ATE466850T1 - Tocopherole, tocotrienole, sonstige chroman- und seitenkettenderivate, sowie deren verwendungen - Google Patents
Tocopherole, tocotrienole, sonstige chroman- und seitenkettenderivate, sowie deren verwendungenInfo
- Publication number
- ATE466850T1 ATE466850T1 AT99948352T AT99948352T ATE466850T1 AT E466850 T1 ATE466850 T1 AT E466850T1 AT 99948352 T AT99948352 T AT 99948352T AT 99948352 T AT99948352 T AT 99948352T AT E466850 T1 ATE466850 T1 AT E466850T1
- Authority
- AT
- Austria
- Prior art keywords
- benzyl
- saccharide
- amine
- carboxylic acid
- carboxamide
- Prior art date
Links
- GJJVAFUKOBZPCB-ZGRPYONQSA-N (r)-3,4-dihydro-2-methyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2h-1-benzopyran-6-ol Chemical class OC1=CC=C2OC(CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-ZGRPYONQSA-N 0.000 title 1
- QZHPTGXQGDFGEN-UHFFFAOYSA-N chromene Chemical compound C1=CC=C2C=C[CH]OC2=C1 QZHPTGXQGDFGEN-UHFFFAOYSA-N 0.000 title 1
- 229930003802 tocotrienol Natural products 0.000 title 1
- 239000011731 tocotrienol Substances 0.000 title 1
- 229940068778 tocotrienols Drugs 0.000 title 1
- 235000019148 tocotrienols Nutrition 0.000 title 1
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 abstract 9
- 150000001720 carbohydrates Chemical class 0.000 abstract 5
- 150000001412 amines Chemical class 0.000 abstract 4
- LSBDFXRDZJMBSC-UHFFFAOYSA-N 2-phenylacetamide Chemical compound NC(=O)CC1=CC=CC=C1 LSBDFXRDZJMBSC-UHFFFAOYSA-N 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- -1 benzylester Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000003857 carboxamides Chemical class 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000007942 carboxylates Chemical class 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 150000002170 ethers Chemical class 0.000 abstract 1
- AEOCXXJPGCBFJA-UHFFFAOYSA-N ethionamide Chemical compound CCC1=CC(C(N)=S)=CC=N1 AEOCXXJPGCBFJA-UHFFFAOYSA-N 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
- 150000007970 thio esters Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- AIDS & HIV (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10154298P | 1998-09-23 | 1998-09-23 | |
| PCT/US1999/021778 WO2000016772A1 (en) | 1998-09-23 | 1999-09-23 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE466850T1 true ATE466850T1 (de) | 2010-05-15 |
Family
ID=22285189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99948352T ATE466850T1 (de) | 1998-09-23 | 1999-09-23 | Tocopherole, tocotrienole, sonstige chroman- und seitenkettenderivate, sowie deren verwendungen |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6417223B1 (de) |
| EP (1) | EP1115398B1 (de) |
| JP (1) | JP2002526446A (de) |
| KR (1) | KR100712383B1 (de) |
| CN (2) | CN1195513C (de) |
| AT (1) | ATE466850T1 (de) |
| AU (1) | AU757013B2 (de) |
| CA (1) | CA2345079C (de) |
| DE (1) | DE69942342D1 (de) |
| DK (1) | DK1115398T3 (de) |
| IL (1) | IL142082A (de) |
| NZ (1) | NZ510732A (de) |
| RU (1) | RU2232758C2 (de) |
| TW (1) | TW592695B (de) |
| WO (1) | WO2000016772A1 (de) |
| ZA (1) | ZA200102057B (de) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6703384B2 (en) * | 1998-09-23 | 2004-03-09 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
| US6048891A (en) | 1998-12-17 | 2000-04-11 | Loma Linda University Medical Center | Use of γ-tocopherol and its oxidative metabolite LLU-α in the treatment of natriuretic disease |
| EP1241165A4 (de) * | 1999-12-13 | 2003-03-19 | Chugai Pharmaceutical Co Ltd | Optisch aktive chroman- und thiochromanderivate |
| KR20010055766A (ko) * | 1999-12-13 | 2001-07-04 | 이경하 | 3-메틸-크로만 또는 티오크로만 유도체의 금속염 |
| AU1888201A (en) * | 1999-12-13 | 2001-06-18 | Chugai Seiyaku Kabushiki Kaisha | 3-ethyl-, 3-propyl- or 3-butyl-chroman and -thiochroman derivatives |
| KR20010055765A (ko) * | 1999-12-13 | 2001-07-04 | 이경하 | 3-메틸-크로만 또는 티오크로만 유도체 |
| KR100847678B1 (ko) * | 2000-02-11 | 2008-07-23 | 리서치 디벨럽먼트 파운데이션 | 토코페롤, 토코트리에놀, 다른 크로만 및 측쇄 유도체, 및이들의 용도 |
| US7144919B1 (en) * | 2000-08-23 | 2006-12-05 | Youngdae Kim | Polyoxyethylene-polyoxypropylene vitamin E and process for preparation thereof |
| AUPR549901A0 (en) * | 2001-06-06 | 2001-07-12 | Vital Health Sciences Pty Ltd | Topical formulation containing tocopheryl phosphates |
| ATE444756T1 (de) * | 2000-11-14 | 2009-10-15 | Vital Health Sciences Pty Ltd | Zusammensetzungen umfassend komplexe von tocopherolphosphatderivaten |
| ES2250434T3 (es) * | 2001-07-02 | 2006-04-16 | Tas, Sinan | Utilizacion de ciclopamina en el tratamiento del carcinoma de celulas basales y de otros tumores. |
| WO2003011303A1 (en) * | 2001-07-27 | 2003-02-13 | Vital Health Sciences Pty Ltd | Dermal therapy using phosphate derivatives of electron transfer agents |
| JP2005505586A (ja) * | 2001-10-04 | 2005-02-24 | ワイス | ５−ヒドロキシトリプタミン−６リガンドとしてのクロマン誘導体 |
| CA2466536C (en) * | 2001-12-13 | 2012-02-07 | Vital Health Sciences Pty Ltd | Transdermal transport of compounds |
| US20030236301A1 (en) * | 2001-12-19 | 2003-12-25 | Bob Sanders | Liposomal delivery of vitamin E based compounds |
| EP1463487B1 (de) * | 2001-12-19 | 2010-05-19 | Research Development Foundation | Liposomale abgabe von verbindungen auf vitamin-e-basis |
| US20040034093A1 (en) * | 2002-05-30 | 2004-02-19 | Hensley Kenneth L. | Methods for enhancing motor performance and/or endurance |
| AU2002950713A0 (en) | 2002-08-09 | 2002-09-12 | Vital Health Sciences Pty Ltd | Carrier |
| AU2003900200A0 (en) * | 2003-01-17 | 2003-01-30 | Vital Health Sciences Pty Ltd | Compounds having antiproliferative properties |
| WO2004064831A1 (en) * | 2003-01-17 | 2004-08-05 | Vital Health Sciences Pty Ltd | Compounds having anti-proliferative properties |
| US6716873B1 (en) * | 2003-03-20 | 2004-04-06 | Yasoo Health Inc. | Tocopherol ester compounds |
| AU2003901815A0 (en) * | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Phosphate derivatives |
| ITTO20030140U1 (it) * | 2003-09-16 | 2005-03-17 | Interfila Srl | Matita cosmetica |
| WO2005033092A1 (en) | 2003-09-19 | 2005-04-14 | Galileo Pharmaceuticals, Inc. | Chroman derivatives |
| US20050080109A1 (en) * | 2003-10-09 | 2005-04-14 | Papas Andreas M. | Gamma-tocopherol and gamma-tocotrienol therapy for multiple sclerosis |
| US20080045559A1 (en) * | 2003-10-29 | 2008-02-21 | Sonus Pharmaceuticals, Inc. | Tocopherol-modified therapeutic drug compounds |
| BRPI0415858A (pt) * | 2003-10-29 | 2007-01-09 | Sonus Pharma Inc | compostos de medicamentos terapêuticos modificados por tocoferol |
| DK1720551T3 (da) | 2004-03-03 | 2011-05-16 | Vital Health Sciences Pty Ltd | Alkaloidformuleringer |
| US20060165769A1 (en) * | 2004-09-30 | 2006-07-27 | Hyatt John A | Pharmaceutical formulations containing vitamin E TPGS molecules that solubilize lipophilic drugs without significant efflux inhibition, and use of such formulations |
| CA2599424A1 (en) * | 2005-03-03 | 2006-09-08 | Vital Health Sciences Pty Ltd | Compounds having anti-cancer properties |
| CN100334080C (zh) * | 2005-06-01 | 2007-08-29 | 华东理工大学 | 苯并二氢吡喃碳糖苷衍生物 |
| NZ565049A (en) * | 2005-06-17 | 2012-02-24 | Vital Health Sciences Pty Ltd | A carrier comprising one or more DI and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof |
| US20090005348A1 (en) * | 2005-12-23 | 2009-01-01 | Vital Health Sciences Pty Ltd | Compounds Having Cytokine Modulating Properties |
| AU2007217810B2 (en) * | 2006-02-21 | 2012-10-11 | The Ohio State University Research Foundation | Anticancer agents |
| ES2414205T3 (es) * | 2006-06-02 | 2013-07-18 | The Ohio State University Research Foundation | Agentes terapéuticos para el tratamiento de linfoma de células del manto |
| US8288369B2 (en) * | 2006-06-27 | 2012-10-16 | University Of South Florida | Delta-tocotrienol treatment and prevention of pancreatic cancer |
| US20100292316A1 (en) * | 2007-07-18 | 2010-11-18 | Research Development Foundation | Improved therapeutic methods and compositions comprising chroman ring compounds |
| WO2010051664A1 (zh) * | 2008-11-05 | 2010-05-14 | 沈阳中海药业有限公司 | 7H-咪唑并[1,2-a]吡喃并[2,3-c]吡啶类衍生物及其应用 |
| JP2012523458A (ja) * | 2009-04-13 | 2012-10-04 | ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション | タンパク質ホスファターゼ２ａ活性化剤 |
| CA2759011A1 (en) * | 2009-04-17 | 2010-10-21 | The Ohio State University Research Foundation | Antiadhesion agents |
| AU2010247800A1 (en) * | 2009-05-11 | 2011-12-15 | Berg Llc | Methods for the diagnosis of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers |
| ES2999020T3 (en) | 2010-02-05 | 2025-02-24 | Phosphagenics Ltd | Carrier comprising non-neutralised tocopheryl phosphate |
| EP2552486B1 (de) | 2010-03-30 | 2020-08-12 | Phosphagenics Limited | Pflaster für transdermale verabreichung |
| US20130158106A1 (en) | 2010-06-02 | 2013-06-20 | The United States Of America As Represented By The Department Of Veteran Affairs | Tocopherol derivatives and methods of use |
| US8309768B2 (en) | 2010-11-29 | 2012-11-13 | The Ohio State University Research Foundation | FTY720-derived anticancer agents |
| WO2012122586A1 (en) | 2011-03-15 | 2012-09-20 | Phosphagenics Limited | New composition |
| CN102516258B (zh) * | 2011-11-11 | 2014-06-25 | 正大天晴药业集团股份有限公司 | 水溶性维生素e衍生物修饰的脂溶性抗癌药物化合物和制剂、该化合物的制备方法及应用 |
| WO2013173823A1 (en) * | 2012-05-18 | 2013-11-21 | The Ohio State University | Methods for improving liver function |
| CN106102464A (zh) * | 2013-05-02 | 2016-11-09 | 牛津大学之校长及学者 | 采用亚氨基糖的糖脂抑制 |
| EP3041831B1 (de) * | 2013-09-06 | 2019-10-23 | Research Development Foundation | Alpha-tea-salzformen: zusammensetzungen und verwendungen zur behandlung von krankheiten |
| KR20160068776A (ko) | 2013-09-13 | 2016-06-15 | 더 보드 오브 트러스티스 오브 더 유니버시티 오브 아칸소 | 방사선 효과의 완화 및 예방을 위한 조성물의 제조 및 용도 |
| WO2015117202A1 (en) * | 2014-02-07 | 2015-08-13 | Novogen Limited | Functionalised benzopyran compounds and use thereof |
| RU2571094C1 (ru) * | 2015-02-11 | 2015-12-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Омский государственный университет им. Ф.М. Достоевского" | СПОСОБ ПОЛУЧЕНИЯ 4-АЛКОКСИ-4Н-ТИЕНО[3,2-с]ХРОМЕН-2-КАРБАЛЬДЕГИДОВ, ОБЛАДАЮЩИХ ПРОТИВОЯЗВЕННОЙ АКТИВНОСТЬЮ |
| US20160324914A1 (en) | 2015-05-05 | 2016-11-10 | Tocol Pharmaceuticals, Llc | Use of rice bran oil distillate extract for prevention and mitigation of the effects of radiation |
| CN114712308A (zh) | 2015-12-09 | 2022-07-08 | 磷肌酸有限公司 | 药物制剂 |
| EP3558903B1 (de) | 2016-12-21 | 2024-07-03 | Avecho Biotechnology Limited | Verfahren zur phosphorylierung eines komplexen alkohols |
| WO2019210422A1 (en) * | 2018-05-04 | 2019-11-07 | Exact Delivery Inc. | Vitamin e derivatives and their use as multi-scale imaging agents |
| US20230203209A1 (en) * | 2020-06-05 | 2023-06-29 | Basf Se | Non-ionic and anionic surfactants based on tocopherol |
| CN120004842A (zh) * | 2025-02-14 | 2025-05-16 | 河南中医药大学 | 一种从箭叶淫羊藿中提取两个生育酚衍生物a、b的方法及其应用 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5118954B2 (de) * | 1972-02-04 | 1976-06-14 | ||
| CS172015B1 (de) * | 1974-05-12 | 1976-12-29 | ||
| JPS5484034A (en) * | 1977-12-16 | 1979-07-04 | Nisshin Flour Milling Co Ltd | Anti-tumor agent |
| EP0008573A1 (de) * | 1977-12-16 | 1980-03-05 | Nisshin Flour Milling Co., Ltd. | Anti-krebs-wirkstoff |
| JPS5573690A (en) * | 1978-11-28 | 1980-06-03 | Eisai Co Ltd | Novel penicillin derivative and antibacterial comprising it |
| JPS6056155B2 (ja) * | 1978-12-04 | 1985-12-09 | エーザイ株式会社 | クロマニルオキシ脂肪酸同族体 |
| JPS57175186A (en) * | 1981-04-20 | 1982-10-28 | Fujimoto Seiyaku Kk | Novel vitamin e derivative and its preparation |
| US4457918A (en) | 1982-05-12 | 1984-07-03 | The General Hospital Corporation | Glycosides of vitamins A, E and K |
| JPS59157085A (ja) * | 1983-02-28 | 1984-09-06 | Green Cross Corp:The | ベンゾジアゼピン誘導体 |
| DE3309159A1 (de) * | 1983-03-15 | 1984-09-20 | Basf Ag, 6700 Ludwigshafen | Neue optisch aktive chromanderivate, verfahren zu deren herstellung sowie neue zwischenprodukte |
| US4617317A (en) * | 1984-10-31 | 1986-10-14 | Bennet Justin D | Method of treating ulcerative colitis |
| US4665204A (en) * | 1985-06-27 | 1987-05-12 | Henkel Corporation | Diester derivatives of tocopherol |
| JPS63303049A (ja) * | 1987-06-04 | 1988-12-09 | Shinagawa Refract Co Ltd | 繊維強化ガラス質溶射材料 |
| JPS6441727A (en) * | 1987-08-07 | 1989-02-14 | Toshiba Corp | Cooking unit |
| US5610180A (en) * | 1988-01-29 | 1997-03-11 | Virginia Commonwealth University | Ionizable congeners of aromatic and aliphatic alcohols as anti-leukemia agents |
| JPH01211578A (ja) * | 1988-02-19 | 1989-08-24 | Fuji Kagaku Kogyo Kk | ビタミンｅ誘導体及びその製造法 |
| US5260294A (en) * | 1988-08-09 | 1993-11-09 | Hoffman-La Roche Inc. | Chromanes and their pharmaceutical compositions and methods |
| JPH02149577A (ja) * | 1988-11-30 | 1990-06-08 | Eisai Co Ltd | トコフェロール アミノアルキルカルボン酸エステルおよびその塩 |
| JPH03206089A (ja) * | 1990-01-05 | 1991-09-09 | Eisai Co Ltd | 新規ビタミンｅ誘導体及びその製造方法 |
| US5114957A (en) * | 1990-05-08 | 1992-05-19 | Biodor U.S. Holding | Tocopherol-based antiviral agents and method of using same |
| DE4014708C2 (de) * | 1990-05-08 | 1994-03-10 | Heidelberger Druckmasch Ag | Verfahren zum Ermitteln von Registerfehlern |
| FR2672601B1 (fr) * | 1991-02-08 | 1994-10-14 | Synthelabo | Derives de benzo-1,5-thiazepine, leur preparation et leur application en therapeutique. |
| JPH05213982A (ja) * | 1991-03-26 | 1993-08-24 | Dainippon Ink & Chem Inc | オリゴ糖トコフェロール配糖体及び硫酸化オリゴ糖トコフェロール配糖体並びにこれを有効成分とする抗ウイルス剤 |
| FR2676056B1 (fr) | 1991-05-03 | 1993-07-16 | Adir | Nouveaux derives du benzopyranne leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| ZA923816B (en) * | 1991-05-30 | 1993-11-25 | Bristol Myers Squibb Co | Prepartion of 6-0-alkylesamicin a derivatives |
| EP0636618A1 (de) * | 1991-06-04 | 1995-02-01 | Marigen S.A. | Spontan dispergierbare Konzentrate und Mikroemulsionen mit Vitamin-E-Verbindungen zur Herstellung von Arzneimitteln mit Antitumoraler Wirksamkeit |
| US5135945A (en) | 1991-06-05 | 1992-08-04 | Merrell Dow Pharmaceuticals Inc. | Cholesterol-lowering tocopherol analogs |
| HRP920935A2 (en) * | 1991-10-08 | 1995-08-31 | Astra Ab | New therapeutically active compound |
| US5545660A (en) | 1992-04-07 | 1996-08-13 | Merrell Pharmaceuticals Inc. | Hydrazide derivatives of 3,4-dihydro-2H-1-benzopyrans |
| FR2695387B1 (fr) * | 1992-09-09 | 1994-10-21 | Adir | Nouveaux composés benzopyraniques, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| DE4304303C2 (de) * | 1993-01-22 | 1997-01-30 | Pacific Corp | Vitamin-E-Derivate mit einem quartären Stickstoffatom, Verfahren zu deren Herstellung und kosmetische Mittel enthaltend dieselben |
| GB9301611D0 (en) * | 1993-08-04 | 1993-08-04 | Parisella Gerald | Dexterity game |
| JPH07138159A (ja) * | 1993-11-19 | 1995-05-30 | Kuraray Co Ltd | ビタミンｅ誘導体を有効成分とする皮膚疾患治療剤 |
| CA2152693A1 (en) * | 1994-08-05 | 1996-02-06 | Kazumi Ogata | Therapeutic composition for pancreatitis |
| US5596095A (en) * | 1994-12-12 | 1997-01-21 | Procept, Inc. | Formation and utility of sulfonic acid protecting groups |
| US5670255A (en) * | 1995-01-23 | 1997-09-23 | Ppg Industries, Inc. | Antioxidant compositions for coating substrates, substrates coated with the same and methods for inhibiting the oxidation of such compositions applied to a substrate |
| DE19523079A1 (de) * | 1995-06-26 | 1997-01-02 | Basf Ag | Ester und Amide der 9(Z)-Retinsäure |
| CA2179940A1 (en) * | 1995-07-18 | 1997-01-19 | Kazumi Ogata | Antiallergic composition comprising a phosphoric diester compound |
| US5798356A (en) * | 1995-08-07 | 1998-08-25 | Alcon Laboratories, Inc. | Angiostatic compounds |
| CA2186654A1 (en) * | 1995-10-13 | 1997-04-14 | Masayuki Nakamura | Phosphoric diester |
| JPH09301969A (ja) * | 1996-05-15 | 1997-11-25 | Fuji Photo Film Co Ltd | クロマン系化合物及びそれを使用する感熱記録材料 |
| EP0815858B1 (de) * | 1996-07-01 | 2001-08-22 | Nisshin Flour Milling Co., Ltd. | Pharmazeutische Zusammensetzung zur Behandlung der Leukämie enthaltend 9-cis-Retinoinsäure-alpha-Tocopherolester |
| US6022560A (en) | 1996-08-27 | 2000-02-08 | Clarion Pharmaceuticals Inc. | Pharmaceutical compositions, novel uses, and novel form of α-tocopherylphosphocholine |
| FR2754713B1 (fr) * | 1996-10-22 | 1999-01-08 | Roc Sa | Utilisation de complexes pour la preparation de compositions pour le traitement des peaux sensibles, procede de preparation et compositions hypoallergeniques |
| EP0939616A1 (de) | 1996-10-23 | 1999-09-08 | The Procter & Gamble Company | Wässrige topische zusammensetzungen die ein kojisäure, salicylsäure und ein wasserlösliche glykolether enthalten |
| CA2220541A1 (en) * | 1997-11-07 | 1999-05-07 | Mcgill University | Analogs of vitamin e |
| US5917060A (en) * | 1997-12-17 | 1999-06-29 | Basf Aktiengesellschaft | Preparation of chromanyl derivatives |
| US5990322A (en) * | 1999-03-09 | 1999-11-23 | Sk Corporation | Alpha-tocopherol cyclopropylates, the new vitamin E derivatives and method for producing the same |
-
1999
- 1999-09-23 JP JP2000573733A patent/JP2002526446A/ja active Pending
- 1999-09-23 IL IL14208299A patent/IL142082A/en not_active IP Right Cessation
- 1999-09-23 RU RU2001111019/04A patent/RU2232758C2/ru not_active IP Right Cessation
- 1999-09-23 CA CA2345079A patent/CA2345079C/en not_active Expired - Fee Related
- 1999-09-23 NZ NZ510732A patent/NZ510732A/en unknown
- 1999-09-23 KR KR1020017003703A patent/KR100712383B1/ko not_active Expired - Fee Related
- 1999-09-23 DE DE69942342T patent/DE69942342D1/de not_active Expired - Lifetime
- 1999-09-23 US US09/404,001 patent/US6417223B1/en not_active Expired - Lifetime
- 1999-09-23 CN CNB998128295A patent/CN1195513C/zh not_active Expired - Fee Related
- 1999-09-23 EP EP99948352A patent/EP1115398B1/de not_active Expired - Lifetime
- 1999-09-23 AU AU61553/99A patent/AU757013B2/en not_active Ceased
- 1999-09-23 CN CNB2005100038550A patent/CN1318413C/zh not_active Expired - Fee Related
- 1999-09-23 WO PCT/US1999/021778 patent/WO2000016772A1/en not_active Ceased
- 1999-09-23 AT AT99948352T patent/ATE466850T1/de not_active IP Right Cessation
- 1999-09-23 DK DK99948352.2T patent/DK1115398T3/da active
- 1999-11-17 TW TW088120073A patent/TW592695B/zh not_active IP Right Cessation
-
2001
- 2001-03-13 ZA ZA200102057A patent/ZA200102057B/xx unknown
-
2002
- 2002-04-12 US US10/122,019 patent/US6645998B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1325303A (zh) | 2001-12-05 |
| EP1115398A4 (de) | 2002-10-16 |
| CA2345079A1 (en) | 2000-03-30 |
| TW592695B (en) | 2004-06-21 |
| DE69942342D1 (de) | 2010-06-17 |
| CN1706838A (zh) | 2005-12-14 |
| US6645998B2 (en) | 2003-11-11 |
| EP1115398B1 (de) | 2010-05-05 |
| IL142082A (en) | 2005-12-18 |
| US20020156024A1 (en) | 2002-10-24 |
| IL142082A0 (en) | 2002-03-10 |
| DK1115398T3 (da) | 2010-08-16 |
| NZ510732A (en) | 2004-01-30 |
| ZA200102057B (en) | 2002-03-19 |
| WO2000016772A1 (en) | 2000-03-30 |
| CA2345079C (en) | 2011-06-21 |
| US6417223B1 (en) | 2002-07-09 |
| JP2002526446A (ja) | 2002-08-20 |
| AU6155399A (en) | 2000-04-10 |
| CN1195513C (zh) | 2005-04-06 |
| KR100712383B1 (ko) | 2007-05-02 |
| KR20010075306A (ko) | 2001-08-09 |
| AU757013B2 (en) | 2003-01-30 |
| CN1318413C (zh) | 2007-05-30 |
| RU2232758C2 (ru) | 2004-07-20 |
| EP1115398A1 (de) | 2001-07-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE466850T1 (de) | Tocopherole, tocotrienole, sonstige chroman- und seitenkettenderivate, sowie deren verwendungen | |
| WO2003039461A3 (en) | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof | |
| DE59401923D1 (de) | Substituierte heterocyclische Carbonsäureamidester, ihre Herstellung und ihre Verwendung als Arzneimittel | |
| DE60306547D1 (de) | Substituierte 3-alkyl- und 3-arylalkyl-1h-indol-1-yl-essigsäure-derivate als plasminogen aktivator inhibitor-1 (pai-1) inhibitoren | |
| ATE424722T1 (de) | Verbesserte synthese von polyanhydriden | |
| EA199600104A1 (ru) | Повышенная биодоступность биологически активных соединений при связывании с производными полипирролкарбоксамидонафталиновой кислоты | |
| DE69527072D1 (de) | Endothelin antagoniste | |
| DE60012809D1 (de) | 2-Pyridinylguanidine als Urokinase Inhibitoren | |
| IS7482A (is) | Fjölhringa efnasambönd sem sterk alfa2-adrenóviðtakamótlyf | |
| DE50308003D1 (de) | St rkederivate, st rke-wirkstoff-konj ugate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel | |
| ATE261941T1 (de) | Heterocyclische amide als inhibitoren von faktor xa | |
| IE830310L (en) | 1,2,5-trisubstituted pyrroles | |
| NO931482L (no) | Farmasoeytiske sammensetninger inneholdende quinolin- og quinazolinderivater og nye forbindelser for disse | |
| EP1576127A4 (de) | Kristallform der fettsäureaminhydrolase (faah) | |
| ES2119872T3 (es) | Procedimiento de preparacion de derivados de beta-lactama y su intermediario de sintesis. | |
| PT916651E (pt) | DERIVADOS DE áCIDO FENILALQUILCARBOXILICO | |
| DE69309454D1 (de) | Pyridincarboximidamide und deren anwendung | |
| YU60796A (sh) | Derivati nadražujuće aminokiseline | |
| EP0806421A4 (de) | Derivate der chinolincarbonsäure | |
| ATE228520T1 (de) | Lactamverbindungen als inhibitoren der cholesterin-esterase | |
| NO306297B1 (no) | FremgangsmÕte for fremstilling av HIV-proteaseinhibitorer | |
| TR200300019T3 (tr) | N-(merkaptoasil)-amino-asitleri türevlerinin A-ikame edici akrilik asitlerle sentezlenmesi işlemi | |
| GR3027710T3 (en) | Novel antiviral agents | |
| BR9605027A (pt) | Processo para preparar um carboxilato de b-trifluor-metila & b-insaturado | |
| ATE201877T1 (de) | Kondensierte heterocyclische glutaminsäurederivate als antiproliferative mittel |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |