ATE194338T1 - Diphenylthiazolderivate mit antiinflammatorischer aktivität - Google Patents
Diphenylthiazolderivate mit antiinflammatorischer aktivitätInfo
- Publication number
- ATE194338T1 ATE194338T1 AT91905483T AT91905483T ATE194338T1 AT E194338 T1 ATE194338 T1 AT E194338T1 AT 91905483 T AT91905483 T AT 91905483T AT 91905483 T AT91905483 T AT 91905483T AT E194338 T1 ATE194338 T1 AT E194338T1
- Authority
- AT
- Austria
- Prior art keywords
- alkanesulfonyl
- halogenated
- inflammatory activity
- represents hydrogen
- diphenylthiazole
- Prior art date
Links
- MIECVJDZXBUVSN-UHFFFAOYSA-N 2,4-diphenyl-1,3-thiazole Chemical class C=1SC(C=2C=CC=CC=2)=NC=1C1=CC=CC=C1 MIECVJDZXBUVSN-UHFFFAOYSA-N 0.000 title abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 5
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 abstract 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000029142 excretion Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- -1 nitro, amino, methanesulfonyloxy Chemical group 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 229940116269 uric acid Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/50—Nitrogen atoms bound to hetero atoms
- C07D277/52—Nitrogen atoms bound to hetero atoms to sulfur atoms, e.g. sulfonamides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP1991/000310 WO1992015570A1 (en) | 1991-03-07 | 1991-03-07 | Novel diphenylthyazole derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE194338T1 true ATE194338T1 (de) | 2000-07-15 |
Family
ID=14014315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91905483T ATE194338T1 (de) | 1991-03-07 | 1991-03-07 | Diphenylthiazolderivate mit antiinflammatorischer aktivität |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5449783A (de) |
| EP (1) | EP0592664B1 (de) |
| KR (1) | KR960009425B1 (de) |
| AT (1) | ATE194338T1 (de) |
| AU (1) | AU654125B2 (de) |
| DE (1) | DE69132293D1 (de) |
| WO (1) | WO1992015570A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU689972B2 (en) * | 1994-11-29 | 1998-04-09 | Hisamitsu Pharmaceutical Co., Inc. | Antibacterial preparation or bactericide comprising 2-aminothiazole derivative and/or salt thereof |
| US6515014B2 (en) | 1995-06-02 | 2003-02-04 | G. D. Searle & Co. | Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
| US6512121B2 (en) | 1998-09-14 | 2003-01-28 | G.D. Searle & Co. | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
| CA2223154A1 (en) | 1995-06-02 | 1996-12-05 | G.D. Searle & Co. | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
| US6677364B2 (en) | 1998-04-20 | 2004-01-13 | G.D. Searle & Co. | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
| US20030105144A1 (en) | 2001-04-17 | 2003-06-05 | Ping Gao | Stabilized oral pharmaceutical composition |
| WO2003015777A1 (en) * | 2001-08-13 | 2003-02-27 | Lion Bioscience Ag | Nr1h4 nuclear receptor binding compounds |
| US7329401B2 (en) | 2002-04-15 | 2008-02-12 | The Regents Of The University Of California | Cyclooxygenase-2 selective agents useful as imaging probes and related methods |
| JP4758337B2 (ja) * | 2003-03-31 | 2011-08-24 | 株式会社アールテック・ウエノ | 血管透過性亢進疾患を治療する方法 |
| MX2022005809A (es) * | 2019-11-12 | 2022-06-08 | Genzyme Corp | Heteroarilaminosulfonamidas de 5 miembros para tratar afecciones mediadas por una actividad deficiente del regulador de la conductancia a nivel transmembranario de la fibrosis quistica (cftr). |
| EP4058434A1 (de) | 2019-11-12 | 2022-09-21 | Genzyme Corporation | 6-gliedrige heteroarylaminosulfonamide zum behandeln von krankheiten und zuständen, die durch mangelnde cftr-aktivität vermittelt werden |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3458526A (en) * | 1966-09-26 | 1969-07-29 | Upjohn Co | Certain 2-amino-4,5-bis(p-methoxyphenyl)thiazoles |
| CH587836A5 (de) * | 1974-01-31 | 1977-05-13 | Serono Lab | |
| US4168315A (en) * | 1977-09-28 | 1979-09-18 | The Upjohn Company | Dianisyl thiazole compound, compositions and method of antithrombotic treatment |
| DK150068C (da) * | 1978-06-02 | 1987-06-29 | Pfizer | Analogifremgangsmaade til fremstilling af aminothiazoler |
| JPS57118574A (en) * | 1981-01-13 | 1982-07-23 | Mitsui Toatsu Chem Inc | N-(4-phenylthiazol-2-yl)carbamate derivative, its preparation and medicinal composition containing the same |
| JPS5857366A (ja) * | 1981-10-02 | 1983-04-05 | Yamanouchi Pharmaceut Co Ltd | ３，５−ジ−ｔｅｒｔ−ブチル−４−ヒドロキシフエニル置換複素環化合物 |
| JPS58198474A (ja) * | 1982-05-13 | 1983-11-18 | Mitsui Toatsu Chem Inc | アミノメチレンマロン酸エステル誘導体と製造法及び殺菌剤 |
| DD225130A1 (de) * | 1983-08-31 | 1985-07-24 | Univ Berlin Humboldt | Verfahren zur herstellung n-funktionalisierter 2-aminothiazole |
| JPH0753666B2 (ja) * | 1987-09-14 | 1995-06-07 | 久光製薬株式会社 | 置換ジフェニルチアゾール誘導体からなる抗炎症剤 |
| JP3003148B2 (ja) * | 1989-01-05 | 2000-01-24 | 藤沢薬品工業株式会社 | チアゾール化合物、その製造法およびそれを含有する医薬組成物 |
| CA2012716A1 (en) * | 1989-03-22 | 1990-09-22 | Akito Tanaka | Thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same |
| JPH078863B2 (ja) * | 1989-09-21 | 1995-02-01 | 久光製薬株式会社 | 新規なジフェニルチアゾール誘導体 |
| JPH04173782A (ja) * | 1990-11-08 | 1992-06-22 | Taisho Pharmaceut Co Ltd | ２―スルホンアミド―４，５―ジフェニルチアゾール誘導体 |
| GB2253297B (en) * | 1991-02-27 | 1994-11-16 | Mars Inc | Coin validation |
-
1991
- 1991-03-07 AU AU74527/91A patent/AU654125B2/en not_active Ceased
- 1991-03-07 DE DE69132293T patent/DE69132293D1/de not_active Expired - Lifetime
- 1991-03-07 AT AT91905483T patent/ATE194338T1/de not_active IP Right Cessation
- 1991-03-07 WO PCT/JP1991/000310 patent/WO1992015570A1/ja not_active Ceased
- 1991-03-07 EP EP91905483A patent/EP0592664B1/de not_active Expired - Lifetime
-
1992
- 1992-03-07 US US08/108,572 patent/US5449783A/en not_active Expired - Fee Related
-
1993
- 1993-08-26 KR KR93702563A patent/KR960009425B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5449783A (en) | 1995-09-12 |
| WO1992015570A1 (en) | 1992-09-17 |
| AU7452791A (en) | 1992-10-06 |
| EP0592664B1 (de) | 2000-07-05 |
| EP0592664A4 (en) | 1994-06-22 |
| KR960009425B1 (en) | 1996-07-19 |
| DE69132293D1 (de) | 2000-08-10 |
| KR930703278A (ko) | 1993-11-29 |
| EP0592664A1 (de) | 1994-04-20 |
| AU654125B2 (en) | 1994-10-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |