ATE333465T1 - Methoden und mittel zur hemmung der cdk4- aktivität - Google Patents
Methoden und mittel zur hemmung der cdk4- aktivitätInfo
- Publication number
- ATE333465T1 ATE333465T1 AT97920857T AT97920857T ATE333465T1 AT E333465 T1 ATE333465 T1 AT E333465T1 AT 97920857 T AT97920857 T AT 97920857T AT 97920857 T AT97920857 T AT 97920857T AT E333465 T1 ATE333465 T1 AT E333465T1
- Authority
- AT
- Austria
- Prior art keywords
- cdk4
- activity
- methods
- sup
- cdk4 activity
- Prior art date
Links
- 102000013701 Cyclin-Dependent Kinase 4 Human genes 0.000 title abstract 5
- 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 title abstract 5
- 230000000694 effects Effects 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000006311 Cyclin D1 Human genes 0.000 abstract 1
- 108010058546 Cyclin D1 Proteins 0.000 abstract 1
- 102100033270 Cyclin-dependent kinase inhibitor 1 Human genes 0.000 abstract 1
- 101000944380 Homo sapiens Cyclin-dependent kinase inhibitor 1 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000007079 Peptide Fragments Human genes 0.000 abstract 1
- 108010033276 Peptide Fragments Proteins 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 125000001151 peptidyl group Chemical group 0.000 abstract 1
- 230000026731 phosphorylation Effects 0.000 abstract 1
- 238000006366 phosphorylation reaction Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9609521.1A GB9609521D0 (en) | 1996-05-08 | 1996-05-08 | Substances and their therapeutic use |
| GBGB9621314.5A GB9621314D0 (en) | 1996-10-09 | 1996-10-09 | Substances and their therapeutic use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE333465T1 true ATE333465T1 (de) | 2006-08-15 |
Family
ID=26309279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97920857T ATE333465T1 (de) | 1996-05-08 | 1997-05-08 | Methoden und mittel zur hemmung der cdk4- aktivität |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US6962792B1 (de) |
| EP (1) | EP0898580B9 (de) |
| JP (1) | JP4205165B2 (de) |
| AT (1) | ATE333465T1 (de) |
| AU (1) | AU2707797A (de) |
| DE (2) | DE69736351T4 (de) |
| WO (1) | WO1997042222A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69736351T4 (de) | 1996-05-08 | 2009-07-23 | Cyclacel Ltd. | Methoden und mittel zur hemmung der cdk4-aktivität |
| GB9727277D0 (en) * | 1997-12-23 | 1998-02-25 | Medical Res Council | Assay |
| CA2321480A1 (en) * | 1998-02-18 | 1999-08-26 | Laurence Anthony Seabra | Treating cancer |
| EP1338652A3 (de) * | 1998-03-23 | 2004-05-19 | E.I.Du pont de nemours and company | Pflanzenzelle Cyclin Gene |
| AU3103599A (en) * | 1998-03-23 | 1999-10-18 | E.I. Du Pont De Nemours And Company | Plant cell cyclin genes |
| AU762006B2 (en) * | 1998-12-24 | 2003-06-19 | Ucb | Peptidic product, process and composition |
| AU4203300A (en) * | 1999-04-07 | 2000-10-23 | E.I. Du Pont De Nemours And Company | Cell cycle genes in plants |
| GB2369823B (en) * | 1999-11-30 | 2003-06-04 | Cyclacel Ltd | Assays for cyclin-interacting compounds |
| GB9928323D0 (en) * | 1999-11-30 | 2000-01-26 | Cyclacel Ltd | Peptides |
| US7449544B2 (en) | 1999-11-30 | 2008-11-11 | Cyclacel Limited | p21 peptides |
| US20050153894A1 (en) * | 1999-11-30 | 2005-07-14 | Cyclacel Limited | p21 peptides |
| GB0012528D0 (en) * | 2000-05-23 | 2000-07-12 | Univ Palackeho | Triterpenoid derivatives |
| GB0030378D0 (en) | 2000-12-13 | 2001-01-24 | Cyclacel Ltd | Compound |
| CA2494236A1 (en) * | 2002-08-07 | 2004-02-19 | Exelixis, Inc. | Csnk1gs as modifiers of the p21 pathway and methods of use |
| GB0229151D0 (en) | 2002-12-13 | 2003-01-15 | St Georges Entpr Ltd | Product and method |
| EP1687331A1 (de) * | 2003-10-20 | 2006-08-09 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Tyrosinphosphorylierung von cdk-inhibitorproteinen der cip/kip-familie |
| CA2542880A1 (en) * | 2003-10-21 | 2005-05-12 | Cyclacel Limited | Pyrimidin-4-yl-3, 4-thione compounds and their use in therapy |
| GB0402653D0 (en) * | 2004-02-06 | 2004-03-10 | Cyclacel Ltd | Compounds |
| GB0411791D0 (en) * | 2004-05-26 | 2004-06-30 | Cyclacel Ltd | Compounds |
| PL1799230T3 (pl) | 2004-08-27 | 2013-05-31 | Cyclacel Ltd | Purynowe i pirymidynowe inhibitory CDK i ich zastosowanie do leczenia chorób autoimmunologicznych |
| EP1909811B1 (de) * | 2005-06-29 | 2012-02-01 | St. George's Enterprises Limited | Hox peptide als pbx-modulatoren zur behandlung von krebs |
| WO2009070650A1 (en) * | 2007-11-26 | 2009-06-04 | The Research Foundation Of State University Of New York | Small molecule cancer treatments that cause necrosis in cancer cells but do not affect normal cells |
| US9040046B2 (en) | 2011-01-31 | 2015-05-26 | Kai Xu | Sodium pump antibody agonists and methods of treating heart disease using the same |
| WO2019195851A1 (en) | 2018-04-06 | 2019-10-10 | Oncolyze, Inc. | Compositions for use in lysis of selective cancer cells |
| ES3004338T3 (en) | 2018-09-10 | 2025-03-12 | Mirati Therapeutics Inc | Combination therapies |
| CN118324906A (zh) * | 2024-06-14 | 2024-07-12 | 上海交通大学医学院附属上海儿童医学中心 | p21特异性修饰的抗体及制备方法和应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2759164A1 (de) | 1977-12-31 | 1979-07-12 | Basf Ag | Photopolymerisierbare ueberzugs- und aufzeichnungsmaterialien, enthaltend einen photoinitiator und eine organische halogenverbindung |
| US5229018A (en) | 1986-02-24 | 1993-07-20 | Forrest Gabriel T | Completion and workover fluid for oil and gas wells comprising ground peanut hulls |
| FR2662698A1 (fr) * | 1990-06-05 | 1991-12-06 | Centre Nat Rech Scient | Nouveaux facteurs de croissance neurotropes comprenant un peptide homeoboite. |
| US5596079A (en) | 1991-12-16 | 1997-01-21 | Smith; James R. | Mimetics of senescent cell derived inhibitors of DNA synthesis |
| US5302706A (en) | 1991-12-16 | 1994-04-12 | Baylor College Of Medicine | Senescent cell derived inhibitors of DNA synthesis |
| EP0665886B1 (de) | 1992-10-16 | 2003-06-11 | Cold Spring Harbor Laboratory | Umlagerung des cyclin komlexes und seine darauf bezogenen anwendungen |
| GB9305448D0 (en) | 1993-03-17 | 1993-05-05 | British Tech Group | Semiconductor structure and method of manufacturing same |
| EP0723402B1 (de) | 1993-08-30 | 2010-08-18 | Baylor College Of Medicine | Inhibitoren der dna synthese aus alternden zellen |
| WO1995013375A1 (en) | 1993-11-10 | 1995-05-18 | The Johns Hopkins University | Tumor suppressor waf1 |
| ATE283355T1 (de) | 1994-05-24 | 2004-12-15 | Baylor College Medicine | Mimetika von aus alternden zellen abgeleitete hemmer der dna synthese |
| GB9422175D0 (en) | 1994-11-03 | 1994-12-21 | Univ Dundee | Indentification of the p21 waf1-pcna interaction site and therapeutic applications thereof |
| GB9509557D0 (en) | 1995-05-11 | 1995-07-05 | Univ Dundee | PCNA binding substance |
| WO1997003681A1 (en) | 1995-07-20 | 1997-02-06 | Worcester Foundation For Biomedical Research, Inc. | Methods for selectively killing or inhibiting the growth of cells expressing the waf1 gene |
| US5672508A (en) | 1996-01-23 | 1997-09-30 | Mitotix, Inc. | Inhibitors of cell-cycle progression, and uses related thereto |
| DE69736351T4 (de) | 1996-05-08 | 2009-07-23 | Cyclacel Ltd. | Methoden und mittel zur hemmung der cdk4-aktivität |
-
1997
- 1997-05-08 DE DE69736351T patent/DE69736351T4/de not_active Expired - Lifetime
- 1997-05-08 DE DE69736351A patent/DE69736351D1/de not_active Expired - Fee Related
- 1997-05-08 JP JP52963597A patent/JP4205165B2/ja not_active Expired - Fee Related
- 1997-05-08 US US09/180,269 patent/US6962792B1/en not_active Expired - Fee Related
- 1997-05-08 EP EP97920857A patent/EP0898580B9/de not_active Expired - Lifetime
- 1997-05-08 AU AU27077/97A patent/AU2707797A/en not_active Abandoned
- 1997-05-08 WO PCT/GB1997/001250 patent/WO1997042222A1/en not_active Ceased
- 1997-05-08 AT AT97920857T patent/ATE333465T1/de not_active IP Right Cessation
-
2003
- 2003-08-22 US US10/646,267 patent/US20040214765A1/en not_active Abandoned
-
2008
- 2008-06-04 US US12/133,242 patent/US20080249025A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP0898580B9 (de) | 2009-08-12 |
| DE69736351T2 (de) | 2007-07-12 |
| EP0898580B1 (de) | 2006-07-19 |
| WO1997042222A1 (en) | 1997-11-13 |
| EP0898580A1 (de) | 1999-03-03 |
| US6962792B1 (en) | 2005-11-08 |
| DE69736351D1 (de) | 2006-08-31 |
| AU2707797A (en) | 1997-11-26 |
| EP0898580B3 (de) | 2008-10-29 |
| DE69736351T4 (de) | 2009-07-23 |
| US20080249025A1 (en) | 2008-10-09 |
| JP4205165B2 (ja) | 2009-01-07 |
| JP2000513805A (ja) | 2000-10-17 |
| US20040214765A1 (en) | 2004-10-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69736351D1 (de) | Methoden und mittel zur hemmung der cdk4-aktivität | |
| EP1322307A4 (de) | Verfahren zur behandlung von zellproliferationen störungen und virusinfektionen | |
| TR199902053T2 (xx) | Prostat kanserinin immunoterapisine y�nelik bile�ikler ve bunlar�n kullan�lmas�na matuf metodlar. | |
| DK0961780T3 (da) | Proteinmarkörer for lungecancer og anvendelse deraf | |
| ATE286053T1 (de) | Naphthyridinone zur hemmung der durch protein- tyrosin-kinase und zellzyklus kinase hervorgerufenen zellvermehrung | |
| JO2373B1 (en) | W-carboxy-aryl diphenyl urease substitutes used as RAV inhibitors | |
| TR199901971T2 (xx) | Bir resept�re ba�lanan peptidler ve bile�ikler. | |
| ATE354588T1 (de) | Verfahren und zusammestellungen zum nachweis und behandlung von brustkrebs, beruhend auf brustkrebs-assoziierten polypeptiden | |
| AU2003209636A1 (en) | Novel chemokine binding peptides capable of modulating the biological activity of chemokines | |
| WO2003029418A3 (en) | Proliferation and differentiation of stem cells using extracellular matrix and other molecules | |
| ATE552270T1 (de) | Wechselwirkung zwischen dem von hippel-lindau tumorsuppressor und hypoxia inducible factor, sowie diesbezügliche testverfahren | |
| EP2261667A3 (de) | Nucleinsäuremoleküle und Proteine zur Identifizierung, Beurteilung, Vorbeugung und Therapie von Eierstockkrebs | |
| WO2003000012A3 (en) | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast and ovarian cancer | |
| DK1192247T3 (da) | Sphingosinkinaseenzym | |
| WO2004005481A3 (en) | Methods for identifying modulators of mda-7 mediated apoptosis | |
| WO2004069200A3 (en) | Specific inhibitors of nfat activation by calcineurin and their use in treating immune-related diseases | |
| MA27880A1 (fr) | Derives de tetrahydrocarbazole et leur utilisation pharmaceutique | |
| DE69940980D1 (de) | Rana pipiens proteine und deren verwendung in der behandlung von tumoren | |
| PT862622E (pt) | Metodo de rastreio para compostos que interagem com proteina cinase rac | |
| MXPA04001720A (es) | Acido nucleicos bv8 y polipeptidos con actividad mitogenica. | |
| IL149416A0 (en) | Human enzymes of the metalloprotease family | |
| EP1887082A3 (de) | TADG-15: Eine extrazelluläre Serinprotease die in Karzinomen überexprimiert wird | |
| AU7525398A (en) | Inhibitors for urokinase receptor | |
| Nikolaev et al. | PARC: a potential target for cancer therapy | |
| ATE362768T1 (de) | Prb2/p130 peptidinhibitoren der cdk2 kinaseaktivität |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0898580 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee | ||
| UEP | Publication of translation of european patent specification |
Ref document number: 0898580 Country of ref document: EP |