ATE191645T1 - Hämolyse vorbeugung durch tenside - Google Patents

Hämolyse vorbeugung durch tenside

Info

Publication number
ATE191645T1
ATE191645T1 AT95940391T AT95940391T ATE191645T1 AT E191645 T1 ATE191645 T1 AT E191645T1 AT 95940391 T AT95940391 T AT 95940391T AT 95940391 T AT95940391 T AT 95940391T AT E191645 T1 ATE191645 T1 AT E191645T1
Authority
AT
Austria
Prior art keywords
pct
surfactants
emulsion
sec
active agent
Prior art date
Application number
AT95940391T
Other languages
English (en)
Inventor
Timothy Harrison
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE191645T1 publication Critical patent/ATE191645T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/77—Polymers containing oxygen of oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT95940391T 1994-12-23 1995-12-15 Hämolyse vorbeugung durch tenside ATE191645T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9426104.7A GB9426104D0 (en) 1994-12-23 1994-12-23 Use of surfactants and emulsions
PCT/GB1995/002936 WO1996019970A1 (en) 1994-12-23 1995-12-15 Hemolysis prevention by surfactants and emulsions

Publications (1)

Publication Number Publication Date
ATE191645T1 true ATE191645T1 (de) 2000-04-15

Family

ID=10766511

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95940391T ATE191645T1 (de) 1994-12-23 1995-12-15 Hämolyse vorbeugung durch tenside

Country Status (9)

Country Link
US (1) US5880123A (de)
EP (1) EP0799026B1 (de)
JP (1) JPH10511382A (de)
AT (1) ATE191645T1 (de)
AU (1) AU714121B2 (de)
DE (1) DE69516311T2 (de)
ES (1) ES2144648T3 (de)
GB (1) GB9426104D0 (de)
WO (1) WO1996019970A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69912441T2 (de) * 1998-08-19 2004-08-19 Skyepharma Canada Inc., Verdun Injizierbare wässerige propofoldispersionen
IN188843B (de) * 2000-06-22 2002-11-09 Vinod Daftary Gautam Dr
AU2002218535A8 (en) * 2000-12-12 2008-01-17 Japan Tobacco Inc Pharmaceutical composition containing an active with a hemolytic action and a surfactant
DE10144030A1 (de) * 2001-09-07 2003-03-27 Boehringer Ingelheim Pharma Verbesserung der lokalen Verträglichkeit bei intravenöser Verabreichung von 4-(4-(2-Pyrrolylcarbonyl-1-piperazinyl)-3-trifluormethyl-benzoylguanidin
US6982256B2 (en) 2001-09-07 2006-01-03 Boehringer Ingelheim Pharma Kg Tolerance of 4-(4-(2-pyrrolylcarbonyl)-1-piperazinyl)-3-trifluoromethyl-benzoylguanidine in intravenous administration
DE102006029573A1 (de) 2006-06-22 2007-12-27 Bayer Schering Pharma Ag Neue Quinazoline als Kinase-Inhibitoren
WO2010020052A1 (en) * 2008-08-21 2010-02-25 Edouard Kouassi Methods and compounds for increasing red blood cell survival

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1202370B (it) * 1976-07-12 1989-02-09 Hoffmann La Roche Soluzioni inietabili in cui l'atti vita' emolitica degli agenti di formazione di micelle naturali e' evitata mediante l'aggiunta di lipoidi e relativi prodotti
JPS5919525B2 (ja) * 1976-09-03 1984-05-07 武田薬品工業株式会社 注射剤
JPS6117512A (ja) * 1984-07-03 1986-01-25 Ss Pharmaceut Co Ltd 低溶血性ビタミンｅ注射液
JPS6336826A (ja) * 1986-07-30 1988-02-17 Shiseido Co Ltd 可溶化組成物
JPH03106812A (ja) * 1989-09-16 1991-05-07 Shiseido Co Ltd 注射剤用低刺激性組成物
JPH07173079A (ja) * 1992-12-22 1995-07-11 Nippon Oil & Fats Co Ltd 両親媒性ポリエチレングリコール誘導体および用途
JP3534199B2 (ja) * 1993-11-10 2004-06-07 株式会社薬研 界面活性剤組成物
IL112134A (en) * 1993-12-29 1999-12-22 Merck Sharp & Dohme Substituted morpholine derivatives their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DE69516311T2 (de) 2000-11-09
DE69516311D1 (de) 2000-05-18
EP0799026A1 (de) 1997-10-08
GB9426104D0 (en) 1995-02-22
AU714121B2 (en) 1999-12-16
EP0799026B1 (de) 2000-04-12
AU4185996A (en) 1996-07-19
ES2144648T3 (es) 2000-06-16
JPH10511382A (ja) 1998-11-04
US5880123A (en) 1999-03-09
WO1996019970A1 (en) 1996-07-04

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties