sus usos en reacciones de acilación y/o desacilación
CN114891836A (zh) * 2022-05-31 2022-08-12 重庆张邦医药科技有限责任公司 一种手性二茂铁衍生物的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0080671B1 (de) * 1981-11-19 1985-08-21 Sumitomo Chemical Company, Limited 4-Cyclopentenone und ihre Herstellung
EP0149674B1 (de) * 1983-03-18 1988-08-10 Sumitomo Chemical Company, Limited Verfahren zur optisch-biochemischen auflösung eines cyclopentenolonabkömmlings
EP0247620B1 (de) * 1986-05-29 1993-05-05 Sumitomo Chemical Company, Limited Herstellung von Cyclopentenonen
US4916074A (en) * 1986-10-30 1990-04-10 Chisso Corporation Process for producing optically active compounds
IT1198266B (it) * 1986-12-30 1988-12-21 Montedison Spa Processo per la separazione enzimatica degli isomeri ottici di derivati ossazolidinonici racemi
DD264707A1 (de) * 1987-10-23 1989-02-08 Akad Wissenschaften Ddr Verfahren zur herstellung von (1r,4s)-4-acyloxy-1-hydroxycyclopent-2-enen
DE58909383D1 (de) * 1988-04-14 1995-09-21 Hoechst Ag Verfahren zur hochregioselektiven Veresterung und Esterspaltung an ungesättigten Zuckerverbindungen mit Hilfe von Lipasen und Esterasen und mit diesem Verfahren herstellbare Produkte.

Also Published As

Publication number Publication date
DE68913393D1 (de) 1994-04-07
US5106750A (en) 1992-04-21
JPH02167098A (ja) 1990-06-27
EP0357009A2 (de) 1990-03-07
EP0560408A1 (de) 1993-09-15
JP2843606B2 (ja) 1999-01-06
EP0560408B1 (de) 2000-04-05
CA1341217C (en) 2001-04-24
DE68913393T2 (de) 1994-07-14
DE68929190D1 (de) 2000-05-11
EP0357009A3 (en) 1990-12-19
DE68929190T2 (de) 2000-09-21
ES2061844T3 (es) 1994-12-16
KR910004809A (ko) 1991-03-29
EP0357009B1 (de) 1994-03-02
ES2145017T3 (es) 2000-07-01

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REN Ceased due to non-payment of the annual fee