ATE194345T1 - Xanthinderivate - Google Patents

Xanthinderivate

Info

Publication number: ATE194345T1
Authority: AT; Austria
Prior art keywords: substituted; group; unsubstituted; formula; pct
Prior art date: 1990-12-21

Application number

AT92901589T

Other languages

English (en)

Inventor

David Glynn Smith

Derek Richard Buckle

Ashley Edward Fenwick

Original Assignee

Beecham Group Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-21

Filing date

1991-12-19

Publication date

2000-07-15

1990-12-21 Priority claimed from GB909027899A external-priority patent/GB9027899D0/en

1990-12-21 Priority claimed from GB909027752A external-priority patent/GB9027752D0/en

1991-12-19 Application filed by Beecham Group Plc filed Critical Beecham Group Plc

2000-07-15 Application granted granted Critical

2000-07-15 Publication of ATE194345T1 publication Critical patent/ATE194345T1/de

Links

LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 title 1
229940083747 low-ceiling diuretics xanthine derivative Drugs 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 6
150000001875 compounds Chemical class 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000003118 aryl group Chemical group 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000005544 phthalimido group Chemical group 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Pulmonology (AREA)
Animal Behavior & Ethology (AREA)
Immunology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Led Devices (AREA)
Crystals, And After-Treatments Of Crystals (AREA)
Medicines Containing Plant Substances (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT92901589T 1990-12-21 1991-12-19 Xanthinderivate ATE194345T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB909027899A GB9027899D0 (en)	1990-12-21	1990-12-21	Novel compounds
GB909027752A GB9027752D0 (en)	1990-12-21	1990-12-21	Novel compounds
PCT/GB1991/002286 WO1992011260A1 (en)	1990-12-21	1991-12-19	Xanthine derivatives

Publications (1)

Publication Number	Publication Date
ATE194345T1 true ATE194345T1 (de)	2000-07-15

Family

ID=26298155

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92901589T ATE194345T1 (de)	1990-12-21	1991-12-19	Xanthinderivate

Country Status (14)

Country	Link
US (1)	US5409934A (de)
EP (1)	EP0563168B1 (de)
JP (1)	JPH06504534A (de)
KR (1)	KR930703319A (de)
AT (1)	ATE194345T1 (de)
AU (1)	AU649091B2 (de)
CA (1)	CA2098846A1 (de)
DE (1)	DE69132291T2 (de)
ES (1)	ES2148170T3 (de)
IE (1)	IE914502A1 (de)
MX (1)	MX9102766A (de)
NZ (1)	NZ241158A (de)
PT (1)	PT99919B (de)
WO (1)	WO1992011260A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9210839D0 (en) *	1992-05-21	1992-07-08	Smithkline Beecham Plc	Novel compounds
US5646156A (en) *	1994-04-25	1997-07-08	Merck & Co., Inc.	Inhibition of eosinophil activation through A3 adenosine receptor antagonism
WO1996036638A1 (en) *	1995-05-19	1996-11-21	Chiroscience Limited	Xanthines and their therapeutic use
US5981549A (en) *	1997-02-14	1999-11-09	Synapse Pharmaceutical International	Method for controlling or alleviating the symptoms of respiratory disease and allergies
AR015966A1 (es) *	1997-10-17	2001-05-30	Smithkline Beecham Corp	Uso de un compuesto inhibidor de pde4 para la preparacion de un medicamento util para el tratamiento de prurito
US6133273A (en) *	1998-05-08	2000-10-17	American Home Products Corporation	Pyrazolopyrimidine-2,4-dione sulfonamides
US6221874B1 (en) *	1998-05-08	2001-04-24	American Home Products Corporation	Method of treating bone loss by stimulation of calcitonin
CA2383351C (en) *	1999-08-31	2005-11-01	Vanderbilt University	Xanthine derivatives as selective antagonists of a2b adenosine receptors
US6821978B2 (en) *	2000-09-19	2004-11-23	Schering Corporation	Xanthine phosphodiesterase V inhibitors
JP3998118B2 (ja) *	2000-10-10	2007-10-24	本田技研工業株式会社	電動車両
ATE395349T1 (de) *	2001-08-28	2008-05-15	Schering Corp	Polycyclische guanin phosphodiesterase inhibitoren
CA2465893A1 (en) *	2001-11-09	2003-05-22	Schering Corporation	Polycyclic guanine derivative phosphodiesterase v inhibitors
SI1509525T1 (sl)	2002-05-31	2006-12-31	Schering Corp	Postopek priprave inhibitorjev ksantinske fosfodiesteraze V in njihovih prekurzorjev
US6924140B2 (en) *	2002-06-14	2005-08-02	Lewis J. Daly	Closed loop work station bioremediation using mini-reactor cartridges
WO2004009091A1 (en)	2002-06-17	2004-01-29	Glaxo Group Limited	Purine derivatives as liver x receptor agonists
ES2284056T3 (es) *	2003-07-31	2007-11-01	Schering Corporation	Metabolito de inhibidor de fosfodiesterasa 5 de xantina y sus derivados, utiles para el tratamiento de la disfuncion erectil.
AR047948A1 (es) *	2003-11-21	2006-03-15	Schering Corp	Formulaciuones de inhibidores de la fosfodiesterasa v
US20070004745A1 (en) *	2005-03-25	2007-01-04	Schering-Plough Corporation	Methods of treating benign prostatic hyperplasia or lower urinary tract symptoms by using PDE 5 inhibitors
WO2007143705A2 (en)	2006-06-06	2007-12-13	Intra-Cellular Therapies, Inc.	Organic compounds
JP5701608B2 (ja)	2007-12-06	2015-04-15	イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−ＣｅｌｌｕｌａｒＴｈｅｒａｐｉｅｓ，Ｉｎｃ．	有機化合物
EP2367430B1 (de)	2008-12-06	2014-08-13	Intra-Cellular Therapies, Inc.	Organische verbindungen
EA201170773A1 (ru)	2008-12-06	2012-01-30	Интра-Селлулар Терапиз, Инк.	Органические соединения
BRPI0922809A2 (pt)	2008-12-06	2018-05-29	Intracellular Therapies Inc	compostos orgânicos
US9434730B2 (en)	2010-05-31	2016-09-06	Intra-Cellular Therapies, Inc.	PDE1 inhibitor compounds
EP2590657A4 (de)	2010-05-31	2014-02-12	Intra Cellular Therapies Inc	Organische verbindungen
US9546175B2 (en)	2014-08-07	2017-01-17	Intra-Cellular Therapies, Inc.	Organic compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3900474A (en) *	1973-05-14	1975-08-19	Kendall & Co	Trifluoroalkyl, fluorobenzyl, pentafluorobenzyl, fluorobenzenesulfonyl, and pentafluorobenzenesulfonyl theophyllines
GB8906792D0 (en) *	1989-03-23	1989-05-10	Beecham Wuelfing Gmbh & Co Kg	Treatment and compounds
DE3916469A1 (de) *	1989-05-20	1990-11-22	Basf Ag	Sulfonamide
GB9020921D0 (en) *	1990-09-26	1990-11-07	Beecham Group Plc	Novel compounds
GB9020959D0 (en) *	1990-09-26	1990-11-07	Beecham Group Plc	Novel compounds

1991
- 1991-12-19 DE DE69132291T patent/DE69132291T2/de not_active Expired - Fee Related
- 1991-12-19 KR KR1019930701921A patent/KR930703319A/ko not_active Withdrawn
- 1991-12-19 ES ES92901589T patent/ES2148170T3/es not_active Expired - Lifetime
- 1991-12-19 AU AU91227/91A patent/AU649091B2/en not_active Ceased
- 1991-12-19 WO PCT/GB1991/002286 patent/WO1992011260A1/en not_active Ceased
- 1991-12-19 AT AT92901589T patent/ATE194345T1/de not_active IP Right Cessation
- 1991-12-19 EP EP92901589A patent/EP0563168B1/de not_active Expired - Lifetime
- 1991-12-19 CA CA002098846A patent/CA2098846A1/en not_active Abandoned
- 1991-12-19 US US08/078,152 patent/US5409934A/en not_active Expired - Fee Related
- 1991-12-19 JP JP4502143A patent/JPH06504534A/ja active Pending
- 1991-12-20 IE IE450291A patent/IE914502A1/en not_active Application Discontinuation
- 1991-12-20 PT PT99919A patent/PT99919B/pt not_active IP Right Cessation
- 1991-12-23 NZ NZ241158A patent/NZ241158A/en unknown
- 1991-12-23 MX MX9102766A patent/MX9102766A/es unknown

Also Published As

Publication number	Publication date
IE914502A1 (en)	1992-07-01
DE69132291D1 (en)	2000-08-10
WO1992011260A1 (en)	1992-07-09
EP0563168A1 (de)	1993-10-06
JPH06504534A (ja)	1994-05-26
NZ241158A (en)	1994-12-22
PT99919A (pt)	1992-12-31
DE69132291T2 (de)	2000-12-14
CA2098846A1 (en)	1992-06-22
EP0563168B1 (de)	2000-07-05
AU649091B2 (en)	1994-05-12
PT99919B (pt)	1999-06-30
AU9122791A (en)	1992-07-22
ES2148170T3 (es)	2000-10-16
KR930703319A (ko)	1993-11-29
US5409934A (en)	1995-04-25
MX9102766A (es)	1992-09-01

Legal Events

Date	Code	Title	Description
2001-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE194345T1 (de)	2000-07-15	Xanthinderivate
MY109737A (en)	1997-05-31	Treatment and compounds.
HUP0302969A2 (hu)	2003-12-29	NPY Y5 antagonisták, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
ES8101563A1 (es)	1980-12-16	Un procedimiento para la preparacion de nuevos derivados he-terociclicos
DK490288D0 (da)	1988-09-02	Hidtil ukendte forbindelser
HUP0400757A2 (hu)	2004-07-28	Protein kináz gátló hatású kondenzált pirazolszármazékok és ezeket tartalmazó gyógyszerkészítmények
DK0590919T3 (da)	2000-04-17	Terapeutiske midler mod Parkinsons sygdom
NZ331319A (en)	2000-03-27	Cyclic amine derivatives that are CCR-3 receptor (chemokine receptor) antagonists, compositions containing them and methods for their use (to combat eosinophil induced diseases).
CO5280046A1 (es)	2003-05-30	Agonistas alfa 7 y sus composiciones farmaceuticas
EP0365364A3 (de)	1991-12-11	2-Azetidinonderivate
DK0501892T3 (da)	1996-11-25	Diazoterede heterocykliske N-substituerede derivater, der indeholder en biphenylmethylgruppe, fremstilling af derivaterne samt lægemidler indeholdende disse
DE69003200D1 (de)	1993-10-14	Arylsubstituierte Aminderivate verwendbar in der Krebstherapie.
IL106387A (en)	1997-04-15	Indole derivatives, their preparation and pharmaceutical compositions containing them
SE8101464L (sv)	1981-09-11	2-penem-3-karboxylsyraderivat, deras framstellning och anvendning
MY116952A (en)	2004-04-30	4 substituted 2-carboxy-tetrahydroquinoline derivatives, pharmaceutical compositions comprising them and process for their preparation
DE69206274D1 (de)	1996-01-04	3-ureido-benzodiazepinone verwendbar als cck- oder gastrin-antagonisten.
KR910007883A (ko)	1991-05-30	퀴놀린 유도체, 그의 제조방법 및 용도
BG97221A (bg)	1993-12-24	Ортозаместени бифениламидини и бифенилизанидини и съдържащите ги антидиабетични или хипогликемични средства
ES466366A1 (es)	1978-10-01	Un procedimiento para preparar derivados de metasulfonamido-benzamida.
ATE57930T1 (de)	1990-11-15	Dihydropyridine.
FI830831L (fi)	1983-09-13	Teofyllinyl-alkyl-oxadiazoler, foerfarande foer framstaellning daerav och farmaceutiska kompositioninnehaollande dessa
TW324007B (en)	1998-01-01	N-substituted diazabicycloheptane derivative and its pharmaceutical use
HUP9900914A2 (hu)	1999-07-28	Simaizom sejtburjánzást gátló sztiril-benzimidazol-származékok
ES8401456A1 (es)	1983-12-01	Procedimiento para la preparacion de 2-aminometilfenoles.
HK67287A (en)	1987-09-25	Ergoline derivatives