ES2148170T3 - Derivados de xantina. - Google Patents
Derivados de xantina.Info
- Publication number
- ES2148170T3 ES2148170T3 ES92901589T ES92901589T ES2148170T3 ES 2148170 T3 ES2148170 T3 ES 2148170T3 ES 92901589 T ES92901589 T ES 92901589T ES 92901589 T ES92901589 T ES 92901589T ES 2148170 T3 ES2148170 T3 ES 2148170T3
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- group
- unsubstituted
- formula
- pct
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000005544 phthalimido group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Led Devices (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
UN COMPUESTO DE LA FORMULA (I) O, SI ES APROPIADO, UNA SAL DEL MISMO FARMACEUTICAMENTE ACEPTABLE, EN LA QUE R1 Y R2 CADA UNO INDEPENDIENTEMENTE REPRESENTAN UN GRUPO ALQUILO O UNA MITAD DE LA FORMULA (A): -(CH2)M-A, EN LA QUE M REPRESENTA CERO O UN ENTERO 1,2 O 3 Y A REPRESENTA UN RADICAL HIDROCARBONO CICLICO SUSTITUIDO O INSUSTITUIDO; R3 REPRESENTA HIDROGENO, NO2 O UN ATOMO DE HALOGENO, UN GRUPO ALCOXI O UN GRUPO DE LA FORMULA NRSRT EN LA QUE RS Y RT CADA UNO INDEPENDIENTEMENTE REPRESENTAN HIDROGENO O ALQUILO O RS Y RT JUNTOS CON EL NITROGENO AL CUAL ESTAN UNIDOS, FORMAN UN GRUPO FTALIMIDO, ESTANDO SUSTITUIDO O INSUSTITUIDO EL GRUPO FTALIMIDO EN LA MITAD FENILENO, O R3 REPRESENTA UNA MITAD DE LA FORMULA (B), EN LA QUE R5 REPRESENTA ALQUILO SUSTITUIDO O INSUSTITUIDO O UN GRUPO ARILO SUSTITUIDO O INSUSTITUIDO; Y R6 REPRESENTA HIDROGENO O UN GRUPO SO2R7 EN LA QUE R7 REPRESENTA ALQUILO SUSTITUIDO O INSUSTITUIDO, UN GRUPO ARILO SUSTITUIDO O INSUSTITUIDO; R4 REPRESENTA SO2R8, EN LA QUE R8 REPRESENTA ALQUILO SUSTITUIDO O INSUSTITUIDO O UN GRUPO ARILO SUSTITUIDO O INSUSTITUIDO, O, CUANDO R3 REPRESENTA UNA MITAD DE LA FORMULA ARRIBA DEFINIDA (B), ENTONCES R4 REPRESENTA HIDROGENO O UN GRUPO ALQUILO SUSTITUIDO O INSUSTITUIDO O UN GRUPO BENCILO SUSTITUIDO O INSUSTITUIDO EN EL ANILLO FENILO, UN PROCESO PARA PREPARAR SEMEJANTE COMPUESTO, UNA COMPOSICION QUE COMPRENDE TAL COMPUESTO Y EL USO DE SEMEJANTE COMPUESTO Y COMPOSICION EN MEDICINA.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909027752A GB9027752D0 (en) | 1990-12-21 | 1990-12-21 | Novel compounds |
| GB909027899A GB9027899D0 (en) | 1990-12-21 | 1990-12-21 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2148170T3 true ES2148170T3 (es) | 2000-10-16 |
Family
ID=26298155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92901589T Expired - Lifetime ES2148170T3 (es) | 1990-12-21 | 1991-12-19 | Derivados de xantina. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5409934A (es) |
| EP (1) | EP0563168B1 (es) |
| JP (1) | JPH06504534A (es) |
| KR (1) | KR930703319A (es) |
| AT (1) | ATE194345T1 (es) |
| AU (1) | AU649091B2 (es) |
| CA (1) | CA2098846A1 (es) |
| DE (1) | DE69132291T2 (es) |
| ES (1) | ES2148170T3 (es) |
| IE (1) | IE914502A1 (es) |
| MX (1) | MX9102766A (es) |
| NZ (1) | NZ241158A (es) |
| PT (1) | PT99919B (es) |
| WO (1) | WO1992011260A1 (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9210839D0 (en) * | 1992-05-21 | 1992-07-08 | Smithkline Beecham Plc | Novel compounds |
| US5646156A (en) * | 1994-04-25 | 1997-07-08 | Merck & Co., Inc. | Inhibition of eosinophil activation through A3 adenosine receptor antagonism |
| AU692104B2 (en) * | 1995-05-19 | 1998-05-28 | Darwin Discovery Limited | Xanthines and their therapeutic use |
| US5981549A (en) * | 1997-02-14 | 1999-11-09 | Synapse Pharmaceutical International | Method for controlling or alleviating the symptoms of respiratory disease and allergies |
| AR015966A1 (es) * | 1997-10-17 | 2001-05-30 | Smithkline Beecham Corp | Uso de un compuesto inhibidor de pde4 para la preparacion de un medicamento util para el tratamiento de prurito |
| US6133273A (en) * | 1998-05-08 | 2000-10-17 | American Home Products Corporation | Pyrazolopyrimidine-2,4-dione sulfonamides |
| US6221874B1 (en) * | 1998-05-08 | 2001-04-24 | American Home Products Corporation | Method of treating bone loss by stimulation of calcitonin |
| DE60001969T2 (de) * | 1999-08-31 | 2004-02-05 | Vanderbilt University, Nashville | Selektive antagonisten von a2b adenosinrezeptoren |
| US6821978B2 (en) * | 2000-09-19 | 2004-11-23 | Schering Corporation | Xanthine phosphodiesterase V inhibitors |
| JP3998118B2 (ja) * | 2000-10-10 | 2007-10-24 | 本田技研工業株式会社 | 電動車両 |
| ATE395349T1 (de) * | 2001-08-28 | 2008-05-15 | Schering Corp | Polycyclische guanin phosphodiesterase inhibitoren |
| CA2465893A1 (en) * | 2001-11-09 | 2003-05-22 | Schering Corporation | Polycyclic guanine derivative phosphodiesterase v inhibitors |
| SI1509525T1 (sl) | 2002-05-31 | 2006-12-31 | Schering Corp | Postopek priprave inhibitorjev ksantinske fosfodiesteraze V in njihovih prekurzorjev |
| US6924140B2 (en) * | 2002-06-14 | 2005-08-02 | Lewis J. Daly | Closed loop work station bioremediation using mini-reactor cartridges |
| WO2004009091A1 (en) * | 2002-06-17 | 2004-01-29 | Glaxo Group Limited | Purine derivatives as liver x receptor agonists |
| WO2005012303A1 (en) * | 2003-07-31 | 2005-02-10 | Schering Corporation | Metabolite of xanthine phosphodiesterase 5 inhibitor and derivatives thereof useful for treatment of erectile dysfunction |
| KR20060101762A (ko) * | 2003-11-21 | 2006-09-26 | 쉐링 코포레이션 | 포스포디에스테라제 ｖ 억제제 제형 |
| US20070004745A1 (en) * | 2005-03-25 | 2007-01-04 | Schering-Plough Corporation | Methods of treating benign prostatic hyperplasia or lower urinary tract symptoms by using PDE 5 inhibitors |
| KR20090042227A (ko) | 2006-06-06 | 2009-04-29 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
| EP2240028B1 (en) | 2007-12-06 | 2016-07-20 | Intra-Cellular Therapies, Inc. | Pyrazolopyrimidine-4,6-dione derivatives and their use as pharmaceutical |
| BRPI0922809A2 (pt) | 2008-12-06 | 2018-05-29 | Intracellular Therapies Inc | compostos orgânicos |
| EP2367431B1 (en) | 2008-12-06 | 2015-08-05 | Intra-Cellular Therapies, Inc. | Organic compounds |
| EP2367430B1 (en) | 2008-12-06 | 2014-08-13 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2011153136A1 (en) | 2010-05-31 | 2011-12-08 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2011153135A1 (en) | 2010-05-31 | 2011-12-08 | Intra-Cellular Therapies, Inc. | Organic compounds |
| US9546175B2 (en) | 2014-08-07 | 2017-01-17 | Intra-Cellular Therapies, Inc. | Organic compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3900474A (en) * | 1973-05-14 | 1975-08-19 | Kendall & Co | Trifluoroalkyl, fluorobenzyl, pentafluorobenzyl, fluorobenzenesulfonyl, and pentafluorobenzenesulfonyl theophyllines |
| GB8906792D0 (en) * | 1989-03-23 | 1989-05-10 | Beecham Wuelfing Gmbh & Co Kg | Treatment and compounds |
| DE3916469A1 (de) * | 1989-05-20 | 1990-11-22 | Basf Ag | Sulfonamide |
| GB9020921D0 (en) * | 1990-09-26 | 1990-11-07 | Beecham Group Plc | Novel compounds |
| GB9020959D0 (en) * | 1990-09-26 | 1990-11-07 | Beecham Group Plc | Novel compounds |
-
1991
- 1991-12-19 ES ES92901589T patent/ES2148170T3/es not_active Expired - Lifetime
- 1991-12-19 KR KR1019930701921A patent/KR930703319A/ko not_active Withdrawn
- 1991-12-19 JP JP4502143A patent/JPH06504534A/ja active Pending
- 1991-12-19 EP EP92901589A patent/EP0563168B1/en not_active Expired - Lifetime
- 1991-12-19 WO PCT/GB1991/002286 patent/WO1992011260A1/en not_active Ceased
- 1991-12-19 AU AU91227/91A patent/AU649091B2/en not_active Ceased
- 1991-12-19 CA CA002098846A patent/CA2098846A1/en not_active Abandoned
- 1991-12-19 US US08/078,152 patent/US5409934A/en not_active Expired - Fee Related
- 1991-12-19 AT AT92901589T patent/ATE194345T1/de not_active IP Right Cessation
- 1991-12-19 DE DE69132291T patent/DE69132291T2/de not_active Expired - Fee Related
- 1991-12-20 PT PT99919A patent/PT99919B/pt not_active IP Right Cessation
- 1991-12-20 IE IE450291A patent/IE914502A1/en not_active Application Discontinuation
- 1991-12-23 NZ NZ241158A patent/NZ241158A/en unknown
- 1991-12-23 MX MX9102766A patent/MX9102766A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1992011260A1 (en) | 1992-07-09 |
| PT99919A (pt) | 1992-12-31 |
| AU9122791A (en) | 1992-07-22 |
| US5409934A (en) | 1995-04-25 |
| JPH06504534A (ja) | 1994-05-26 |
| KR930703319A (ko) | 1993-11-29 |
| MX9102766A (es) | 1992-09-01 |
| ATE194345T1 (de) | 2000-07-15 |
| AU649091B2 (en) | 1994-05-12 |
| CA2098846A1 (en) | 1992-06-22 |
| EP0563168B1 (en) | 2000-07-05 |
| DE69132291T2 (de) | 2000-12-14 |
| DE69132291D1 (en) | 2000-08-10 |
| EP0563168A1 (en) | 1993-10-06 |
| PT99919B (pt) | 1999-06-30 |
| NZ241158A (en) | 1994-12-22 |
| IE914502A1 (en) | 1992-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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