ATE191923T1 - Interleukine-6 mutante mit verbesserter biologischer aktivität im vergleich zu wildtyp il-6 - Google Patents

Interleukine-6 mutante mit verbesserter biologischer aktivität im vergleich zu wildtyp il-6

Info

Publication number: ATE191923T1
Authority: AT; Austria
Prior art keywords: wild; mutant; type; biological activity; interleukine
Prior art date: 1992-11-06

Application number

AT94900984T

Other languages

English (en)

Inventor

Gennaro Ciliberto

Rocco Savino

Original Assignee

Angeletti P Ist Richerche Bio

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-11-06

Filing date

1993-11-02

Publication date

2000-05-15

1993-11-02 Application filed by Angeletti P Ist Richerche Bio filed Critical Angeletti P Ist Richerche Bio

2000-05-15 Application granted granted Critical

2000-05-15 Publication of ATE191923T1 publication Critical patent/ATE191923T1/de

Links

108090001005 Interleukin-6 Proteins 0.000 title abstract 5
230000004071 biological effect Effects 0.000 title abstract 2
102000004889 Interleukin-6 Human genes 0.000 abstract 4
229940100601 interleukin-6 Drugs 0.000 abstract 4
239000004475 Arginine Substances 0.000 abstract 2
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 2
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5412—IL-6
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
- Y10S930/141—Interleukin
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
- Y10S930/142—Interferon

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)

AT94900984T 1992-11-06 1993-11-02 Interleukine-6 mutante mit verbesserter biologischer aktivität im vergleich zu wildtyp il-6 ATE191923T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ITRM920809A IT1263022B (it)	1992-11-06	1992-11-06	Interleuchina-6 mutante con attivita' biologica migliorata rispetto all'interleuchina-6 selvatica.
PCT/IT1993/000114 WO1994011402A1 (en)	1992-11-06	1993-11-02	Mutant interleukin 6 with improved biological activity over wild interleukin 6

Publications (1)

Publication Number	Publication Date
ATE191923T1 true ATE191923T1 (de)	2000-05-15

Family

ID=11401276

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94900984T ATE191923T1 (de)	1992-11-06	1993-11-02	Interleukine-6 mutante mit verbesserter biologischer aktivität im vergleich zu wildtyp il-6

Country Status (12)

Country	Link
US (1)	US5681723A (de)
EP (1)	EP0667872B1 (de)
JP (1)	JP2515491B2 (de)
AT (1)	ATE191923T1 (de)
CA (1)	CA2129824C (de)
DE (1)	DE69328437T2 (de)
DK (1)	DK0667872T3 (de)
ES (1)	ES2145819T3 (de)
GR (1)	GR3033685T3 (de)
IT (1)	IT1263022B (de)
PT (1)	PT667872E (de)
WO (1)	WO1994011402A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1274782B (it) *	1994-12-14	1997-07-24	Angeletti P Ist Richerche Bio	Metodo per selezionare superagonisti, antagonisti e superantagonisti di ormoni del cui complesso recettoriale fa parte gp 130
IT1277926B1 (it) *	1995-09-01	1997-11-12	Angeletti P Ist Richerche Bio	Uso di muteine di citochine naturali come immunogeni per la preparazione di composizioni farmaceutiche per curare o prevenire
WO1997010338A1 (en) *	1995-09-12	1997-03-20	Chiron Corporation	Improved interleukin-6 receptor antagonist
WO2001016166A2 (en) *	1999-08-27	2001-03-08	The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Polypeptides, comprising il-6 ligand-binding receptor domains, and related nucleic acids, antibodies, compositions, and methods of use
IL161673A0 (en)	2004-04-29	2004-09-27	Applied Research Systems	Compositions and methods for therapy of chemotherapy-induced neuropathy
US9751942B2 (en)	2012-03-29	2017-09-05	Chugai Seiyaku Kabushiki Kaisha	Anti-LAMP5 antibody and utilization thereof
CN113698467A (zh) *	2020-05-19	2021-11-26	甘李药业股份有限公司	Il-6变体及其用途
US20240269236A1 (en)	2021-06-04	2024-08-15	Sonnet BioTherapeutics, Inc.	Methods of treating age-related frailty with interleukin-6

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUT52962A (en) *	1988-03-04	1990-09-28	Sandoz Ag	Process for production of medical compositions eliminating bone-absorption and promoting forming of bones
US5210075A (en) *	1990-02-16	1993-05-11	Tanabe Seiyaku Co., Ltd.	Interleukin 6 antagonist peptides

1992
- 1992-11-06 IT ITRM920809A patent/IT1263022B/it active IP Right Grant
1993
- 1993-11-02 JP JP6511903A patent/JP2515491B2/ja not_active Expired - Fee Related
- 1993-11-02 PT PT94900984T patent/PT667872E/pt unknown
- 1993-11-02 DE DE69328437T patent/DE69328437T2/de not_active Expired - Fee Related
- 1993-11-02 DK DK94900984T patent/DK0667872T3/da active
- 1993-11-02 AT AT94900984T patent/ATE191923T1/de not_active IP Right Cessation
- 1993-11-02 WO PCT/IT1993/000114 patent/WO1994011402A1/en not_active Ceased
- 1993-11-02 ES ES94900984T patent/ES2145819T3/es not_active Expired - Lifetime
- 1993-11-02 CA CA002129824A patent/CA2129824C/en not_active Expired - Fee Related
- 1993-11-02 EP EP94900984A patent/EP0667872B1/de not_active Expired - Lifetime
1995
- 1995-05-05 US US08/437,680 patent/US5681723A/en not_active Expired - Fee Related
2000
- 2000-06-14 GR GR20000401372T patent/GR3033685T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
JPH07501947A (ja)	1995-03-02
EP0667872A1 (de)	1995-08-23
PT667872E (pt)	2000-08-31
ITRM920809A1 (it)	1994-05-06
GR3033685T3 (en)	2000-10-31
ES2145819T3 (es)	2000-07-16
DE69328437D1 (de)	2000-05-25
EP0667872B1 (de)	2000-04-19
JP2515491B2 (ja)	1996-07-10
WO1994011402A1 (en)	1994-05-26
DE69328437T2 (de)	2000-11-02
CA2129824C (en)	1997-03-04
DK0667872T3 (da)	2000-09-18
CA2129824A1 (en)	1994-05-26
US5681723A (en)	1997-10-28
ITRM920809A0 (it)	1992-11-06
IT1263022B (it)	1996-07-23

Legal Events

Date	Code	Title	Description
2000-10-15	UEP	Publication of translation of european patent specification
2008-08-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ES2162132T3 (es)	2001-12-16	Polimerasa de adn termoestable procedente de thermoanaerobacter thermohydrosulfuricus y enzimas mutantes, de actividad exonucleasa suprimida asi obtenidos.
DE69635452D1 (de)	2005-12-22	Hohe expressionsrate des grün-fluoreszierenden proteins
DE69112207D1 (en)	1995-09-21	"walk-through"-mutagenese.
ATE335078T1 (de)	2006-08-15	Überexpression von säugetier- und virusproteinen
MY102806A (en)	1992-11-30	Human interleukin-3 and muteins thereof
ATE63749T1 (de)	1991-06-15	Synthetisches peptid mit menschlicher interleukin 1-wirksamkeit.
DE69941701D1 (de)	2010-01-07	Mutanten von flt3-l und ihre verwendungen
DE69534468D1 (de)	2006-02-02	Wachstums-differenzierungsfaktor-11
SE8804570L (sv)	1989-06-22	Ciclosporinkristallform, foerfarande foer dess framstaellning, farmaceutiska kompositioner innehaallande densamma samt dess anvaendning
DE69328437D1 (de)	2000-05-25	Interleukine-6 Mutante mit verbesserter biologischer Aktivität im vergleich zu wildtyp IL-6
DK0592566T3 (da)	1999-12-13	IL-6-muteiner med reduceret cysteinantal
DK1200561T3 (da)	2006-10-16	Rekombinant stabil celleklon, dens fremstilling og anvendelse
ATE264913T1 (de)	2004-05-15	Protease-resistente analoge des thrombomodulin
SE9201966D0 (sv)	1992-06-25	Interleukin-1beta deletion mutant
DE59410132D1 (de)	2002-07-11	Humanes zirkulierendes cytokin cc-1
DE58908428D1 (de)	1994-11-03	Sekretormutante von Escherichia coli.
AU2415599A (en)	1999-07-19	Rantes mutants and therapeutic applications thereof
ATE209252T1 (de)	2001-12-15	Rekombinante d-hydantoinase, verfahren zur herstellung und verwendung
EP0330700A4 (de)	1990-01-08	Menschlicher Prourokinase ähnliches Polypeptid.
MY104405A (en)	1994-03-31	Structural gene comprising dna coding for an endotoxin protein having toxic activity against insects.
ATE25708T1 (de)	1987-03-15	Biologisch aktive konjugate, ihre herstellung und ihre anwendung.
DK0757994T3 (da)	2004-01-19	TCF-mutanter
ATE103979T1 (de)	1994-04-15	Menschliches lymphotoxin.
KR920703636A (ko)	1992-12-18	온코스타틴 m 활성을 가진 신규한 단백질과 그 제조과정
Biedermann et al.	1990	Homogeneity analysis of a nuclease secreted by E. coli.