ATE193528T1 - Vitamin d analoge - Google Patents

Vitamin d analoge

Info

Publication number: ATE193528T1
Authority: AT; Austria
Prior art keywords: pct; hydroxy; groups; hydrocarbylene; sec
Prior art date: 1995-12-05

Application number

AT96939817T

Other languages

English (en)

Inventor

Martin John Calverley

Original Assignee

Leo Pharm Prod Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-05

Filing date

1996-12-02

Publication date

2000-06-15

1996-12-02 Application filed by Leo Pharm Prod Ltd filed Critical Leo Pharm Prod Ltd

2000-06-15 Application granted granted Critical

2000-06-15 Publication of ATE193528T1 publication Critical patent/ATE193528T1/de

Links

229940088594 vitamin Drugs 0.000 title 1
229930003231 vitamin Natural products 0.000 title 1
235000013343 vitamin Nutrition 0.000 title 1
239000011782 vitamin Substances 0.000 title 1
150000003722 vitamin derivatives Chemical class 0.000 title 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 2
125000000743 hydrocarbylene group Chemical group 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
125000002837 carbocyclic group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
230000004069 differentiation Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000002519 immonomodulatory effect Effects 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Diabetes (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Transplantation (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT96939817T 1995-12-05 1996-12-02 Vitamin d analoge ATE193528T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9524812.6A GB9524812D0 (en)	1995-12-05	1995-12-05	Chemical compounds
PCT/DK1996/000502 WO1997020811A1 (en)	1995-12-05	1996-12-02	Vitamin d analogues

Publications (1)

Publication Number	Publication Date
ATE193528T1 true ATE193528T1 (de)	2000-06-15

Family

ID=10784912

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96939817T ATE193528T1 (de)	1995-12-05	1996-12-02	Vitamin d analoge

Country Status (20)

Country	Link
US (1)	US5994332A (de)
EP (1)	EP0865428B1 (de)
JP (1)	JP2000502063A (de)
KR (1)	KR100548972B1 (de)
CN (1)	CN1079791C (de)
AT (1)	ATE193528T1 (de)
AU (1)	AU701108B2 (de)
CZ (1)	CZ290096B6 (de)
DE (1)	DE69608701T2 (de)
DK (1)	DK0865428T3 (de)
ES (1)	ES2148816T3 (de)
GB (1)	GB9524812D0 (de)
GR (1)	GR3034198T3 (de)
HU (1)	HUP9802731A3 (de)
NZ (1)	NZ322878A (de)
PL (1)	PL185100B1 (de)
PT (1)	PT865428E (de)
RO (1)	RO117616B1 (de)
RU (1)	RU2194694C2 (de)
WO (1)	WO1997020811A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5972917A (en) *	1998-05-29	1999-10-26	Bone Care Int Inc	1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
US7351869B2 (en) *	2002-11-18	2008-04-01	Teva Pharmaceutical Industries Ltd	Crystallization method for purification of calcipotriene
CN1934078B (zh) *	2004-03-18	2011-07-06	利奥制药有限公司	维生素d类似物的立体选择性合成
EP1768662A2 (de)	2004-06-24	2007-04-04	Novartis Vaccines and Diagnostics, Inc.	Immunstimulatoren kleiner moleküle und assays für deren nachweis
US7094775B2 (en)	2004-06-30	2006-08-22	Bone Care International, Llc	Method of treating breast cancer using a combination of vitamin D analogues and other agents
EP2392328A1 (de)	2005-05-09	2011-12-07	Hydra Biosciences, Inc.	Verbindungen zur Modulierung der TRPV3-Funktion
BRPI0715636A2 (pt) *	2006-08-29	2013-07-02	Teva Pharma	composiÇÕes farmacologicamente ativas estÁveis incluindo compostos contendo vitamina d e corticosteràide com compatibilidade para ph baixo
WO2009002933A1 (en)	2007-06-22	2008-12-31	Hydra Biosciences, Inc.	Methods and compositions for treating disorders
SG173119A1 (en)	2009-01-27	2011-08-29	Berg Biosystems Llc	Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
MX366076B (es)	2009-08-14	2019-06-27	Berg Llc	Vitamina d3 y analogos de la misma para tratar alopecia.
SG10201709894RA (en)	2013-05-29	2018-01-30	Berg Llc	Preventing or mitigating chemotherapy induced alopecia using vitamin d
US20190354482A1 (en) *	2018-05-21	2019-11-21	Microsoft Technology Licensing, Llc	Time-based mechanism supporting flush operation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4495181A (en) *	1983-10-03	1985-01-22	The Regents Of The University Of California	1,25-Dihydroxy-24-oxo-vitamin D3 and 1,23,25-trihydroxy-24-oxo-vitamin D3
GB8914963D0 (en) *	1989-06-29	1989-08-23	Leo Pharm Prod Ltd	Chemical compounds
WO1991012238A1 (de) *	1990-02-06	1991-08-22	Schering Aktiengesellschaft Berlin Und Bergkamen	Seitenketten-homologe vitamin-d-derivative, verfahren zu ihrer herstellung, diese derivate enthaltende pharmazeutische präparate sowie deren verwendung als arzneimittel
US5362719A (en) *	1990-03-01	1994-11-08	Leo Pharmaceutical Products, Ltd. A/S Lovens Kemiske Fabrik Produktionsaktieselskab)	Use of vitamin-D analogues in the treatment of acne
US5274142A (en) *	1992-03-12	1993-12-28	The Johns Hopkins University	Vitamin D3 analogues
GB9206648D0 (en) *	1992-03-26	1992-05-06	Leo Pharm Prod Ltd	Chemical compounds
US5401733A (en) *	1993-10-01	1995-03-28	Hoffmann-La Roche Inc.	Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol

1995
- 1995-12-05 GB GBGB9524812.6A patent/GB9524812D0/en active Pending
1996
- 1996-12-02 US US08/981,646 patent/US5994332A/en not_active Expired - Fee Related
- 1996-12-02 AT AT96939817T patent/ATE193528T1/de not_active IP Right Cessation
- 1996-12-02 EP EP96939817A patent/EP0865428B1/de not_active Expired - Lifetime
- 1996-12-02 KR KR1019970709904A patent/KR100548972B1/ko not_active Expired - Fee Related
- 1996-12-02 WO PCT/DK1996/000502 patent/WO1997020811A1/en not_active Ceased
- 1996-12-02 RU RU98112341/04A patent/RU2194694C2/ru not_active IP Right Cessation
- 1996-12-02 CN CN96195083A patent/CN1079791C/zh not_active Expired - Fee Related
- 1996-12-02 ES ES96939817T patent/ES2148816T3/es not_active Expired - Lifetime
- 1996-12-02 DK DK96939817T patent/DK0865428T3/da active
- 1996-12-02 DE DE69608701T patent/DE69608701T2/de not_active Expired - Fee Related
- 1996-12-02 JP JP9520882A patent/JP2000502063A/ja not_active Ceased
- 1996-12-02 HU HU9802731A patent/HUP9802731A3/hu unknown
- 1996-12-02 PT PT96939817T patent/PT865428E/pt unknown
- 1996-12-02 AU AU76913/96A patent/AU701108B2/en not_active Ceased
- 1996-12-02 PL PL96324920A patent/PL185100B1/pl not_active IP Right Cessation
- 1996-12-02 NZ NZ322878A patent/NZ322878A/en unknown
- 1996-12-02 RO RO97-02190A patent/RO117616B1/ro unknown
- 1996-12-02 CZ CZ19973593A patent/CZ290096B6/cs not_active IP Right Cessation
2000
- 2000-08-14 GR GR20000401892T patent/GR3034198T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
CZ290096B6 (cs)	2002-05-15
WO1997020811A1 (en)	1997-06-12
KR100548972B1 (ko)	2006-10-24
AU701108B2 (en)	1999-01-21
JP2000502063A (ja)	2000-02-22
GB9524812D0 (en)	1996-02-07
EP0865428B1 (de)	2000-05-31
CN1079791C (zh)	2002-02-27
KR19990028583A (ko)	1999-04-15
NZ322878A (en)	2001-03-30
CN1189151A (zh)	1998-07-29
DK0865428T3 (da)	2000-09-25
PT865428E (pt)	2000-09-29
RO117616B1 (ro)	2002-05-30
DE69608701T2 (de)	2001-02-08
CZ359397A3 (cs)	1998-09-16
PL185100B1 (pl)	2003-02-28
HUP9802731A2 (hu)	1999-02-01
DE69608701D1 (de)	2000-07-06
HUP9802731A3 (en)	1999-06-28
EP0865428A1 (de)	1998-09-23
GR3034198T3 (en)	2000-11-30
ES2148816T3 (es)	2000-10-16
AU7691396A (en)	1997-06-27
US5994332A (en)	1999-11-30
PL324920A1 (en)	1998-06-22
RU2194694C2 (ru)	2002-12-20

Legal Events

Date	Code	Title	Description
2000-11-15	UEP	Publication of translation of european patent specification
2007-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69409811D1 (de)	1998-05-28	Neue vitamin d-derivate
FI943099A0 (fi)	1994-06-28	Uudet D-vitamiinianalogit
DE69608701D1 (de)	2000-07-06	Vitamin d analoge
ATE150013T1 (de)	1997-03-15	Vitamin d derivate
ES2115665T3 (es)	1998-07-01	Derivado de triterpeno.
AU5114893A (en)	1994-04-26	Novel method of esterification of baccatine iii an 10-deacetylbaccatine iii
EP0990650B8 (de)	2005-10-19	Trizyklische pyrol- oder pyrazolderivate
DE69714590D1 (de)	2002-09-12	Vitamin d analoge verbindungen
PL333068A1 (en)	1999-11-08	Analoques of vitamin d
DE69834271D1 (de)	2006-05-24	Steroid-3-o-sulfamat-derivate als estronsulfatase-hemmer
NO924670D0 (no)	1992-12-03	Derivater av 6-aminooktahydroindolizintriol
DE69720966D1 (de)	2003-05-22	Benzo[c]chinolizin derivate,deren herstellung und verwendung als 5-alfa-reduktase inhibitoren
CA2222785A1 (en)	1997-06-12	Vitamin d analogues
DK0835117T3 (da)	2005-01-10	Etherderivater af pseudopterosin
DE69708054D1 (de)	2001-12-13	Aromatische polycyclische derivate des retinoidtyps, verfahren zu ihrer herstellung und ihre verwendung zur herstellung der pharmazeutischen und kosmetischen zusammensetzungen