ES2159231B1 - Procedimiento de resolucion de mezclas enantiomericas de alcoholes catalizada por lipasas. - Google Patents

Procedimiento de resolucion de mezclas enantiomericas de alcoholes catalizada por lipasas.

Info

Publication number
ES2159231B1
ES2159231B1 ES009900729A ES9900729A ES2159231B1 ES 2159231 B1 ES2159231 B1 ES 2159231B1 ES 009900729 A ES009900729 A ES 009900729A ES 9900729 A ES9900729 A ES 9900729A ES 2159231 B1 ES2159231 B1 ES 2159231B1
Authority
ES
Spain
Prior art keywords
alcohols
resolution
enantiomeric mixtures
streptomyces
lipases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES009900729A
Other languages
English (en)
Other versions
ES2159231A1 (es
Inventor
Franco Fernando Cardenas
Castro Alvarez M Soledad De
Montero Jose Maria Sanchez
Gago Jose Maria Sinisterra
W Steve Elson
Ruiz Emilio Alvarez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Haleon Alcala SA
Original Assignee
SmithKline Beecham SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham SA filed Critical SmithKline Beecham SA
Priority to ES009900729A priority Critical patent/ES2159231B1/es
Publication of ES2159231A1 publication Critical patent/ES2159231A1/es
Application granted granted Critical
Publication of ES2159231B1 publication Critical patent/ES2159231B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Procedimiento de resolución de mezclas enantioméricas de alcoholes catalizada por lipasas. La presente invención se refiere a un procedimiento para la resolución de mezclas enantioméricas de alcoholes orgánicos que comprende la esterificación selectiva de los mismos. Dichos alcoholes pueden ser secundarios o primarios quirales en alfa. La invención se refiere también a procedimientos para la resolución de mezclas enantioméricas de alcoholes, que se llevan a cabo haciendo reaccionar en el seno de un disolvente orgánico apolar la mezcla a resolver con un éster en presencia de un biocatalizador, y la posterior separación del éster enantioméricamente enriquecido de los productos de partida. Dicho biocatalizador es una lipasa, o mezcla de lipasas, en diversos grados de purificación, producida por un microorganismo seleccionado del siguiente grupo: Fusarium oxysporum, Penicillium. chrysogenum, Arthroderma ciferrii Ovadendron sulphureo-ochraceum, Pseudomonas cepacia, Streptomyces halstedii Streptomyces fradiae y Streptomyces sp. Dichos procedimientos son de interés en la Industria Farmacéutica, Industria de aditivos alimentarios e Industria de Química Fina.
ES009900729A 1999-04-09 1999-04-09 Procedimiento de resolucion de mezclas enantiomericas de alcoholes catalizada por lipasas. Expired - Fee Related ES2159231B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES009900729A ES2159231B1 (es) 1999-04-09 1999-04-09 Procedimiento de resolucion de mezclas enantiomericas de alcoholes catalizada por lipasas.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009900729A ES2159231B1 (es) 1999-04-09 1999-04-09 Procedimiento de resolucion de mezclas enantiomericas de alcoholes catalizada por lipasas.

Publications (2)

Publication Number Publication Date
ES2159231A1 ES2159231A1 (es) 2001-09-16
ES2159231B1 true ES2159231B1 (es) 2002-05-16

Family

ID=8307962

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009900729A Expired - Fee Related ES2159231B1 (es) 1999-04-09 1999-04-09 Procedimiento de resolucion de mezclas enantiomericas de alcoholes catalizada por lipasas.

Country Status (1)

Country Link
ES (1) ES2159231B1 (es)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK289083A (da) * 1983-06-23 1984-12-24 Novo Industri As Lipase, fremgangsmaade til fremstilling deraf og anvendelse deraf
DE3743824C2 (de) * 1987-12-23 1997-03-06 Hoechst Ag Verfahren zur enzymatischen Racematspaltung von racemischen Alkoholen mit/in Vinylestern durch Umesterung
IT1216743B (it) * 1988-02-10 1990-03-08 Donegani Guido Ist Processo per la preparazioenenzimatica degli isomeri ottici di alcoli primari alfa alchilsostituiti racemi.
US5106750A (en) * 1988-08-30 1992-04-21 G. D. Searle & Co. Enantio- and regioselective synthesis of organic compounds using enol esters as irreversible transacylation reagents
CA2039857A1 (en) * 1990-04-26 1991-10-27 Wilfred Po-Sum Shum Process for producing epoxyalcohols of high optical purity
DE19505672A1 (de) * 1995-02-20 1996-08-22 Hoechst Ag Verfahren zur enzymatischen Acylierung von Alkoholen mit Alkoxyvinylacetaten durch Umesterung
JPH1057094A (ja) * 1996-06-14 1998-03-03 Yasuyuki Kita ケテンアセタール型アシル化剤を用いるアルコール類の酵素的光学分割法
JP3673603B2 (ja) * 1996-09-18 2005-07-20 長谷川香料株式会社 光学活性２，４，４−トリメチル−２−シクロヘキセン−１−オール及びそのエステル類の製造方法

Also Published As

Publication number Publication date
ES2159231A1 (es) 2001-09-16

Similar Documents

Publication Publication Date Title
Baumann et al. Rapid screening of hydrolases for the enantioselective conversion of ‘difficult-to-resolve’substrates
Chen et al. Microbiological transformations. 27. The first examples for preparative-scale enantioselective or diastereoselective epoxide hydrolyses using microorganisms. An unequivocal access to all four bisabolol stereoisomers
US4275011A (en) Method of producing improved glyceride by lipase
Faber et al. Selectivity-enhancement of hydrolase reactions
DE69721292D1 (de) Enzymatisches verfahren zur herstellung von ascorbinsäure,2-keto-l-gulonsäure und 2-keto-l-gulonsäure-estern
KR900004711A (ko) 광학 활성-3-페닐글리시드산 에스테르의 제조방법
CA2175734A1 (en) Process for the fractionation of fatty acids
López-Garcı́a et al. Desymmetrization of dimethyl 3-substituted glutarates through enzymatic ammonolysis and aminolysis reactions
ES2159231B1 (es) Procedimiento de resolucion de mezclas enantiomericas de alcoholes catalizada por lipasas.
HU217814B (hu) Eljárás Corey-féle lakton-diolok rezolválására
JPS5610152A (en) Stereoselective division of phenylglycine
Mukherjee et al. Enrichment of very-long-chain mono-unsaturated fatty acids by lipase-catalysed hydrolysis and transesterification
KR940000459A (ko) (r,s)-3-퀴누클리디놀의 에난티오머 증가방법
Schudok et al. Enzyme catalyzed resolution of alcohols using ethoxyvinyl acetate
Okazaki et al. Enantioselective esterification of glycidol by surfactant-lipase complexes in organic media
De Raadt et al. Microbial hydroxylation of 2-cycloalkylbenzoxazoles. Part I. Product spectrum obtained from Cunninghamella blakesleeana DSM 1906 and Bacillus megaterium DSM 32
JPH0260599A (ja) 酵素分解方法
ES2159232B1 (es) Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de acidos organicos.
EP0528607B1 (en) Process for preparing optically active 3-phenylglycidic acid esters
EP4291670A1 (en) Method for manufacturing triacylglycerols enriched either in palmitic acid at sn-2 position or oleic acid at sn-2 position
Theil et al. “Double enantioselection” by a lipase-catalyzed transesterification of a meso-Diol with a racemic carboxylic ester
Kámán et al. Enzymatic resolution of bicyclic 1, 3-amino alcohols in organic media
Chevandier et al. Lipase catalysed synthesis of propanediol monoesters in biphasic aqueous medium
US6995001B2 (en) Processing for preparing monoprotected diols from symmetric diols
ATE192501T1 (de) Bakteriologisches verfahren zur trennung von racematartigen cis-diolen

Legal Events

Date Code Title Description
EC2A Search report published

Date of ref document: 20160120

Kind code of ref document: A1

Effective date: 20160120

FD2A Announcement of lapse in spain

Effective date: 20180807