ATE194142T1 - Verfahren zur herstellung von nukleotiden - Google Patents

Verfahren zur herstellung von nukleotiden

Info

Publication number
ATE194142T1
ATE194142T1 AT91915336T AT91915336T ATE194142T1 AT E194142 T1 ATE194142 T1 AT E194142T1 AT 91915336 T AT91915336 T AT 91915336T AT 91915336 T AT91915336 T AT 91915336T AT E194142 T1 ATE194142 T1 AT E194142T1
Authority
AT
Austria
Prior art keywords
producing nucleotides
novel
nucleotides
producing
hpmp
Prior art date
Application number
AT91915336T
Other languages
English (en)
Inventor
Purushotham Vemishetti
Paul R Brodfuehrer
Henry G Howell
Chester Sapino Jr
Original Assignee
Acad Of Science Czech Republic
Rega Stichting
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acad Of Science Czech Republic, Rega Stichting filed Critical Acad Of Science Czech Republic
Application granted granted Critical
Publication of ATE194142T1 publication Critical patent/ATE194142T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT91915336T 1990-08-10 1991-08-06 Verfahren zur herstellung von nukleotiden ATE194142T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56620090A 1990-08-10 1990-08-10
PCT/US1991/005578 WO1992002511A1 (en) 1990-08-10 1991-08-06 Novel process for the preparation of nucleotides

Publications (1)

Publication Number Publication Date
ATE194142T1 true ATE194142T1 (de) 2000-07-15

Family

ID=24261919

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91915336T ATE194142T1 (de) 1990-08-10 1991-08-06 Verfahren zur herstellung von nukleotiden

Country Status (11)

Country Link
US (2) US5476938A (de)
EP (1) EP0574386B1 (de)
JP (1) JP3116079B2 (de)
KR (1) KR100221981B1 (de)
AT (1) ATE194142T1 (de)
AU (1) AU653552B2 (de)
CA (1) CA2088363C (de)
DE (1) DE69132276T2 (de)
ES (1) ES2149157T3 (de)
FI (1) FI930552A7 (de)
WO (1) WO1992002511A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS387190A3 (en) * 1990-08-06 1992-03-18 Ustav Organicke Chemie A Bioch (2r)-2-/di(2-propyl)phosphonylmethoxy/-3-p-toluenesulfonyloxy -1- trimethylacetoxypropane and process for preparing thereof
JP3116079B2 (ja) * 1990-08-10 2000-12-11 インスティチュート オブ オーガニック ケミストリ アンド バイオケミストリ アカデミー オブ サイエンス オブ ザ チェコ リパブリック ヌクレオチドの新規な製法
EP0481214B1 (de) * 1990-09-14 1998-06-24 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Wirkstoffvorläufer von Phosphonaten
US6057305A (en) * 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
US6448373B1 (en) * 1994-01-11 2002-09-10 Isis Pharmaceuticals, Inc. Phosphate linked oligomers formed of monomeric diols and processes for preparing same
US20020119443A1 (en) 2000-07-21 2002-08-29 Gilead Sciences, Inc. Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
DK1583542T3 (da) 2003-01-14 2008-09-22 Gilead Sciences Inc Sammensætninger og fremgangsmåder til antiviral kombinationsterapi
US20060252729A1 (en) * 2003-07-30 2006-11-09 Krawczyk Steven H Nucleobase phosphonate analogs for antiviral treatment
EP2842559A3 (de) * 2005-04-08 2015-03-18 Chimerix, Inc. Verbindungen, Zusammensetzungen und Verfahren zur Behandlung viraler Infektionen und anderer Erkrankungen
US8642577B2 (en) 2005-04-08 2014-02-04 Chimerix, Inc. Compounds, compositions and methods for the treatment of poxvirus infections
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
CA2683316A1 (en) 2007-04-13 2009-02-19 Southern Research Institute Anti-angiogenic agents and methods of use
ES2572631T3 (es) 2008-01-25 2016-06-01 Chimerix, Inc. Métodos de tratamiento de infecciones virales
WO2011011519A1 (en) 2009-07-21 2011-01-27 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
US9006218B2 (en) 2010-02-12 2015-04-14 Chimerix Inc. Nucleoside phosphonate salts
CA2797601A1 (en) 2010-04-26 2011-11-10 Chimerix, Inc. Methods of treating retroviral infections and related dosage regimes
WO2012031045A2 (en) * 2010-08-31 2012-03-08 Chimerix, Inc. Phosphonate ester derivatives and methods of synthesis thereof
WO2012079035A1 (en) 2010-12-10 2012-06-14 Sigmapharm Laboratories, Llc Highly stable compositions of orally active nucleotide analogues or orally active nucleotide analogue prodrugs
EP3578563B1 (de) 2011-12-22 2021-04-14 Geron Corporation Guanin-analoga als telomerasesubstrate und telomerlängenaffektoren
US8962829B1 (en) 2013-11-15 2015-02-24 Chimerix, Inc. Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof
CN103951703A (zh) * 2014-04-28 2014-07-30 中国人民解放军军事医学科学院微生物流行病研究所 制备膦酯衍生物的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS233665B1 (en) * 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
EP0167385B1 (de) * 1984-07-03 1992-03-18 The Wellcome Foundation Limited Antiviren-Verbindungen, Behandlung und Formulierungen
CS263951B1 (en) * 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
IL82998A0 (en) * 1986-07-07 1987-12-20 Koller Werner Dental sleeve,its production and its use for producing a ceramic crown
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
JP3116079B2 (ja) * 1990-08-10 2000-12-11 インスティチュート オブ オーガニック ケミストリ アンド バイオケミストリ アカデミー オブ サイエンス オブ ザ チェコ リパブリック ヌクレオチドの新規な製法

Also Published As

Publication number Publication date
AU653552B2 (en) 1994-10-06
EP0574386A1 (de) 1993-12-22
US5591852A (en) 1997-01-07
ES2149157T3 (es) 2000-11-01
EP0574386B1 (de) 2000-06-28
FI930552L (fi) 1993-02-22
WO1992002511A1 (en) 1992-02-20
US5476938A (en) 1995-12-19
EP0574386A4 (de) 1993-10-27
FI930552A7 (fi) 1993-02-22
CA2088363A1 (en) 1992-02-11
AU8492891A (en) 1992-03-02
JPH06503807A (ja) 1994-04-28
JP3116079B2 (ja) 2000-12-11
FI930552A0 (fi) 1993-02-09
DE69132276T2 (de) 2001-03-01
DE69132276D1 (de) 2000-08-03
KR100221981B1 (ko) 1999-09-15
KR930702349A (ko) 1993-09-08
CA2088363C (en) 2002-05-28

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Legal Events

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