ATE191922T1 - Feststellung der wechselwirkungsstelle zwischen p21-waf und pcna und deren therapeutischen verwendungen - Google Patents
Feststellung der wechselwirkungsstelle zwischen p21-waf und pcna und deren therapeutischen verwendungenInfo
- Publication number
- ATE191922T1 ATE191922T1 AT95936023T AT95936023T ATE191922T1 AT E191922 T1 ATE191922 T1 AT E191922T1 AT 95936023 T AT95936023 T AT 95936023T AT 95936023 T AT95936023 T AT 95936023T AT E191922 T1 ATE191922 T1 AT E191922T1
- Authority
- AT
- Austria
- Prior art keywords
- pcna
- binding
- substances
- waf
- determination
- Prior art date
Links
- 108050006400 Cyclin Proteins 0.000 title abstract 7
- 102000009339 Proliferating Cell Nuclear Antigen Human genes 0.000 title abstract 7
- 230000003993 interaction Effects 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 230000027455 binding Effects 0.000 abstract 5
- 239000000126 substance Substances 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 238000012216 screening Methods 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 238000001086 yeast two-hybrid system Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Computational Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9422175A GB9422175D0 (en) | 1994-11-03 | 1994-11-03 | Indentification of the p21 waf1-pcna interaction site and therapeutic applications thereof |
| PCT/GB1995/002583 WO1996014334A1 (en) | 1994-11-03 | 1995-11-03 | IDENTIFICATION OF THE p21WAF1-PCNA INTERACTION SITE AND THERAPEUTIC APPLICATIONS THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE191922T1 true ATE191922T1 (de) | 2000-05-15 |
Family
ID=10763826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95936023T ATE191922T1 (de) | 1994-11-03 | 1995-11-03 | Feststellung der wechselwirkungsstelle zwischen p21-waf und pcna und deren therapeutischen verwendungen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6242201B1 (de) |
| EP (1) | EP0789711B1 (de) |
| JP (1) | JPH10509312A (de) |
| AT (1) | ATE191922T1 (de) |
| CA (1) | CA2203909A1 (de) |
| DE (1) | DE69516416T2 (de) |
| GB (1) | GB9422175D0 (de) |
| WO (1) | WO1996014334A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE283355T1 (de) * | 1994-05-24 | 2004-12-15 | Baylor College Medicine | Mimetika von aus alternden zellen abgeleitete hemmer der dna synthese |
| GB9509557D0 (en) | 1995-05-11 | 1995-07-05 | Univ Dundee | PCNA binding substance |
| DE69736351T4 (de) | 1996-05-08 | 2009-07-23 | Cyclacel Ltd. | Methoden und mittel zur hemmung der cdk4-aktivität |
| SE520392C2 (sv) | 1996-09-27 | 2003-07-01 | Creative Peptides Sweden Ab C | Specifika peptider för behandling av diabetes mellitus |
| FR2754822B1 (fr) * | 1996-10-18 | 1998-11-27 | Rhone Poulenc Rorer Sa | Polypeptides comprenant des domaines de la proteine gax, impliques dans la repression de transcription et/ou interagissant avec d'autres proteines, acides nucleiques correspondants et leurs utilisations |
| ATE374369T1 (de) | 1997-03-14 | 2007-10-15 | Crusade Lab Ltd | Verfahren zur erkennung von regulatoren des zellzyklus |
| US6489305B1 (en) * | 1998-05-08 | 2002-12-03 | Canji, Inc. | Methods and compositions for the treatment of ocular diseases |
| EP0974649A1 (de) * | 1998-06-22 | 2000-01-26 | Universität Zürich | Screening-System |
| EP1204099B1 (de) * | 1999-05-21 | 2003-11-05 | Matsushita Electric Industrial Co., Ltd. | Disque optique enregistrable |
| US7449544B2 (en) | 1999-11-30 | 2008-11-11 | Cyclacel Limited | p21 peptides |
| GB9928323D0 (en) * | 1999-11-30 | 2000-01-26 | Cyclacel Ltd | Peptides |
| GB0012528D0 (en) * | 2000-05-23 | 2000-07-12 | Univ Palackeho | Triterpenoid derivatives |
| US7259232B1 (en) * | 2000-10-27 | 2007-08-21 | Nymox Pharmaceutical Corporation | Preferred segments of neural thread protein |
| WO2003016491A2 (en) * | 2001-08-15 | 2003-02-27 | The Regents Of The University Of California | Retrovirus isolated from mantle histiocytes in mantle cell lymphoma |
| EP1687331A1 (de) * | 2003-10-20 | 2006-08-09 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Tyrosinphosphorylierung von cdk-inhibitorproteinen der cip/kip-familie |
| NZ546983A (en) * | 2003-11-24 | 2009-05-31 | Canji Inc | Reduction of dermal scarring |
| GB0410498D0 (en) * | 2004-05-11 | 2004-06-16 | Cyclacel Ltd | Crystal |
| PL1799230T3 (pl) | 2004-08-27 | 2013-05-31 | Cyclacel Ltd | Purynowe i pirymidynowe inhibitory CDK i ich zastosowanie do leczenia chorób autoimmunologicznych |
| GB0803352D0 (en) | 2008-02-22 | 2008-04-02 | Ntnu Technology Transfer As | Oligopeptidic compounds and uses thereof |
| WO2011104309A1 (en) * | 2010-02-24 | 2011-09-01 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Compounds for the treatment of inflammation and neutropenia |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2662698A1 (fr) | 1990-06-05 | 1991-12-06 | Centre Nat Rech Scient | Nouveaux facteurs de croissance neurotropes comprenant un peptide homeoboite. |
| US5596079A (en) | 1991-12-16 | 1997-01-21 | Smith; James R. | Mimetics of senescent cell derived inhibitors of DNA synthesis |
| US5302706A (en) | 1991-12-16 | 1994-04-12 | Baylor College Of Medicine | Senescent cell derived inhibitors of DNA synthesis |
| EP0665886B1 (de) | 1992-10-16 | 2003-06-11 | Cold Spring Harbor Laboratory | Umlagerung des cyclin komlexes und seine darauf bezogenen anwendungen |
| EP0723402B1 (de) | 1993-08-30 | 2010-08-18 | Baylor College Of Medicine | Inhibitoren der dna synthese aus alternden zellen |
| WO1995013375A1 (en) | 1993-11-10 | 1995-05-18 | The Johns Hopkins University | Tumor suppressor waf1 |
| ATE283355T1 (de) | 1994-05-24 | 2004-12-15 | Baylor College Medicine | Mimetika von aus alternden zellen abgeleitete hemmer der dna synthese |
| WO1997003681A1 (en) | 1995-07-20 | 1997-02-06 | Worcester Foundation For Biomedical Research, Inc. | Methods for selectively killing or inhibiting the growth of cells expressing the waf1 gene |
-
1994
- 1994-11-03 GB GB9422175A patent/GB9422175D0/en active Pending
-
1995
- 1995-11-03 WO PCT/GB1995/002583 patent/WO1996014334A1/en not_active Ceased
- 1995-11-03 EP EP95936023A patent/EP0789711B1/de not_active Expired - Lifetime
- 1995-11-03 DE DE69516416T patent/DE69516416T2/de not_active Expired - Fee Related
- 1995-11-03 US US08/817,895 patent/US6242201B1/en not_active Expired - Fee Related
- 1995-11-03 AT AT95936023T patent/ATE191922T1/de not_active IP Right Cessation
- 1995-11-03 CA CA002203909A patent/CA2203909A1/en not_active Abandoned
- 1995-11-03 JP JP8515137A patent/JPH10509312A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2203909A1 (en) | 1996-05-17 |
| AU3811395A (en) | 1996-05-31 |
| EP0789711A1 (de) | 1997-08-20 |
| JPH10509312A (ja) | 1998-09-14 |
| US6242201B1 (en) | 2001-06-05 |
| DE69516416D1 (de) | 2000-05-25 |
| DE69516416T2 (de) | 2000-10-26 |
| EP0789711B1 (de) | 2000-04-19 |
| WO1996014334A1 (en) | 1996-05-17 |
| AU694574B2 (en) | 1998-07-23 |
| GB9422175D0 (en) | 1994-12-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |