ES2144648T3 - Prevencion de la hemolisis mediante agentes tensioactivos. - Google Patents

Prevencion de la hemolisis mediante agentes tensioactivos.

Info

Publication number
ES2144648T3
ES2144648T3 ES95940391T ES95940391T ES2144648T3 ES 2144648 T3 ES2144648 T3 ES 2144648T3 ES 95940391 T ES95940391 T ES 95940391T ES 95940391 T ES95940391 T ES 95940391T ES 2144648 T3 ES2144648 T3 ES 2144648T3
Authority
ES
Spain
Prior art keywords
hemolysis
prevention
compound
surface agents
amphyphilic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95940391T
Other languages
English (en)
Inventor
Timothy Harrison
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Application granted granted Critical
Publication of ES2144648T3 publication Critical patent/ES2144648T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/77—Polymers containing oxygen of oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE AL USO DE UN AGENTE TENSIOACTIVO NO IONICO O UNA EMULSION PARA LA REDUCCION DE LOS EFECTOS HEMOLITICOS DE UN COMPUESTO ANFIFILICO. TAMBIEN SE DESCRIBE UN METODO PARA REDUCIR LOS EFECTOS HEMOLITICOS DE UN COMPUESTO ANFIFILICO QUE INCLUYE LA FORMULACION DE DICHO COMPUESTO CON UN AGENTE TENSIOACTIVO NO IONICO O EN FORMA DE EMULSION.
ES95940391T 1994-12-23 1995-12-15 Prevencion de la hemolisis mediante agentes tensioactivos. Expired - Lifetime ES2144648T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9426104.7A GB9426104D0 (en) 1994-12-23 1994-12-23 Use of surfactants and emulsions

Publications (1)

Publication Number Publication Date
ES2144648T3 true ES2144648T3 (es) 2000-06-16

Family

ID=10766511

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95940391T Expired - Lifetime ES2144648T3 (es) 1994-12-23 1995-12-15 Prevencion de la hemolisis mediante agentes tensioactivos.

Country Status (9)

Country Link
US (1) US5880123A (es)
EP (1) EP0799026B1 (es)
JP (1) JPH10511382A (es)
AT (1) ATE191645T1 (es)
AU (1) AU714121B2 (es)
DE (1) DE69516311T2 (es)
ES (1) ES2144648T3 (es)
GB (1) GB9426104D0 (es)
WO (1) WO1996019970A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69912441T2 (de) * 1998-08-19 2004-08-19 Skyepharma Canada Inc., Verdun Injizierbare wässerige propofoldispersionen
IN188843B (es) * 2000-06-22 2002-11-09 Vinod Daftary Gautam Dr
AU2002218535A8 (en) * 2000-12-12 2008-01-17 Japan Tobacco Inc Pharmaceutical composition containing an active with a hemolytic action and a surfactant
DE10144030A1 (de) * 2001-09-07 2003-03-27 Boehringer Ingelheim Pharma Verbesserung der lokalen Verträglichkeit bei intravenöser Verabreichung von 4-(4-(2-Pyrrolylcarbonyl-1-piperazinyl)-3-trifluormethyl-benzoylguanidin
US6982256B2 (en) 2001-09-07 2006-01-03 Boehringer Ingelheim Pharma Kg Tolerance of 4-(4-(2-pyrrolylcarbonyl)-1-piperazinyl)-3-trifluoromethyl-benzoylguanidine in intravenous administration
DE102006029573A1 (de) 2006-06-22 2007-12-27 Bayer Schering Pharma Ag Neue Quinazoline als Kinase-Inhibitoren
WO2010020052A1 (en) * 2008-08-21 2010-02-25 Edouard Kouassi Methods and compounds for increasing red blood cell survival

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1202370B (it) * 1976-07-12 1989-02-09 Hoffmann La Roche Soluzioni inietabili in cui l'atti vita' emolitica degli agenti di formazione di micelle naturali e' evitata mediante l'aggiunta di lipoidi e relativi prodotti
JPS5919525B2 (ja) * 1976-09-03 1984-05-07 武田薬品工業株式会社 注射剤
JPS6117512A (ja) * 1984-07-03 1986-01-25 Ss Pharmaceut Co Ltd 低溶血性ビタミンｅ注射液
JPS6336826A (ja) * 1986-07-30 1988-02-17 Shiseido Co Ltd 可溶化組成物
JPH03106812A (ja) * 1989-09-16 1991-05-07 Shiseido Co Ltd 注射剤用低刺激性組成物
JPH07173079A (ja) * 1992-12-22 1995-07-11 Nippon Oil & Fats Co Ltd 両親媒性ポリエチレングリコール誘導体および用途
JP3534199B2 (ja) * 1993-11-10 2004-06-07 株式会社薬研 界面活性剤組成物
IL112134A (en) * 1993-12-29 1999-12-22 Merck Sharp & Dohme Substituted morpholine derivatives their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DE69516311T2 (de) 2000-11-09
DE69516311D1 (de) 2000-05-18
EP0799026A1 (en) 1997-10-08
GB9426104D0 (en) 1995-02-22
AU714121B2 (en) 1999-12-16
EP0799026B1 (en) 2000-04-12
AU4185996A (en) 1996-07-19
ATE191645T1 (de) 2000-04-15
JPH10511382A (ja) 1998-11-04
US5880123A (en) 1999-03-09
WO1996019970A1 (en) 1996-07-04

Similar Documents

Publication Publication Date Title
ES2160631T3 (es) Composiciones de retinoides para aplicacion topica.
ES2115733T3 (es) Composicion antialergica para uso oftalmico o nasal.
ES2196160T3 (es) Uso de una combinacion de tensioactivos, agentes quelantes y aceites esenciales para desinfeccion efectiva.
DE3785054D1 (de) Stabile emulsionen von stark fluorierten, organischen verbindungen.
ES2172024T3 (es) Composicion para el tratamiento del cabello que contiene un complejo de aminoacido-metal.
BR9711832A (pt) Composições lìquidas para a limpeza pessoal que contêm óleos e tensoativos sintéticos
ES2093219T3 (es) Composiciones detergentes que comprenden tensioactivos glicolipidos no ionicos.
ES2153686T3 (es) Composiciones liquidas de limpieza para multiples usos en microemulsion.
MX9204734A (es) Composiciones detergentes para superficies duras.
ES2113521T3 (es) Composiciones estables que contienen sales de persulfato.
DK0695171T3 (da) Lyosfærer indeholdende gonadotropin
AR023158A1 (es) Composiciones desodorantes liquidas para todo proposito
ES2102424T3 (es) Composicion de eliminacion de tapones queratosicos.
ES2179103T3 (es) Composicion detergente.
ES2086771T3 (es) Composicion dermatologica y/o cosmetologica que contiene retinoides.
ES2180540T3 (es) Composicion antitranspirante en aerosol de alta eficacia.
ES2144648T3 (es) Prevencion de la hemolisis mediante agentes tensioactivos.
MX9303412A (es) Composiciones controladoras de espuma.
ES2051461T3 (es) Medios de contraste.
CO4920180A1 (es) Composiciones liquidas que constan de agentes tensoactivos que mejoran la estabilidad y un metodo para mejorar la es- tabilidad a baja temperatura
DK0799035T3 (da) Emulsion egnet til indgivelse af et sphingolipid og anvendelse deraf
ES2076320T3 (es) Adyuvante angiografico.
MX170928B (es) Composicion limpiadora para superficies duras
MX166414B (es) Composiciones de champu
ES2107195T3 (es) Agentes para la limpieza de suelos.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 799026

Country of ref document: ES