ATE194143T1 - Stabile radioiodium-konjugate und verfahren zu deren herstellung - Google Patents

Stabile radioiodium-konjugate und verfahren zu deren herstellung

Info

Publication number
ATE194143T1
ATE194143T1 AT97941363T AT97941363T ATE194143T1 AT E194143 T1 ATE194143 T1 AT E194143T1 AT 97941363 T AT97941363 T AT 97941363T AT 97941363 T AT97941363 T AT 97941363T AT E194143 T1 ATE194143 T1 AT E194143T1
Authority
AT
Austria
Prior art keywords
radioiodinated
coupled
conjugates
antibody
antibodies
Prior art date
Application number
AT97941363T
Other languages
English (en)
Inventor
Serengulam V Govindan
Gary L Griffiths
Original Assignee
Immunomedics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunomedics Inc filed Critical Immunomedics Inc
Application granted granted Critical
Publication of ATE194143T1 publication Critical patent/ATE194143T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1069Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from blood cells, e.g. the cancer being a myeloma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/04Disaccharides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT97941363T 1996-08-28 1997-08-27 Stabile radioiodium-konjugate und verfahren zu deren herstellung ATE194143T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2473896P 1996-08-28 1996-08-28
PCT/US1997/014998 WO1998008548A2 (en) 1996-08-28 1997-08-27 Stable radioiodine conjugates and methods for their synthesis

Publications (1)

Publication Number Publication Date
ATE194143T1 true ATE194143T1 (de) 2000-07-15

Family

ID=21822150

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97941363T ATE194143T1 (de) 1996-08-28 1997-08-27 Stabile radioiodium-konjugate und verfahren zu deren herstellung

Country Status (7)

Country Link
EP (1) EP0915710B1 (de)
JP (1) JP3992745B2 (de)
AT (1) ATE194143T1 (de)
AU (1) AU718859B2 (de)
CA (1) CA2263985A1 (de)
DE (1) DE69702398T2 (de)
WO (1) WO1998008548A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6663866B1 (en) * 1996-08-28 2003-12-16 Immunomedics, Inc. Stable radioiodine conjugates and methods for their synthesis
US6558669B1 (en) 1996-08-28 2003-05-06 Immunomedics, Inc. Stable radioiodine conjugates and methods for their synthesis
US7521531B2 (en) * 1996-08-28 2009-04-21 Immunomedics, Inc. Methods for the purification of stable radioiodine conjugates
US6998106B1 (en) * 1998-12-01 2006-02-14 Duke University Radioconjugation of internalizing antibodies
DE10350484B4 (de) * 2003-12-20 2006-02-02 Ehrfeld Mikrotechnik Bts Gmbh Verfahren und Vorrichtung zur Markierung von Proteinen
CN117466980A (zh) * 2023-11-02 2024-01-30 浙江普罗亭健康科技有限公司 基于多肽链骨架应用于金属抗体标记的负载金属缀合物及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2652004B1 (fr) * 1989-09-21 1994-10-28 Immunotech Partners Nouveaux derives hydrophiles, application au diagnostic et a la therapeutique, kits diagnostiques ou therapeutiques et reactifs immunologiques.
DE69111401T2 (de) * 1990-12-21 1996-02-22 Pliva Pharm & Chem Works Tert-Butyloxycarbonyl-L-Tyrosyl-Peptidoglycanmonomer und deren 125 I-markiertes Derivat, deren Herstellung und Verwendung.

Also Published As

Publication number Publication date
JP2000517316A (ja) 2000-12-26
DE69702398T2 (de) 2001-02-15
EP0915710A2 (de) 1999-05-19
DE69702398D1 (de) 2000-08-03
WO1998008548A3 (en) 1998-04-23
AU718859B2 (en) 2000-04-20
CA2263985A1 (en) 1998-03-05
EP0915710B1 (de) 2000-06-28
JP3992745B2 (ja) 2007-10-17
AU4328797A (en) 1998-03-19
WO1998008548A2 (en) 1998-03-05

Similar Documents

Publication Publication Date Title
ATE220336T1 (de) Stabile radiojodkonjugate und verfahren zu deren herstellung
EE05435B1 (et) Antikeha, mis on spetsiifilise afiinsusega fibronektiini ED-B regioonile iseloomuliku epitoobi suhtes ja seda sisaldav konjugaat ning nende kasutamine meditsiinis
DK0684843T3 (da) Technetium-99m-mærkede peptider til diagnostisk billeddannelse af inflammation
DK1135498T3 (da) Antistofvarianter med höjere bindingsaffinitet end forældreantistoffer
ATE58297T1 (de) Kupplungsmittel zum radiomarkieren von proteinen.
ATE470714T1 (de) Antikörper gegen doppelintegrinen, zusammensetzungen, verfahren und verwendungen
ATE230020T1 (de) Katalytische antikörperkomponente
WO2005084390A3 (en) Partially loaded antibodies and methods of their conjugation
EP1420032A4 (de) ANTIKÖRPER, DER DAS GM1-GANGLIOSID-GEBUNDENE AMYLOID-b-PROTEIN ERKENNT, UND DNA, DIE FÜR DIESEN ANTIKÖRPER CODIERT
DE69937899D1 (de) Antikörper-serumprotein hybride
DE3750342D1 (de) Menschliches gamma-interferon-spezifisches Rezeptorprotein, Antikörper gegen dieses Protein, Verfahren zur Herstellung dieses Proteins und dieses Antikörpers und dieses Protein und diesen Antikörper enthaltende Zusammensetzungen.
DE69834808D1 (de) Multiple,kohlenhydrathaltige glycopeptid-antigene, daraus entwickelte impfstoffe sowie deren verwendung
ATE160222T1 (de) Photoaktivierung von proteinen zu konjugationszwecken
DE69434384D1 (de) Metalkomplexbildner
FI893428A7 (fi) TNF-a:n in vitro ja in vivo toksisten ominaisuuksien eliminointi monoklonaalisilla vasta-aineilla ja niistä johdetuilla fragmenteilla
ATE194143T1 (de) Stabile radioiodium-konjugate und verfahren zu deren herstellung
ATE395363T1 (de) Monoklonale antikörper gegen das protein g3bp und deren verwendungen
WO2001057219A3 (en) Mammalian interleukin-1-delta and -epsilon. their use in therapeutic and diagnostic methods
ATE193534T1 (de) Benzodiazepin-derivate sowie deren konjugate mit proteinen und polypeptiden
ES2092514T3 (es) Conjugados de anticuerpos de dominio variable.
WO2002002150A8 (en) Stable radioiodine conjugates and methods for their synthesis
FI956041A7 (fi) Kompositiot ja diagnostiset menetelmät, joissa käytetään monoklonaalis ia vasta-aineita CD44V6 vastaan
NO951061L (no) Antistoffkonjugater med forbedrede egenskaper
WO1999018131A3 (de) Anti-bip-antikörper bei rheumatoider arthritis sowie verfahren und testkits zu ihrer bestimmung
DE59913439D1 (de) Anti-petasin-antikörper, verfahren zu ihrer herstellung und ihre verwendung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties