ATE194143T1 - Stabile radioiodium-konjugate und verfahren zu deren herstellung - Google Patents
Stabile radioiodium-konjugate und verfahren zu deren herstellungInfo
- Publication number
- ATE194143T1 ATE194143T1 AT97941363T AT97941363T ATE194143T1 AT E194143 T1 ATE194143 T1 AT E194143T1 AT 97941363 T AT97941363 T AT 97941363T AT 97941363 T AT97941363 T AT 97941363T AT E194143 T1 ATE194143 T1 AT E194143T1
- Authority
- AT
- Austria
- Prior art keywords
- radioiodinated
- coupled
- conjugates
- antibody
- antibodies
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 8
- 230000001588 bifunctional effect Effects 0.000 abstract 3
- 150000001720 carbohydrates Chemical group 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 230000001268 conjugating effect Effects 0.000 abstract 1
- MGNCLNQXLYJVJD-UHFFFAOYSA-N cyanuric chloride Chemical compound ClC1=NC(Cl)=NC(Cl)=N1 MGNCLNQXLYJVJD-UHFFFAOYSA-N 0.000 abstract 1
- 229940127121 immunoconjugate Drugs 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000011363 radioimmunotherapy Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A61K51/1069—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from blood cells, e.g. the cancer being a myeloma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/04—Disaccharides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2473896P | 1996-08-28 | 1996-08-28 | |
| PCT/US1997/014998 WO1998008548A2 (en) | 1996-08-28 | 1997-08-27 | Stable radioiodine conjugates and methods for their synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE194143T1 true ATE194143T1 (de) | 2000-07-15 |
Family
ID=21822150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97941363T ATE194143T1 (de) | 1996-08-28 | 1997-08-27 | Stabile radioiodium-konjugate und verfahren zu deren herstellung |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0915710B1 (de) |
| JP (1) | JP3992745B2 (de) |
| AT (1) | ATE194143T1 (de) |
| AU (1) | AU718859B2 (de) |
| CA (1) | CA2263985A1 (de) |
| DE (1) | DE69702398T2 (de) |
| WO (1) | WO1998008548A2 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6663866B1 (en) * | 1996-08-28 | 2003-12-16 | Immunomedics, Inc. | Stable radioiodine conjugates and methods for their synthesis |
| US6558669B1 (en) | 1996-08-28 | 2003-05-06 | Immunomedics, Inc. | Stable radioiodine conjugates and methods for their synthesis |
| US7521531B2 (en) * | 1996-08-28 | 2009-04-21 | Immunomedics, Inc. | Methods for the purification of stable radioiodine conjugates |
| US6998106B1 (en) * | 1998-12-01 | 2006-02-14 | Duke University | Radioconjugation of internalizing antibodies |
| DE10350484B4 (de) * | 2003-12-20 | 2006-02-02 | Ehrfeld Mikrotechnik Bts Gmbh | Verfahren und Vorrichtung zur Markierung von Proteinen |
| CN117466980A (zh) * | 2023-11-02 | 2024-01-30 | 浙江普罗亭健康科技有限公司 | 基于多肽链骨架应用于金属抗体标记的负载金属缀合物及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2652004B1 (fr) * | 1989-09-21 | 1994-10-28 | Immunotech Partners | Nouveaux derives hydrophiles, application au diagnostic et a la therapeutique, kits diagnostiques ou therapeutiques et reactifs immunologiques. |
| DE69111401T2 (de) * | 1990-12-21 | 1996-02-22 | Pliva Pharm & Chem Works | Tert-Butyloxycarbonyl-L-Tyrosyl-Peptidoglycanmonomer und deren 125 I-markiertes Derivat, deren Herstellung und Verwendung. |
-
1997
- 1997-08-27 JP JP51183698A patent/JP3992745B2/ja not_active Expired - Fee Related
- 1997-08-27 AU AU43287/97A patent/AU718859B2/en not_active Ceased
- 1997-08-27 CA CA002263985A patent/CA2263985A1/en not_active Abandoned
- 1997-08-27 EP EP97941363A patent/EP0915710B1/de not_active Expired - Lifetime
- 1997-08-27 AT AT97941363T patent/ATE194143T1/de not_active IP Right Cessation
- 1997-08-27 WO PCT/US1997/014998 patent/WO1998008548A2/en not_active Ceased
- 1997-08-27 DE DE69702398T patent/DE69702398T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000517316A (ja) | 2000-12-26 |
| DE69702398T2 (de) | 2001-02-15 |
| EP0915710A2 (de) | 1999-05-19 |
| DE69702398D1 (de) | 2000-08-03 |
| WO1998008548A3 (en) | 1998-04-23 |
| AU718859B2 (en) | 2000-04-20 |
| CA2263985A1 (en) | 1998-03-05 |
| EP0915710B1 (de) | 2000-06-28 |
| JP3992745B2 (ja) | 2007-10-17 |
| AU4328797A (en) | 1998-03-19 |
| WO1998008548A2 (en) | 1998-03-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |