ATE193302T1 - Glutathionanaloge und paraloge mischungen aus glutathion-ähnlichen substanzen - Google Patents

Glutathionanaloge und paraloge mischungen aus glutathion-ähnlichen substanzen

Info

Publication number
ATE193302T1
ATE193302T1 AT94929323T AT94929323T ATE193302T1 AT E193302 T1 ATE193302 T1 AT E193302T1 AT 94929323 T AT94929323 T AT 94929323T AT 94929323 T AT94929323 T AT 94929323T AT E193302 T1 ATE193302 T1 AT E193302T1
Authority
AT
Austria
Prior art keywords
glutathione
alanine
beta
ester
tumor cell
Prior art date
Application number
AT94929323T
Other languages
English (en)
Inventor
Lawrence M Kauvar
Matthew H Lyttle
Original Assignee
Telik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/126,229 external-priority patent/US5599903A/en
Application filed by Telik Inc filed Critical Telik Inc
Application granted granted Critical
Publication of ATE193302T1 publication Critical patent/ATE193302T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C12N9/1088—Glutathione transferase (2.5.1.18)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57595—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving intracellular compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/9116—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • G01N2333/91165—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5) general (2.5.1)
    • G01N2333/91171—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5) general (2.5.1) with definite EC number (2.5.1.-)
    • G01N2333/91177—Glutathione transferases (2.5.1.18)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT94929323T 1993-09-24 1994-09-23 Glutathionanaloge und paraloge mischungen aus glutathion-ähnlichen substanzen ATE193302T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/126,229 US5599903A (en) 1992-04-03 1993-09-24 Glutathione analogs and paralog panels comprising glutathione mimics
US08/305,993 US5786336A (en) 1991-04-29 1994-09-19 Target-selective protocols based on mimics
PCT/US1994/010797 WO1995008563A1 (en) 1993-09-24 1994-09-23 Glutathione analogs and paralog panels comprising glutathione mimics

Publications (1)

Publication Number Publication Date
ATE193302T1 true ATE193302T1 (de) 2000-06-15

Family

ID=26824416

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94929323T ATE193302T1 (de) 1993-09-24 1994-09-23 Glutathionanaloge und paraloge mischungen aus glutathion-ähnlichen substanzen

Country Status (12)

Country Link
US (1) US5786336A (de)
EP (1) EP0720620B1 (de)
JP (3) JP3503641B2 (de)
AT (1) ATE193302T1 (de)
AU (1) AU693807B2 (de)
CA (1) CA2171453C (de)
DE (1) DE69424678T2 (de)
DK (1) DK0720620T3 (de)
ES (1) ES2148348T3 (de)
GR (1) GR3033230T3 (de)
PT (1) PT720620E (de)
WO (1) WO1995008563A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599903A (en) * 1992-04-03 1997-02-04 Terrapin Technologies, Inc. Glutathione analogs and paralog panels comprising glutathione mimics
US5679643A (en) * 1987-10-13 1997-10-21 Terrapin Technologies, Inc. Glutathione analogs and paralog panels comprising glutathione mimics
US5955432A (en) * 1992-04-03 1999-09-21 Terrapin Technologies, Inc. Metabolic effects of certain glutathione analogs
US5908919A (en) * 1993-10-01 1999-06-01 Terrapin Technologies Urethane mediated, GST specific molecular release systems
CA2221568C (en) * 1995-06-07 2010-05-04 Terrapin Technologies, Inc. Metabolic effects of certain glutathione analogs
US5880097A (en) * 1996-01-04 1999-03-09 Terrapin Techologies, Inc. Tethered prodrugs
AU4124697A (en) * 1996-09-02 1998-03-26 Manchester Metropolitan University, The S-blocked glutathiones
WO1999037802A1 (en) * 1998-01-21 1999-07-29 Telik, Inc. Methods to identify myelostimulants
AU778340B2 (en) * 1999-01-27 2004-12-02 Telik, Inc. Therapeutic compositions containing glutathione analogs
US6783929B1 (en) * 1999-11-02 2004-08-31 Chiron Corporation Biological sample component purification and differential display
US7153682B2 (en) * 2000-06-05 2006-12-26 Chiron Corporation Microarrays on mirrored substrates for performing proteomic analyses
US7148058B2 (en) * 2000-06-05 2006-12-12 Chiron Corporation Protein microarrays on mirrored surfaces for performing proteomic analyses
US7029695B2 (en) 2001-07-10 2006-04-18 Telik, Inc. Therapeutic compositions containing glutathione analogs
US7172905B2 (en) 2001-08-07 2007-02-06 The University Of Chicago Polypeptide immobilization
US7683026B2 (en) * 2003-01-24 2010-03-23 L'oreal Method for synthesizing KPV tripeptide diamide derivatives
TWI317738B (en) * 2005-01-06 2009-12-01 Telik Inc Tripeptide and tetrapeptide thioethers
US20070154963A1 (en) * 2005-12-30 2007-07-05 Danying Cai Method to determine whether a compound is a cellular GSTpi inhibitor
EP1974739A1 (de) * 2007-03-21 2008-10-01 Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Verfahren und Verbindungen zur Modulation von Entzündungsprozessen
WO2009014177A1 (ja) * 2007-07-25 2009-01-29 Ajinomoto Co., Inc. ジベンゾフルベン誘導体の淘汰方法
CN102265160B (zh) * 2008-12-24 2014-07-23 学校法人庆应义塾 肝病标记物、其测定方法、装置和医药品的检验方法
US8759303B2 (en) 2010-06-07 2014-06-24 Telik, Inc. Compositions and methods for treating myelodysplastic syndrome
EP2576592A1 (de) 2010-06-07 2013-04-10 Telik, Inc. Zubereitung von kristallinem ezatiostat- hydrochlorid-ansolvat form d
US20110300215A1 (en) 2010-06-07 2011-12-08 Telik, Inc. Tablet formulation of ezatiostat
CA2797501A1 (en) * 2010-06-07 2011-12-15 Telik, Inc. Crystalline ezatiostat hydrochloride ansolvate
WO2012176282A1 (ja) 2011-06-21 2012-12-27 日東電工株式会社 アポトーシス誘導剤
JP6340162B2 (ja) 2012-12-20 2018-06-06 日東電工株式会社 アポトーシス誘導剤
EP3159009B1 (de) 2014-06-17 2021-10-27 Nitto Denko Corporation Inhibitoren von gst-pi und rp1cc1 zur behandlung von krebs
US10264976B2 (en) 2014-12-26 2019-04-23 The University Of Akron Biocompatible flavonoid compounds for organelle and cell imaging
EP4365289A3 (de) 2018-11-16 2024-07-10 Nitto Denko Corporation Rna-interferenz-freisetzungsformulierung und verfahren für maligne tumore
CN114126652A (zh) 2019-05-14 2022-03-01 学校法人庆应义塾 抗肿瘤剂和配合剂
CN111704566A (zh) * 2020-06-16 2020-09-25 吉尔生化（上海）有限公司 一种N-芴甲氧羰基-γ-（S-三苯甲基-半胱胺基）-L-谷氨酸的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4830624B1 (de) * 1969-06-19 1973-09-21
JPH07119760B2 (ja) * 1984-07-24 1995-12-20 コモンウエルス・セ−ラム・ラボラトリ−ズ・コミッション ミモトープを検出または決定する方法
HU201094B (en) * 1986-01-23 1990-09-28 Pfizer Process for producing immunostimulant acyltripeptides and pharmaceutical compositions comprising same as active ingredient
US4963263A (en) * 1988-03-24 1990-10-16 Terrapin Technologies, Inc. Method of identity analyte-binding peptides
US5133866A (en) * 1988-03-24 1992-07-28 Terrapin Technologies, Inc. Method to identify analyte-bending ligands
AU5435990A (en) * 1989-04-13 1990-11-05 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Monoclonal antibodies to human glutathione s transferase pi
DE69122831T2 (de) * 1990-04-26 1997-03-27 Senju Pharma Co S-(niedere fettsäuren)-substituierte glutathionderivate
ATE129019T1 (de) * 1990-05-07 1995-10-15 Dade Int Inc Verfahren und vorrichtung zur ausführung des zytotoxizitätsassays auf tumorzellen.
IT1248994B (it) * 1990-06-26 1995-02-11 Co Ri T S A S Di Buoso Maria & Processo per la preparazione di s-acil derivati di glutatione composti ottenuti da detto processo e intermedio utile per la loro preparazione
US5204241A (en) * 1990-10-22 1993-04-20 Oxi-Gene Inc. Glutathione-S-transferase mu as a measure of drug resistance
JPH06507549A (ja) * 1991-04-29 1994-09-01 テラピン　テクノロジーズ，インコーポレイテッド 異常細胞のプロフィール作成および治療方法
US5430045A (en) * 1992-04-23 1995-07-04 Free Radical Sciences, Inc. Method of reducing or preventing bone marrow hypoplasia

Also Published As

Publication number Publication date
CA2171453C (en) 2001-06-12
EP0720620A1 (de) 1996-07-10
CA2171453A1 (en) 1995-03-30
JP4025248B2 (ja) 2007-12-19
US5786336A (en) 1998-07-28
DE69424678T2 (de) 2000-09-07
GR3033230T3 (en) 2000-08-31
DE69424678D1 (de) 2000-06-29
ES2148348T3 (es) 2000-10-16
AU693807B2 (en) 1998-07-09
JP2004002442A (ja) 2004-01-08
DK0720620T3 (da) 2000-08-07
JP3503641B2 (ja) 2004-03-08
JP4099430B2 (ja) 2008-06-11
JP2004059586A (ja) 2004-02-26
PT720620E (pt) 2000-11-30
WO1995008563A1 (en) 1995-03-30
JPH09506336A (ja) 1997-06-24
EP0720620B1 (de) 2000-05-24
AU7842194A (en) 1995-04-10

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UEP Publication of translation of european patent specification