ES2145819T3 - Interleucina 6 mutante de actividad biologica mejorada con relacion a la de la interleucina 6 salvaje. - Google Patents

Interleucina 6 mutante de actividad biologica mejorada con relacion a la de la interleucina 6 salvaje.

Info

Publication number
ES2145819T3
ES2145819T3 ES94900984T ES94900984T ES2145819T3 ES 2145819 T3 ES2145819 T3 ES 2145819T3 ES 94900984 T ES94900984 T ES 94900984T ES 94900984 T ES94900984 T ES 94900984T ES 2145819 T3 ES2145819 T3 ES 2145819T3
Authority
ES
Spain
Prior art keywords
interleukin
wild
mutant
biological activity
relation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94900984T
Other languages
English (en)
Inventor
Gennaro Ciliberto
Rocco Savino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto di Ricerche di Biologia Molecolare P Angeletti SpA
Original Assignee
Istituto di Ricerche di Biologia Molecolare P Angeletti SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto di Ricerche di Biologia Molecolare P Angeletti SpA filed Critical Istituto di Ricerche di Biologia Molecolare P Angeletti SpA
Application granted granted Critical
Publication of ES2145819T3 publication Critical patent/ES2145819T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/142—Interferon

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

INTERLEUQUINO 6 MUTANTE, CARACTERIZADO POR EL HECHO DE QUE TIENE EN LA POSICION 176, LA ARGININA DEL AMINOACIDO EN LUGAR DE LA SERINA DEL AMINOACIDO COMO EN EL INTERLEUQUINO 6 SILVESTRE, Y POR EL HECHO DE QUE MUESTRA MAYOR ACTIVIDAD BIOLOGICA QUE EL INTERLEUQUINO 6 SILVESTRE. LA FIGURA REPRESENTA EL CAMPO GENETICO DEL PLASMIDO PBKS IL-6 SER 176ARG QUE CONTIENE LA CODIFICACION DE SECUENCIA NUCLEOTIDA PARA EL INTERLEUQUINO 6 MUTANTE DE ACUERDO CON LA INVENCION, NO GLICOSILATADA. ESTE PLASMIDO HA SIDO ARCHIVADO EN E. COLI K12 POR EL NATIONAL COLLECTION OF INDUSTRIAL AND MARINE BACTERIA LTD. EL 02/11/1992 BAJO EL NUMERO DE ACCESO NCIMB 40526.
ES94900984T 1992-11-06 1993-11-02 Interleucina 6 mutante de actividad biologica mejorada con relacion a la de la interleucina 6 salvaje. Expired - Lifetime ES2145819T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM920809A IT1263022B (it) 1992-11-06 1992-11-06 Interleuchina-6 mutante con attivita' biologica migliorata rispetto all'interleuchina-6 selvatica.

Publications (1)

Publication Number Publication Date
ES2145819T3 true ES2145819T3 (es) 2000-07-16

Family

ID=11401276

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94900984T Expired - Lifetime ES2145819T3 (es) 1992-11-06 1993-11-02 Interleucina 6 mutante de actividad biologica mejorada con relacion a la de la interleucina 6 salvaje.

Country Status (12)

Country Link
US (1) US5681723A (es)
EP (1) EP0667872B1 (es)
JP (1) JP2515491B2 (es)
AT (1) ATE191923T1 (es)
CA (1) CA2129824C (es)
DE (1) DE69328437T2 (es)
DK (1) DK0667872T3 (es)
ES (1) ES2145819T3 (es)
GR (1) GR3033685T3 (es)
IT (1) IT1263022B (es)
PT (1) PT667872E (es)
WO (1) WO1994011402A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1274782B (it) * 1994-12-14 1997-07-24 Angeletti P Ist Richerche Bio Metodo per selezionare superagonisti, antagonisti e superantagonisti di ormoni del cui complesso recettoriale fa parte gp 130
IT1277926B1 (it) * 1995-09-01 1997-11-12 Angeletti P Ist Richerche Bio Uso di muteine di citochine naturali come immunogeni per la preparazione di composizioni farmaceutiche per curare o prevenire
AU6961796A (en) * 1995-09-12 1997-04-01 Chiron Corporation Improved interleukin-6 receptor antagonist
WO2001016166A2 (en) * 1999-08-27 2001-03-08 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Polypeptides, comprising il-6 ligand-binding receptor domains, and related nucleic acids, antibodies, compositions, and methods of use
IL161673A0 (en) 2004-04-29 2004-09-27 Applied Research Systems Compositions and methods for therapy of chemotherapy-induced neuropathy
JP6280031B2 (ja) 2012-03-29 2018-02-14 中外製薬株式会社 抗ｌａｍｐ５抗体およびその利用
CN113698467A (zh) * 2020-05-19 2021-11-26 甘李药业股份有限公司 Il-6变体及其用途
WO2022256688A1 (en) 2021-06-04 2022-12-08 Sonnet BioTherapeutics, Inc. Methods of treating age-related frailty with interleukin-6

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT52962A (en) * 1988-03-04 1990-09-28 Sandoz Ag Process for production of medical compositions eliminating bone-absorption and promoting forming of bones
US5210075A (en) * 1990-02-16 1993-05-11 Tanabe Seiyaku Co., Ltd. Interleukin 6 antagonist peptides

Also Published As

Publication number Publication date
WO1994011402A1 (en) 1994-05-26
JP2515491B2 (ja) 1996-07-10
JPH07501947A (ja) 1995-03-02
EP0667872A1 (en) 1995-08-23
PT667872E (pt) 2000-08-31
US5681723A (en) 1997-10-28
IT1263022B (it) 1996-07-23
CA2129824C (en) 1997-03-04
DK0667872T3 (da) 2000-09-18
DE69328437T2 (de) 2000-11-02
GR3033685T3 (en) 2000-10-31
EP0667872B1 (en) 2000-04-19
ITRM920809A0 (it) 1992-11-06
CA2129824A1 (en) 1994-05-26
ATE191923T1 (de) 2000-05-15
ITRM920809A1 (it) 1994-05-06
DE69328437D1 (de) 2000-05-25

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